My lab is interested in the mechanisms that control vascular damage and how to influence repair and regeneration of the vascular system using innovative therapies, including gene- and RNA-based approaches. Focusing on vascular remodelling and regeneration, we are defining the coding and non-coding RNA pathways and networks that influence cell function in health and disease and developing interventions to influence beneficially repair and regeneration. We have a strong focus on viral-mediated gene therapy, both in the translational and basic sense. We have developed an innovative gene therapy approach to prevent pathological vascular remodelling associated with coronary artery bypass graft failure and are pursuing this at the clinical interface, now in phase I clinical trials. We are also generating RNA based therapeutics to target lncRNA and miRNA for vascular repair and regeneration using a combination of informatic and wet lab approaches.