Chloromethyl-triazole: A new motif for site-selective pseudo-acylation of proteins

  • Richard Brewster (Creator)
  • Georgina C. Gavins (Creator)
  • Barbara Günthardt (Creator)
  • Sarah Farr (Creator)
  • Kimberly M. Webb (Creator)
  • Philipp Voigt (Creator)
  • Alison Hulme (Creator)

Dataset

Abstract

Rapid, site-selective modification of cysteine residues with chloromethyl-triazole derivatives generates pseudo-acyl sLys motifs, mimicking important post-translational modifications. Near-native biotinylation of peptide and protein substrates is shown to be site-selective and modified histone H4 retains functional activity.

Data Citation

Brewster, Richard C; Gavins, Georgina C; Günthardt, Barbara; Farr, Sarah; Webb, Kimberly M; Voigt, Philipp; Hulme, Alison N. (2016). Chloromethyl-triazole: A new motif for site-selective pseudo-acylation of proteins, [dataset]. University of Edinburgh. School of Chemistry. http://dx.doi.org/10.7488/ds/1484.
Date made available16 Sep 2016
PublisherEdinburgh DataShare

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