Institute of Genetics and Cancer

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Crewe Road, Western General Hospital
EH4 2XU Edinburgh
United Kingdom

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2023

Preclinical efficacy of NXP900, a YES1/SRC kinase inhibitor in esophageal squamous cancer models.
Dash, S., Nyswaner, K., Harvey, M. J. B., King, B., Woods, A., Carragher, N. O., Unciti, A., Poradosu, E. & Brognard, J., 31 May 2023, In: Journal of Clinical Oncology. 41, 16_suppl, p. e15133-e15133
Research output: Contribution to journal › Meeting abstract
Abstract 4031: In vivo studies demonstrate differences in target inhibition and anticancer efficacy between NXP900 and dasatinib in ovarian clear cell carcinoma model
Navarro-Marchal, S., Temps, C., Lanzagorta-Calvillo, I., Dawson, J. C., Poradosu, E., Carragher, N. O., Brunton, V. G. & Unciti-Broceta, A., 1 Apr 2023, In: Cancer Research. 83, 7_Supplement, p. 4031-4031
Research output: Contribution to journal › Meeting abstract
2021

P-OGC32 Copper-dependent cell death is a cancer specific vulnerability in oesophageal adenocarcinoma and provides the opportunity for future biomarker-stratified clinical trials
Hughes, R. E., Elliott, R., Munro, A., Hupp, T., Carragher, N. O. & O'neill, J. R., 15 Dec 2021, In: British Journal of Surgery. 108, Supplement_9
Research output: Contribution to journal › Meeting abstract
2020
Predicting late xerostomia in head and neck cancer patients from imaging biomarkers calculated on daily TomoTherapy MVCT images
Berger, T., Noble, D. J., Shelley, L. E., McMullan, T., Romanchikova, M., Carruthers, L. J., Cebamanos, L., Beckett, G., Duffton, A., Paterson, C., Jena, R., McLaren, D. B., Burnet, N. G. & Nailon, W. H., 26 Nov 2020, (E-pub ahead of print) In: Radiotherapy & Oncology. 152, Supplement 1, p. S859-S860
Research output: Contribution to journal › Meeting abstract › peer-review
Sub-regional analysis of the parotid glands: predicting late xerostomia with imaging biomarkers in head and neck cancer patients
Berger, T., Noble, D. J., Shelley, L. E., McMullan, T., Romanchikova, M., Carruthers, L. J., Cebamanos, L., Beckett, G., Duffton, A., Paterson, C., Jena, R., McLaren, D. B., Burnet, N. G. & Nailon, W. H., 26 Nov 2020, (E-pub ahead of print) In: Radiotherapy & Oncology. 152, Supplement 1, p. S860-S861 1 p.
Research output: Contribution to journal › Meeting abstract › peer-review
Analysis of the Intra-Fractional Motion of the Prostate During SBRT Using an EM Transmitter
Trainer, M., Carruthers, L., McLaren, D., Nailon, B. & Kirby, M., 1 Nov 2020, In: International Journal of Radiation Oncology - Biology - Physics. 108, 3, Supplement, p. e340 1 p.
Research output: Contribution to journal › Meeting abstract › peer-review
Cancer detection using quantitative faecal immunochemical test in symptomatic patients
Garside, H., Ball, G., Thom, F., Burton, T., Gunn, R., Maeda, Y., Dunlop, M. G. & Din, F. V. N., 6 Jul 2020, In: Colorectal Disease. 22, S1, 306.
Research output: Contribution to journal › Meeting abstract › peer-review
Colorectal cancer incidence following acute diverticulitis
McIntyre, J. L., Kedziora, M., Au, S., Reddy, C. T., Maeda, Y. & Din, F. V. N., 6 Jul 2020, In: Colorectal Disease. 22, S1, 205.
Research output: Contribution to journal › Meeting abstract › peer-review
2019

PD-025 Hand-foot syndrome is a biomarker of improved survival following treatment with capecitabine
Jandu, H., Church, D., Paul, J., Tomlinson, I., Iveson, T., Kerr, R., Kerr, D. & Palles, C., 2 Jul 2019, (E-pub ahead of print) In: Annals of Oncology. 30, Supplement_4
Research output: Contribution to journal › Meeting abstract › peer-review
A deep learning approach for identifying focal prostate cancer from multi-parametric MRI
Rooney, M., Killean, A., Mitchell, J., McLaren, D. & Nailon, B., 1 Apr 2019, In: Radiotherapy & Oncology. 133, 1 p.
Research output: Contribution to journal › Meeting abstract › peer-review
Applying the Linear Quadratic Model to PC-3 cells irradiated under different O2 conditions
McMullan, T., Meehan, J., Langdon, S. P., McLaren, D., McLaughlin, S. & Nailon, B., 1 Apr 2019, In: Radiotherapy & Oncology. 133
Research output: Contribution to journal › Meeting abstract › peer-review
Development of a deep learning network using a pre-trained convolutional neural network
Rooney, M., McLaren, D., Nailon, B. & Mitchell, J., 1 Apr 2019, In: Radiotherapy & Oncology. 133, 1 p.
Research output: Contribution to journal › Meeting abstract › peer-review
Evaluating the Safety of Up-front Docetaxel in the Treatment of Metastatic and Locally Advanced Prostate Cancer
Killean, A., Law, A., Malik, J., Sundaramurthy, A. & McLaren, D., Feb 2019, In: Clinical Oncology. 31, 2, p. E21-E23 5 p.
Research output: Contribution to journal › Meeting abstract › peer-review
2018

PO-413 Immune modulating properties of cyclophosphamide synergise with immunotherapy in preclinical models of neuroblastoma
Webb, E., Lanati, S., Cragg, M., Beers, S. & Gray, J., 30 Jun 2018, In: ESMO Open. 3, Supp.2, p. A392 1 p.
Research output: Contribution to journal › Meeting abstract › peer-review

Open Access
File
A Clinical Decision Support Tool Based on Active Appearance Modelling for Prostate Segmentation
Cheng, K., Li, H., McLaren, D., McLaughlin, S. & Nailon, W., 18 Jun 2018, In: Radiotherapy & Oncology. 127, p. S550-S551
Research output: Contribution to journal › Meeting abstract › peer-review

Open Access
Abstract P4-03-01: Causes of endocrine therapy resistance: An in-depth genomic analysis of resistant multidrug ER+ breast cancers
Martinez-Perez, C., 14 Feb 2018, In: Cancer Research. 78, 4 Supplement
Research output: Contribution to journal › Meeting abstract › peer-review
Abstract P4-08-02: Understanding the mechanisms of action underlying the role of IL6ST, a key biomarker for prediction of response to endocrine therapy
Martinez-Perez, C., 14 Feb 2018, In: Cancer Research. 78, 4 Supplement
Research output: Contribution to journal › Meeting abstract › peer-review
Abstract P5-11-02: Predicting local recurrence in patients treated for ductal carcinoma in situ of the breast (DCIS)
Martinez-Perez, C., 14 Feb 2018, In: Cancer Research. 78, 4 Supplement
Research output: Contribution to journal › Meeting abstract › peer-review
Abstract P2.11: Stratification of patients treated for ductal carcinoma in situ of the breast (DCIS) according to risk of local recurrence
Martinez-Perez, C., 10 Jan 2018, In: Breast cancer research and treatment. 167, 1
Research output: Contribution to journal › Meeting abstract › peer-review
Hepatic corticosterone binding globulin (CBG) mRNA expression across life history stages in migratory and nonmigratory subspecies of White-crowned sparrow
Krause, J. S., Reid, A., Perez, J., Bishop, V., Cheah, J. C., Wingfield, J. C. & Meddle, S., 2018, In: Integrative & Comparative Biology. 58, p. E356
Research output: Contribution to journal › Meeting abstract › peer-review
TCP modelling of a hypoxic subvolume within the prostate
McMullan, T. J., McLaren, D. B. & Nailon, W. H., 2018, In: Radiotherapy & Oncology. 127, p. S1269-S1270 2 p.
Research output: Contribution to journal › Meeting abstract › peer-review

Open Access
2017

Machine Learning Optimised for Personalized Medicine: Predicting Lifetime and Recurrent Depression in the Generation Scotland Cohort Study
Gountouna, V-E., Campbell, A., Porteous, D. J. & Nicodemus, K. K., Nov 2017, In: Genetic Epidemiology. 41, 7, p. 679-679 1 p.
Research output: Contribution to journal › Meeting abstract › peer-review
Phenotypic and Genetic Analysis of Cognitive Performance in Major Depressive Disorder in the Generation Scotland: Scottish Family Health Study
Meijsen, J. J., Campbell, A., Hayward, C., Porteous, D. J., Deary, I. J., Marioni, R. E. & Nicodemus, K. K., Nov 2017, In: Genetic Epidemiology. 41, 7, p. 684-684 1 p.
Research output: Contribution to journal › Meeting abstract › peer-review
1211TiPFAK-PD1: a phase I/IIa trial of FAK (defactinib) & PD-1 (pembrolizumab) inhibition
Symeonides, S., Evans, T. R. J., Coyle, V., Serrels, A., Thomson, F., Currie, D., Dillon, S., Paul, J., Fennell, D. A. & Ottensmeier, C., 1 Sept 2017, In: Annals of Oncology. 28, suppl_5
Research output: Contribution to journal › Meeting abstract › peer-review
Gene expression differences between Crohn's disease aphthous ulcers and healthy Peyer's patches highlight novel therapeutic targets
O'Brien, C. L., Patel, H. R., Freeman, T. C., Zhang, K., Peng, K., Virgin, H. W., Zhao, G. & Pavli, P., Aug 2017, In: Journal of Gastroenterology and Hepatology. 32, S1, p. 119-119 1 p.
Research output: Contribution to journal › Meeting abstract › peer-review
Cognitive Performance in Major Depressive Disorder in Generation Scotland: The Scottish Family Health Study (GS:SFHS)
Meijsen, J., Campbell, A., McIntosh, A., Porteous, D., Deary, I., Marioni, R. & Nicodemus, K., 15 May 2017, In: Biological Psychiatry. 81, 10, p. S217-S217 1 p.
Research output: Contribution to journal › Meeting abstract › peer-review
Gene-By-Environment Analyses Reveal Obstetric Complications Interact with Genetics to Influence Psychopathology and Personality
Gountouna, V-E., Hafferty, J., Campbell, A., Porteous, D., McIntosh, A. & Nicodemus, K., 15 May 2017, In: Biological Psychiatry. 81, 10, p. S368-S368 1 p.
Research output: Contribution to journal › Meeting abstract › peer-review
Automatic delineation of the gross-tumour volume in prostate cancer using shape models
Cheng, K., Feng, Y., Montgomery, D., McLaren, D., McLaughlin, S. & Nailon, W. H., 1 May 2017, In: Radiotherapy & Oncology. 123, p. S940 EP-1714.
Research output: Contribution to journal › Meeting abstract › peer-review

Open Access
In-vivo dosimetry using Dosimetry Check: 5-year experience on 345 prostate cancer patients
Nailon, W. H., Welsh, D., MacDonald, K., Burns, D., Forsyth, J., Cooke, G., Cutanda, F., McLaren, D., Puxeu-Vaqué, J., Kehoe, T. & Andiappa, S., 1 May 2017, In: Radiotherapy & Oncology. 123, p. S777 1 p., EP-1456.
Research output: Contribution to journal › Meeting abstract › peer-review

Open Access
Predicting radiation-induced pneumonitis in NSCLC: a radiobiological and texture analysis study
Nailon, W., Lu, W., Montgomery, D., Carruthers, L., Murchiston, J., Yong, AW., Ritchie, G., Evans, T., Little, F., Erridge, SC., McLaren, D. & Campbell, S., 1 May 2017, In: Radiotherapy & Oncology. 123, p. S947 1 p., EP-1725.
Research output: Contribution to journal › Meeting abstract › peer-review

Open Access
Abstract OT1-02-09: A phase 2 randomized, double-blinded, controlled study of ONT-380 vs. placebo in combination with capecitabine (C) and trastuzumab (T) in patients with pretreated HER2+ unresectable locally advanced or metastatic breast carcinoma (MBC) (HER2CLIMB)
Hamilton, E., Borges, V., Murthy, R., Anders, C., Cameron, D., Carey, L., Müller, V., Curigliano, G., Gelmon, K., Hortobagy, G., Krop, I., Loibl, S., Pivort, X., Pegram, M., Slamon, D., Hurvitz, S., Tsai, M. & Winer, E., 14 Feb 2017, In: Cancer Research. 77, 4 Supplement, p. OT1-02-09-OT1-02-09
Research output: Contribution to journal › Meeting abstract › peer-review
Abstract P6-09-27: The EA2clin test significantly predicts response and survival in both pre and post-menopausal women with ER-positive breast cancers
Turnbull, A., Pearce, D., Arthur, L., Martinez Perez, C., Thomas, J., Fernando, A., Renshaw, L., Sims, A. & Dixon, J., 14 Feb 2017, In: Cancer Research. 77, 4 Supplement, p. P6-09-27-P6-09-27
Research output: Contribution to journal › Meeting abstract › peer-review
Identifying the dominant prostate cancer focal lesion using 3D image texture analysis
Montgomery, D., Cheng, K., Feng, Y., McLaren, DB., McLaughlin, S. & Nailon, W., 2017, In: Radiotherapy & Oncology. 123, p. S498-S499
Research output: Contribution to journal › Meeting abstract › peer-review

Open Access
2016

A logical approach to understanding physiological mechanisms underpinning growth efficiency in broilers explained by a single selected genetic locus
Reid, A., Wilson, P., Whenham, N. & Dunn, I., 12 Dec 2016, In: British Poultry Abstracts. 12, 1, p. 11-12 2 p.
Research output: Contribution to journal › Meeting abstract › peer-review
Endothelial function is impaired in women who had pre-eclampsia
Delles, C., Brown, C., Flynn, J., Kerr, S. & Carty, D., 1 Dec 2016, In: Artery Research. 16, p. 74
Research output: Contribution to journal › Meeting abstract
Polygenic risk of alzheimer's disease and neurodegenerative related traits and their association with cognitive function: UK Biobank and the Dementias Platform UK
Fawns-Ritchie, C., Hagenaars, S., Harris, S., Davies, G., Liewald, D., Hill, W. D., Pell, J. P., Gallacher, J., Smith, D. J., Gale, C. & Deary, I., 17 Oct 2016, In: Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 12, 7, Supplement, p. P179 1 p.
Research output: Contribution to journal › Meeting abstract › peer-review
PISARRO: A EUTROC phase 1b study of APR-246 with carboplatin (C) and pegylated liposomal doxorubicin (PLD) in relapsed platinum-sensitive high grade serous ovarian cancer (HGSOC)
Basu, B., Gourley, C., Gabra, H., Vergote, I. B., Brenton, J. D., Abrahmsen, L., Smith, A., Von Euler, M. & Green, J. A., 11 Oct 2016, In: Annals of Oncology.
Research output: Contribution to journal › Meeting abstract › peer-review
Abstract 2698: Transcriptional profiling of human TAMs highlights differences in breast and endometrial tumour microenvironments
Fragkogianni, M., Cassetta, L., Swierczak, A., Wiechmann, L., Smith, H. O., Sims, A. H., Zhang, H., Coussens, L. M. & Pollard, J. W., 15 Jul 2016, In: Cancer Research. 76, 14 Supplement, p. 2698-2698
Research output: Contribution to journal › Meeting abstract › peer-review
Abstract 453: MEK activation is associated with a molecular subgroup in high grade serous ovarian cancer
Mccabe, N., Gourley, C., Mcgavigan, A., Michie, C. O., Mcgivern, N., Churchman, M., O’brien, E. J., Hill, L., Davison, T. S., Williams, A., Mccluggage, G., Keating, K. E., Harkin, D. P. & Kennedy, R. D., 15 Jul 2016, In: Cancer Research. 76, 14 Supplement, p. 453-453
Research output: Contribution to journal › Meeting abstract › peer-review
Abstract 855: p53 isoform Ä133p53â triple negative breast cancer and increased relapse with neoadjuvant taxanes
Bourdon, J., Diot, A., Meuray, V., Slaets, L., Iggo, R., Bonnefoi, H., Cameron, D. & Thompson, A. M., 15 Jul 2016, In: Cancer Research. 76, 14 Supplement, p. 855-855
Research output: Contribution to journal › Meeting abstract › peer-review
A novel mutation in TGM1 causing nonbullous congenital ichthyosiform erythroderma in identical twins
Leitch, C., Williams, T. & Taylor, L., Jul 2016, In: British journal of dermatology. 175, S1
Research output: Contribution to journal › Meeting abstract
Can Glomerular Filtration Rate by Wright Formula Replace Technetium-99m Labelled Glomerular Filtration Rate in Patients Receiving Adjuvant Carboplatin for Stage I Seminoma
Sundaramurthy, A., Malik, J., McLaren, D. & Law, A., May 2016, In: Clinical Oncology. 28, 5, p. E16-E16 1 p.
Research output: Contribution to journal › Meeting abstract › peer-review
Using texture analysis to detect prostate cancer for automated outlining and adaptive radiotherapy
Welsh, D., Montgomery, D., McLaren, D. & Nailon, W. H., 1 Apr 2016, In: Radiotherapy & Oncology. 119, p. s31 oc-0069.
Research output: Contribution to journal › Meeting abstract › peer-review
ROLE OF TRIM32 IN OSTEOARTHRITIS: TRIM32-DEFICIENT MICE DEVELOP ACCELERATED KNEE OSTEOARTHRITIS AFTER DESTABILISATION OF THE MEDIAL MENISCUS (DMM) SURGERY AND UPON AGEING
Roberts, S. B., Borjesson, A. E., Sophocleous, A., Salter, D. M. & Ralston, S. H., Apr 2016, In: Osteoarthritis and Cartilage. 24, p. S18-S18 1 p.
Research output: Contribution to journal › Meeting abstract › peer-review
Association of neuropathic limb pain in multiple sclerosis with cognition , behaviour, and measures of brain structure: a case-control MRI neuroimaging study
Foley, P., Pernet, C., Valdes Hernandez, M., Roberts, N., Kong, Y., Sellar, R., Colvin, L., Weir, C., Bak, T., Chandran, S., Tracey, I. & Fallon, M., 25 Feb 2016, In: The Lancet. 387, S45, p. 45 1 p.
Research output: Contribution to journal › Meeting abstract › peer-review
Brainstem processing of peripheral punctate stimuli in patients with and without chemotherapy-induced peripheral neuropathy: a prospective cohort functional MRI study
Seretny, M., Romaniuk, L., Sibley, H., Warnaby, C., Murnane, J., Roberts, N., Lawrie, S., Colvin, L., Tracey, I. & Fallon, M., 25 Feb 2016, In: The Lancet. Feb 25, p. 15 1 p.
Research output: Contribution to journal › Meeting abstract › peer-review
Structural modifications of the antimicrobial peptide ubiquicidin for pulmonary imaging of bacteria in the alveolar space.
Akram, A., Avlonitis, N., Craven, T., Vendrell Escobar, M., McDonald, N., Scholefield, E., Fisher, A., Corris, P., Haslett, C., Bradley, M. & Dhaliwal, K., 25 Feb 2016, In: The Lancet. 387, p. S17
Research output: Contribution to journal › Meeting abstract › peer-review
Abstract P4-08-06: Modulation of hypoxia-inducible factors and the HIF transcriptional response to hypoxia by ERBB2 overexpression in the MCF7 breast cancer cell line
Jarman, EJ., Turnbull, AK., Martinez-Perez, C., Meehan, J., Xintralopoulou, C., Ward, C. & Langdon, SP., 1 Feb 2016, In: Cancer Research. 76, 4 , p. P4-08-06-
Research output: Contribution to journal › Meeting abstract › peer-review
Abstract P5-04-05: Targeting the pH regulatory mechanisms of breast cancer cells
Meehan, J., Ward, C., Jarman, E., Xintaropoulou, C., Martinez-Perez, C., Turnbull, A., Supuran, C., Dixon, M., Kunkler, I. & Langdon, SP., 1 Feb 2016, In: Cancer Research. 76, 4Supplement, p. P5-04-05
Research output: Contribution to journal › Meeting abstract › peer-review
Investigation of gene–environment interactions between vitamin D and colorectal cancer susceptibility genetic variants in large bowel epithelium
Vaughan-shaw, P. G., Grimes, G. R., Ochocka, A., Dunbar, K., Timofeeva, M., Din, F., Farrington, S. M. & Dunlop, M. G., 1 Feb 2016, In: The Lancet. 387, p. S102
Research output: Contribution to journal › Meeting abstract › peer-review