Abstract
Summary statistics from the genome-wide association study (GWAS) of cornea resistance factor (CRF) of 76,029 UK Biobank samples of British ancestry obtained through the application number 19655.
The CRF analysis was performed on the average of the left and right eye measurements. Any outliers (i.e. CRF greater than population mean difference + 3 standard deviations) were removed. Further phenotypic filtering was applied by removing samples linked to, or self-reporting, ocular conditions that could affect the measurements accuracy such as eye surgery, refractive laser surgery, cataract surgery, glaucoma high pressure surgery or laser treatment, corneal graft surgery, eye injury , keratoconus or cornea disorders. A total of 102490 samples were kept.
Using the genetic quality control of the UK Biobank the 76318 samples of British ancestry with imputed data failing heterozygosity or/and missingness, or having a mismatch between self-reported and genotype-derived gender or showing putative sex chromosome aneuploidy as well as individuals who have withdrawn from the study at the time of analysis were removed. An total of N-76029 were included in the GWAS.
The GWAS was performed on common and low-frequency (MAF > 0.5%) well imputed (INFO > 0.6) variants using a linear mixed model accounting for population structure and (cryptic) relatedness, implemented in the software BOLT_LMM v1.3. Covariates fitted in the model were: age, sex, assessment centre, genotyping array, genotyping batch and the 20 first principal components of ancestry provided by the UK Biobank.
The CRF analysis was performed on the average of the left and right eye measurements. Any outliers (i.e. CRF greater than population mean difference + 3 standard deviations) were removed. Further phenotypic filtering was applied by removing samples linked to, or self-reporting, ocular conditions that could affect the measurements accuracy such as eye surgery, refractive laser surgery, cataract surgery, glaucoma high pressure surgery or laser treatment, corneal graft surgery, eye injury , keratoconus or cornea disorders. A total of 102490 samples were kept.
Using the genetic quality control of the UK Biobank the 76318 samples of British ancestry with imputed data failing heterozygosity or/and missingness, or having a mismatch between self-reported and genotype-derived gender or showing putative sex chromosome aneuploidy as well as individuals who have withdrawn from the study at the time of analysis were removed. An total of N-76029 were included in the GWAS.
The GWAS was performed on common and low-frequency (MAF > 0.5%) well imputed (INFO > 0.6) variants using a linear mixed model accounting for population structure and (cryptic) relatedness, implemented in the software BOLT_LMM v1.3. Covariates fitted in the model were: age, sex, assessment centre, genotyping array, genotyping batch and the 20 first principal components of ancestry provided by the UK Biobank.
Data Citation
Boutin, Thibaud. (2020). Cornea resistance factor GWAS in the UK Biobank, [dataset]. https://doi.org/10.7488/ds/2944
| Date made available | 4 Dec 2020 |
|---|---|
| Publisher | Edinburgh DataShare |
| Geographical coverage | UK,UNITED KINGDOM |