Edinburgh Research Explorer
Profile photo

Phone: +44 (0)131 651 9162

Current Research Interests

Pathophysiologic mechanisms underlying complex lung disease with an emphasis on the potential utility of lung-directed gene therapy using the sheep as a model system.

Research Interests

Our group has a longstanding interest in developing a closer understanding of the mechanisms that underlay lung disease in domestic animals and man such that appropriate directed therapies can be developed and validated in a pre-clinical setting prior to their evaluation in a clinical context.

Current emphasis is largely directed towards developing lung-directed gene therapy as a viable clinical entity. The driver in this instance is our involvement as a core facility within the UK Cystic Fibrosis Gene Therapy Consortium, a grouping of the leading gene therapists in the UK and whose focus is a major UK initiative to conduct the largest ever human gene therapy trial for this condition.

Our current interests also extend to understanding the molecular and cellular mechanisms underlying airway epithelial repair in response to injury and exploring novel therapeutic concepts in this regard. Whilst repair mechanisms involving a range of processes including cellular dedifferentiation, migration, and re-differentiation or transition, are usually very efficient in the normal lung, they are clearly overwhelmed in the context of such chronic diseases as cystic fibrosis, COPD and asthma. With the ever rising burden of such chronic lung disease in the UK the need for developing original therapeutic angles and validating those approaches using relevant model systems is clear.


This group is part of the UK Cystic Fibrosis Gene Therapy Consortium

Medical Genetics Section, Centre for Molecular Medicine, Western General Hospital

The Cystic Fibrosis Trust

Administrative Roles


Internal Committees

University of Edinburgh ethical review committee

R(D)SVS veterinary ethical review committee

Research and graduate studies committee

EBVC Genetic Modification Safety Committee


Highlighted research activities & awards

  1. Big Bang Scotland event 2013

    Activity: Public engagement and outreachFestival/Exhibition

View all (1) »

ID: 6068