Summary statistics for the MWAS meta-analysis for major depression (AHRR model)

Xueyi Shen (Creator)
Miruna Carmen Barbu (Contributor)
Doretta Caramaschi (Contributor)
Ryan Arathimos (Contributor)
Darina Czamara (Contributor)
Friederike S. David (Contributor)
Anna Dearman (Contributor)
Evelyn Dilkes (Contributor)
Herrera-Rivero Marisol (Contributor)
Floris Huider (Contributor)
Annemarie Luise Kühn (Contributor)
Kuan-Chen Lu (Contributor)
Teemu Palviainen (Contributor)
Alicia Schowe (Contributor)
Gemma Shireby (Contributor)
Antoine Weihs (Contributor)
Chloe Wong (Contributor)
Eleanor Davidson (Contributor)
Hannah Casey (Contributor)
Mark Adams (Contributor)
Antje-Kathrin Allgaier (Contributor)
Michael Barber (Contributor)
Joe Burrage (Contributor)
Avshalom Caspi (Contributor)
Ricardo Costeira (Contributor)
Erin Dunn (Contributor)
Lisa Feldmann (Contributor)
Josef Franke (Contributor)
Franz J Freisleder (Contributor)
Danni Gadd (Contributor)
Ellen Greimel (Contributor)
Eilis Hannon (Contributor)
Sarah Harris (Contributor)
Georg Homuth (Contributor)
David Howard (King's College London) (Contributor)
Stella Iurato (Contributor)
Tellervo Korhonen (Contributor)
Tzu-Pin Lu (Contributor)
Nicholas G Martin (Contributor)
Jade Martins (Contributor)
Edel McDermott (Contributor)
Susanne Meinert (Contributor)
Pau Navarro (Contributor)
Miina Ollikainen (Contributor)
Verena Pehl (Contributor)
Charlotte Piechaczek (Contributor)
Aline Scherff (Contributor)
Frederike Stein (Contributor)
Fabian Streit (Contributor)
Alexander Teumer (Contributor)
Henry Völzke (Contributor)
Jenny van Dongen (Contributor)
Rosie Walker (University of Exeter) (Contributor)
Natan Yusupov (Contributor)
Louise Arseneault (Contributor)
Jordana Bell (Contributor)
Klaus Berger (Contributor)
Elisabeth Binder (Contributor)
Dorret Boomsma (Contributor)
Simon Cox (Contributor)
Udo Dannlowski (Contributor)
Kathy Evans (Contributor)
Helen Fisher (Contributor)
Andreas J. Forstner (Contributor)
Hans J Grabe (Contributor)
Jaakko Kaprio (Contributor)
Tilo Kircher (Contributor)
Johannes Kopf-Beck (Contributor)
Meena Kumari (Contributor)
Po-Hsiu Kuo (Contributor)
Qingqin S. Li (Contributor)
Terrie Moffitt (Contributor)
Hugh Mulcahy (Contributor)
Therese Murphy (Contributor)
Gerd Schulte-körne (Contributor)
Jonathan Mill (Contributor)
Cathryn Lewis (Contributor)
Naomi Wray (Contributor)
Andrew McIntosh (Contributor)
Marisol Herrera-Rivero (Creator)
Alicia M Schowe (Creator)
Chloe C.Y. Wong (Creator)
Dorret I Boomsma (Creator)
Helen L Fisher (Creator)
Terrie E. Moffitt (Creator)
Therese M Murphy (Creator)
Cathryn M Lewis (Creator)
Naomi R Wray (Creator)
Eleanor Davyson (Creator)
Erin C. Dunn (Creator)
Josef Frank (Creator)
Danni A Gadd (Creator)
Sarah E Harris (Creator)
Aline D Scherff (Creator)
Rosie M Walker (Creator)
Jordana T Bell (Creator)

Dataset

Description

This dataset contains the summary statistics from a large-scale meta-analysis of methylome-wide association studies (MWAS) for Major Depression (MD), conducted by the Psychiatric Genomics Consortium Major Depressive Disorder Working Group and published in Nature Mental Health. The analysis included data from 18 studies comprising 24,754 European-ancestry participants (5,443 MD cases) and an East Asian sample (243 cases, 1846 controls). The study identified fifteen CpG sites significantly associated with lifetime MD, and provided evidence for the involvement of DNA methylation and immune system in MD.

Data Citation

Shen, X. (2025). Summary statistics for the MWAS meta-analysis for major depression (AHRR model) (https://doi.org/10.7488/ds/7929) [Data set]. Nature Publishing House. https://doi.org/10.5281/zenodo.15350052

Date made available	6 May 2025
Publisher	Zenodo
Geographical coverage	UK,UNITED KINGDOM

DOI
10.5281/zenodo.15350052

Access Dataset

software

Cite this

Shen, X. (Creator), Barbu, M. C. (Contributor), Caramaschi, D. (Contributor), Arathimos, R. (Contributor), Czamara, D. (Contributor), David, F. S. (Contributor), Dearman, A. (Contributor), Dilkes, E. (Contributor), Marisol, H. (Contributor), Huider, F. (Contributor), Kühn, A. L. (Contributor), Lu, K. (Contributor), Palviainen, T. (Contributor), Schowe, A. (Contributor), Shireby, G. (Contributor), Weihs, A. (Contributor), Wong, C. (Contributor), Davidson, E. (Contributor), Casey, H. (Contributor), Adams, M. J. (Contributor), Allgaier, A. (Contributor), Barber, M. (Contributor), Burrage, J. (Contributor), caspi, A. (Contributor), Costeira, R. (Contributor), Dunn, E. (Contributor), Feldmann, L. (Contributor), Franke, J. (Contributor), Freisleder, F. J. (Contributor), Gadd, D. (Contributor), Greimel, E. (Contributor), Hannon, E. (Contributor), Harris, S. (Contributor), Homuth, G. (Contributor), Howard, D. (Contributor), Iurato, S. (Contributor), Korhonen, T. (Contributor), LU, T. (Contributor), Martin, N. G. (Contributor), Martins, J. (Contributor), McDermott, E. (Contributor), Meinert, S. (Contributor), Navarro, P. (Contributor), Ollikainen, M. (Contributor), Pehl, V. (Contributor), Piechaczek, C. (Contributor), Scherff, A. (Contributor), Stein, F. (Contributor), Streit, F. (Contributor), Teumer, A. (Contributor), Völzke, H. (Contributor), van Dongen, J. (Contributor), Walker, R. (Contributor), Yusupov, N. (Contributor), Arseneault, L. (Contributor), Bell, J. (Contributor), Berger, K. (Contributor), Binder, E. (Contributor), Boomsma, D. (Contributor), Cox, S. R. (Contributor), Dannlowski, U. (Contributor), Evans, K. (Contributor), Fisher, H. (Contributor), Forstner, A. J. (Contributor), Grabe, H. J. (Contributor), Kaprio, J. (Contributor), Kircher, T. (Contributor), Kopf-Beck, J. (Contributor), Kumari, M. (Contributor), Kuo, P. (Contributor), Li, Q. S. (Contributor), Moffitt, T. (Contributor), mulcahy, H. (Contributor), Murphy, T. (Contributor), Schulte-Körne, G. (Contributor), Mill, J. (Contributor), Lewis, C. (Contributor), Wray, N. (Contributor), McIntosh, A. (Contributor), Herrera-Rivero, M. (Creator), Schowe, A. M. (Creator), Wong, C. C. Y. (Creator), Boomsma, D. I. (Creator), Fisher, H. L. (Creator), Moffitt, T. E. (Creator), Murphy, T. M. (Creator), Lewis, C. M. (Creator), Wray, N. R. (Creator), Davyson, E. (Creator), Dunn, E. C. (Creator), Frank, J. (Creator), Gadd, D. A. (Creator), Harris, S. E. (Creator), Scherff, A. D. (Creator), Walker, R. M. (Creator), Bell, J. T. (Creator) (6 May 2025). Summary statistics for the MWAS meta-analysis for major depression (AHRR model). Zenodo. 10.5281/zenodo.15350052

Summary statistics for the MWAS meta-analysis for major depression (AHRR model)

Description

Data Citation

DOI

Access Dataset

Cite this