Global burden of acute lower respiratory infection associated with human metapneumovirus in children under five years for 2018: a systematic review and modelling study

We provide datasets used in this study in this folder. The datasets include (1) the incidence rate of hMPV associated ALRI (see "ALRI" file); (2) hospitalisation rates of hMPV associated ALRI (see "Hos" file); (3) hospitalisation rates of hMPV with hypoxemia (see "sHos" file); (4) CFR of hMPV associated ALRI (see "CFR" file); (5) main table results (see "main table results" file); (6) proportion positives of hMPV in hospitalised ALRI (see "Prop" file).
Background of this study:
Acute lower respiratory infections (ALRI) are one of the leading causes of morbidity and mortality in children globally, accounting for 10% of mortality in children under five years in 2017.1 Human metapneumovirus (hMPV), first identified in 2001, is an important virus causing ALRI in young children. Previous evidence indicates that almost all children have been infected with hMPV by the age of five, and with most severe infections occurring in infants. Available pooled analyses among different populations have focused on broad age groups, and have shown that hMPV is associated with 6.1–6.4% of hospitalised ALRI among patients under 20 years of age worldwide. Incidence and mortality of hMPV–associated ALRI have only been available in a very limited number of published literature, especially for narrow age groups. There are no global or regional burden estimates for children under five years.
Using the published and unpublished data on laboratory–confirmed (culture, immunofluorescence assay, or molecular test) hMPV morbidity and mortality, we sought to estimate the global and regional number of hMPV–associated ALRI cases, hospitalisations, and mortality by age strata in children under five years for 2018. Since the presence of hMPV in children’s upper respiratory tract does not imply causation, we estimated the global burden of ALRI that are attributable to hMPV by accounting for the causal attribution of hMPV.

Wang, Xin; Nair, Harish. (2020). Global burden of acute lower respiratory infection associated with human metapneumovirus in children under five years for 2018: a systematic review and modelling study, 1995-2019 [dataset]. University of Edinburgh, Usher Institute, Center for Global Health.