Ananda Mirchandani

2023

Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function

Watts, E., Willson, J. A., Arienti, S., Sadiku, P., Coelho, P., Sanchez Garcia, M. A., Zhang, A., Murphy, F., Dickinson, R., Mirchandani, A. S., Morrison, T., Lewis, A., Vermaelen, W., Ghesquiere, B., Carmeliet, P., Mazzone, M., Maxwell, P. H., Pugh, C. W., Dockrell, D. H., Whyte, M., & 1 othersWalmsley, S. R., 11 Dec 2023, (E-pub ahead of print) In: Wellcome Open Research .

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2022

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

Mirchandani, A. S., Jenkins, S. J., Bain, C. C., Sanchez Garcia, M. A., Lawson, H., Coelho, P., Murphy, F., Griffith, D., Zhang, A., Morrison, T., Ly, T., Arienti, S., Sadiku, P., Watts, E. R., Dickinson, R., Reyes, L., Cooper, G., Clark, S., Lewis, D., Kelly, V., & 22 othersSpanos, C., Musgrave, K. M., Delaney, L., Harper, I., Scott, J., Parkinson, N., Rostron, A. J., Baillie, J. K., Clohisey, S., Pridans, C., Campana, L., Starkey Lewis, P., Simpson, A. J., Dockrell, D. H., Schwarze, J., Hirani, N., Ratcliffe, P. J., Pugh, C. W., Kranc, K., Forbes, S. J., Whyte, M. K. B. & Walmsley, S. R., 27 May 2022, In: Nature Immunology.

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2021

The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair

Mccowan, J., Fercoq, F., Kirkwood, P. M., T’jonck, W., Hegarty, L. M., Mawer, C. M., Cunningham, R., Mirchandani, A. S., Hoy, A., Humphries, D. C., Jones, G., Hansen, C. G., Hirani, N., Jenkins, S. J., Henri, S., Malissen, B., Walmsley, S. R., Dockrell, D. H., Saunders, P. T. K., Carlin, L. M., & 1 othersBain, C. C., 19 Nov 2021, In: Science Immunology. 6, 65

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Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation

Virga, F., Cappellesso, F., Stijlemans, B., Henze, A-T., Trotta, R., Van Audenaerde, J., Mirchandani, A. S., Sanchez Garcia, M. A., Vandewalle, J., Orso, F., Riera-Domingo, C., Griffa, A., Ivan, C., Smits, E., Laoui, D., Martelli, F., Langouche, L., Van den Berghe, G., Feron, O., Ghesquiere, B., & 8 othersPrenen, H., Libert, C., Walmsley, S. R., Corbet, C., Van Ginderachter, J. A., Ivan, M., Taverna, D. & Mazzone, M., 7 May 2021, In: Science Advances.

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Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism

Watts, E. R., Howden, A. J. M., Morrison, T., Sadiku, P., Hukelmann, J. L., Von Kriegsheim, A., Ghesquière, B., Murphy, F., Mirchandani, A. S., Humphries, D. C., Grecian, R., Ryan, E. M., Coelho, P., Rodriguez-blanco, G., Plant, T. M., Dickinson, R. S., Finch, A. J., Vermaelen, W., Cantrell, D. A., Whyte, M. K. B., & 1 othersWalmsley, S. R., 6 Apr 2021, (E-pub ahead of print) In: Journal of Clinical Investigation.

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A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS

Reyes, L., Sanchez Garcia, M. A., Morrison, T., Howden, A. J. M., Watts, E. R., Arienti, S., Sadiku, P., Coelho, P., Mirchandani, A. S., Zhang, A., Hope, D., Clark, S. K., Singleton, J., Johnston, S., Grecian, R., Poon, A. S., McNamara, S., Harper, I., Fourman, M. H., Brenes, A. J., & 14 othersPathak, S., Lloyd, A., Rodriguez Blanco, G., von Kriegsheim, A., Ghesquiere, B., Vermaelen, W., Cologna, C. T., Dhaliwal, K., Hirani, N., Dockrell, D. H., Whyte, M. K. B., Griffith, D. M., Cantrell, D. & Walmsley, S. R., 22 Feb 2021, In: Wellcome Open Research .

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Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis

Sadiku, P., Willson, J. A., Ryan, E. M., Sammut, D., Coelho, P., Watts, E. R., Grecian, R., Young, J. M., Bewley, M., Arienti, S., Mirchandani, A. S., Sanchez Garcia, M. A., Morrison, T., Zhang, A., Reyes, L., Griessler, T., Jheeta, P., Paterson, G. G., Graham, C. J., Thompson, J. P., & 16 othersBaillie, K., Thompson, A. A. R., Morgan, J-M., Acosta-Sanchez, A., Dardé, V. M., Duran, J., Guinovart, J. J., Rodriguez-Blanco, G., Von Kriegsheim, A., Meehan, R. R., Mazzone, M., Dockrell, D. H., Ghesquiere, B., Carmeliet, P., Whyte, M. K. B. & Walmsley, S. R., 2 Feb 2021, In: Cell Metabolism. 33, 2, p. 411-423.e4

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2020

Semaphorin 3F signaling actively retains neutrophils at sites of inflammation

Plant, T., Eamsamarng, S., Sanchez-Garcia, M. A., Reyes, L., Renshaw, S. A., Coelho, P., Mirchandani, A. S., Morgan, J-M., Ellett, F. E., Morrison, T., Humphries, D., Watts, E. R., Murphy, F., Raffo-Iraolagoitia, X. L., Zhang, A., Cash, J. L., Loynes, C., Elks, P. M., Van Eeden, F., Carlin, L. M., & 3 othersFurley, A. J. W., Whyte, M. K. B. & Walmsley, S. R., 1 Jun 2020, In: Journal of Clinical Investigation. 130, 6, p. 3221-3237

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2019

IL4Rα signaling abrogates hypoxic neutrophil survival and limits acute lung injury responses in vivo

Harris, A. J., Mirchandani, A. S., Lynch, R. W., Murphy, F., Delaney, L., Small, D., Coelho, P., Watts, E. R., Sadiku, P., Griffith, D., Dickinson, R. S., Clark, E., Willson, J. A., Morrison, T., Mazzone, M., Carmeliet, P., Ghesquiere, B., O'Kane, C., McAuley, D., Jenkins, S. J., & 2 othersWhyte, M. K. B. & Walmsley, S. R., 15 Jul 2019, In: American Journal of Respiratory and Critical Care Medicine. 200, 2, p. 235–246 12 p.

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2017

Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo

Dickinson, R. S., Murphy, F., Doherty, C., Williams, S., Mirchandani, A., Willson, J. A., Scotti, J. S., Preston, G., Schofield, C. J., Whyte, M. K. B. & Walmsley, S. R., 26 Oct 2017, In: Wellcome Open Research . 2, p. 104

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Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

Sadiku, P., Willson, J. A., Dickinson, R., Murphy, F., Harris, A., Lewis, A., Sammut, D., Mirchandani, A. S., Ryan, E., Watts, E. R., Thompson, A. A. R., Marriott, H. M., Dockrell, D. H., Taylor, C. T., Schneider, M., Maxwell, P. H., Chilvers, E. R., Mazzone, M., Moral, V., Pugh, C. W., & 6 othersRatcliffe, P. J., Schofield, C. J., Ghesquiere, B., Carmeliet, P., Whyte, M. K. B. & Walmsley, S. R., 1 Sept 2017, In: Journal of Clinical Investigation. 127, 9, p. 3407-3420 14 p.

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Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism

Thompson, A. A. R., Dickinson, R. S., Murphy, F., Thomson, J. P., Marriott, H. M., Tavares, A., Willson, J., Williams, L., Lewis, A., Mirchandani, A., Dos Santos Coelho, P., Doherty, C., Ryan, E., Watts, E., Morton, N. M., Forbes, S., Stimson, R. H., Hameed, A. G., Arnold, N., Preston, J. A., & 15 othersLawrie, A., Finisguerra, V., Mazzone, M., Sadiku, P., Goveia, J., Taverna, F., Carmeliet, P., Foster, S. J., Chilvers, E. R., Cowburn, A. S., Dockrell, D. H., Johnson, R. S., Meehan, R. R., Whyte, M. K. B. & Walmsley, S. R., 24 Feb 2017, In: Science Immunology. 2, 8, eaal2861.

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2014

Type 2 Innate Lymphoid Cells Drive CD4⁺ Th2 Cell Responses

Mirchandani, A. S., Besnard, A-G., Yip, E., Scott, C., Bain, C. C., Cerovic, V., Salmond, R. J. & Liew, F. Y., 1 Mar 2014, In: The Journal of Immunology. 192, 5, p. 2442-2448 7 p.

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Ananda Mirchandani

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