Ailith Ewing

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Ailith Ewing

DR

 https://orcid.org/0000-0002-2272-1277
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Personal profile

Biography

Originally trained as a statistician, in 2012, I received a MMath Statistics degree from the University of St Andrews. On graduation I moved to Cambridge to start a PhD, with Prof. Paul Pharoah, investigating the role of rare germline genetic variation in ovarian cancer susceptibility and survival after diagnosis. On completion in 2015, I gained further research experience of working as a Medical Statistician for 10 months in the Clinical Trial Service Unit at the University of Oxford. 

In 2016, I joined the lab of Prof. Colin Semple in the MRC Institute of Genetics and Molecular Medicine (IGMM) working as a bioinformatician for the Scottish Genomes Partnership. In December 2017, I was awarded a UKRI Innovation Fellowship to investigate the mutational landscape of high grade serous ovarian cancer in collaboration with Prof. Charles Gourley, AstraZeneca and the Scottish Genomes Partnership. 

Current Research Interests

Mutational landscape of high grade serous ovarian cancer.

Education/Academic qualification

Public Health and Primary Care, Doctor of Philosophy (PhD), The role of rare germline genetic variation in the genetic epidemiology of ovarian cancer risk and survival after diagnosis., University of Cambridge

Statistics, Master of Mathematics, University of St Andrews

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  • Unravelling the tumour genome: the evolutionary and clinical impacts of structural variants in tumourigenesis

    Hamdan, A. & Ewing, A., 31 Mar 2022, In: The Journal of Pathology.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File

  • Structural variants at the BRCA1/2 loci are a common source of homologous repair deficiency in high grade serous ovarian carcinoma

    Ewing, A., Meynert, A. M., Churchman, M., Grimes, G. R., Hollis, R., Herrington, C. S., Rye, T., Bartos, C., Croy, I., Ferguson, M., Lennie, M., McGoldrick, T., McPhail, N., Siddiqui, N., Dowson, S., Glasspool, R., MacKean, M., Nussey, F., McDade, B., Ennis, D., & 11 othersThe Scottish Genomes Partnership, McMahon, L., Matakidou, A., Dougherty, B., March, R., Barrett, J. C., A. McNeish, I., V. Biankin, A., Roxburgh, P., Gourley, C. & Semple, C. A., 1 Jun 2021, In: Clinical Cancer Research.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File

  • Breaking point: the genesis and impact of structural variation in tumours

    Ewing, A. & Semple, C., 19 Nov 2018, In: F1000Research.

    Research output: Contribution to journal › Review article › peer-review

    Open Access
    File

  • Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

    Phelan, C. M., Kuchenbaecker, K. B., Tyrer, J. P., Kar, S. P., Lawrenson, K., Winham, S. J., Dennis, J., Pirie, A., Riggan, M. J., Chornokur, G., Earp, M. A., Lyra, P. C., Lee, J. M., Coetzee, S., Beesley, J., Mcguffog, L., Soucy, P., Dicks, E., Lee, A., Barrowdale, D., & 394 othersLecarpentier, J., Leslie, G., Aalfs, C. M., Aben, K. K. H., Adams, M., Adlard, J., Andrulis, I. L., Anton-culver, H., Antonenkova, N., Aravantinos, G., Arnold, N., Arun, B. K., Arver, B., Azzollini, J., Balmaña, J., Banerjee, S. N., Barjhoux, L., Barkardottir, R. B., Bean, Y., Beckmann, M. W., Beeghly-fadiel, A., Benitez, J., Bermisheva, M., Bernardini, M. Q., Birrer, M. J., Bjorge, L., Black, A., Blankstein, K., Blok, M. J., Bodelon, C., Bogdanova, N., Bojesen, A., Bonanni, B., Borg, Å., Bradbury, A. R., Brenton, J. D., Brewer, C., Brinton, L., Broberg, P., Brooks-wilson, A., Bruinsma, F., Brunet, J., Buecher, B., Butzow, R., Buys, S. S., Caldes, T., Caligo, M. A., Campbell, I., Cannioto, R., Carney, M. E., Cescon, T., Chan, S. B., Chang-claude, J., Chanock, S., Chen, X. Q., Chiew, Y., Chiquette, J., Chung, W. K., Claes, K. B. M., Conner, T., Cook, L. S., Cook, J., Cramer, D. W., Cunningham, J. M., D'aloisio, A. A., Daly, M. B., Damiola, F., Damirovna, S. D., Dansonka-mieszkowska, A., Dao, F., Davidson, R., Defazio, A., Delnatte, C., Doheny, K. F., Diez, O., Ding, Y. C., Doherty, J. A., Domchek, S. M., Dorfling, C. M., Dörk, T., Dossus, L., Duran, M., Dürst, M., Dworniczak, B., Eccles, D., Edwards, T., Eeles, R., Eilber, U., Ejlertsen, B., Ekici, A. B., Ellis, S., Elvira, M., Eng, K. H., Engel, C., Evans, D. G., Fasching, P. A., Ferguson, S., Ferrer, S. F., Flanagan, J. M., Fogarty, Z. C., Fortner, R. T., Fostira, F., Foulkes, W. D., Fountzilas, G., Fridley, B. L., Friebel, T. M., Friedman, E., Frost, D., Ganz, P. A., Garber, J., García, M. J., Garcia-barberan, V., Gehrig, A., Gentry-maharaj, A., Gerdes, A., Giles, G. G., Glasspool, R., Glendon, G., Godwin, A. K., Goldgar, D. E., Goranova, T., Gore, M., Greene, M. H., Gronwald, J., Gruber, S., Hahnen, E., Haiman, C. A., Håkansson, N., Hamann, U., Hansen, T. V. O., Harrington, P. A., Harris, H. R., Hauke, J., Hein, A., Henderson, A., Hildebrandt, M. A. T., Hillemanns, P., Hodgson, S., Høgdall, C. K., Høgdall, E., Hogervorst, F. B. L., Holland, H., Hooning, M. J., Hosking, K., Huang, R., Hulick, P. J., Hung, J., Hunter, D. J., Huntsman, D. G., Huzarski, T., Imyanitov, E. N., Isaacs, C., Iversen, E. S., Izatt, L., Izquierdo, A., Jakubowska, A., James, P., Janavicius, R., Jernetz, M., Jensen, A., Jensen, U. B., John, E. M., Johnatty, S., Jones, M. E., Kannisto, P., Karlan, B. Y., Karnezis, A., Kast, K., Kennedy, C. J., Khusnutdinova, E., Kiemeney, L. A., Kiiski, J. I., Kim, S., Kjaer, S. K., Köbel, M., Kopperud, R. K., Kruse, T. A., Kupryjanczyk, J., Kwong, A., Laitman, Y., Lambrechts, D., Larrañaga, N., Larson, M. C., Lazaro, C., Le, N. D., Le Marchand, L., Lee, J. W., Lele, S. B., Leminen, A., Leroux, D., Lester, J., Lesueur, F., Levine, D. A., Liang, D., Liebrich, C., Lilyquist, J., Lipworth, L., Lissowska, J., Lu, K. H., Lubinński, J., Luccarini, C., Lundvall, L., Mai, P. L., Mendoza-fandiño, G., Manoukian, S., Massuger, L. F. A. G., May, T., Mazoyer, S., Mcalpine, J. N., Mcguire, V., Mclaughlin, J. R., Mcneish, I., Meijers-heijboer, H., Meindl, A., Menon, U., Mensenkamp, A. R., Merritt, M. A., Milne, R. L., Mitchell, G., Modugno, F., Moes-sosnowska, J., Moffitt, M., Montagna, M., Moysich, K. B., Mulligan, A. M., Musinsky, J., Nathanson, K. L., Nedergaard, L., Ness, R. B., Neuhausen, S. L., Nevanlinna, H., Niederacher, D., Nussbaum, R. L., Odunsi, K., Olah, E., Olopade, O. I., Olsson, H., Olswold, C., O'malley, D. M., Ong, K., Onland-moret, N. C., Orr, N., Orsulic, S., Osorio, A., Palli, D., Papi, L., Park-simon, T., Paul, J., Pearce, C. L., Pedersen, I. S., Peeters, P. H. M., Peissel, B., Peixoto, A., Pejovic, T., Pelttari, L. M., Permuth, J. B., Peterlongo, P., Pezzani, L., Pfeiler, G., Phillips, K., Piedmonte, M., Pike, M. C., Piskorz, A. M., Poblete, S. R., Pocza, T., Poole, E. M., Poppe, B., Porteous, M. E., Prieur, F., Prokofyeva, D., Pugh, E., Pujana, M. A., Pujol, P., Radice, P., Rantala, J., Rappaport-fuerhauser, C., Rennert, G., Rhiem, K., Rice, P., Richardson, A., Robson, M., Rodriguez, G. C., Rodríguez-antona, C., Romm, J., Rookus, M. A., Rossing, M. A., Rothstein, J. H., Rudolph, A., Runnebaum, I. B., Salvesen, H. B., Sandler, D. P., Schoemaker, M. J., Senter, L., Setiawan, V. W., Severi, G., Sharma, P., Shelford, T., Siddiqui, N., Side, L. E., Sieh, W., Singer, C. F., Sobol, H., Song, H., Southey, M. C., Spurdle, A. B., Stadler, Z., Steinemann, D., Stoppa-lyonnet, D., Sucheston-campbell, L. E., Sukiennicki, G., Sutphen, R., Sutter, C., Swerdlow, A. J., Szabo, C. I., Szafron, L., Tan, Y. Y., Taylor, J. A., Tea, M., Teixeira, M. R., Teo, S., Terry, K. L., Thompson, P. J., Thomsen, L. C. V., Thull, D. L., Tihomirova, L., Tinker, A. V., Tischkowitz, M., Tognazzo, S., Toland, A. E., Tone, A., Trabert, B., Travis, R. C., Trichopoulou, A., Tung, N., Tworoger, S. S., Van Altena, A. M., Van Den Berg, D., Van Der Hout, A. H., Van Der Luijt, R. B., Van Heetvelde, M., Van Nieuwenhuysen, E., Van Rensburg, E. J., Vanderstichele, A., Varon-mateeva, R., Vega, A., Edwards, D. V., Vergote, I., Vierkant, R. A., Vijai, J., Vratimos, A., Walker, L., Walsh, C., Wand, D., Wang-gohrke, S., Wappenschmidt, B., Webb, P. M., Weinberg, C. R., Weitzel, J. N., Wentzensen, N., Whittemore, A. S., Wijnen, J. T., Wilkens, L. R., Wolk, A., Woo, M., Wu, X., Wu, A. H., Yang, H., Yannoukakos, D., Ziogas, A., Zorn, K. K., Narod, S. A., Easton, D. F., Amos, C. I., Schildkraut, J. M., Ramus, S. J., Ottini, L., Goodman, M. T., Park, S. K., Kelemen, L. E., Risch, H. A., Thomassen, M., Offit, K., Simard, J., Schmutzler, R. K., Hazelett, D., Monteiro, A. N., Couch, F. J., Berchuck, A., Chenevix-trench, G., Goode, E. L., Sellers, T. A., Gayther, S. A., Antoniou, A. C. & Pharoah, P. D. P., 1 May 2017, In: Nature Genetics. 49, 5, p. 680-691

    Research output: Contribution to journal › Article › peer-review

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