Metagenomic characterisation of the caecal microbiota of XCR1 knockout chickens (ANI 99% MAGs: ENA project PRJEB64517)

XCR1+ dendritic cells play an important role in limiting the immune response to members of the gut microbiota, preventing inflammation and maintaining gut homeostasis. Mice lacking XCR1+ cDCs have a proinflammatory gut environment and are prone to opportunistic infections by commensals. As chickens contain greater numbers of these cells in their guts than mammals, it is expected that they would play a larger role in controlling gut inflammation. Increased inflammation caused by a lack of these cells is expected to select against commensal bacteria and promote opportunistic pathogen growth.

Raw sequencing files, primary assemblies and metagenome assembled genomes (MAGs) that were dereplicated at the species level (95% ANI) have been uploaded to the European Nucleotide Archive (project PRJEB64517). This dataset contains all MAGs produced from this project, dereplicated at a strain level (99% ANI).