Weighted 2D-kernel density estimations provide a new probabilistic measure for epigenetic age - Additional files

This repository contains the following files: Additional file 2: kernels.Rds. .Rds file containing the 27 kernels calculated with our algorithm for the 27 CpG clock (WKDE). Additional file 3: best_parameters.Rds. .Rds file containing the 27 weights for the 27 CpG clock (WKDE). Additional file 4: WKDE_functions.R. .R script containing the functions w2dkage (to calculate epigenetic age), w2dkrange (to calculate probability age functions) and w2dkvs (to calculate variation score) with the 27CpG WKDE method. All the 3 functions have one input: a matrix of DNAm beta values (CpGs in rows, samples in columns).

Perez-Correa, J.-F., Stiehl, T., Marioni, R. E., Corley, J., Cox, S. R., Costa, I. G., & Wagner, W. (2024). Weighted 2D-kernel density estimations provide a new probabilistic measure for epigenetic age - Additional files. Zenodo. https://doi.org/10.5281/zenodo.13890091