Centre for Inflammation Research

2021

Obesity, chronic disease, age, and in-hospital mortality in patients with covid-19: analysis of ISARIC clinical characterisation protocol UK cohort

Yates, T., Zaccardi, F., Islam, N., Razieh, C., Gillies, C. L., Lawson, C. A., Chudasama, Y., Rowlands, A., Davies, M. J., Docherty, A. B., Openshaw, P. J. M., Baillie, J. K., Semple, M. G. & Khunti, K., 31 Jul 2021, In: BMC Infectious Diseases. 21, 1, p. 717

Research output: Contribution to journal › Article › peer-review

Open Access

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Clinical Outcomes of Ablation Compared with Resection for Single Hepatocellular Carcinoma Lesions, as a Primary Treatment or Bridging to Liver Transplantation: A Retrospective Comparative Study

Ward, E. M., Sherif, A. E., O'Neill, S., Hughes, M., Ireland, H., Wigmore, S. J. & Adair, A., 30 Jul 2021, In: Annals of Transplantation : Quarterly of the Polish Transplantation Society. 26, p. e931980

Research output: Contribution to journal › Article › peer-review

Open Access

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Glutamate and functional connectivity - support for the excitatory-inhibitory imbalance hypothesis in autism spectrum disorders

Siegel-Ramsay, J., Romaniuk, L., Whalley, H., Roberts, N., Branigan, H. P., Stanfield, A., Lawrie, S. M. & Dauvermann, M. R., 30 Jul 2021, In: Psychiatry Research: Neuroimaging. 313, 111302.

Research output: Contribution to journal › Article › peer-review

EAACI Biologicals Guidelines—Omalizumab for the treatment of chronic spontaneous urticaria in adults and in the paediatric population 12–17 years old

Agache, I., Akdis, C. A., Akdis, M., Brockow, K., Chivato, T., Giacco, S., Eiwegger, T., Eyerich, K., Giménez‐arnau, A., Gutermuth, J., Guttman‐yassky, E., Maurer, M., Ogg, G., Ong, P. Y., O’mahony, L., Schwarze, J., Warner, A., Werfel, T., Palomares, O. & Jutel, M., 29 Jul 2021, (E-pub ahead of print) In: Allergy.

Research output: Contribution to journal › Article › peer-review

Open Access

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Near-infrared fluorescent probes for the detection of cancer-associated proteases

Scott, J., Deng, Q. & Vendrell, M., 27 Jul 2021, In: Acs chemical biology.

Research output: Contribution to journal › Article › peer-review

Open Access

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Resilience in survivors of critical illness: a scoping review of the published literature in relation to definitions, prevalence, and relationship to clinical outcomes

Pauley, E. & Walsh, T. S., 27 Jul 2021, In: Journal of the Intensive Care Society.

Research output: Contribution to journal › Article › peer-review

Open Access

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Global infectious disease research collaborations in crises: building capacity and inclusivity through cooperation

Fanning, J. P., Murthy, S., Obonyo, N. G., Baillie, J. K., Webb, S., Dalton, H. J. & Fraser, J. F., 26 Jul 2021, In: Globalization and Health. 17, 1, p. 84

Research output: Contribution to journal › Article › peer-review

Open Access

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Longitudinal assessment of lung clearance index to monitor disease progression in children and adults with cystic fibrosis

Horsley, A., Belcher, J., Bayfield, K. J., Bianco, B., Cunningham, S., Fullwood, C., Jones, A. M., Shawcross, A., Smith, J. A., Maitra, A. & Gilchrist, F. J., 22 Jul 2021, (E-pub ahead of print) In: Thorax.

Research output: Contribution to journal › Article › peer-review

Open Access

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Managing pneumonia through facility-based Integrated Management of Childhood Management (IMCI) Services: An analysis of the service availability and readiness among public health facilities in Bangladesh

Rahamn, A., Mhajabin, S., Dockrell, D. H., Nair, H., El Arifeen, S. & Campbell, H., 21 Jul 2021, In: BMC Health Services Research. 21, 667.

Research output: Contribution to journal › Article › peer-review

Open Access

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Role of Tim4 in the regulation of ABCA1+ adipose tissue macrophages and post-prandial cholesterol levels

Magalhaes, M. S., Smith, P., Portman, J., Jackson-Jones, L. H., Bain, C. C., Ramachandran, P., Michailidou, Z., Stimson, R. H., Dweck, M. R., Denby, L., Henderson, N. C., Jenkins, S. J. & Benezech, C., 21 Jul 2021, (E-pub ahead of print) In: Nature Communications.

Research output: Contribution to journal › Article › peer-review

Open Access

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The transformative impact of extracellular vesicles on developing sperm

Rimmer, M., Gregory, C. D. & Mitchell, R. T., 21 Jul 2021, In: Reproduction & Fertility. 2, 3, p. R51–R66 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation

Medina, C. B., Chiu, Y-H., Stremska, M. E., Lucas, C. D., Poon, I., Tung, K. S., Elliott, M. R., Desai, B., Bayliss, D. A., Lorenz, U. M. & Ravichandran, K. S., 19 Jul 2021, In: Immunity.

Research output: Contribution to journal › Article › peer-review

Open Access

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Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: A prospective, multicentre cohort study

ISARIC4C Investigators, Drake, T., Riad, A. M., Fairfield, C. J., Egan, C., Knight, S. R., Pius, R., Hardwick, H. E., Norman, L., Shaw, C., McLean, K. A., Thompson, A. A. R., Ho, A., Swann, O. V., Sullivan, M., Soares, F., Holden, K. A., Merson, L., Plotkin, D., Sigfrid, L., & 15 othersDe Silva, T. I., Girvan, M., Jackson, C., Russell, C. D., Dunning, J., Solomon, T., Carson, G., Olliaro, P., Nguyen-Van-Tam, J. S., Turtle, L., Docherty, A. B., Openshaw, P. J. M., Baillie, J. K., Harrison, E. M. & Semple, M. G., 17 Jul 2021, In: The Lancet. 398, 10296

Research output: Contribution to journal › Article › peer-review

Open Access

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Operational definitions of paediatric asthma used in epidemiological studies: A systematic review

Islam, S., Ahmed, S., Roy, S., Sheikh, A., Cunningham, S., Nair, H., Huq, S., Schwarze, J. & Saha, S. K., 17 Jul 2021, In: Journal of Global Health.

Research output: Contribution to journal › Article › peer-review

Open Access

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ARDS subphenotypes: searching for Rorschach among the roentgenograms?

Morris, A. C., Kohler, K. & Shankar-Hari, M., 12 Jul 2021, In: Thorax. 77, 1, p. 2-4 3 p.

Research output: Contribution to journal › Editorial › peer-review

Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial

REMAP-CAP Investigators, 12 Jul 2021, In: Intensive Care Medicine. 47, 8, p. 867-886 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Editorial: metformin for portal hypertension - old dog, new tricks?

Palaniyappan, N. & Fallowfield, J. A., 8 Jul 2021, In: Alimentary Pharmacology and Therapeutics.

Research output: Contribution to journal › Editorial › peer-review

Open Access

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Mapping the human genetic architecture of COVID-19

COVID-19 Host Genetics Initiative, Baillie, J. K., Wilson, J. F., Bulteel, N., Hayward, C., Klaric, L., Porteous, D. J., Russell, C. D., Tenesa, A., Norman, L., Scott-Brown, J. & Swann, O., 8 Jul 2021, (E-pub ahead of print) In: Nature.

Research output: Contribution to journal › Article › peer-review

Open Access

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T cells drive negative feedback mechanisms in Cancer Associated Fibroblasts, promoting expression of co-inhibitory ligands, CD73 and IL-27 in non-small cell lung cancer

O'Connor, R. A., Chauhan, V., Mathieson, L., Titmarsh, H., Koppensteiner, L., Young, I., Tagliavini, G., Dorward, D., Prost, S., Dhaliwal, K., Wallace, W. & Akram, A. R., 8 Jul 2021, In: OncoImmunology.

Research output: Contribution to journal › Article › peer-review

Open Access

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Acute plate fixation of displaced midshaft clavicular fractures is not associated with earlier return of normal shoulder function when union is achieved

Nicholson, J. A., Clement, N. D., Clelland, A. D., MacDonald, D. J., Simpson, A. H. R. W. & Robinson, C. M., 7 Jul 2021, In: Bone & Joint Open. 2, 7, p. 522-529 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Low dose dexamethasone as treatment for women with heavy menstrual bleeding: a response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM)

Warner, P., Whitaker, L. H. R., Parker, R. A., Weir, C. J., Douglas, A., Holm Hansen, C., Madhra, M., Hillier, S., Saunders, P. T. K., Iredale, J. P., Semple, S. I. K., Slayden, O. D., Walker, B. R. & Critchley, H. O. D., 2 Jul 2021, In: EBioMedicine. 69

Research output: Contribution to journal › Article › peer-review

Open Access

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Venous thromboembolism after total knee arthroplasty is associated with a worse functional outcome at one year

Calabro, L., Clement, N. D., MacDonald, D., Patton, J. T., Howie, C. R. & Burnett, R., 1 Jul 2021, In: The Bone & Joint Journal. 103-B, 7, p. 1254-1260 7 p.

Research output: Contribution to journal › Article › peer-review

Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study

ISARIC4C Investigators, Jul 2021, In: The Lancet Rheumatology. 3, 7, p. e498-e506

Research output: Contribution to journal › Article › peer-review

Open Access

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Delirium in COVID-19: can we make the unknowns knowns?

Wilcox, M. E., Shankar-Hari, M. & McAuley, D. F., 30 Jun 2021, (E-pub ahead of print) In: Intensive Care Medicine. 47, 10, p. 1144-1147 4 p.

Research output: Contribution to journal › Article › peer-review

A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS

Reyes, L., Sanchez Garcia, M. A., Morrison, T., Howden, A. J. M., Watts, E. R., Arienti, S., Sadiku, P., Coelho, P., Mirchandani, A. S., Zhang, A., Hope, D., Clark, S. K., Singleton, J., Johnston, S., Grecian, R., Poon, A. S., McNamara, S., Harper, I., Fourman, M. H., Brenes, A. J., & 14 othersPathak, S., Lloyd, A., Rodriguez Blanco, G., von Kriegsheim, A., Ghesquiere, B., Vermaelen, W., Cologna, C. T., Dhaliwal, K., Hirani, N., Dockrell, D. H., Whyte, M. K. B., Griffith, D. M., Cantrell, D. & Walmsley, S. R., 25 Jun 2021, (E-pub ahead of print) Wellcome Open Research, (wellcome Open Research).

Research output: Working paper

Open Access

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Progress in the production of haematopoietic stem and progenitor cells from human pluripotent stem cells

Fidanza, A. & Forrester, L. M., 24 Jun 2021, In: Journal of Immunology and Regenerative Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

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Relation of severe COVID-19 in Scotland to transmission-related factors and risk conditions eligible for shielding support: REACT-SCOT case-control study

McKeigue, PM., McAllister, DA., Caldwell, D., Gribben, C., Bishop, J., McGurnaghan, S., Armstrong, M., Delvaux, J., Colville, S., Hutchinson, S., Robertson, C., Lone, N. & Colhoun, HM., 23 Jun 2021, In: BMC Medicine. 19, 149.

Research output: Contribution to journal › Article › peer-review

Open Access

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All coffee types decrease the risk of adverse clinical outcomes in chronic liver disease: A UK Biobank study

Kennedy, O. J., Fallowfield, J. A., Poole, R., Hayes, P. C., Parkes, J. & Roderick, P. J., 22 Jun 2021.

Research output: Contribution to conference › Paper › peer-review

Open Access

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Comparing performance on the months of the year backwards test in hospitalised patients with delirium, dementia and no cognitive impairment: an exploratory study

Hasemann, W., Duncan, N., Clarke, C., Nouzova, E., Süßenbach, L. M., Keerie, C., Assi, V., Weir, C. J., Evans, J., Walsh, T. S., Wilson, E., Quasim, T., Middleton, D. G., Weir, A. J., Barnett, J. H., Stott, D. J., MacLullich, A. M. J. & Tieges, Z., 22 Jun 2021, In: European geriatric medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

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Bioengineering Self-organizing Signalling Centres to Control Embryoid Body Pattern Elaboration

Glykofrydis, F., Cachat, E., Berzanskyte, I., Dzierzak, E. & Davies, J. A., 18 Jun 2021, In: ACS Synthetic Biology. 10, 6, p. 1465–1480 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Multimorbidity and its relationship with long-term outcomes following critical care discharge: a prospective cohort study

McPeake, J., Quasim, T., Henderson, P., Leyland, AH., Lone, NI., Walters, M., Iwashyna, TJ. & Shaw, M., 18 Jun 2021, (E-pub ahead of print) In: Chest Journal.

Research output: Contribution to journal › Article › peer-review

Open Access

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The effect of COVID-19 restrictions on rehabilitation and functional outcome following total hip and knee arthroplasty during the first wave of the pandemic

MacDonald, D. J., Clement, N. D., Howie, C. R. & Scott, C. E. H., 18 Jun 2021, In: Bone & Joint Open. 2, 6, p. 380-387 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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The Role of Ageing and Parenchymal Senescence on Macrophage Function and Fibrosis

Campbell, R. A., Docherty, M., Ferenbach, D. A. & Mylonas, K. J., 17 Jun 2021, In: Frontiers in Immunology. 12

Research output: Contribution to journal › Article › peer-review

Open Access

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Ultrafast laser ablation of a multicore polymer optical fiber for multipoint light emission

Chandrasekharan, H. K., McShane, E. P., Dhaliwal, K., Thomson, R. R. & Tanner, M. G., 17 Jun 2021, In: Optics Express. 29, 13, p. 20765-20775 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Developing a novel set of quality performance indicators (QPIs) for metastatic bone disease (MBD)

Downie, S., Stillie, A., Moran, M., Sudlow, C. L. M. & Simpson, A. H. R. W., 15 Jun 2021, In: BMJ Supportive & Palliative Care. 47, 1

Research output: Contribution to journal › Meeting abstract

Open Access

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Feasibility of shortening intravenous antibiotic therapy based on bacterial load- a proof of concept randomised controlled trial

Bedi, P., Cartlidge, M., Zhang, Y., Turnbull, K., Donaldson, S., Clarke, A., Crowe, J., Campbell, K., Graham, C., Frangulyan, R., Rossi, A. G. & Hill, A., 10 Jun 2021, (E-pub ahead of print) In: European Respiratory Journal.

Research output: Contribution to journal › Article › peer-review

Open Access

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Systematic review of studies investigating ventilator associated pneumonia diagnostics in intensive care

Al-omari, B., Mcmeekin, P., Allen, A. J., Akram, A. R., Graziadio, S., Suklan, J., Jones, W. S., Lendrem, B. C., Winter, A., Cullinan, M., Gray, J., Dhaliwal, K., Walsh, T. S. & Craven, T. H., 9 Jun 2021, (E-pub ahead of print) In: BMC pulmonary medicine. 21, 1

Research output: Contribution to journal › Article › peer-review

Open Access

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The expanding world of tissue resident macrophages

Jenkins, S. J. & Allen, J. E., 9 Jun 2021, (E-pub ahead of print) In: European Journal of Immunology.

Research output: Contribution to journal › Review article › peer-review

Open Access

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High purity isolation of low density neutrophils casts doubt on their exceptionality in health and disease

Hardisty, G., Llanwarne, F., Minns, D., Gillan, J., Davidson, D. J., Gwyer Findlay, E. L. & Gray, R. D., 8 Jun 2021, In: Frontiers in Immunology. 12, 625922.

Research output: Contribution to journal › Article › peer-review

Open Access

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Assessment of Stunned and Viable Myocardium Using Manganese-Enhanced Magnetic Resonance Imaging

Spath, N., Singh, T., Papanastasiou, G., Baker, A. H., Janiczek, R. L., McCann, G. P., Dweck, M. R., Kershaw, L., Newby, D. E. & Semple, S. I. K., 7 Jun 2021, (E-pub ahead of print) In: Open heart.

Research output: Contribution to journal › Article › peer-review

Open Access

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Chemodivergent Manganese-Catalyzed C–H Activation: Modular Synthesis of Fluorogenic Probes

Kaplaneris, N., Son, J., Mendive Tapia, L., Kopp, A., Barth, N., Maksso, I., Vendrell, M. & Ackermann, L., 7 Jun 2021, In: Nature Communications.

Research output: Contribution to journal › Article › peer-review

Open Access

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Implementation of High-Sensitivity Cardiac Troponin in Patients with Renal Impairment

Gallacher, P., Miller-Hodges, E., Shah, A., Anand, A., Dhaun, N. & Mills, N. L., 7 Jun 2021, (E-pub ahead of print) In: JAMA Internal Medicine.

Research output: Contribution to journal › Letter › peer-review

Open Access

SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care

Gutmann, C., Takov, K., Burnap, S. A., Singh, B., Ali, H., Theofilatos, K., Reed, E., Hasman, M., Nabeebaccus, A., Fish, M., McPhail, M. J., O'Gallagher, K., Schmidt, L. E., Cassel, C., Rienks, M., Yin, X., Auzinger, G., Napoli, S., Mujib, S. F., Trovato, F., & 17 othersSanderson, B., Merrick, B., Niazi, U., Saqi, M., Dimitrakopoulou, K., Fernández-Leiro, R., Braun, S., Kronstein-Wiedemann, R., Doores, K. J., Edgeworth, J. D., Shah, A. M., Bornstein, S. R., Tonn, T., Hayday, A. C., Giacca, M., Shankar-Hari, M. & Mayr, M., 7 Jun 2021, In: Nature Communications. 12, 1, p. 3406

Research output: Contribution to journal › Article › peer-review

Open Access

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Effectiveness and Safety of Adalimumab Biosimilar SB5 in IBD: Outcomes in Originator to SB5 Switch, Double Biosimilar Switch and Bio-Naieve SB5 Observational Cohorts

Derikx, L. A. A. P., Dolby, H. W., Plevris, N., Lucaciu, L., Rees, C. S., Lyons, M., Siakavellas, S. I., Constantine-Cooke, N., Jenkinson, P., Su, S., O'Hare, C., Kirckpatrick, L., Merchant, L. M., Noble, C., Arnott, I. D., Jones, G-R. & Lees, C. W., 5 Jun 2021, (E-pub ahead of print) In: Journal of Crohn's and Colitis.

Research output: Contribution to journal › Article › peer-review

Open Access

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Variation in performance on common content items at UK medical schools

Hope, D., Kluth, D., Homer, M., Dewar, A., Fuller, R. & Cameron, H., 5 Jun 2021, In: BMC Medical Education. 21, 1

Research output: Contribution to journal › Article › peer-review

Open Access

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Resident macrophages and their potential in cardiac tissue engineering

Suku, M., Forrester, L. M., Biggs, M. & Monaghan, M., 4 Jun 2021, (E-pub ahead of print) In: Tissue engineering.

Research output: Contribution to journal › Review article › peer-review

Open Access

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COVID-19 Pneumothorax in the United Kingdom: a prospective observational study using the ISARIC WHO clinical characterisation protocol

Marciniak, S. J., Farrell, J., Rostron, A., Smith, I., Openshaw, P. J. M., Baillie, J. K., Docherty, A. & Semple, M. G., 3 Jun 2021, (E-pub ahead of print) In: European Respiratory Journal.

Research output: Contribution to journal › Letter › peer-review

Open Access

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CSF1R-dependent macrophages control postnatal somatic growth and organ maturation

Keshvan, S., Caruso, M., Teakle, N., Batoon, L., Sehgal, A., Patkar, O. L., Ferrari-Cestari, M., Snell, C. E., Chen, C., Stevenson, A., Davis, F. M., Bush, S. J., Pridans, C., Summers, K., Pettit, A. R., Irvine, K. M. & Hume, D. A., 3 Jun 2021, In: PLoS Genetics.

Research output: Contribution to journal › Article › peer-review

Open Access

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