Research output per year
Research output per year
Personal profile
Biography
Biochemist
Joint Honours degree in Pharmacology and Biochemistry (King's College, University of London)
MSc in Clinical Biochemistry (Newcastle University)
PhD "Use of brain-specific proteins in the diagnosis of dementia" (National Hospital for Neurology, London; University College, London)
Creation of an analytical and interpretation diagnostic service for cerebrospinal fluid (CSF) 14-3-3 and other proteins for diagnosis of Creutzfeldt-jakob disease (CJD) within the National CJD Research & Surveillance Unit (NCJDRSU) at University of Edinburgh
Development of protein aggregation assays for the diagnosis of CJD, Lewy body dementia, Parkinson's disease and other neurodegenerative dementias
Qualifications
BSc: Biochemistry/Pharmacolgy 2i (King's College, London) (1983)
MSc: Clinical Chemistry (Newcastle University) (1984)
PhD: "Use of brain-specific proteins in the diagnosis of dementia" (University College, London) (1999)
Fellow of Royal College of Pathologists (2002)
Current Research Interests
Use of CSF 14-3-3 and S100b in the diagnosis of patients with suspected CJD
Development of Real-time Quaking Induced Conversion (RT-QuIC) as a diagnostic tool for CJD
CSF tau, p-tau and amyloid proteins in the differentaion diagnosis of dementia
Development of protein aggregation assays for the diagnosis of Parkinson's disease and Lewy body dementia and other neurodegenerative diseases
Development and Evaluation of Protein aggregations assays in the diagnosis of patients with CJD
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Research output
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Application of telehealth for comprehensive Creutzfeldt-Jakob disease surveillance in the United Kingdom
Watson, N., Kurudzhu, H., Green, A., Summers, D., Smith, C. & Pal, S., 15 Jan 2021, In: Journal of the Neurological Sciences. 420, p. 117221Research output: Contribution to journal › Article › peer-review
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Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease
Hermann, P., Appleby, B., Brandel, J., Caughey, B., Collins, S., Geschwind, M. D., Green, A., Haïk, S., Kovacs, G. G., Ladogana, A., Llorens, F., Mead, S., Nishida, N., Pal, S., Parchi, P., Pocchiari, M., Satoh, K., Zanusso, G. & Zerr, I., 1 Mar 2021, In: The Lancet Neurology. 20, 3, p. 235-246Research output: Contribution to journal › Article › peer-review
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Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study
Iranzo, A., Fairfoul, G., Ayudhaya, A. C. N., Serradell, M., Gelpi, E., Vilaseca, I., Sanchez-valle, R., Gaig, C., Santamaria, J., Tolosa, E., Riha, R. L. & Green, A. J. E., 1 Mar 2021, In: The Lancet Neurology. 20, 3, p. 203-212Research output: Contribution to journal › Article › peer-review
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Regional Differences in Neuroinflammation-Associated Gene Expression in the Brain of Sporadic Creutzfeldt–Jakob Disease Patients
Areškevičiūtė, A., Litman, T., Broholm, H., Melchior, L. C., Nielsen, P. R., Green, A., Eriksen, J. O., Smith, C. & Lund, E. L., 25 Dec 2020, In: International Journal of Molecular Sciences. 22, 1, p. 140Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Ring trial of 2nd generation RT‐QuIC diagnostic tests for sporadic CJD
Orrú, C. D., Groveman, B. R., Foutz, A., Bongianni, M., Cardone, F., Mckenzie, N., Culeux, A., Poleggi, A., Grznarova, K., Perra, D., Fiorini, M., Liu, X., Ladogana, A., Sbriccoli, M., Hughson, A. G., Haïk, S., Green, A. J., Geschwind, M. D., Pocchiari, M., Safar, J. G. & 2 others, , 7 Nov 2020, In: Annals of Clinical and Translational Neurology. 7, 11, p. 2262-2271Research output: Contribution to journal › Article › peer-review
Open AccessFile
Projects
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CSF RT-QuIC alpha-synuclein amplification in LRRK2-Parkinson¿s disease
26/03/21 → 31/03/22
Project: Research
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Evaluation of commercial recombinant a-synuclein for use as RT-QuIC substrate
26/02/21 → 25/02/22
Project: Research
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A matrix reference material for human Cerebrospinal fluid (CSF): the key for the optimisation and harmonisation of neurodegenerative disease clinical diagnostic tests based on protein aggregation assays.
Piconi, G. & Green, A.
4/01/21 → 9/07/21
Project: University Awarded Project Funding
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Establishing alpha-synuclein RT-QuIC assay as a diagnostic technique in REM Sleep Behaviour Disorder
Riha, R. & Green, A.
1/09/18 → 31/05/22
Project: Research
Press / Media
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CSF Biomarkers Flags Parkinson's Pathology Years Before Symptoms Appear
4/03/21
1 Media contribution
Press/Media: Project or Organisational News Item
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Dr Alison Green works on test that can detect Parkinson's disease and Lewy body dementia
6/02/17
1 item of Media coverage
Press/Media: Research
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Parkinson’s study could pave way for early detection test, says Dr Alison Green
29/08/16
37 items of Media coverage
Press/Media: Research
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Dr Alison Green (Clinical Sciences) working on a modified version of a capable of detecting Parkinson's disease and Lewy body dementia
24/02/17
1 item of Media coverage
Press/Media: Research