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Development of clinical immunity to Plasmodium vivax following repeat controlled human malaria infection

Dataset

Description

This dataset contains details from a multi-cohort, repeat controlled human malaria infection (CHMI) study with Plasmodium vivax, and a heterologous rechallenge with P. falciparum. Malaria-naïve adults underwent P. vivax CHMI up to three times, at an interval of 5 to 20 months, by administration of red blood cells infected with the P. vivax PvW1 clone. In the final cohort of the study, a subset of participants underwent heterologous repeat CHMI with the P. falciparum 3D7 clone. Clinical parameters and the host response to infection were measured up to 3 months after each CHMI. The dataset includes parasite qPCR and multiplication rates (PMR), serum IgG anti-malarial antibody titres, solicited adverse events, alanine aminotransferase (ALT), albumin and haemoglobin (Hb) measurements as well as lymphocyte and platelet counts and a legendplex assay measuring inflammatory cytokines/chemokines as well as markers of coagulation and endothelium activation. This project was funded by funded by Horizon 2020 MultiViVax (Grant agreement ID: 733073).

Data Citation

Hou, M., & Harding, A. (2025). Development of clinical immunity to Plasmodium vivax following repeat controlled human malaria infection [Data set]. In Nature Communications (Vol. 16, Number 1, p. 8385). Zenodo. https://doi.org/10.5281/zenodo.15927920
Date made available15 Jul 2025
PublisherZenodo

  • Development of clinical immunity to Plasmodium vivax following repeat controlled human malaria infection

    Hou, M. M., Harding, A. C., Barber, N. M., Kundu, P., Bach, F. A., Salkeld, J., Themistocleous, Y., Greenwood, N. M., Cho, J.-S., Barrett, J. R., Nugent, F. L., Rawlinson, T. A., Hodgson, S. H., Khozoee, B., Mac Lochlainn, D. J., Cowan, R. E., Poulton, I. D., Baker, M., Kingham, L. & Mitton, C. H. & 19 others, Platt, A., Lopez Ramon, R., Ramos Lopez, F., Thomas, M., Skinner, K., Quinkert, D., Pipini, D., Lias, A. M., Bardelli, M., Edwards, N. J., Donnellan, F. R., Biswas, S., Rayner, J. C., Nielsen, C. M., Silk, S. E., Draper, S. J., Nahrendorf, W., Spence, P. J. & Minassian, A. M., 25 Sept 2025, (E-pub ahead of print) In: Nature Communications. 16, 1, 13 p., 8385 .

    Research output: Contribution to journal › Article › peer-review

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