Alan Archibald

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Personal profile

Current Research Interests

Understanding the genetic control of complex traits, including responses to infectious disease, in farmed animals, primarily pigs and cattle.

Websites

This research group is an active participant in several international collaborative projects and networks including:

Functional Annotation of Animal Genomes (FAANG) www.faang.org

COST Action CA15112 Functional Annotation of Animal Genomes - European network (FAANG-Europe) www.faang-europe.org

Swine Genome Sequencing Consortium see: 
www.sanger.ac.uk/Projects/S_scrofa
FPC physical map available at: http://pre.ensembl.org/Sus_scrofa_map/Info/Index/
Annotated Sscrofa10.2 reference genome sequence available at: http://www.ensembl.org/Sus_scrofa/Info/Index
View of Sscrofa10.2 reference genome sequence and aligned clone end sequences available at:
http://geval.sanger.ac.uk/PGP_pig_10_2/Info/Index

International Sheep Genomics Consortium see:
http://www.sheephapmap.org/
Annotated Oar_v3.1 reference genome available at:
http://www.ensembl.org/Ovis_aries/Info/Index

 

Administrative Roles

External Committees

Swine Genome Sequencing Consortium – steering committee (Alan Archibald)

ELIXIR Scientific Advisory Board (Alan Archibald)

Scientific Impact and Advisory Board - Institute of Biological, Evironmental and Rural Sciences (IBERS), University of Aberystwyth (Alan Archibald)

Scientific Advisory Committee – Animal Health Trust, Newmarket (Alan Archibald)

Knowledge Transfer Network, Animal Sector Advisory Board (Alan Archibald)

BBSRC Animal Health Research Club Steering Group(Alan Archibald)

Internal Committees

The Roslin Institute Science Management Group (Alan Archibald)
The Roslin Institute Finance and Contracts Committee (Alan Archibald)
Edinburgh Genomics Governance Board (Alan Archibald)

 

Teaching

Postgraduate students, Honours students

Previous students:
Sorensen G, Host-virus interactions in Porcine Reproductive and Respiratory Syndrome virus infection. (PhD, 2014)

Hernandez SC, Genetics of litter size and prenatal survival in pigs. (PhD, 2011)

King AH, Identification of candidate genes controlling porcine female reproductive traits (PhD, 2003)

Kathirvel P, Mapping and manipulation of the murine ryanodine receptor gene (Ryr1) (PhD, )

George S, Physical mapping of the murine casein locus (PhD, 1996)

Biography

Alan L. Archibald is Head of the Division of Genetics and Genomics at The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh. Professor Alan Archibald is internationally recognised in the field of farm animal genetics and genomics research. He co-led the first international farm animal genome project – PiGMaP. Together with Professor Chris Haley he was awarded the Royal Agricultural Society of England’s Research Medal in 1997 for research work of benefit to agriculture. He is a member of the Steering Committee of the Swine Genome Sequencing Consortium that is promoting efforts to sequence the pig genome and chair of the Governing Council of the European Animal Disease Genomics network of Excellence for Animal Health and Food Safety.

His research is concerned with understanding the genetic control of complex traits, including production efficiency, product quality and host response to infectious disease, mainly in pigs and cattle. His current research of relevance to this conference includes dissecting the genetic control of predisposition to boar taint.

He has a personal chair in Mammalian Molecular Genetics in the Royal (Dick) School of Veterinary Studies at the University of Edinburgh and is as a Fellow of the Royal Society of Edinburgh which is Scotland’s National Academy of Science and Letters.

Education/Academic qualification

Doctor of Philosophy (PhD), University of Edinburgh

1981

Award Date: 1 Jan 1981

Biochemistry, Bachelor of Science, University of Edinburgh

1973

Award Date: 1 Jan 1973

External positions

Head of Division of Genetics and Genomics (Band 2), Roslin Institute

2004 → …

Head of Genomics and Bioinformatics (Band 3), Roslin Institute

20002004

Band 3 Principal Investigator, Roslin Institute

19992000

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  • Analyses of pig genomes provide insight into porcine demography and evolution

    Groenen, M. A. M., Archibald, A. L., Uenishi, H., Tuggle, C. K., Takeuchi, Y., Rothschild, M. F., Rogel-Gaillard, C., Park, C., Milan, D., Megens, H-J., Li, S., Larkin, D. M., Kim, H., Frantz, L. A. F., Caccamo, M., Ahn, H., Aken, B. L., Anselmo, A., Anthon, C., Auvil, L. & 116 others, Badaoui, B., Beattie, C. W., Bendixen, C., Berman, D., Blecha, F., Blomberg, J., Bolund, L., Bosse, M., Botti, S., Zhan Bujie, N. V., Bystrom, M., Capitanu, B., Carvalho-Silva, D., Chardon, P., Chen, C., Cheng, R., Choi, S-H., Chow, W., Clark, R. C., Clee, C., Crooijmans, R. P. M. A., Dawson, H. D., Dehais, P., De Sapio, F., Dibbits, B., Drou, N., Du, Z-Q., Eversole, K., Fadista, J., Fairley, S., Faraut, T., Faulkner, G., Fowler, K. E., Fredholm, M., Fritz, E., Gilbert, J. G. R., Giuffra, E., Gorodkin, J., Griffin, D. K., Harrow, J. L., Hayward, A., Howe, K., Hu, Z-L., Humphray, S. J., Hunt, T., Hornshoj, H., Jeon, J-T., Jern, P., Jones, M., Jurka, J., Kanamori, H., Kapetanovic, R., Kim, J., Kim, J-H., Kim, K-W., Kim, T-H., Larson, G., Lee, K., Lee, K-T., Leggett, R., Lewin, H. A., Li, Y., Liu, W., Loveland, J. E., Lu, Y., Lunney, J. K., Ma, J., Madsen, O., Mann, K., Matthews, L., McLaren, S., Morozumi, T., Murtaugh, M. P., Narayan, J., Dinh Truong Nguyen, N. V., Ni, P., Oh, S-J., Onteru, S., Panitz, F., Park, E-W., Park, H-S., Pascal, G., Paudel, Y., Perez-Enciso, M., Ramirez-Gonzalez, R., Reecy, J. M., Rodriguez-Zas, S., Rohrer, G. A., Rund, L., Sang, Y., Schachtschneider, K., Schraiber, J. G., Schwartz, J., Scobie, L., Scott, C., Searle, S., Servin, B., Southey, B. R., Sperber, G., Stadler, P., Sweedler, J. V., Tafer, H., Thomsen, B., Wali, R., Wang, J., Wang, J., White, S., Xu, X., Yerle, M., Zhang, G., Zhang, J., Zhang, J., Zhao, S., Rogers, J., Churcher, C. & Schook, L. B., 15 Nov 2012, In: Nature. 491, 7424, p. 393-398 6 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    File
  • Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function

    Burkard, C., Lillico, S., Reid, E., Jackson, B., Mileham, A. J., Ait-Ali, T., Whitelaw, C. & Archibald, A., 23 Feb 2017, (E-pub ahead of print) In: PLoS Pathogens. 13, 2, 28 p., e1006206.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    File
  • Coordinated international action to accelerate genome-to-phenome with FAANG, the Functional Annotation of Animal Genomes project

    The FAANG Consortium, 1 Dec 2015, In: Genome Biology. 16, 1, 57.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    File
  • The sheep genome illuminates biology of the rumen and lipid metabolism

    Jiang, Y., Xie, M., Chen, W., Talbot, R., Maddox, J. F., Faraut, T., Wu, C., Muzny, D. M., Li, Y., Zhang, W., Stanton, J-A., Brauning, R., Barris, W. C., Hourlier, T., Aken, B. L., Searle, S. M. J., Adelson, D. L., Bian, C., Cam, G. R., Chen, Y. & 53 others, Cheng, S., DeSilva, U., Dixen, K., Dong, Y., Fan, G., Franklin, I. R., Fu, S., Fuentes-Utrilla, P., Guan, R., Highland, M. A., Holder, M. E., Huang, G., Ingham, A. B., Jhangiani, S. N., Kalra, D., Kovar, C. L., Lee, S. L., Liu, W., Liu, X., Lu, C., Lv, T., Mathew, T., McWilliam, S., Menzies, M., Pan, S., Robelin, D., Servin, B., Townley, D., Wang, W., Wei, B., White, S. N., Yang, X., Ye, C., Yue, Y., Zeng, P., Zhou, Q., Hansen, J. B., Kristiansen, K., Gibbs, R. A., Flicek, P., Warkup, C. C., Jones, H. E., Oddy, V. H., Nicholas, F. W., McEwan, J. C., Kijas, J. W., Wang, J., Worley, K. C., Archibald, A. L., Cockett, N., Xu, X., Wang, W. & Dalrymple, B. P., 6 Jun 2014, In: Science. 344, 6188, p. 1168-1173 6 p.

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  • Genome sequencing reveals fine scale diversification and reticulation history during speciation in Sus

    Frantz, L. A., Schraiber, J. G., Madsen, O., Megens, H-J., Bosse, M., Paudel, Y., Semiadi, G., Meijaard, E., Li, N., Crooijmans, R. P., Archibald, A. L., Slatkin, M., Schook, L. B., Larson, G. & Groenen, M. A., 26 Sep 2013, In: Genome Biology. 14, 9, p. R107

    Research output: Contribution to journalArticlepeer-review

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