We profile the transcriptomes of non-parenchymal cell types present in healthy and cirrhotic human liver. In particular, we uncover a novel scar-associated TREM2+CD9+ macrophage subpopulation, which expands in liver fibrosis, differentiates from circulating monocytes, has a corollary population in mouse liver fibrosis and is pro-fibrogenic. We also define novel ACKR1+ and PLVAP+ endothelial cells which expand in cirrhosis, are topographically scar-restricted and enhance leucocyte transmigration.
Ramachandran, Prakash; Henderson, Neil; Wilson-Kanamori, John Roger. (2019). Resolving the fibrotic niche of human liver cirrhosis at single-cell level - Seurat RData object, [dataset]. University of Edinburgh Centre for Inflammation Research. https://doi.org/10.7488/ds/2637.