Mitotic chromosomes fold by condensin-dependent helical winding of chromatin loop arrays

Johan H. Gibcus (Creator)
Anton Goloborodko (Creator)
Kumiko Samejima (Creator)
Itaru Samejima (Creator)
Natalia Naumova (Creator)
Masato T Kanemaki (Creator)
Linfeng Xie (Creator)
James R. Paulson (Creator)
Bill Earnshaw (Creator)
Leonid A Mirny (Creator)
Job Dekker (Creator)

School of Biological Sciences

Dataset

Description

Chromosome organization investigation through Hi-C

Abstract

Mitotic chromosome morphogenesis occurs through condensin-mediated disassembly of the interphase conformation and formation of extended prophase loop arrays that then shorten by condensin-dependent helical winding.

Data Citation

Gibcus JH, Samejima K, Goloborodko A, Samejima I et al. A pathway for mitotic chromosome formation. Science 2018 Feb 9;359(6376). PMID: 29348367

Date made available	18 Jan 2018
Publisher	National Center for Biotechnology Information (Gene Expression Omnibus)

Access Dataset

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE102740

1 Article

A pathway for mitotic chromosome formation
Gibcus, J. H., Samejima, K., Goloborodko, A., Samejima, I., Naumova, N., Nuebler, J., Kanemaki, M. T., Xie, L., Paulson, J. R., Earnshaw, W. C., Mirny, L. A. & Dekker, J., 9 Feb 2018, In: Science. 359, 6376, 14 p., eaao6135.
Research output: Contribution to journal › Article › peer-review

Open Access
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Cite this

Gibcus, J. H. (Creator), Goloborodko, A. (Creator), Samejima, K. (Creator), Samejima, I. (Creator), Naumova, N. (Creator), Kanemaki, M. T. (Creator), Xie, L. (Creator), Paulson, J. R. (Creator), Earnshaw, W. (Creator), Mirny, L. A. (Creator), Dekker, J. (Creator) (18 Jan 2018). Mitotic chromosomes fold by condensin-dependent helical winding of chromatin loop arrays. National Center for Biotechnology Information (Gene Expression Omnibus).