Young participants data supporting for "An investigation into semantic cognition in the ageing brain"



This pre-registered fMRI study investigated the nature of age-related neural activation changes within the domain of semantic cognition. We used functional magnetic resonance imaging (fMRI) to examine the neural activity patterns of classic semantic regions and large-scale brain networks and their relationships with task demands. We found that both left and right inferior frontal gyri (IFG) exhibited a linear activation-demand relationship across age groups and semantic tasks, indicating the left IFG as a main semantic area accompanied with a compensation-related recruitment of the right IFG for increasing semantic demands. However, a similar effect was not replicated in anterior temporal regions (ATL). At network-level, we found that aligning with older people’s greater reserves of prior knowledge and declined executive control ability, the senior brain exhibited a greater engagement of the default mode network (DMN) and less of the executive multiple demand network (MDN). Older adults also showed a degraded ability in modulating the activation of MDN as a function of demand in the non-semantic task (but not in the semantic tasks), whereas this ability was preserved in the network contributing specifically for semantic control (SCN). No age-related changes in network coupling were found in the current dataset. These findings depict a comprehensive picture of how the brain adapts in older age, and the factors we found may account for the preserved performance of older people in the semantic domain.
Date made available4 May 2023
PublisherEdinburgh DataShare
Temporal coverage2022 - 2023
Geographical coverageScotland

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