Edinburgh Imaging

2024

Fine-mapping genomic loci refines bipolar disorder risk genes

Koromina, M., Ravi, A., Panagiotaropoulou, G., Schilder, B. M., Humphrey, J., Braun, A., Bidgeli, T., Chatzinakos, C., Coombes, B., Kim, J., Liu, X., Terao, C., O 'Connell, K. S., Adams, M., Adolfsson, R., Alda, M., Alfredsson, L., Andlauer, T. F. M., Andreassen, O. A., Antoniou, A., & 110 othersBaune, B. T., Bengesser, S., Biernacka, J., Boehnke, M., Bosch, R., Cairns, M., Carr, V. J., Casas, M., Catts, S., Cichon, S., Corvin, A., Craddock, N., Dafnas, K., Dalkner, N., Dannlowski, U., Degenhardt, F., Di Florio, A., Dikeos, D., Fellendorf, F. T., Ferentinos, P., Forstner, A. J., Forty, L., Frye, M., Fullerton, J. M., Gawlik, M., Gizer, I. R., Gordon-Smith, K., Green, M. J., Grigoroiu-Serbanescu, M., Guzman-Parra, J., Hahn, T., Henskens, F., Hillert, J., Jablensky, A. V., Jones, L., Jones, I., Jonsson, L., Kelsoe, J. R., Kircher, T., Kirov, G., Kittel-Schneider, S., Kogevinas, M., Landén, M., Leboyer, M., Lenger, M., Lissowska, J., Lochner, C., Loughland, C., MacIntyre, D., Martin, N. G., Maratou, E., Mathews, C. A., Mayoral, F., McElroy, S. L., McGregor, N. W., McIntosh, A., McQuillin, A., Michie, P., Milanova, V., Mitchell, P. B., Moutsatsou, P., Mowry, B., Müller-Myhsok, B., Myers, R., Nenadić, I., Nöthen, M. M., O'Donovan, C., O'Donovan, M., Ophoff, R. A., Owen, M. J., Pantelis, C., Pato, C., Pato, M. T., Patrinos, G. P., Pawlak, J. M., Perlis, R. H., Porichi, E., Posthuma, D., Ramos-Quiroga, J. A., Reif, A., Reininghaus, E. Z., Ribasés, M., Rietschel, M., Schall, U., Schulze, T. G., Scott, L., Scott, R. J., Serretti, A., Weickert, C. S., Smoller, J. W., Artigas, M. S., Stein, D. J., Streit, F., Toma, C., Tooney, P., Vieta, E., Vincent, J. B., Waldman, I. D., Weickert, T., Witt, S. H., Świątkowska, B., Hong, K. S. S., Ikeda, M., Iwata, N., Ripke, S., Won, H-H., Edenberg, H. J., Raj, T., Coleman, J. R. I. & Mullins, N., 17 Sept 2024, medRxiv.

Research output: Working paper › Preprint

Human induced pluripotent stem cell-derived microglia contribute to the pathophysiology of Fragile X syndrome via increased RAC1 signaling

Banerjee, P., Das Sharma, S., Burr, K., Morris, K., Ritakari, T., Baxter, P., Cooper, J., Cardinalli, A., Subash, S., Paza, E., Story, D., Chattarji, S., Kind, P. C., Carragher, N. O., Thangaraj Selvaraj, B., Priller, J. & Chandran, S., 28 Jun 2024, University of Edinburgh.

Research output: Working paper › Preprint

The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology

Stables, J., Pal, R., Bradford, B., Carter-Cusack, D., Taylor, I., Pridans, C., Khan, N., Woodruff, T., Irvine, K., Summers, K. M., Mabbott, N. & Hume, D. A., 13 Jun 2024, bioRxiv, p. 1-55, 55 p.

Research output: Working paper › Preprint

Open Access

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Genome-wide study of half a million individuals with major depression identifies 697 independent associations, infers causal neuronal subtypes and biological targets for novel pharmacotherapies

McIntosh, A. M., Lewis, C. M., Adams, M. J. & Psychiatric Genomics Consortium Major Depressive Disorder Working Group, 1 May 2024, medRxiv.

Research output: Working paper › Preprint

Implementation of a shared decision making process for severe stroke-a mixed methods study

Visvanathan, A., Morton, S., Macraild, A., Black, P., Barber, M., Dennis, M., O'Brien, R. & Mead, G., 23 Feb 2024, medRxiv.

Research output: Working paper › Preprint

2023

Feasibility Study of the CT Clock Tool for Estimating Onset Time of Ischaemic Stroke: Study Protocol

Mair, G., Whiteley, W., Chappell, F., MacRaild, A. & Wardlaw, J., 8 Sept 2023, medRxiv.

Research output: Working paper › Preprint

General and specific patterns of cortical gene expression as substrates of complex cognitive functioning

Moodie, J. E., Harris, S., Harris, M., Buchanan, C., Taylor, A., Redmond, P., Liewald, D. C., Shenkin, S. D., Russ, T. C., Muñoz Maniega, S., Luciano, M., Corley, J., Stolicyn, A., Shen, X., Bastin, ME., Wardlaw, J. M., McIntosh, A. M., Whalley, H., Tucker-Drob, E. M., Deary, I. J., & 1 othersCox, S. R., 20 Jul 2023, bioRxiv.

Research output: Working paper › Preprint

Childhood cognitive ability and self-harm and suicide in later life

Iveson, M. H., Ball, E. L., Whalley, H. C., Deary, I. J., Cox, S. R., Batty, G. D., John, A. & McIntosh, A. M., 11 Feb 2023, medRxiv, 30 p.

Research output: Working paper › Preprint

Phenome-wide analysis identifies parent-of-origin effects on the human methylome associated with changes in the rate of aging

Gao, C., Amador, C., Walker, R. M., Campbell, A., Madden, R. A., Adams, M. J., Bai, X., Liu, Y., Li, M., Hayward, C., Porteous, D. J., Shen, X., Evans, K. L., Haley, C. S., McIntosh, A. M., Navarro, P. & Zeng, Y., 20 Jan 2023, bioRxiv.

Research output: Working paper › Preprint

2022

Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: a systematic review

Kampaite, A., Gustafsson, R., York, E. N., Foley, P., MacDougall, N., Bastin, M. E., Chandran, S., Waldman, A. & Meijboom, R., 7 Dec 2022, (Submitted).

Research output: Working paper › Preprint

A novel deep learning method for large-scale analysis of bone marrow adiposity using UK Biobank Dixon MRI data

Morris, D. M., Wang, C., Papanastasiou, G., Gray, C. D., Badr, S., Paccou, J., Semple, S. I. K., MacGillivray, T. & Cawthorn, W. P., 6 Dec 2022, medRxiv, (medRxiv).

Research output: Working paper › Preprint

Dementia diagnosis and prevalence in the Lothian Birth Cohort 1936 using medical data linkage

Mullin, D., Stirland, L., Buchanan, E., Lothian, NHS., Cox, S. R., Deary, I. J., Centre, A., Centre, A., Page, D., Centre, A., Shenkin, S. D., Szalek, A., Taylor, A., Weatherdon, G., Wilkinson, T. & Russ, T., 18 Nov 2022, medRxiv.

Research output: Working paper › Preprint

Ontology-based and weakly supervised rare disease phenotyping from clinical notes

Dong, H., Suárez-Paniagua, V., Zhang, H., Wang, M., Casey, A., Davidson, E., Chen, J., Alex, B., Whiteley, W. & Wu, H., 1 May 2022, ArXiv.

Research output: Working paper › Preprint

Life-course exposure to air pollution and biological ageing in the Lothian Birth Cohort 1936

Baranyi, G., Deary, I. J., McCartney, D. L., Harris, S., Shortt, N., Reis, S., Russ, T., Ward Thompson, C., Vieno, M., Cox, S. R. & Pearce, J., 18 Apr 2022, medRxiv.

Research output: Working paper › Preprint

Open Access

Integrative single cell and spatial transcriptomic analysis reveal reciprocal microglia-plasma cell crosstalk in the mouse brain during chronic Trypanosoma brucei infection

Quintana, J., Chandrasegaran, P., Sinton, M., Briggs, E. M., Otto, T. D., Heslop, R., Bentley-Abbot, C., Loney, C., de Lecea, L., Mabbott, N. & MacLeod, A., 28 Mar 2022, (Accepted/In press) bioRxiv, at Cold Spring Harbor Laboratory, (bioRxiv).

Research output: Working paper › Preprint

Open Access

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Community views on medication use in fragile X syndrome

Eley, S., McKechanie, A. G. & Stanfield, A. C., 25 Mar 2022, Research Square , 10 p.

Research output: Working paper › Preprint

Automated Clinical Coding: What, Why, and Where We Are?

Dong, H., Falis, M., Whiteley, W., Alex, B., Ji, S., Chen, J. & Wu, H., 21 Mar 2022, ArXiv, 8 p.

Research output: Working paper › Preprint

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Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence

Mirchandani, A. S., Jenkins, S. J., Bain, C. C., Lawson, H., Coelho, P., Murphy, F., Griffith, D., Zhang, A., Sanchez-Garcia, M. A., Reyes, L., Morrison, T., Arienti, S., Sadiku, P., Watts, E. R., Dickinson, R. S., Clark, S., Ly, T., Lewis, D., Kelly, V., Spanos, C., & 21 othersMusgrave, K. M., Delaney, L., Harper, I., Scott, J., Parkinson, N. J., Rostron, A. J., Baillie, K. J., Clohisey, S., Pridans, C., Campana, L., Starkey-Lewis, P., Simpson, A. J., Dockrell, D., Schwarze, J., Hirani, N., Ratcliffe, P. J., Pugh, C. W., Kranc, K., Forbes, S. J., Whyte, M. K. & Walmsley, S. R., 12 Mar 2022, bioRxiv, p. 1-53, 53 p.

Research output: Working paper › Preprint

Motor Neuron Disease is not clustered or associated with socioeconomic deprivation in Scotland

Chang, Y-T., Kearns, P. K. A., Newton, J., Larraz, J., Forbes, D., Beswick, E., Leighton, D., Langlands, G., Swingler, R. J., Chandran, S. & Pal, S., 28 Feb 2022, medRxiv.

Research output: Working paper › Preprint

The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent

Suchacki, K., Thomas, B. J., Fyfe, C., Tavares, A. A. S., Sulston, R., Lovdel, A., Woodward, H. J., Han, X., Mattiucci, D., Brain, E. J., Alcaide-Corral, C. J., Gray, G. A., Whitfield, P. D., Stimson, R. H., Morton, N. M., Johnstone, A. M. & Cawthorn, W. P., 22 Feb 2022, bioRxiv, (bioRxiv).

Research output: Working paper › Preprint

Oligodendrocytes form paranodal bridges that generate chains of myelin sheaths that are vulnerable to degeneration with age

Call, C. L., Neely, S. A., Early, J. J., James, O. G., Zoupi, L., Williams, A. C., Chandran, S., Lyons, D. A. & Bergles, D. E., 17 Feb 2022, bioRxiv.

Research output: Working paper › Preprint

Data-driven analysis shows robust links between fatigue and depression in early multiple sclerosis

Chang, Y-T., Kearns, P. K. A., Carson, A., Gillespie, D. C., Meijboom, R., Kampaite, A., Hernández, M. D. C. V., Weaver, C., Stenson, A., MacDougall, N., O’Riordan, J., Macleod, M. A., Carod-Artal, F. J., Connick, P., Waldman, A. D., Chandran, S. & Foley, P., 13 Jan 2022, medRxiv.

Research output: Working paper › Preprint

2021

FutureMS Cohort Profile: A Scottish Multi-Centre Inception Cohort Study of Relapsing-Remitting Multiple Sclerosis

Kearns, P. K. A., Martin, S. J., Chang, J., Meijboom, R., York, E. N., Chen, Y., Weaver, C., Stenson, A., Hafezi, K., Thomson, S., Freyer, E., Murphy, L., Harroud, A., Foley, P., Hunt, D., McLeod, M., O’Riordan, J., Carod-Artal, F. J., MacDougall, N. J. J., Baranzini, S. E., & 3 othersWaldman, A. D., Connick, P. & Chandran, S., 8 Sept 2021, medRxiv.

Research output: Working paper › Preprint

Socioeconomic position and mental health during the COVID-19 pandemic: a cross-sectional analysis of the CovidLife study

Pierre, M., Keller, M., Altschul, D., Fawns-Ritchie, C., Hartley, L., Nangle, C., Edwards, R., Dawson, R., Campbell, A., Flaig, R. & Porteous, D. J., 3 Jun 2021, Wellcome Open Research, (Wellcome Open Research).

Research output: Working paper › Preprint

A systematic review and meta-analysis of non-workplace interventions to reduce time spend in sedentary in adults

Hall, J. F., Corepal, R., Crocker, T. F., Lam, N., Burton, L-J., Birch, K., Carter, G., Clarke, D. J., English, C., Farrin, A. J., Fitzsimons, C., Hall, J., Holloway, I., Ozer, S., Lawton, R., Mead, G., Morton, S., Patel, A. & Forster, A., 29 May 2021, medRxiv.

Research output: Working paper › Preprint

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Mechanisms and Stages of Covid-19 Immunopathology Revealed by Tissue-Specific Proteomes

Russell, C. D., Valanciute, A., Gachanja, N. N., Stephen, J., Penrice-Randal, R., Armstrong, S. D., Clohisey, S., Wang, B., Al Qsous, W., Wallace, W. A., Oniscu, G. C., Stevens, J., Harrison, D. J., Dhaliwal, K., Hiscox, J. A., Baillie, J. K., Akram, A. R., Dorward, D. A. & Lucas, C. D., 27 May 2021, Social Science Research Network (SSRN).

Research output: Working paper › Preprint

The Automated Systematic Search Deduplicator (ASySD): a rapid, open-source, interoperable tool to remove duplicate citations in biomedical systematic reviews

Hair, K., Bahor, Z., Macleod, M., Liao, J. & Sena, E. S., 4 May 2021, bioRxiv, 16 p.

Research output: Working paper › Preprint

Results of a randomised controlled trial comparing two different incentives to improve survey response rates

Macleod, M. R., Hair, K., Ezgi, TANRIVER. AYDER., Craske, D., Shinton, S., Campbell, A., Mellifont, B. & Thomson, L., 10 Feb 2021, SocArXiv.

Research output: Working paper › Preprint

2020

The hepatic compensatory response to elevated systemic sulfide promotes diabetes

Carter, R. N., Gibbins, M. T. G., Barrios-Llerena, M. E., Wilkie, S. E., Freddolino, P. L., Libiad, M., Vitvitsky, V., Emerson, B., Le Bihan, T., Brice, M., Su, H., Denham, S. G., Homer, N. Z. M., Mc Fadden, C., Tailleux, A., Faresse, N., Sulpice, T., Briand, F., Gillingwater, T., Ahn, K. H., & 9 othersSingha, S., McMaster, C., Hartley, R. C., Staels, B., Gray, G. A., Finch, A. J., Selman, C., Banerjee, R. & Morton, N. M., 1 Oct 2020, bioRxiv.

Research output: Working paper › Preprint

Supporting the resilience and retention of frontline care workers in care homes for older people: A scoping review and thematic synthesis

Johnston, L., Malcolm, C., Rambabu, L., Hockley, J. & Shenkin, S. D., 8 Sept 2020, medRxiv.

Research output: Working paper › Preprint

Genetic control of Campylobacter colonisation in broiler chickens: Genomic and transcriptomic characterisation

Psifidi, A., Kranis, A., Rothwell, L. M., Bremner, A., Russell, K., Robledo, D., Bush, S. J., Fife, M., Hocking, P. M., Banos, G., Hume, D. A., Kaufman, J., Bailey, R. A., Avendano, S., Watson, K. A., Kaiser, P. & Stevens, M. P., 14 Apr 2020, bioRxiv, 45 p.

Research output: Working paper › Preprint

Edinburgh Imaging

Research output

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