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Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours

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    Rights statement: © 2005 Tomlinson et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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http://www.biomedcentral.com/1471-2407/5/113
Original languageEnglish
Pages (from-to)113
JournalBMC Cancer
Volume5
DOIs
StatePublished - 2005

Abstract

The tissue-specific translation elongation factor eEF1A2 was recently shown to be a potential oncogene that is overexpressed in ovarian cancer. Although there is no direct evidence for an involvement of eEF1A2 in breast cancer, the genomic region to which EEF1A2 maps, 20q13, is frequently amplified in breast tumours. We therefore sought to establish whether eEF1A2 expression might be upregulated in breast cancer.

Research areas

  • Apoptosis, Blotting, Western, Breast Neoplasms, Cytoskeleton, Female, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Models, Statistical, Ovarian Neoplasms, Peptide Elongation Factor 1, RNA, Receptors, Estrogen, Reverse Transcriptase Polymerase Chain Reaction, Up-Regulation

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