cAge and bAge EWAS - Epigenome-wide association study of chronological age (linear and quadratic) and of survival

Dataset

Abstract

These datasets correspond to the manuscript “Refining epigenetic prediction of chronological and biological age“. Here, we include the summary statistics for an epigenome-wide association study (EWAS) of age, considering both CpG (linear) and CpG^2 (quadratic) associations, as well as for an EWAS of survival (using a fixed effects Cox Proportional Hazards Model; results for a mixed effects model to account for relatedness included in Supplementary Table 8 of manuscript). Further methodological details, including quality control steps, software used, and covariates adjusted for, are described in the accompanying manuscript. Analyses were conducted using the Generation Scotland cohort (N = 18,413).

Data Citation

Bernabeu, E.; McCartney, Daniel L.; Gadd, Danni A.; Hillary, Robert F.; Lu, Ake T.; Murphy, Lee; Wrobel, Nicola; Campbell, Archie; Harris, Sara E.; Liewald, David; Hayward, Caroline; Porteous, David J.; Sudlow, Cathie; Cox, Simon R.; Evans, Kathy L.; Horvath, Steve; McIntosh, Andrew M.; Robinson, Matthew R.; Vallejos, Catalina A.; Marioni, Riccardo E.. (2022). cAge and bAge EWAS - Epigenome-wide association study of chronological age (linear and quadratic) and of survival, [dataset]. University of Edinburgh. College of Medicine & Veterinary Medicine. Institute of Genetics and Cancer. Centre for Genomic & Experimental Medicine (CGEM). https://doi.org/10.7488/ds/3513.
Date made available1 Oct 2022
PublisherEdinburgh DataShare
Geographical coverageUK,UNITED KINGDOM

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