Alison Munro

2025

Drug Combinations Targeting FAK and MEK Overcomes 2 Tumour Heterogeneity in Glioblastoma

Furqan, M., Elliott, R., Nagle, P., Dawson, J. C., Masalmeh, R., Alvarez Garcia, V., Munro, A., Drake, C., Morrison, G., Pollard, S. M., Ebner, D., Brunton, V. G., Frame, M. C. & Carragher, N. O., 23 Apr 2025, (E-pub ahead of print) In: Pharmaceutics.

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2024

Targeting the PREX2/RAC1/PI3Kβ Signaling Axis Confers Sensitivity to Clinically Relevant Therapeutic Approaches in Melanoma

Ford, C. A., Koludrovic, D., Centeno, P. P., Foth, M., Tsonou, E., Vlahov, N., Sphyris, N., Gilroy, K., Bull, C., Nixon, C., Serrels, B., Munro, A. F., Dawson, J. C., Carragher, N. O., Pavet, V., Hornigold, D. C., Dunne, P. D., Downward, J., Welch, H. C. & Barry, S. T. & 2 others, Sansom, O. J. & Campbell, A. D., 5 Dec 2024, (E-pub ahead of print) In: Cancer Research.

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Abstract 615: NXP900, a novel YES1/SRC kinase inhibitor in phase 1, demonstrates potent inhibition of proliferation in cell lines resistant to ALK and EGFR inhibitors

Carragher, N. O., Poradosu, E., King, B., Munro, A. F., Dawson, J. C. & Unciti-Broceta, A., 15 Mar 2024, In: Cancer Research. 84, 6_Supplement, p. 615-615

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2023

A cautionary note on the use of N-acetylcysteine as a reactive oxygen species antagonist to assess copper mediated cell death

Hughes, B., Elliott, R., Munro, A. & Carragher, N. O., 11 Dec 2023, (E-pub ahead of print) In: PLoS ONE.

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Crosstalk with lung fibroblasts shapes the growth and therapeutic response of mesothelioma cells

Chrisochoidou, Y., Roy, R., Farahmand, P., Gonzalez, G., Doig, J., Krasny, L., Rimmer, E., Willis, A., MacFarlane, M., Huang, P., Carragher, N. O., Munro, A., Murphy, D. J., Veselkov, K., Seckl, M. J., Moffatt, M. F., Cookson, W. O. C. & Pardo, O. E., 8 Nov 2023, (E-pub ahead of print) In: Cell Death and Disease.

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Open Access

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Distinct neuroinflammatory signatures exist across genetic and sporadic amyotrophic lateral sclerosis cohorts

Rifai, O. M., O’Shaughnessy, J., Dando, O. R., Munro, A. F., Sewell, M. D. E., Abrahams, S., Waldron, F. M., Sibley, C. R. & Gregory, J. M., 14 Jul 2023, In: Brain.

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2022

Multiparametric High-Content Cell Painting Identifies Copper Ionophores as Selective Modulators of Esophageal Cancer Phenotypes

Hughes, R. E., Elliott, R. J. R., Li, X., Munro, A. F., Makda, A., Carter, R. N., Morton, N. M., Fujihara, K., Clemons, N. J., Fitzgerald, R., O’neill, J. R., Hupp, T. & Carragher, N. O., 13 Jun 2022, (E-pub ahead of print) In: Acs chemical biology.

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Open Access

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2021

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors

Dawson, J. C., Munro, A., Macleod, K., Muir, M., Timpson, P., Williams, R. J., Frame, M. C., Brunton, V. G. & Carragher, N. O., 2 Dec 2021, (E-pub ahead of print) In: Molecular Oncology.

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A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability

Temps, C., Leitha, D., Webb, E., Li, X.-F., Dawson, J. C., Muir, M., Macleod, K., Valero, T., Munro, A., Contreras-montoya, R., Luque-Ortega, J. R., Fraser, C., Beetham, H., Schoenherr, C., Lopalco, M., Arends, M. J., Frame, M. C., Qian, B.-Z., Brunton, V. G. & Carragher, N. O. & 1 others, Unciti-Broceta, A., 20 Aug 2021, (E-pub ahead of print) In: Cancer Research.

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2020

The autophagy protein Ambra1 regulates gene expression by supporting novel transcriptional complexes

Schoenherr, C., Byron, A., Griffith, B., Loftus, A., Wills, J. C., Munro, A. F., Von Kriegsheim, A. & Frame, M. C., 2 Jul 2020, (E-pub ahead of print) In: Journal of Biological Chemistry. p. jbc.RA120.012565

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Open Access

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High Content Phenotypic Profiling in Oesophageal Adenocarcinoma Identifies Selectively Active Pharmacological Classes of Drugs for Repurposing and Chemical Starting Points for Novel Drug Discovery

Hughes, B., Elliott, R., Munro, A., Makda, A., O'Neill, R., Hupp, T. & Carragher, N., 22 May 2020, (E-pub ahead of print) In: Slas Discovery.

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Unlocking the transcriptomic potential of formalin-fixed paraffin embedded clinical tissues: Comparison of gene expression profiling approaches

Turnbull, A. K., Selli Karakaya, C., Martinez-Perez, C., Fernando, A., Renshaw, L., Keys, J., Figueroa, J., He, X., Tanioka, M., Munro, A., Murphy, L., Fawkes, A., Clark, R., Coutts, A., M. Perou, C., A. Carey, L., Dixon, M. & Sims, A., 28 Jan 2020, (E-pub ahead of print) In: BMC Bioinformatics.

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High Content Phenotypic Screening Identifies Serotonin Receptor Modulators with Selective Activity upon Breast Cancer Cell Cycle and Cytokine Signaling Pathways

Warchal, S., Dawson, J., Shepherd, E., Munro, A., Hughes, R., Makda, A. & Carragher, N., 1 Jan 2020, In: Bioorganic and Medicinal Chemistry. 28, 1, 115209.

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Open Access

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2017

Pharmaco-genomic investigations of organo-iridium anticancer complexes reveal novel mechanism of action

Hearn, J. M., Hughes, G. M., Romero-Canelón, I., Munro, A., Rubio Ruiz, B., Liu, Z., Carragher, N. & Sadler, P. J., 13 Nov 2017, In: Metallomics.

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2016

Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines that Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase

Fraser, C., Dawson, J. C., Dowling, R., Houston, D. R., Weiss, J. T., Munro, A. F., Muir, M., Harrington, L., Webster, S. P., Frame, M. C., Brunton, V. G., Patton, E. E., Carragher, N. O. & Unciti-Broceta, A., 26 May 2016, In: Journal of Medicinal Chemistry.

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2015

A four gene signature predicts benefit from anthracyclines: Evidence from the BR9601 and MA.5 clinical trials

Spears, M., Yousif, F., Lyttle, N., Boutros, P. C., Munro, A. F., Twelves, C., Pritchard, K. I., Levine, M. N., Shepherd, L. & Bartlett, J. M. S., 10 Sept 2015, In: Oncotarget. 6, 31, p. 31693-31701 9 p.

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FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis

Qian, B.-Z., Zhang, H., Li, J., He, T., Yeo, E.-J., Soong, D. Y. H., Carragher, N. O., Munro, A., Chang, A., Bresnick, A. R., Lang, R. A. & Pollard, J. W., 24 Aug 2015, In: Journal of Experimental Medicine. 212, 9, p. 1433-1448 16 p.

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Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells

Hearn, J. M., Romero-Canelón, I., Munro, A. F., Fu, Y., Pizarro, A. M., Garnett, M. J., McDermott, U., Carragher, N. O. & Sadler, P. J., 21 Jul 2015, In: Proceedings of the National Academy of Sciences (PNAS). 112, 29, p. E3800-5

Research output: Contribution to journal › Article › peer-review

Predicting Anthracycline Benefit: TOP2A and CEP17--Not Only but Also

Bartlett, J. M. S., Mcconkey, C. C., Munro, A. F., Desmedt, C., Dunn, J. A., Larsimont, D. P., O'malley, F. P., Cameron, D. A., Earl, H. M., Poole, C. J., Shepherd, L. E., Cardoso, F., Jensen, M.-B., Caldas, C., Twelves, C. J., Rea, D. W., Ejlertsen, B., Di Leo, A. & Pritchard, K. I., 20 May 2015, In: Journal of Clinical Oncology. 33, 15, p. 1680-1687

Research output: Contribution to journal › Article › peer-review

2013

Is TIMP-1 immunoreactivity alone or in combination with other markers a predictor of benefit from anthracyclines in the BR9601 adjuvant breast cancer chemotherapy trial?

Munro, A. F., Bartels, A., Balslev, E., Twelves, C. J., Cameron, D. A., Brünner, N. & Bartlett, J. M., 9 Apr 2013, In: Breast Cancer Research. 15, 2, p. R31

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2012

GSK3β and cyclin D1 expression predicts outcome in early breast cancer patients

Quintayo, M. A., Munro, A. F., Thomas, J., Kunkler, I. H., Jack, W., Kerr, G. R., Dixon, J. M., Chetty, U. & Bartlett, J. M. S., Nov 2012, In: Breast cancer research and treatment. 136, 1, p. 161-8 8 p.

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Adjuvant epirubicin followed by cyclophosphamide, methotrexate and fluorouracil (CMF) vs CMF in early breast cancer: results with over 7 years median follow-up from the randomised phase III NEAT/BR9601 trials

NEAT Investigators, SCTBG, Earl, H. M., Hiller, L., Dunn, J. A., Vallier, A.-L., Bowden, S. J., Jordan, S. D., Blows, F., Munro, A., Bathers, S., Grieve, R., Spooner, D. A., Agrawal, R., Fernando, I., Brunt, A. M., O'Reilly, S. M., Crawford, S. M., Rea, D. W. & Simmonds, P. & 12 others, Mansi, J. L., Stanley, A., McAdam, K., Foster, L., Leonard, R. C. F., Twelves, C. J., Cameron, D., Bartlett, J. M. S., Pharoah, P., Provenzano, E., Caldas, C. & Poole, C. J., Sept 2012, In: British Journal of Cancer. 107, 8, p. 1257-1267 11 p.

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Chromosome instability and benefit from adjuvant anthracyclines in breast cancer

Munro, A. F., Twelves, C., Thomas, J., Cameron, D. A. & Bartlett, J. M. S., 26 Jun 2012, In: British Journal of Cancer. 107, 1, p. 71-74 4 p.

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The p160 ER co-regulators predict outcome in ER negative breast cancer

Spears, M., Oesterreich, S., Migliaccio, I., Guiterrez, C., Hilsenbeck, S., Quintayo, M. A., Pedraza, J., Munro, A. F., Thomas, J., Kerr, G. R., Jack, W. J. L., Kunkler, I., Cameron, D. A., Chetty, U. & Bartlett, J. M. S., Jan 2012, In: Breast cancer research and treatment. 131, 2, p. 463-472

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Co-expression of SNAIL and TWIST determines prognosis in estrogen receptor-positive early breast cancer patients

van Nes, J. G. H., de Kruijf, E. M., Putter, H., Faratian, D., Munro, A., Campbell, F., Smit, V. T. H. B. M., Liefers, G.-J., Kuppen, P. J. K., van de Velde, C. J. H. & Bartlett, J. M. S., 2012, In: Breast cancer research and treatment. 133, 1, p. 49-59 11 p.

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In situ detection of HER2:HER2 and HER2:HER3 protein-protein interactions demonstrates prognostic significance in early breast cancer

Spears, M., Taylor, K. J., Munro, A. F., Cunningham, C. A., Mallon, E. A., Twelves, C. J., Cameron, D., Thomas, J. S. & Bartlett, J. M. S., 2012, In: Breast cancer research and treatment.

Research output: Contribution to journal › Article › peer-review

2011

HER2 and TOP2A as predictive markers for anthracycline-containing chemotherapy regimens as adjuvant treatment of breast cancer: a meta-analysis of individual patient data

HER2/TOP2A Meta-analysis Study Group, Di Leo, A., Desmedt, C., Bartlett, J. M. S., Piette, F., Ejlertsen, B., Pritchard, K. I., Larsimont, D., Poole, C., Isola, J., Earl, H., Mouridsen, H., O'Malley, F. P., Cardoso, F., Tanner, M., Munro, A., Twelves, C. J., Sotiriou, C., Shepherd, L. & Cameron, D. & 2 others, Piccart, M. J. & Buyse, M., 2011, In: The Lancet Oncology. 12, 12, p. 1134-42 9 p.

Research output: Contribution to journal › Article › peer-review

2010

Mammostrat (R) as a tool to stratify breast cancer patients at risk of recurrence during endocrine therapy

Bartlett, J. M. S., Thomas, J., Ross, D. T., Seitz, R. S., Ring, B. Z., Beck, R. A., Pedersen, H. C., Munro, A., Kunkler, I., Campbell, F. M., Jack, W., Kerr, G. R., Johnstone, L., Cameron, D. A. & Chetty, U., Jul 2010, In: Breast Cancer Research. 12, 4, p. - 11 p., R47.

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Predictive markers of anthracycline benefit: a prospectively planned analysis of the UK National Epirubicin Adjuvant Trial (NEAT/BR9601)

Bartlett, J. M. S., Munro, A. F., Dunn, J. A., McConkey, C., Jordan, S., Twelves, C. J., Cameron, D. A., Thomas, J., Campbell, F. M., Rea, D. W., Provenzano, E., Caldas, C., Pharoah, P., Hiller, L., Earl, H. & Poole, C. J., 2010, In: The Lancet Oncology. 11, 3, p. 266-74 9 p.

Research output: Contribution to journal › Article › peer-review

Targeting anthracyclines in early breast cancer: new candidate predictive biomarkers emerge

Munro, A. F., Cameron, D. A. & Bartlett, J. M. S., 2010, In: Oncogene. 29, 38, p. 5231-40 10 p.

Research output: Contribution to journal › Article › peer-review

2009

Membranous and cytoplasmic staining of Ki67 is associated with HER2 and ER status in invasive breast carcinoma

Faratian, D., Munro, A., Twelves, C. & Bartlett, J. M. S., Jan 2009, In: Histopathology. 54, 2, p. 254-7 4 p.

Research output: Contribution to journal › Article › peer-review

2008

Type 1 receptor tyrosine kinase profiles identify patients with enhanced benefit from anthracyclines in the BR9601 adjuvant breast cancer chemotherapy trial

Bartlett, J. M. S., Munro, A., Cameron, D. A., Thomas, J., Prescott, R. & Twelves, C. J., Nov 2008, In: Journal of Clinical Oncology. 26, 31, p. 5027-35 9 p.

Research output: Contribution to journal › Article › peer-review

2004

Isolation and expression of the reverse transcriptase component of the Canis familiaris telomerase ribonucleoprotein (dogTERT)

Nasir, L., Gault, E., Campbell, S., Veeramalai, M., Gilbert, D., McFarlane, R., Munro, A. & Argyle, D. J., 2004, In: Gene. 336, 1, p. 105-13 9 p.

Research output: Contribution to journal › Article › peer-review

2000

Probing the NADPH-binding site of Escherichia coli flavodoxin oxidoreductase

Leadbeater, C., McIver, L., Campopiano, D. J., Webster, S. P., Baxter, R. L., Kelly, S. M., Price, N. C., Lysek, D. A., Noble, M. A., Chapman, S. K. & Munro, A. W., 2000, In: Biochemical Journal. 352 Pt 2, p. 257-66 10 p.

Research output: Contribution to journal › Article › peer-review

1998

Characterisation of flavodoxin NADP+ oxidoreductase and flavodoxin; key components of electron transfer in Escherichia coli

McIver, L., Leadbeater, C., Campopiano, D. J., Baxter, R. L., Daff, S. N., Chapman, S. K. & Munro, A. W., 1998, In: European Journal of Biochemistry. 257, 3, p. 577-85 9 p.

Research output: Contribution to journal › Article › peer-review

Alison Munro

Research output

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