Research output per year
Research output per year
Personal profile
Biography
Andrew McIntosh is Professor of Biological Psychiatry at the University of Edinburgh and Director of the UKRI Mental Health Platform. He qualified in Medicine from Aberdeen before completing postgraduate training in Edinburgh. He is involved in several genetic consortia, including ENIGMA and the Psychiatric Genomics Consortium (PGC). He co-chairs to Major Depressive Disorder Working Group of the PGC.
My research in a nutshell
Professor McIntosh’s aims to better understand the causes and consequences of depression and other related psychiatric disorders. He currently works with large population-based studies of depression, such as Generation Scotland and UK Biobank in the UK, and DepGenAfrica and others, globally.
Research Interests
- The genetic and environmental causes of major depressive disorder
- The mechanisms and causal consequences of depression
- Public enagagement around the use of mental health data in research
Education/Academic qualification
Master of Science, Applied Statistics, Edinburgh Napier University
Award Date: 1 Jan 2004
Doctor of Medicine, Commonalities and differences between schizophrenia and bipolar disorder, University of Edinburgh
Award Date: 1 Jan 2004
Master of Philosophy (MPhil), Anatomy of the functional psychoses, University of Edinburgh
Award Date: 1 Jan 2000
Bachelor of Medicine and Bachelor of Surgery, Robert Gordon University
Award Date: 1 Jan 1995
Bachelor of Science, Close coupling of mRNA synthesis to amino acid metabolism, Robert Gordon University
Award Date: 1 Jan 1992
Keywords
- RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Research Themes and Networks
- Edinburgh Mental Health Network
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Parent of origin genetic effects on methylation in humans are common and influence complex trait variation
Zeng, Y., Amador, C., Xia, C., Marioni, R., Sproul, D., Walker, R. M., Morris, S. W., Bretherick, A., Canela-Xandri, O., Boutin, T. S., Clark, D. W., Campbell, A., Rawlik, K., Hayward, C., Nagy, R., Tenesa, A., Porteous, D. J., Wilson, J. F., Deary, I. J. & Evans, K. L. & 3 others, , 27 Mar 2019, In: Nature Communications. 10, 13 p., 1383.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Uncovering the genetic architecture of major depression
McIntosh, A., Sullivan, P. F. & Lewis, C. M., 3 Apr 2019, (E-pub ahead of print) In: Neuron.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
Addendum: Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways
Howard, D. M., Adams, M. J., Shirali, M., Clarke, T.-K., Marioni, R. E., Davies, G., Coleman, J. R. I., Alloza, C., Shen, X., Barbu, M. C., Wigmore, E. M., Gibson, J., Hagenaars, S. P., Lewis, C. M., Ward, J., Smith, D. J., Sullivan, P. F., Haley, C. S., Breen, G. & Deary, I. J. & 1 others, , 30 Aug 2018, In: Nature Communications. 9, 1, p. 3578Research output: Contribution to journal › Article › peer-review
Open AccessFile -
An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort
Hamilton, O., Zhang, Q., Mcrae, A. F., Walker, R., Morris, S., Redmond, P., Campbell, A., Murray, A., Porteous, D., Evans, K., McIntosh, A., Deary, I. & Marioni, R., 6 Mar 2019, In: International Journal of Obesity.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Epigenetic signatures of starting and stopping smoking
McCartney, D. L., Stevenson, A. J., Hillary, R., Walker, R. M., Bermingham, M. L., Morris, S. W., Clarke, T.-K., Campbell, A., Murray, A. D., Whalley, H. C., Porteous, D. J., Visscher, P. M., McIntosh, A. M., Evans, K. L., Deary, I. J. & Marioni, R. E., 1 Nov 2018, In: EBioMedicine. 37, p. 214-220Research output: Contribution to journal › Article › peer-review
Open AccessFile
Activities
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Song writing workshop for harmony choir
McIntosh, A. (Speaker)
13 Nov 2017Activity: Participating in or organising an event types › Public Engagement – Public lecture/debate/seminar
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Resilience Ceilidh on mental health
McIntosh, A. (Contributor)
3 Feb 2018Activity: Participating in or organising an event types › Public Engagement – Festival/Exhibition
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Mental Health in STEM Panel
McIntosh, A. (Advisor)
12 Nov 2018Activity: Participating in or organising an event types › Public Engagement – Public lecture/debate/seminar
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Scottish Parliament
McIntosh, A. (Contributor), Iveson, M. (Contributor) & Deary, I. (Contributor)
6 Feb 2019Activity: Visiting an external institution types › Research and Teaching at External Organisation
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Celebration of Scottish Health Research Cohorts
McIntosh, A. (Advisor), Lawrie, S. (Invited speaker), Porteous, D. (Invited speaker), Deary, I. (Invited speaker), Batty, G. D. (Invited speaker), Black, C. (Invited speaker) & Beange, I. (Advisor)
10 Jun 2018Activity: Participating in or organising an event types › Public Engagement – Public lecture/debate/seminar
Prizes
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Clarivate Analytics Highly Cited Researcher
McIntosh, A. (Recipient), Nov 2018
Prize: Other distinctions
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Association of European Psychiatrists Poster Prize 2007
McIntosh, A. (Recipient), 2002
Prize: Prize (including medals and awards)
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Fellow of the Academy of Medical Sciences
McIntosh, A. (Recipient), 27 Jun 2022
Prize: Election to learned society
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Fellow of the Royal Society of Edinburgh
McIntosh, A. (Recipient), 1 Apr 2021
Prize: Election to learned society
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Good Research Practice Award
Beange, I. (Recipient), McIntosh, A. (Recipient), Adams, M. (Recipient), Whalley, H. (Recipient), Kirkham, E. (Recipient), Iveson, M. (Recipient), Kwong, A. (Recipient), Lewins, M. (Recipient), Chan, S. (Recipient), MacSweeney, N. (Recipient), Barbu, M. (Recipient), Romaniuk, L. (Recipient), Ecks, S. (Recipient), Higgins, C. (Recipient), Smith, D. (Recipient), Campbell, M. A. (Recipient), Goodall, K. (Recipient), Christie, H. (Recipient), Happer, R. (Recipient) & Boynton, P. M. (Recipient), Dec 2022
Prize: Prize (including medals and awards)
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Mental Health Mission (Mood Clinic)
McIntosh, A. (Principal Investigator) & Smith, D. (Co-investigator)
National Institute for Health Research
1/10/24 → 31/01/28
Project: Research
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DATAMIND: The Data Hub for Mental Health Informatics Research and Development (Phase 2)
McIntosh, A. (Principal Investigator)
1/09/24 → 31/08/29
Project: Research
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Mental health platform Capacity Building fund
McIntosh, A. (Principal Investigator)
1/08/24 → 31/03/29
Project: Research
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Director of mental health platform
McIntosh, A. (Principal Investigator)
1/08/24 → 31/03/29
Project: Research
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Mental Health platform Collaboration and Innovation fund
McIntosh, A. (Principal Investigator)
1/08/24 → 31/03/29
Project: Research
Datasets
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Comparison of DNA methylation profiles from Generation Scotland blood samples stored on Whatman FTA cards and in EDTA tubes: EWAS summary statistics
Porteous, D. (Creator), Evans, K. (Creator), McCafferty, S. (Creator), Walker, R. (Creator), MacGillivray, L. (Creator), Wrobel, N. (Creator), Kerr, S. (Creator), Morris, S. (Creator), Campbell, A. (Creator) & McIntosh, A. (Creator), Edinburgh DataShare, 26 Feb 2019
DOI: 10.7488/ds/2502, https://doi.org/10.1101/546606
Dataset
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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Howard, D. (Creator), Adams, M. (Creator), Clarke, T.-K. (Creator), Hafferty, J. (Creator), Gibson, J. (Creator), Shirali, M. (Creator), Coleman, J. (Creator), Ward, J. (Creator), Wigmore, E. (Creator), Alloza, C. (Creator), Barbu, M. (Creator), Xu, E. (Creator), Sibley, H. (Creator), Marioni, R. (Creator), Porteous, D. (Creator), Davies, G. (Creator), Deary, I. (Creator), Hemani, G. (Creator), Tian, C. (Creator), Hinds, D. (Creator), Team, 2. R. (Creator), Consortium, M. D. D. W. G. O. T. P. G. (Creator), Trzaskowshi, M. (Creator), Byrne, E. (Creator), Ripke, S. (Creator), Smith, D. (Creator), Sullivan, P. (Creator), Wray, N. (Creator), Breen, G. (Creator), Shen, X. (Creator), Lewis, C. (Creator) & McIntosh, A. (Creator), Edinburgh DataShare, 30 Jan 2019
DOI: 10.7488/ds/2458
Dataset
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Summary statistics for three depression phenotypes in UK Biobank.
Howard, D. M. (Creator), Adams, M. J. (Creator), Shirali, M. (Creator), Clarke, T.-K. (Creator), Marioni, R. (Creator), Davies, G. (Creator), Alloza, C. (Creator), Shen, X. (Creator), Barbu, M. (Creator), Wigmore, E. (Creator), Gibson, J. (Creator), Hagenaars, S. (Creator), Lewis, C. M. (Creator), Ward, J. (Creator), Haley, C. (Creator), Breen, G. (Creator), Deary, I. (Creator) & McIntosh, A. (Creator), Edinburgh DataShare, 5 Mar 2018
DOI: 10.7488/ds/2350
Dataset
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STratifying Resilience and Depression Longitudinally (STRADL): A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments
Adams, M. (Creator), McIntosh, A. (Owner), Hawkins, E. (Data Manager), Habota, T. (Creator), Steele, J. D. (Creator), Whalley, H. (Creator), Porteous, D. (Project Leader), Deary, I. (Project Leader), Murray, A. (Creator) & Campbell, A. (Data Manager), Edinburgh DataVault, 2019
DOI: 10.7488/8f68f1ae-0329-4b73-b189-c7288ea844d7
Dataset
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Scottish Family Mental Health (SFMH) Study Dataset
Cooper, A. (Creator), Blackwood, D. (Creator), Lawrie, S. (Creator), McIntosh, A. (Creator), Romaniuk, L. (Creator), Semple, S. (Creator), Duff, B. (Creator) & Whalley, H. (Creator), Edinburgh DataVault, 10 Oct 2023
DOI: 10.7488/7f08e5f1-b300-4a32-bd18-ef511f82c390
Dataset
Press/Media
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Andrew McIntosh & David Howard find nearly 80 genes that could be linked to depression
McIntosh, A., Howard, D. & Howard, D. M.
4/02/19 → 5/02/19
10 items of Media coverage
Press/Media: Research
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£2.2m boost for pioneering research into mental health conditions
31/03/18
3 items of Media coverage
Press/Media: Research
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A study into the causes of clinical depression to receive £4.7 million in the hopes new treatments can be developed
12/05/14
12 items of Media coverage
Press/Media: Research
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Prof Andrew McIntosh links chronic pain to partners of people with depression
17/08/16
13 items of Media coverage
Press/Media: Research
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Three-quarters of people who have taken antidepressants say they were helpful
13/03/25
1 Media contribution
Press/Media: Research