Understanding how genetic variation influences normal and pathological variation in humans.

Albert is investigating how our genes make some of us more susceptible to certain diseases, such as cancer, than others. In the long term this research could be used to predict what diseases individuals are prone to and what age they are likely to develop them. With this information better drugs and preventative treatments could be developed. 
To investigate this, Albert takes samples from a large number of patients and controls (people without disease). The genomes of these groups are then studied. If proportionally more patients than controls are carrying a certain genotype, it is thought to be increasing their risk of getting the disease. These genetic risk factors are combined with environmental risk factors (e.g. smoking, exercise) to form an idea of what makes people prone to disease.

An important part of our research, through projects like AIM-CISC, relates to understanding multimorbidity (why people have multiple diseases).

We are always looking for bright and enthusiastic PhD students with a strong numerical and biological background.