3D scanning electron microscope movie of human neocortex

This movie is from serial block face scanning electron microscopy of neocortex from a post-mortem tissue donation of a person who died with Alzheimer's disease (UK Brain bank number BBN001.36378). Brain samples were obtained with ethical approval via the University of Edinburgh Sudden Death Brain Bank and the Alzheimer Scotland Brain and Tissue Bank. This study was reviewed and approved by the Edinburgh Brain Bank ethics committee and the Academic and Clinical Central Office for Research and Development, a joint office of the University of Edinburgh and NHS Lothian (approval number 15-HV-016). The Edinburgh Brain Bank is a Medical Research Council funded facility with research ethics committee (REC) approval (16/ES/0084).