Generation Scotland GWAS Summary Statistics for GDF15

Dataset

Abstract

The Generation Scotland: Scottish Family Health Study (GS:SFHS) is a family-based population cohort with DNA, biological samples, socio-demographic, psychological and clinical data from ~24,000 adult volunteers across Scotland. Although data collection was cross-sectional, GS:SFHS became a prospective cohort due to the ability to link to routine Electronic Health Record (EHR) data. Over 20,000 participants were selected for genotyping using a genome-wide array. Genome-wide association studies (GWAS) were used to test the effects of a spectrum of variants, imputed using the Haplotype Research Consortium (HRC) dataset allowed investigation of variants with low minor allele frequencies in the entire GS:SFHS genotyped cohort. Genome-wide associations were run on 20,032 individuals using both genotyped and HRC imputed data. The dataset contains genome-wide association summary statistics for this project. GWAS summary statistics of GDF15 in the Generation Scotland cohort. Data generated contributed to a paper submitted to Nature, "Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy".
Date made available11 Oct 2023
PublisherEdinburgh DataShare
Geographical coverageUNITED KINGDOM,UK,Scotland and Korcula,Croatia,Scotland

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