This package contains relevant data and scripts for reproducing the results
presented in the article 'Assessing the utility of autofluorescence-based pulmonary optical endomicroscopy to predict the malignant potential of solitary pulmonary nodules in humans' by Seth et al. Refer to README for more detailed information.
Solitary pulmonary nodules are common, often incidental findings on chest CT scans. The investigation of pulmonary nodules is time-consuming and often leads to protracted follow-up with ongoing radiological surveillance, however, clinical calculators that assess the risk of the nodule being malignant exist to help in the stratification of patients. Furthermore recent advances in interventional pulmonology include the ability to both navigate to nodules and also to perform autofluorescence microendoscopy. In this study we assessed the efficacy of incorporating additional information from label-free fibre-based optical endomicroscopy of the nodule on assessing risk of malignancy. Using image analysis and machine learning approaches, we find that this information does not yield any gain in predictive performance in a cohort of patients.
Seth, Sohan; Williams, Christopher K. I.; Dhaliwal, Kevin; Bradley, Mark. (2015). Software to assess the utility of autofluorescence-based pulmonary optical endomicroscopy to predict the malignant potential of solitary pulmonary nodules in humans, [software]. University of Edinburgh. http://dx.doi.org/10.7488/ds/311.