Edinburgh Research Explorer

Prof Maurice Gallagher

Personal Chair of Microbial Science and Education

Education / Academic qualification

Bachelor of Science, University of Strathclyde
Doctor of Philosophy (PhD), University of Strathclyde
Methods of assay and purification of asparagine sythetase from mouse pancreas

Willingness to take Ph.D. students: Yes

Title: Applying biotechnology to understanding, detection, and elimination of bacterial pathogens.
Our lab is focused around exploiting biotechnology for addressing issues of microbiology. We focus mainly on bacterial pathogens associated with food borne infection (e.g. Salmonella, Campylobacter, Clostridia) or medical implant infections (e.g. Staphylococcus, Streptococcus, Enterococcus, Enterobacter, Klebsiella). Our aim is, through understanding of bacterial physiology, to develop better ways of detection and elimination of these pathogens. Key approaches include vaccines development; molecular adaptation mechanisms (e.g. cold shock and peroxide stress), development of antibiotic tolerant persister cells in biofilms; biodetection systems for imaging infected implants; synthetic polymers for binding or repelling bacteria (e.g. for surface coatings).
Applicants who are interested in applying biotechnology to fundamental issues of bacteriology or bacterial physiology are encouraged to apply and to develop a specific project related to ongoing work in the laboratory.
References
1) Stress adaptation - Yamanaka, K et al (1998) Mol. Microbiol. 11, 811-818; Craig, JE et al (1998) Microbiol. 144, 697-704. Morgan, HP, Estibeiro, P, Wear, MA, Max, KEA, Heinemann, U, Cubeddu, L, Gallagher, MP , Sadler, PJ, and MD Walkinshaw (2007). Sequence specificity of single-stranded DNA-binding proteins: a novel DNA microarray approach. Nucleic Acids Res. 35: e75.
(2) Host/pathogen interaction - Francis, KP & MP Gallagher(1992) Infect Immun 61, 640-64; Francis, KP, et al (1997) J Bacteriol 179,4046-4048; Taylor et al (1998) Infect Immun 66, 3208-3217.
3) Pernagallo, S, Wu, M, Gallagher, MP and M Bradley (2011). Colonising new frontiers - microarrays reveal biofilm modulating polymers. J. Mater. Chem. Volume 21(1), 96-101.
Subject areas
Microbiology, Biotechnology, Cell Biology, Genetics, Molecular Biology, Food Science, Biochemistry, Immunology

ID: 19506