Research output per year
Research output per year
Abstract
We profile the transcriptomes of non-parenchymal cell types present in healthy and cirrhotic human liver. In particular, we uncover a novel scar-associated TREM2+CD9+ macrophage subpopulation, which expands in liver fibrosis, differentiates from circulating monocytes, has a corollary population in mouse liver fibrosis and is pro-fibrogenic. We also define novel ACKR1+ and PLVAP+ endothelial cells which expand in cirrhosis, are topographically scar-restricted and enhance leucocyte transmigration.
Data Citation
Ramachandran, Prakash; Henderson, Neil; Wilson-Kanamori, John Roger. (2019). Resolving the fibrotic niche of human liver cirrhosis at single-cell level - Seurat RData object, [dataset]. University of Edinburgh Centre for Inflammation Research. https://doi.org/10.7488/ds/2637.
| Date made available | 25 Oct 2019 |
|---|---|
| Publisher | Edinburgh DataShare |
Research output
- 1 Article
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Resolving the fibrotic niche of human liver cirrhosis at single-cell level
Ramachandran, P., Dobie, R., Wilson-Kanamori, J. R., Dora, E. F., Henderson, B. E. P., Luu, N. T., Portman, J. R., Matchett, K. P., Brice, M., Marwick, J. A., Taylor, R. S., Efremova, M., Vento-Tormo, R., Carragher, N. O., Kendall, T. J., Fallowfield, J. A., Harrison, E. M., Mole, D. J., Wigmore, S. J., Newsome, P. N., & 8 others, 21 Nov 2019, In: Nature. 575, 7783, p. 512–518Research output: Contribution to journal › Article › peer-review
Open AccessFile
Projects
- 2 Finished
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The Role of Tissue-resident Hepatic Macrophages in the Resolution of Chronic Liver Injury
25/07/16 → 24/07/20
Project: Research
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An intravital imaging approach to elucidate novel mechanisms of organ fibrosis and repair
1/08/14 → 31/01/20
Project: Research