Chromosome organization investigation through Hi-C
Mitotic chromosome morphogenesis occurs through condensin-mediated disassembly of the interphase conformation and formation of extended prophase loop arrays that then shorten by condensin-dependent helical winding.
Gibcus JH, Samejima K, Goloborodko A, Samejima I et al. A pathway for mitotic chromosome formation. Science 2018 Feb 9;359(6376). PMID: 29348367
Research output: Contribution to journal › Article › peer-review
Gibcus, J. H. (Creator), Goloborodko, A. (Creator), Samejima, K. (Creator), Samejima, I. (Creator), Naumova, N. (Creator), Kanemaki, M. T. (Creator), Xie, L. (Creator), Paulson, J. R. (Creator), Earnshaw, W. (Creator), Mirny, L. A. (Creator), Dekker, J. (Creator) (18 Jan 2018). Mitotic chromosomes fold by condensin-dependent helical winding of chromatin loop arrays. National Center for Biotechnology Information (Gene Expression Omnibus).