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Mitotic chromosomes fold by condensin-dependent helical winding of chromatin loop arrays

  • Johan H. Gibcus (Creator)
  • Anton Goloborodko (Creator)
  • Kumiko Samejima (Creator)
  • Itaru Samejima (Creator)
  • Natalia Naumova (Creator)
  • Masato T Kanemaki (Creator)
  • Linfeng Xie (Creator)
  • James R. Paulson (Creator)
  • William Earnshaw (Creator)
  • Leonid A Mirny (Creator)
  • Job Dekker (Creator)

Dataset

Description

Chromosome organization investigation through Hi-C

Abstract

Mitotic chromosome morphogenesis occurs through condensin-mediated disassembly of the interphase conformation and formation of extended prophase loop arrays that then shorten by condensin-dependent helical winding.

Data Citation

Gibcus JH, Samejima K, Goloborodko A, Samejima I et al. A pathway for mitotic chromosome formation. Science 2018 Feb 9;359(6376). PMID: 29348367
Date made available18 Jan 2018
PublisherNational Center for Biotechnology Information (Gene Expression Omnibus)

Access Dataset

  • A pathway for mitotic chromosome formation

    Gibcus, J. H., Samejima, K., Goloborodko, A., Samejima, I., Naumova, N., Nuebler, J., Kanemaki, M. T., Xie, L., Paulson, J. R., Earnshaw, W. C., Mirny, L. A. & Dekker, J., 9 Feb 2018, In: Science. 359, 6376, 14 p., eaao6135.

    Research output: Contribution to journal › Article › peer-review

    Open Access
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