CSF Biomarkers Flags Parkinson's Pathology Years Before Symptoms Appear

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Description

Real-time quaking-induced conversion (RT-QuIC), a test for pathological misfolded protein, detected alpha-synuclein in the cerebrospinal fluid (CSF) of patients with isolated rapid-eye-movement (REM) sleep behavior disorder (IRBD), years before clinical symptoms of Parkinson's disease or dementia with Lewy bodies emerged.

In these patients, RT-QuIC detected misfolded alpha-synuclein in CSF with both sensitivity and specificity of 90%, reported Alison Green, PhD, of the University of Edinburgh in Scotland, and co-authors, in Lancet NeurologyAlpha-synuclein positivity was associated with increased risk of subsequent diagnosis of Parkinson's disease or dementia with Lewy bodies.

Period4 Mar 2021

Media contributions

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Media contributions

  • TitleCSF Biomarker Flags Parkinson's Pathology Years Before Symptoms Appear
    Media name/outletMed Page Today
    CountryUnited States
    Date4/03/21
    DescriptionReal-time quaking-induced conversion (RT-QuIC), a test for pathological misfolded protein, detected alpha-synuclein in the cerebrospinal fluid (CSF) of patients with isolated rapid-eye-movement (REM) sleep behavior disorder (IRBD), years before clinical symptoms of Parkinson's disease or dementia with Lewy bodies emerged.

    In these patients, RT-QuIC detected misfolded alpha-synuclein in CSF with both sensitivity and specificity of 90%, reported Alison Green, PhD, of the University of Edinburgh in Scotland, and co-authors, in Lancet Neurology. Alpha-synuclein positivity was associated with increased risk of subsequent diagnosis of Parkinson's disease or dementia with Lewy bodies.

    Producer/AuthorJudy George
    PersonsAlison Green