Centre for Inflammation Research

Projects

Projects per year 1994 2000 2002 2004 2006 2007 2008 2009 2010 2011 2012 2013 2014 2026

• 1 Not started
• 13 Active
• 281 Finished

Projects per year

Search results

• Finished

  Fellowship for Prakash Ramachandran - Bone marrow derived macrophages to target the liver scar

  Iredale, J., Forbes, S. & Kluth, D.

  UK-based charities

  21/07/08 → 20/07/11

  Project: Research

• Purchase of gamma irradiators

  Medvinsky, A., Allen, J., Anderton, S., Blackburn, C. & Gray, D.

  UK-based charities

  1/07/08 → 30/06/11

  Project: Research

• Functional domain definition for the immunomodulatory activities of the human cationic host defence peptide LL-37

  Cavanagh, D., Allshire, R., Davidson, D., Free, A., Marston, A. & Walkinshaw, M.

  UK-based charities

  3/06/08 → 31/07/08

  Project: Research

• Macrophage emigartion from the inflamed kidney interstitium: Regulation by apoptotic cells

  Hughes, J. & Savill, J.

  MRC

  12/05/08 → 11/05/11

  Project: Research

  • Macrophage 100%
  • Factor A 100%
  • Granulocyte Macrophage Colony Stimulating Factor 100%
  • Dendritic Cell 58%
  • Colony Stimulating Factor 1 50%

• Clinical Training Fellowship - Dr Karen Mackenzie - The Influence of viral infection on therapeutic immune tolerance in allergic airways disease

  Anderton, S. & Schwarze, J.

  MRC

  21/04/08 → 20/04/11

  Project: Research

  • Epitope Mapping 100%
  • Pseudomonas aeruginosa 100%
  • Clearance 100%
  • Allergen 100%
  • Host Resistance 100%

• In Vivo Transplantation of Hepatocytes from Human Embryonic Stem Cells

  Iredale, J.

  MRC

  15/04/08 → 16/10/10

  Project: Research

• Role of CD46 in the regulation of T Cell activation and its implication in MS

  Astier, A.

  UK-based charities

  1/03/08 → 31/03/12

  Project: Research

  • CD46 100%
  • Processing 37%
  • Multiple Sclerosis 35%
  • T Cell Activation 26%
  • Regulatory Mechanism 21%

• Monocyte-based gene therapy for acute neutrophil-medicated tissue injury

  Dhaliwal, K. & Simpson, J.

  MRC

  1/02/08 → 31/01/10

  Project: Research

  • Neutrophil 100%
  • Monocyte 100%
  • Macrophage 60%
  • Serositis 50%
  • Lipopolysaccharide 50%

• The cationic host defence peptide LL-37 as a potential anti-viral agent in influenza infection

  Davidson, D. & Barlow, P.

  UK-based charities

  1/02/08 → 31/01/09

  Project: Research

• The influence of mechanical strain on hepatic stellate cell function in relation to the development of hepatic fibrosis

  Iredale, J.

  MRC

  7/01/08 → 6/01/11

  Project: Research

  • Dormancy 100%
  • Carcinoma Cell 100%
  • Hepatocellular Carcinoma 100%
  • Cells 44%
  • Cell Proliferation 33%

• The role of Mcl-1 in CDK inhibitor-mediated neutrophil apoptosis and enhanced resolution of bleomycin induced lung injury

  Rossi, A. & Haslett, C.

  UK-based charities

  1/11/07 → 31/10/10

  Project: Research

• Origin and function of the stroma in cholangiocarcinoma

  Forbes, S., Harrison, D. & Iredale, J.

  MRC

  1/11/07 → 31/10/10

  Project: Research

• Regulation of pulmonary inflammation : the role of P2X7 receptors in LL-37-mediated control of granulocyte apoptosis and function

  Davidson, D. & Haslett, C.

  1/10/07 → 30/09/11

  Project: University Awarded Project Funding

• Induction of heme oxygenase-1: A therapeutic approach to reduce hepatic ischaemia reperfusion injury in liver surgery

  McNally, S., Kluth, D. & Ross, J.

  UK central government bodies/local authorities, health and hospital authorities

  1/10/07 → 30/09/10

  Project: Research

• Induction of neutrophil apoptosis and treatment of severe lung inflammation

  Rossi, A.

  MRC

  1/09/07 → 29/02/12

  Project: Research

  • Apoptosis 100%
  • Neutrophil Granulocyte 96%
  • Inflammation 89%
  • Serositis 86%
  • Neutrophil 65%

• Interdisciplinary Centre for Human and Avian Influenza Research

  Haas, J., Dalziel, R., Dransfield, I., Leigh-Brown, A., Savill, N. & Woolhouse, M.

  UK central government bodies/local authorities, health and hospital authorities

  1/09/07 → 30/04/12

  Project: Research

• Effects of HDAC inhibitors on glucocorticoid alteren human neutrophil apoptosis and subsequent macrophage clerance of apoptotic cells

  Rossi, A.

  UK-based charities

  2/08/07 → 30/09/07

  Project: Research

• The role of dendritic cells in rsv infection and rsv induced reactive airways disease

  Schwarze, J.

  UK-based charities

  1/08/07 → 31/07/10

  Project: Research

  • Human Respiratory Syncytial Virus 100%
  • Bronchiolitis 100%
  • Dendritic Cell 100%
  • Infant 50%
  • Lung Lavage 41%

• Exacerbations of COPD and CHD

  Macnee, B. & McAllister, D.

  UK-based charities

  1/08/07 → 28/02/09

  Project: Research

• Hypoxia inducible factor (HIF1) an endometrial remodelling: relevance to menstrual bleeding

  Critchley, H. & Hirani, N.

  MRC

  1/06/07 → 30/07/11

  Project: Research

  • Menstruation 100%
  • Endometrium 89%
  • Regulatory Mechanism 67%
  • Woman 50%
  • Progesterone 42%

• Research Training Fellowship for David Macfarlane: Determinates of progression on non-alcolholic fatty liver disease

  Walker, B., Andrew, R., Iredale, J. & Nyirenda, M.

  UK-based charities

  1/06/07 → 30/05/09

  Project: Research

• Vacation Scholarship for Miss Pei Pei Lee: The study of the role of elastin turnover in defining reversibility of liver fibrosis.

  Iredale, J.

  UK-based charities

  1/06/07 → 27/07/07

  Project: Research

• The functional role of macrophages in the progression and resolution of lung fibrosis

  Forbes, S., Iredale, J. & Sethi, T.

  MRC

  15/05/07 → 31/07/10

  Project: Research

  • Pulmonary Fibrosis 100%
  • Regulatory Mechanism 100%
  • Idiopathic Pulmonary Fibrosis 52%
  • Monocyte 50%
  • Macrophage 50%

• Equipment Grant "equipment to facilitate studies on bone metabolism and persistant arthritis

  Gray, M., Albagha, O., Ralston, S. & van 't Hof, R.

  Non-EU-based charities

  1/05/07 → 30/11/07

  Project: Research

• Research Training Fellowship for Dr Tom Bird: A functional anaysis of the hepatic stem cell niche.

  Forbes, S. & Iredale, J.

  UK industry, commerce and public corporations

  1/05/07 → 30/04/10

  Project: Research

  • Senescence 100%
  • Liver Injury 100%
  • Paracetamol 44%
  • Injury 33%
  • Regeneration 33%

• can long term nebulised gentamicin reduce the bacterial burden, break the vicious cycle of inflammation and improve quality of life in patients with brochiectasis

  Simpson, J., Govan, J. & Haslett, C.

  UK central government bodies/local authorities, health and hospital authorities

  1/05/07 → 30/06/10

  Project: Research

• Apoptotic cell clearance and the induction of regulatory B cells

  Gray, M.

  UK-based charities

  1/04/07 → 28/02/10

  Project: Research

• Inflammatory Mechanisms in Non-Hodgkins Lymphoma

  Gregory, C.

  UK-based charities

  1/03/07 → 28/02/09

  Project: Research

• The influence of the perinatal environment on vulnerability to CNS autoimmune disease

  Anderton, S.

  UK-based charities

  1/02/07 → 31/01/08

  Project: Research

• Reprogramming of the inflammatory potential of dendritic celld in the lung cancer microenvironment

  Gregory, C. & Sethi, T.

  UK-based charities

  1/02/07 → 31/05/07

  Project: Research

• The role of Elastin degradation in the pathogenes of liver fibrosis

  Iredale, J. & Forbes, S.

  MRC

  1/02/07 → 31/01/12

  Project: Research

  • Liver Fibrosis 100%
  • Macrophage 97%
  • Fibrosis 78%
  • Myofibroblast 76%
  • Liver 67%

• Integrated Clinical Centre Grant

  Ralston, S., Court-brown, C., Gray, M., Salter, D. & Simpson, H.

  UK-based charities

  1/01/07 → 31/08/14

  Project: Research

• Biomakers of oxidative stress and inflammation in patients with COPD

  Macnee, B.

  Non-EU industry, commerce and public corporations

  1/01/07 → 31/12/07

  Project: Research

• The molecular mechanisms involved in ES-derived haematopoiesis

  Forrester, L.

  UK-based charities

  1/11/06 → 31/05/13

  Project: Research

• RCUK Fellowship

  Smith, S., Anderton, S., Bagnaninchi, P., Blythe, R., Calvert, J., Downes, A., Frame, M., Hay, D., Popovic, N. & Rambaut, A.

  EPSRC, STFC

  1/10/06 → 30/06/13

  Project: Research

  • Test Structure 100%
  • Dielectrics 42%
  • Measurement 38%
  • Wetting 38%
  • Fabrication 37%

• ECLIPSE -Multicentre 3 year study

  Macnee, B.

  UK central government bodies/local authorities, health and hospital authorities

  7/08/06 → 31/08/09

  Project: Research

  • Chronic Obstructive Pulmonary Disease 100%
  • Obstructive Lung Disease 54%
  • Muscle 39%
  • Hospitalization 36%
  • Evaluation Study 31%

• Novel determinants of cariovascular risk in patients with chronic obstructive pulmonary disease

  Macnee, B.

  UK central government bodies/local authorities, health and hospital authorities

  1/08/06 → 31/07/08

  Project: Research

• Hepatocyte and Orthopaedic Projects based on hESC Technology

  Newsome, P., Iredale, J., Noble, B. & Simpson, H.

  UK industry, commerce and public corporations

  25/07/06 → 25/07/08

  Project: Research

• An investigation of the molecular signalling mechanisms in skeletal muscle wasting in COPD patients

  Rabinovich, R. & Mullins, J.

  UK central government bodies/local authorities, health and hospital authorities

  1/07/06 → 30/09/08

  Project: Research

• The Role of Myeloid cells and Hif-1 in a multi-hit model of Acute Lung Injury

  Hirani, N. & MacDuff, A.

  MRC

  1/07/06 → 30/07/10

  Project: Research

• Vacation Scholarship for Abigail Culshaw

  Anderton, S.

  UK-based charities

  12/06/06 → 11/08/06

  Project: Research

• Harmful role of human cord blood stem cells in chronic liver injury

  Duff, C.

  UK-based charities

  1/06/06 → 30/07/11

  Project: Research

• Recruitment of macrophanges to B-cell lymphomas

  Gregory, C.

  UK-based charities

  1/04/06 → 31/07/09

  Project: Research

• The role of the human cathelicidin LL-37 as an immunomodulator in infcetious lung disease. RCD Fellowship for Dr D J Davidson

  Haslett, C.

  UK-based charities

  1/03/06 → 28/02/10

  Project: Research

• Effect of hemoxygenase-1 (HO-1) expressing macrophages on glomerular inflammation

  Kluth, D.

  UK-based charities

  1/01/06 → 31/12/08

  Project: Research

• Molecular mechanisms regulating apoptosis in leukocytes and endothelial cells.

  Rossi, A.

  UK-based charities

  17/11/05 → 31/05/07

  Project: Research

• Antigen processing and presentation in the kidney.

  Phelps, R.

  UK-based charities

  1/10/05 → 30/06/10

  Project: Research

• The role of macrophaged in ischaemic acute renal failure.

  Haslett, C.

  UK-based charities

  1/10/05 → 30/09/08

  Project: Research

• A functional characterisation of fms-interacting protein (FMIP) during normal and leukaemic haematopoiesis

  Forrester, L.

  UK-based charities

  1/10/05 → 30/06/13

  Project: Research

• The role of CD4 + CD25 + TCells in the resolution of CN5 autoimmunue disease

  Anderton, S.

  MRC

  1/04/05 → 31/03/08

  Project: Research