Edinburgh Research Explorer

Prof Andrew Jackson, MRCP PhD FRSE FMedSci

Professorial Fellow of Human Genetics, Programme Leader

Profile photo

Willingness to take Ph.D. students: Yes

Education / Academic qualification

Bachelor of Medicine and Bachelor of Surgery, Newcastle University
Bachelor of Science, Newcastle University
B Med Sci: Thyroid antigens in autoimmunity
Doctor of Philosophy (PhD), University of Leeds
Molecular Genetics of Microcephaly

Professional Qualifications

Fellow of Academy of Medical Sciences
Fellow of Royal Society of Edinburgh
Member of European Molecular Biology Organisation
Member of the College of Physicians, MRCP
MB ChB

Biography

Professor Jackson is a Programme Leader at the MRC Human Genetics Unit, University of Edinburgh.   He is also an honorary consultant in Clinical Genetics, and was elected as a member of EMBO in 2013, and as a fellow of the Royal Society of Edinburgh, and the Academy of Medical Sciences in 2014.   He trained in Medicine in Newcastle, graduating BMedSci in 1990 and MBBS in 1993.  His clinical and research postgraduate training was in Newcastle, Leeds and Sheffield, with his PhD undertaken in the laboratory of Prof Geoff Woods on the molecular basis of primary microcephaly. 

Over the past 15 years his research has focussed on the identification of genes for inherited neurological disorders and in defining the functional role of the proteins they encode. The Jackson lab has discovered 12 human disease genes acting in growth and inflammation, all involved in fundamental cellular processes.  From a starting point of human disease, his research goal is to provide new insights into basic biological processes.

Research Interests

My research programme works to identify genes for inherited neurological disorders
and define the functional role of the proteins they encode. I aim to place these genes
into cellular pathways, provide novel insights into biological mechanisms and advance
our understanding of disease processes. In the long term I wish to apply my research
findings to common multifactorial conditions and therapeutics.
Neuro-inflammation. Nucleic acids are potent activators of innate immunity. Innate
immune sensing of nucleic acids provides resistance against viral infection and is
important in the aetiology of autoimmune diseases. Aicardi-Goutières syndrome
(AGS) is an autoinflammatory disorder mimicking in utero viral infection of the brain
and is inherited as an autosomal recessive trait. Phenotypically and immunologically it
exhibits many similarities to Systemic Lupus Erythematosus (SLE). During the last
quinquenium we have identified mutations for this disease in four genes that encode
two nucleases. We hypothesise that in AGS and SLE, nucleic acid byproducts stimulate
a chronic and inappropriate innate immune response. Given that AGS is a monogenic
disorder with a defined molecular basis, we are therefore using it as a model for
common autoimmune disease to explore the cellular pathogenesis and molecular
pathways implicated in nucleic acid triggered inflammatory responses. This should
provide new insights into the aetiology of systemic autoimmune disease and immunemediated
damage of host by its inappropriate response to viral infection.
Growth and human brain size. The greatest difference between mammals is size,
with a 75 million-fold difference between smallest and largest. In addition, a defining
feature of humans is the large evolutionary expansion of the cerebral cortex. In
marked contrast to the exquisite detail in which developmental patterning has been
defined in model organisms, much remains to be learnt about the developmental and
evolutionary factors controlling organ and organism size. Over the last few years we
have identified seven microcephalic primordial dwarfism genes that regulate cerebral
cortex volume and organism size, encoding fundamental components of cellular
machinery controlling cell proliferation. We hypothesise that such genes are
components of common cellular pathway(s) and that these human disorders can
provide novel insights into developmental regulation of organism size. I propose to
pursue genetic, cellular and developmental studies to address this hypothesis and
further define the pathogenesis of these conditions. This work should contribute to our
understanding of vertebrate growth regulation and help us understand how the human
brain evolved. It may also yield new insights into the function of key cellular processes
in development.

Current Research Interests

Genetic disorders of growth, inflammation and the brain

1. Nucleases and Nucleic-acid mediated neuroinflammation

2. Organism growth and human brain size

My research in a nutshell

My research programme identifies new genes for inherited disorders affecting the
human brain. We also study how these genes function using cells and model organisms.
Aicardi-Goutières syndrome is a genetic condition in which faults in genes encoding
enzymes called nucleases, mimic viral infection of the brain. These nucleases may
normally clean up naturally produced ‘waste’ DNA and RNA, with failure of this process
leading to the body mounting an immune reaction against itself. This immune
response mechanism is relevant to common autoimmune diseases such as lupus and
so we are studying these enzymes to understand their normal roles in cells and to
establish what happens when these enzymes fail.
Secondly, we are identifying genes that cause extreme growth failure of the brain and
body. Individuals with primordial dwarfism are often described as the 'smallest people
in the world'. These genes are components of the core cell machinery which controls
cell duplication and mutations likely result in fewer cells being made, leading to a
smaller person. Identifying these genes will help diagnosis and management of these
rare conditions. It may also help us better understand how the body regulates growth,
perhaps shedding light into why humans are bigger than mice and how our brains
evolved to be so large.

Administrative Roles

Co-director of ECAT  (WT funded Clinical PhD programme)

Highlighted research outputs

  1. cGAS surveillance of micronuclei links genome instability to innate immunity

    Research output: Contribution to journalArticle

  2. Ribonuclease H2 mutations induce a cGASSTING-dependent innate immune response

    Research output: Contribution to journalArticle

  3. Lagging-strand replication shapes the mutational landscape of the genome

    Research output: Contribution to journalArticle

  4. Cerebral organoids model human brain development and microcephaly

    Research output: Contribution to journalArticle

  5. Mutations in the pre-replication complex cause Meier-Gorlin syndrome

    Research output: Contribution to journalArticle

View all (75) »

Highlighted research activities & awards

  1. election as Fellow of the Royal Society of Edinburgh

    Activity: Awards and AccoladesElection to learned society

  2. election as Fellow of the Academy of Medical Sciences

    Activity: Awards and AccoladesElection to learned society

  3. Elected to EMBO membership

    Activity: Awards and AccoladesElection to learned society

View all (3) »

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