Centre for Inflammation Research

Projects

Projects per year 1994 2000 2002 2004 2006 2007 2008 2009 2010 2011 2012 2013 2014 2028

• 2 Not started
• 17 Active
• 288 Finished

Projects per year

Search results

• Finished

  ECAT Fellowship Catherine Davidson: Effects of FAK signalling on induction of Th17 cells in the tumour microenvironment.

  Serrels, A.

  UK-based charities

  1/08/15 → 31/07/18

  Project: Research

  • Pancreas Adenocarcinoma 100%
  • Pancreas Cancer 100%
  • Antigen Presentation 100%
  • Immune Evasion 100%
  • Therapeutic Procedure 37%

• Scottish Healthcare Associated Infection Prevention Institute (SHAIPI)

  Walsh, T.

  Other

  1/04/15 → 31/03/20

  Project: Research

• SELEX Pilot: LASER Assisted Staphyloccal ERadication prior to orthopaedic implantation surgery (LASER Study)

  Walsh, T., Simpson, H. & Smith, L.

  UK industry, commerce and public corporations

  1/02/15 → 31/10/19

  Project: Research

• Implementing and evaluating Liver Multiscan MRI in rodent liver disease models

  Fallowfield, J., Jansen, M. & McDonald, N.

  31/01/15 → 31/07/15

  Project: Research Collaboration with external organisation

  • Steatosis 100%
  • Fibrosis 100%
  • Liver Disease 100%
  • Disease Model 100%
  • Magnetic Resonance Imaging 100%

• Non-invasive assessment of haemodynamic response to beta-blockers using magnetic resonance imaging in patients with portal hypertension

  Fallowfield, J., Semple, S., Lilburn, D., Macnaught, G., McDonald, N. & Lachlan, N.

  1/01/15 → 1/01/16

  Project: University Awarded Project Funding

  • Portal Hypertension 100%
  • Beta Adrenergic Receptor Blocking Agent 100%
  • Propranolol 66%
  • Liver Disease 33%
  • Carvedilol 33%

• Interactive Multimedia Public engagement projects for INFLAMMATION Research

  Davidson, D.

  1/01/15 → 31/12/15

  Project: University Awarded Project Funding

• R83382 Biomarker-based cellular analysis to predict stages of infection and sepsis

  Walsh, T.

  UK industry, commerce and public corporations

  1/11/14 → 31/10/16

  Project: Research

• Assessment of immunomodulatory compounds in driving M1 to M2 microglia macrophage activation switch in models of myelin injury and repair

  Miron, V.

  BBSRC

  1/10/14 → 30/09/18

  Project: Research

  • Central Nervous System 100%
  • Remyelinization 62%
  • Nervous System Regeneration 60%
  • Microglia 50%
  • Necroptosis 50%

• Investigation of myofibroblast alpha-v integrins as an anti-fibrotic target in biliary atresia

  Henderson, N.

  UK-based charities

  1/10/14 → 30/09/17

  Project: Research

• Full Proposal - Ulipristal acetate versus conventional management of heavy menstrual bleeding (HMB; including uterine fibroids): a randomised controlled trial and exploration of mechanism of action (UCON trial)

  Critchley, H., Bhattacharya, S., Clark, T. J., Hapangama, D., Jane, D., Lee, M., Lumsden, M. A., Nicolls, E., Roberts, N. & Semple, S.

  UK central government bodies/local authorities, health and hospital authorities

  1/10/14 → 31/10/21

  Project: Research

  • Infertility 100%
  • Pregnancy 100%
  • Ulipristal 100%
  • Menorrhagia 100%
  • Levonorgestrel 100%

• Ahsan Akram - Scottish Alliance Framework Agreement

  Frame, M., Ball, K., Brunton, V. & Haslett, C.

  UK industry, commerce and public corporations

  1/09/14 → 31/07/17

  Project: Research

• An intravital imaging approach to elucidate novel mechanisms of organ fibrosis and repair

  Henderson, N.

  UK-based charities

  1/08/14 → 31/01/20

  Project: Research

  • Cells 100%
  • Integrin 48%
  • Endothelial Cell 37%
  • Hepatic Stellate Cell 33%
  • Macrophage 30%

• Pro-oncogenic roles of the Tyro3/Axl/Mer receptor tyrosine kinase axis in non-Hodgkin's B-lymphoma

  Gregory, C. & Dransfield, I.

  UK-based charities

  1/08/14 → 31/07/18

  Project: Research

  • Cells 100%
  • Macrophage 100%
  • B-Cell Lymphoma 100%
  • Clearance 100%
  • Neoplasm 75%

• Reprogramming Alveolar Macrophages in IPF

  Marwick, J., Hirani, N. & Rossi, A.

  UK central government bodies/local authorities, health and hospital authorities

  1/07/14 → 30/06/16

  Project: Research

• The parameters of tissue resident macrophage autonomy

  Jenkins, S.

  MRC

  1/07/14 → 30/06/17

  Project: Research

  • Macrophage 100%
  • Cells 90%
  • Mouse 52%
  • Monocyte 37%
  • Phenotype 28%

• PREVENTING EARLY UNPLANNED HOSPITAL READMISSION FOLLOWING CRITICAL ILLNESS

  Walsh, T.

  UK central government bodies/local authorities, health and hospital authorities

  1/06/14 → 30/09/16

  Project: Research

• In patients with chronic ischaemic heart disease is a more restrictive transfusion strategy compared with a more liberal strategy as effective/safe in relation to new acute coronary events and/or mortality

  Walsh, T.

  UK central government bodies/local authorities, health and hospital authorities

  1/04/14 → 30/07/17

  Project: Research

• Mechanisms of helminth induced antiviral immunity to RSV infection

  Maizels, R.

  MRC

  1/03/14 → 28/08/17

  Project: Research

  • Microflora 100%
  • Viral Disease 100%
  • Interferon Type I 100%
  • Lactobacillus 100%
  • Infectious Agent 100%

• Mechanisms of helminth induced antiviral immunity to RSV infection

  Schwarze, J. & Davidson, D.

  MRC

  1/03/14 → 31/08/17

  Project: Research

• A Phase II, Open-Label, Mutli-Center Study to Assess the Tolerance, Safety, Efficacy and Pharmacokinetics: POL7080002

  Hill, A.

  Other (Learned Society)

  12/02/14 → 1/07/15

  Project: Research

• Translational and Mechanistic Studies of Hemearginate-Mediated Protection of Human Kidney Cells from Injury - Fellowship for Fiona Duthie

  Hughes, J.

  MRC

  6/01/14 → 5/01/17

  Project: Research

  • Macrophage 100%
  • Nephropathy 100%
  • Cells 33%
  • Phenotypic Plasticity 33%
  • Human Study 33%

• Multiplexed fluorescent probes for in vivo imaging of reactive oxygen species in zebrafish inflammatory models

  Vendrell Escobar, M. & Feng, Y.

  1/01/14 → 1/01/15

  Project: University Awarded Project Funding

• Supportive care in the community for people living with advanced liver disease

  Finucane, A., Murray, S., Kendall, M., Boyd, K., Kimbell, B., MacGilchrist, A., Weir, C., Hayes, P., O’Carroll, R. E., Brookes-Young, P. & Deignan , M.

  1/01/14 → 31/12/16

  Project: Research

  • Liver Disease 100%
  • Nurse Specialist 100%
  • Palliative Therapy 100%
  • Patient 100%
  • Quality of Life 28%

• Molecular Probes to Define the Pulmonary Macrophage Response in Rat and Man

  Dhaliwal, K., Haslett, C. & Vendrell Escobar, M.

  UK central government bodies/local authorities, health and hospital authorities

  15/12/13 → 14/06/14

  Project: Research

• Edinburgh Dermatology Research Fund - “Novel antiproteases in atopic dermatitis”

  McHugh, B. & Davidson, D.

  13/12/13 → 12/12/14

  Project: University Awarded Project Funding

  • Proteinase Inhibitor 100%
  • Atopic Dermatitis 100%
  • Dermatology 100%

• The Apelin/APLNR pathway as a marker in the development of haematopoietic stem cells in vivo

  Forrester, L.

  UK-based charities

  1/12/13 → 31/07/17

  Project: Research

• "MIMIC" - Multifunctional Integrated Microsystem for rapid point-of-care TB IdentifiCation

  Hill, A.

  UK central government bodies/local authorities, health and hospital authorities

  1/10/13 → 30/06/17

  Project: Research

• Safety of Nasal Influenza Immunisation in Egg Allergic Children - a multi centre observational study - the SNIFFLE study

  Schwarze, J.

  UK central government bodies/local authorities, health and hospital authorities

  30/09/13 → 30/09/15

  Project: Research

• Deficiency in Lipoxin (LXA4) contributes to persistent neutrophilic airways inflammation in non cystic fibrosis bronchiectasis

  Bedi, P., Davidson, D., Hill, A. & Rossi, A.

  UK central government bodies/local authorities, health and hospital authorities

  1/09/13 → 31/08/16

  Project: Research

  • Prostaglandin 100%
  • Normal Human 100%
  • Mediator 100%
  • Leukotriene 100%
  • Neutrophil Granulocyte 66%

• Manjit Sidhu Led Award - Can bacterial load define chest infections in bronchiectasis?

  Hill, A.

  UK-based charities

  1/08/13 → 31/07/15

  Project: Research

• ENDOIMAGE - Activatable Fluorescent Probes as Smart Diagnostic Tools for Microendoscopy Imaging

  Vendrell Escobar, M.

  EU other

  1/08/13 → 31/07/17

  Project: Research

  • Fluorescence 100%
  • Macrophage 84%
  • Probe 83%
  • Synthesis 75%
  • Quinone 67%

• The role of heat shock protein 90 inhibition as a novel means of modulating ischemia/reperfusion injury in the kidney

  O'Neill, S.

  MRC

  1/08/13 → 31/07/15

  Project: Research

  • Heat Shock Protein 100%
  • Reperfusion Injury 62%
  • Kidney Injury 62%
  • Kidney Ischemia 62%
  • Reperfusion 62%

• DEVELOPMENTAL CLINICAL STUDIES-VALIDATION OF THE UTILITY OF A NOVEL SMARTPROBE DETECTING NEUTROPHIL ACTIVATION/ELASTASE ACTIVITY IN ACUTE LUNG INJURY

  Haslett, C., Dhaliwal, K. & Walsh, T.

  MRC

  1/08/13 → 31/07/16

  Project: Research

  • Lung 100%
  • Neutrophil 59%
  • Imaging Technique 59%
  • Obstetric Delivery 59%
  • Patient 59%

• Exploring the feasibility of using remote respiratory monitoring to detect and manage exacerbations of chronic obstructive pulmonary disease

  Macnee, B.

  UK central government bodies/local authorities, health and hospital authorities

  1/07/13 → 31/03/15

  Project: Research

• The role of heat shock protein 90 in modulating ischaemia-reperfusion injury in the kidney

  O'Neill, S.

  UK-based charities

  1/06/13 → 31/05/14

  Project: Research

• Inverstigation of the role of hepatic stellate cell alpha-v integrins during liver regeneration using a novel conditional genetic system

  Henderson, N.

  UK-based charities

  1/06/13 → 31/07/13

  Project: Research

• Fellowship for Yi Feng: Live imaging and genetic analysis of the inflammatory response upon oncogene induced tissue homeostasis disruption and its contribution to tumour initiation in zebrafish larvae

  Feng, Y.

  UK-based charities

  1/05/13 → 31/12/19

  Project: Research

  • Zebra Fish 100%
  • Tissues 58%
  • Neutrophil 52%
  • Neutrophil Granulocyte 52%
  • Metabolite 44%

• Stem cell derived macrophages as therapeutic vectors in acute kidney injury

  Kluth, D., Forrester, L. & Hughes, J.

  Other

  1/04/13 → 31/03/14

  Project: Research

• The causes and consequences of clinical diversity in Pseudomonas aeruginosa

  Brown, S., Govan, J., Docherty, C., Davidson, D., Reece, S. & Bachmann, T.

  29/03/13 → 28/03/14

  Project: University Awarded Project Funding

• APOTOSIS AND INNATE IMMUNITY IN NON-HODGKIN'S LYMPHOMA

  Gregory, C.

  UK-based charities

  1/03/13 → 29/02/20

  Project: Research

  • Cells 100%
  • Macrophage 100%
  • B-Cell Lymphoma 100%
  • Clearance 100%
  • Neoplasm 75%

• Metabolic Imaging in Carotid Atherosclerosis (MICA Study)

  Semple, S.

  UK-based charities

  1/01/13 → 30/08/15

  Project: Research

• BREATHE study: Protocolised trail of invasive and non-invasive weaning off ventilation

  Walsh, T.

  Other

  1/01/13 → 31/12/16

  Project: Research

• Edinburgh Cancer Reserach UK Centre Award- Clinical Fellowship Award

  Iredale, J., Cameron, D. & Frame, M.

  UK-based charities

  1/01/13 → 31/08/18

  Project: Research

• Developing near-infrared to visible up-conversion nanoparticles for three-dimensional in vivo cancer imaging

  Liu, X., Vendrell Escobar, M., Chang, Y. & Wang, F.

  1/12/12 → 1/12/15

  Project: Project from a former institution

• Orphans Unite: chILD better together European Management Platform for Childhood Interstitial Lung Diseases

  Cunningham, S.

  EU government bodies

  1/12/12 → 30/11/16

  Project: Research

  • Child 100%
  • Interstitial Lung Disorder 100%
  • Cohort Analysis 100%
  • Age 50%
  • Dyspnea 25%

• Persisiting inflammation following critical illness: prevalence, relationship to physical recovery, and esploration of pro-/anti-inflammatory signalling pathways.

  Griffith, D., Rossi, A. & Walsh, T.

  UK central government bodies/local authorities, health and hospital authorities

  1/12/12 → 30/06/14

  Project: Research

  • Electric Potential 100%
  • Human Cytomegalovirus 100%
  • Systemic Inflammation 100%
  • Critical Illness 100%
  • Appetite 100%

• PRO-INFLAMMATORY LUNG DENDRITIC CELLS IN STRATIFIED SEVERE RSV BRONCHIOLITIS

  Schwarze, J.

  MRC

  1/11/12 → 29/02/16

  Project: Research

  • Human Respiratory Syncytial Virus 100%
  • Bronchiolitis 100%
  • Dendritic Cell 100%
  • Infant 50%
  • Lung Lavage 41%

• BIOMARKER BASED CELLULAR ANALYSIS TO PREDICT STAGES OF INFECTION AND SEPSIS

  Walsh, T., Conway-Morris, A. & Weir, C.

  UK central government bodies/local authorities, health and hospital authorities

  1/10/12 → 30/06/15

  Project: Research

  • Patient 100%
  • Cell Surface 89%
  • Leukocyte 89%
  • Sepsis 89%
  • Biological Marker 89%

• PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY

  Iredale, J.

  MRC

  1/09/12 → 31/08/16

  Project: Research

  • Cells 100%
  • Serositis 97%
  • Chronic Obstructive Pulmonary Disease 95%
  • Patient 91%
  • Inpatient 74%

• S/SHIP : JENNIFER FELTON - FUNDS FM MAIN MRC GRANT RA1298

  Iredale, J.

  MRC

  1/09/12 → 31/08/16

  Project: Research

  • Cells 100%
  • Self Concept 60%
  • Plasmacytoid Dendritic Cell 50%
  • Immunity 50%
  • Immune Tolerance 50%