Institute of Genetics and Cancer

Projects

Projects per year 1994 2011 2012 2025

• 13 Active
• 506 Finished

Projects per year

Search results

• Finished

  Ultra-sensitive Mass spectrometry for Precision Medicine

  Von Kriegsheim, A.

  1/11/22 → 31/03/23

  Project: Research

  • Mass Spectrometry 100%
  • Personalized Medicine 100%

• Identification Of A First-of-a-kind, Small Molecule, Specific, USP18 Inhibitor

  Von Kriegsheim, A.

  1/06/22 → 31/05/23

  Project: Research

• Identification Of A First-of-a-kind, Small Molecule, Specific, USP18 Inhibitor

  Von Kriegsheim, A.

  1/06/22 → 31/05/23

  Project: Research

  • Identification 100%

• Cell fate specification and organogenesis in the gastrulating embryo

  Bates, L. & Nichols, J.

  1/04/22 → 14/02/23

  Project: Research

• Mechanisms of long-range gene regulation in craniofacial development and disease

  Long, H.

  1/11/21 → 31/03/23

  Project: Research

• Mechanism and Regulation of Chromosome Replication

  Deegan, T.

  14/09/21 → 31/03/23

  Project: Research

• Interrogation of nucleic acid mediated inflammation, and of the role of the snoRNA U8 in human disease

  Crow, Y.

  1/09/21 → 31/03/23

  Project: Research

• Use of CRISPR-based genome-wide approach for identification of vulnerabilities in canine oral melanoma

  Parkinson, N., Parys, M., Argyle, D., Baillie, K., Hupp, T. & Schoenebeck, J.

  Non-EU-based charities

  1/03/21 → 28/02/23

  Project: Research

• Use of CRISPR-based genome-wide approach for identification of vulnerabilities in canine oral melanoma

  Parkinson, N., Parys, M., Argyle, D., Baillie, K., Hupp, T. & Schoenebeck, J.

  Non-EU-based charities

  1/03/21 → 28/02/23

  Project: Research

• Depression Detectives

  Beange, I., McIntosh, A., Iveson, M., Kwong, A., Adams, M., Whalley, H., Kirkham, E., Smith, D., MacSweeney, N., Barbu, M. C. & Huggins, C.

  20/02/21 → 8/09/21

  Project: Other (Non-Funded/Miscellaneous)

  • Research Worker 100%
  • Depression 100%
  • Lived Experience 55%
  • Research 55%
  • Facebook 33%

• Evolving Ourselves with Unnatural Selection

  O'Keeffe, L., White, M., Doyle, T. & Brown, A. J.

  1/02/21 → 1/06/22

  Project: Research

  • Project 100%
  • Digital Art 100%
  • Public Audience 100%
  • Emerging Technology 100%
  • Ethical Implication 100%

• Award from Edinburgh Neuroscience RS MacDonald Seedcorn Fund

  Stavrou, M. & Bolado Carrancio, A.

  2/11/20 → 1/05/21

  Project: University Awarded Project Funding

  • Amyotrophic Lateral Sclerosis 100%
  • Neurosciences 100%

• Deep mass spectrometry analysis of plasma samples from Covid-19 patients

  Von Kriegsheim, A.

  1/07/20 → 15/12/20

  Project: Research

  • Patient 100%
  • Sample 100%
  • Analysis 100%
  • Mass Spectrometry 100%
  • Mass Spectroscopy 100%

• Machine learning in myocardial infarction to improve risk prediction and inform treatment decisions

  Vallejos Meneses, C. & Mills, N.

  UK-based charities

  1/03/19 → 28/08/21

  Project: Research

• scEye-Map: Developmental trajectories of progenitor cell populations in the human eye at single cell resolution

  FitzPatrick, D., Ponting, C. & Vallejos Meneses, C.

  MRC

  17/12/18 → 31/12/20

  Project: Research

• How heterogeneous are oligodendroglia from normal human brain and spinal cord?

  Vallejos Meneses, C.

  MRC

  10/12/18 → 31/12/20

  Project: Research

• Neoantigen discovery pipeline- from basic science to better, personalized approach to canine cancer care

  Connelley, T., Hupp, T., Mellanby, R. & Parys, M.

  UK-based charities

  1/12/18 → 1/08/22

  Project: Research

• MC_UU_00007/3 Developmental Disorders: From Diagnosis to Mechanism via Cis-Regulation

  FitzPatrick, D.

  1/04/18 → 31/03/23

  Project: Research

• RNA synthetic biology

  Kudla, G.

  1/04/18 → 31/03/23

  Project: Research

  • RNA 100%
  • Codon Usage 93%
  • Messenger RNA 93%
  • Nested Gene 49%
  • Mutation 41%

• Medical and Regulatory Genomics

  Semple, C.

  1/04/18 → 31/03/23

  Project: Research

  • Mutation 100%
  • Nested Gene 47%
  • Germline 33%
  • Phenotype 33%
  • Krukenberg Tumor 31%

• MC_UU_00007/4 Mouse Models of Human Variation and Disease

  Jackson, I.

  1/04/18 → 31/03/23

  Project: Research

  • Mouse 100%
  • Nested Gene 50%
  • Retinal Degeneration 38%
  • Mutant 36%
  • Phenotype 35%

• Gene-drug interactions in the melanocyte lineage and melanoma

  Patton, E.

  1/04/18 → 31/03/23

  Project: Research

  • Zebra Fish 100%
  • Melanocyte 89%
  • Nodular Melanoma 84%
  • Cells 68%
  • Nested Gene 64%

• MC_UU_00007/5 From Microcephaly to Genome Stability, Inflammation and Growth Regulation

  Jackson, A.

  1/04/18 → 31/03/23

  Project: Research

  • Mutation 100%
  • Phenotype 44%
  • Nested Gene 43%
  • Polymerase 33%
  • Dysplasia 32%

• Composition of a regulatory locus and the impact on phenotype and disease

  Hill, B.

  1/04/18 → 31/03/23

  Project: Research

  • Hedgehog Signaling Pathway 100%
  • Enhancer Region 100%
  • Ligase 100%
  • Homeostasis 100%
  • Protein 100%

• The functional requirement for epigenetic systems in development and disease

  Meehan, R.

  1/04/18 → 31/03/23

  Project: Research

• Quantitative Traits in Health and Disease

  Haley, C.

  1/04/18 → 31/03/23

  Project: Research

  • Age 100%
  • Association 67%
  • Epigenetics 47%
  • Genome Wide Association Study 43%
  • Epstein Barr Virus 36%

• MC_UU_00007/2 The role of spatial nuclear organisation in genome function

  Bickmore, W.

  1/04/18 → 1/04/23

  Project: Research

  • Enhancer Region 100%
  • Chromatin 82%
  • Embryonic Stem Cell 70%
  • Nested Gene 69%
  • Promoter Region 62%

• Chromatin architecture and regulation

  Gilbert, N.

  1/04/18 → 31/03/23

  Project: Research

  • Chromatin Structure 100%
  • Chromatin 94%
  • Comprehension 42%
  • Probe 41%
  • Transcription 38%

• Mutagenesis and its Biological Impact

  Taylor, M.

  1/04/18 → 31/03/23

  Project: Research

  • Phenotype 100%
  • Mutation 69%
  • Promoter Region 60%
  • Human Genome 58%
  • Gene Expression 54%

• Genetic and cellular basis of functional cilia assembly

  Mill, P.

  1/04/18 → 31/03/23

  Project: Research

  • Cilium 100%
  • Dynein 93%
  • Co-Chaperone 60%
  • Mouse 53%
  • Genetic Heterogeneity 46%

• Maintaining Genetic and Chromosomal Stability in the Mammalian Germline

  Adams, I.

  1/04/18 → 31/03/23

  Project: Research

  • Mouse 100%
  • Meiosis 93%
  • Germ Cell 84%
  • Nested Gene 54%
  • Embryonic Stem Cell 54%

• MC_UU_00007/1 Genetic approaches to combating colorectal cancer

  Dunlop, M.

  1/04/18 → 31/03/23

  Project: Research

  • Colorectal Cancer 100%
  • Association 88%
  • Genome-Wide Association Study 61%
  • Survival 49%
  • Single Nucleotide Polymorphism 47%

• Post-transcriptional regulation of Gene Expression

  Caceres, J.

  1/04/18 → 31/03/23

  Project: Research

  • MicroRNA 100%
  • Transcription 64%
  • Processing 64%
  • Biogenesis 57%
  • RNA-binding Protein 53%

• Computational and Disease Genomics

  Ponting, C.

  1/04/18 → 31/03/23

  Project: Research

  • Cells 100%
  • Genetics 99%
  • Protein 97%
  • Nested Gene 78%
  • Animal 73%

• Targeting the Hippo Pathway for Osteosarcoma Therapy

  Hansen, C., Bagnaninchi, P. & Salter, D.

  UK-based charities

  1/11/17 → 31/10/18

  Project: Research

• High resolution metabolite and peptide mass spectrometry

  Von Kriegsheim, A., Christophorou, M., Finch, A., Morton, N., Ponting, C. & Walmsley, S.

  UK-based charities

  2/10/17 → 1/11/22

  Project: Research

  • Protein 100%
  • Proteome 53%
  • Neoplasm 40%
  • Tissues 40%
  • RNA Splicing 35%

• Understanding disease through environmental-wide association studies

  Tenesa, A., Canela Xandri, O., Rawlik, K. & Sudlow, C.

  MRC

  1/08/17 → 31/07/20

  Project: Research

  • Genotyping 100%
  • Genetic Determinism 66%
  • Bovine 66%
  • Human 66%
  • Heritability 50%

• PREdiCCT - The Prognostic Effect of Environmental Factors in Crohn's and Colitis

  Lees, C. & Ennis, H.

  UK central government bodies/local authorities, health and hospital authorities

  1/11/16 → 31/12/22

  Project: Research

• EMBO Fellowship

  Stark, L.

  1/09/16 → 21/12/16

  Project: Other

  • Peptide 100%
  • Colorectal Cancer 100%
  • Acetylsalicylic Acid 100%

• Drug target deconvolution platform

  Von Kriegsheim, A.

  1/03/16 → 28/02/17

  Project: Research

  • Chemotherapeutic Agent 100%
  • Drug 100%
  • Deconvolution 100%

• The Scottish Genomes Partnership (SGP)

  Aitman, T.

  MRC

  1/02/16 → 29/02/20

  Project: Research

  • Haplotype 100%
  • Mutation 96%
  • Phenotype 92%
  • Glycosylation 80%
  • Protein Sequencing 80%

• Identification of Upstream Factors Regulating Autophagy in Disease

  Gammoh, N.

  UK-based charities

  1/02/16 → 31/01/17

  Project: Research

• The Scottish Genomes Partnership

  Aitman, T.

  UK central government bodies/local authorities, health and hospital authorities

  1/02/16 → 29/02/20

  Project: Research

  • Haplotype 100%
  • Mutation 96%
  • Phenotype 92%
  • Glycosylation 80%
  • Protein Sequencing 80%

• Characterisation of autophagic clearance of mitochondrial damage associated molecular patterns in inflammatory bowel disease

  Ho, G.

  4/01/16 → 31/07/16

  Project: MVM - (non-funded) undergraduate research project

  • Clearance 100%
  • Inflammatory Bowel Disease 100%
  • Mitochondrion 100%
  • Crohn's Disease 66%
  • Autophagy 66%

• Identification of a gene signature to predict ER+ breast cancer dormancy by transcriptome analysis of matched pre- and extended-neoadjuvant treatment biopsies

  Selli Karakaya, C. & Sims, A.

  1/01/16 → 31/12/16

  Project: Research

• A pilot study on the genetic epidemiology of oral health disorders with in the Generation Scotland cohort

  Bermingham, M., Walls, A., Porteous, D. & Campbell, A.

  1/10/15 → 30/04/16

  Project: University Awarded Project Funding

  • Major Depressive Episode 100%
  • DNA Methylation 100%
  • Chronic Obstructive Pulmonary Disease 100%
  • Respiratory Physiology 100%
  • Respiratory Function 100%

• Molecular characterisation of a clinical model of estrogen receptor-positive breast cancer dormancy

  Selli Karakaya, C., Sims, A. & Dixon, M.

  1/09/15 → 31/08/17

  Project: Research

• Development of Magnetic Nanoparticle Bearing Mesenchymal Stem Cells for Magnetic Hypertermia treatment of Sarcomas

  Salter, D.

  UK-based charities

  1/09/15 → 28/02/17

  Project: Research

• PREdiCCT - The Prognostic Effect of Environmental Factors in Crohn's and Colitis

  Lees, C.

  UK-based charities

  1/06/15 → 31/03/21

  Project: Research

• PREdiCCT - The Prognostic Effect of Environmental Factors in Crohn's and Colitis

  Lees, C.

  UK-based charities

  1/06/15 → 31/05/19

  Project: Research