Research output per year
Research output per year
Personal profile
Biography
Biochemist
Joint Honours degree in Pharmacology and Biochemistry (King's College, University of London)
MSc in Clinical Biochemistry (Newcastle University)
PhD "Use of brain-specific proteins in the diagnosis of dementia" (National Hospital for Neurology, London; University College, London)
Creation of an analytical and interpretation diagnostic service for cerebrospinal fluid (CSF) 14-3-3 and other proteins for diagnosis of Creutzfeldt-jakob disease (CJD) within the National CJD Research & Surveillance Unit (NCJDRSU) at University of Edinburgh
Development of protein aggregation assays for the diagnosis of CJD, Lewy body dementia, Parkinson's disease and other neurodegenerative dementias
Qualifications
BSc: Biochemistry/Pharmacolgy 2i (King's College, London) (1983)
MSc: Clinical Chemistry (Newcastle University) (1984)
PhD: "Use of brain-specific proteins in the diagnosis of dementia" (University College, London) (1999)
Fellow of Royal College of Pathologists (2002)
Current Research Interests
Use of CSF 14-3-3 and S100b in the diagnosis of patients with suspected CJD
Development of Real-time Quaking Induced Conversion (RT-QuIC) as a diagnostic tool for CJD
CSF tau, p-tau and amyloid proteins in the differentaion diagnosis of dementia
Development of protein aggregation assays for the diagnosis of Parkinson's disease and Lewy body dementia and other neurodegenerative diseases
Development and Evaluation of Protein aggregations assays in the diagnosis of patients with CJD
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Validation of Revised International Creutzfeldt-Jakob Disease Surveillance Network Diagnostic Criteria for Sporadic Creutzfeldt-Jakob Disease
Watson, N., Hermann, P., Ladogana, A., Denouel, A., Baiardi, S., Colaizzo, E., Giaccone, G., Glatzel, M., Green, A. J. E., Haïk, S., Imperiale, D., Mackenzie, J., Moda, F., Smith, C., Summers, D., Tiple, D., Vaianella, L., Zanusso, G., Pocchiari, M., Zerr, I. & 3 others, , 31 Jan 2022, In: JAMA Network Open. 5, 1, p. e2146319Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Impact of the COVID‐19 pandemic on Creutzfeldt–Jakob disease surveillance and patient care in the United Kingdom
Watson, N., Kirby, J., Kurudzhu, H., Leitch, M., Mackenzie, J., Smith‐bathgate, B., Smith, C., Summers, D., Green, A. J. E. & Pal, S., 23 Dec 2021, In: European Journal of Neurology.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders
Kurzawa-akanbi, M., Tammireddy, S., Fabrik, I., Gliaudelytė, L., Doherty, M. K., Heap, R., Matečko-burmann, I., Burmann, B. M., Trost, M., Lucocq, J. M., Gherman, A. V., Fairfoul, G., Singh, P., Burté, F., Green, A., Mckeith, I. G., Härtlova, A., Whitfield, P. D. & Morris, C. M., 13 Sep 2021, In: Acta Neuropathologica.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Case report of homozygous E200D mutation of PRNP in apparently sporadic Creutzfeldt-Jakob disease
Hassan, A., Campbell, T., Darwent, L., Odd, H., Green, A., Collinge, J. & Mead, S., 28 Jun 2021, In: Bmc neurology. 21, 1Research output: Contribution to journal › Article › peer-review
Open AccessFile -
The importance of ongoing international surveillance for Creutzfeldt–Jakob disease
Watson, N., Brandel, J., Green, A., Hermann, P., Ladogana, A., Lindsay, T., Mackenzie, J., Pocchiari, M., Smith, C., Zerr, I. & Pal, S., 10 May 2021, In: Nature Reviews Neurology. 17, 6, p. 362-379Research output: Contribution to journal › Article › peer-review
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Establishing alpha-synuclein RT-QuIC assay as a diagnostic technique in REM Sleep Behaviour Disorder
1/09/18 → 30/06/22
Project: Research
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CSF RT-QuIC alpha-synuclein amplification in LRRK2-Parkinson¿s disease
26/03/21 → 31/03/22
Project: Research
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Evaluation of commercial recombinant a-synuclein for use as RT-QuIC substrate
Green, A. & Piconi, G.
26/02/21 → 25/02/22
Project: Research
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A matrix reference material for human Cerebrospinal fluid (CSF): the key for the optimisation and harmonisation of neurodegenerative disease clinical diagnostic tests based on protein aggregation assays.
Piconi, G. & Green, A.
4/01/21 → 9/07/21
Project: University Awarded Project Funding
Press / Media
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CSF Biomarkers Flags Parkinson's Pathology Years Before Symptoms Appear
4/03/21
1 Media contribution
Press/Media: Project or Organisational News Item
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Parkinson’s study could pave way for early detection test, says Dr Alison Green
29/08/16
37 items of Media coverage
Press/Media: Research
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Dr Alison Green works on test that can detect Parkinson's disease and Lewy body dementia
6/02/17
1 item of Media coverage
Press/Media: Research
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Dr Alison Green (Clinical Sciences) working on a modified version of a capable of detecting Parkinson's disease and Lewy body dementia
24/02/17
1 item of Media coverage
Press/Media: Research