Edinburgh Research Explorer

Software and data for endoscopic sensing of alveolar pH

Dataset

Related Edinburgh Organisations

PublisherEdinburgh DataShare
Date made available9 Dec 2016

Abstract

Previously unobtainable measurements of alveolar pH were obtained using an endoscope-deployable optrode. The pH sensing was achieved using functionalized gold nanoshell sensors and surface enhanced Raman spectroscopy (SERS). The optrode consisted of an asymmetric dual-core optical fiber designed for spatially separating the optical pump delivery and signal collection, in order to circumvent the unwanted Raman signal generated within the fiber. Using this approach, we demonstrate a ~100-fold increase in SERS signal-to-fiber background ratio, and demonstrate multiple site pH sensing with a measurement accuracy of ±0.07 pH units in the respiratory acini of an ex vivo ovine lung model. We also demonstrate that alveolar pH changes in response to ventilation.

Data Citation

Choudhury, Debaditya; Tanner, Michael G.; McAughtrie, Sarah; Yu, Fei; Mills, Bethany; Choudhary, Tushar R.; Seth, Sohan; Craven, Thomas H.; Stone, James M.; Mati, Ioulia K.; Campbell, Colin J.; Bradley, Mark; Williams, Christopher K. I.; Dhaliwal, Kevin; Birks, Timothy A.; Thomson, Robert Roderick. (2016). Software and data for endoscopic sensing of alveolar pH, [software]. http://dx.doi.org/10.7488/ds/1583.

Access status

Open

ID: 29478317