Research output per year
Research output per year
Personal profile
Biography
Andrew McIntosh is Professor of Biological Psychiatry and a Senior Clinical Research Fellow at the University of Edinburgh. He trained in Medicine at the University of Aberdeen before completing further postgraduate training in Edinburgh in Psychiatry and in Applied Statistics. He leads the Generation Scotland Expert Working Group for Psychiatric Disorders and is involved in several genetic consortia, including ENIGMA and the Psychiatric Genomics Consortium.
My research in a nutshell
Professor McIntosh’s aims to better understand the causes and consequences of depression and then use that knowledge to address the unmet needs of the individuals and families affected by the disorder. He currently works with large population-based studies of depression, such as Generation Scotland and UK Biobank, that have information on depression alongside genetic information, data from the electronic medical record and other detailed measurements of physical and mental health.
Research Interests
- Depression and psychological resilience
- The genetic and environmental causes of depression
- The mechanisms and causal consequences of depression
- Public enagagement around the use of mental health data in research
Education/Academic qualification
Master of Science, Applied Statistics, Edinburgh Napier University
Award Date: 1 Jan 2004
Doctor of Medicine, Commonalities and differences between schizophrenia and bipolar disorder, University of Edinburgh
Award Date: 1 Jan 2004
Master of Philosophy (MPhil), Anatomy of the functional psychoses, University of Edinburgh
Award Date: 1 Jan 2000
Bachelor of Medicine and Bachelor of Surgery, Robert Gordon University
Award Date: 1 Jan 1995
Bachelor of Science, Close coupling of mRNA synthesis to amino acid metabolism, Robert Gordon University
Award Date: 1 Jan 1992
Keywords
- RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Parent of origin genetic effects on methylation in humans are common and influence complex trait variation
Zeng, Y., Amador, C., Xia, C., Marioni, R., Sproul, D., Walker, R. M., Morris, S. W., Bretherick, A., Canela-Xandri, O., Boutin, T. S., Clark, D. W., Campbell, A., Rawlik, K., Hayward, C., Nagy, R., Tenesa, A., Porteous, D. J., Wilson, J. F., Deary, I. J., Evans, K. L., & 3 others, 27 Mar 2019, In: Nature Communications. 10, 13 p., 1383.Research output: Contribution to journal › Article › peer-review
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Uncovering the genetic architecture of major depression
McIntosh, A., Sullivan, P. F. & Lewis, C. M., 3 Apr 2019, (E-pub ahead of print) In: Neuron.Research output: Contribution to journal › Review article › peer-review
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Addendum: Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways
Howard, D. M., Adams, M. J., Shirali, M., Clarke, T-K., Marioni, R. E., Davies, G., Coleman, J. R. I., Alloza, C., Shen, X., Barbu, M. C., Wigmore, E. M., Gibson, J., Hagenaars, S. P., Lewis, C. M., Ward, J., Smith, D. J., Sullivan, P. F., Haley, C. S., Breen, G., Deary, I. J., & 1 others, 30 Aug 2018, In: Nature Communications. 9, 1, p. 3578Research output: Contribution to journal › Article › peer-review
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An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort
Hamilton, O., Zhang, Q., Mcrae, A. F., Walker, R., Morris, S., Redmond, P., Campbell, A., Murray, A., Porteous, D., Evans, K., McIntosh, A., Deary, I. & Marioni, R., 6 Mar 2019, In: International Journal of Obesity.Research output: Contribution to journal › Article › peer-review
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Epigenetic signatures of starting and stopping smoking
McCartney, D. L., Stevenson, A. J., Hillary, R., Walker, R. M., Bermingham, M. L., Morris, S. W., Clarke, T-K., Campbell, A., Murray, A. D., Whalley, H. C., Porteous, D. J., Visscher, P. M., McIntosh, A. M., Evans, K. L., Deary, I. J. & Marioni, R. E., 1 Nov 2018, In: EBioMedicine. 37, p. 214-220Research output: Contribution to journal › Article › peer-review
Open AccessFile
Activities
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Song writing workshop for harmony choir
Andrew McIntosh (Speaker)
13 Nov 2017Activity: Participating in or organising an event types › Public Engagement – Public lecture/debate/seminar
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Resilience Ceilidh on mental health
Andrew McIntosh (Contributor)
3 Feb 2018Activity: Participating in or organising an event types › Public Engagement – Festival/Exhibition
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Mental Health in STEM Panel
Andrew McIntosh (Advisor)
12 Nov 2018Activity: Participating in or organising an event types › Public Engagement – Public lecture/debate/seminar
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Scottish Parliament
Andrew McIntosh (Contributor), Matthew Iveson (Contributor) & Ian Deary (Contributor)
6 Feb 2019Activity: Visiting an external institution types › Research and Teaching at External Organisation
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Celebration of Scottish Health Research Cohorts
Andrew McIntosh (Advisor), Stephen Lawrie (Invited speaker), David Porteous (Invited speaker), Ian Deary (Invited speaker), G. D. Batty (Invited speaker), Corri Black (Invited speaker) & Iona Beange (Advisor)
10 Jun 2018Activity: Participating in or organising an event types › Public Engagement – Public lecture/debate/seminar
Prizes
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Clarivate Analytics Highly Cited Researcher
McIntosh, Andrew (Recipient), Nov 2018
Prize: Other distinctions
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Association of European Psychiatrists Poster Prize 2007
McIntosh, Andrew (Recipient), 2002
Prize: Prize (including medals and awards)
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Fellow of the Academy of Medical Sciences
McIntosh, Andrew (Recipient), 27 Jun 2022
Prize: Election to learned society
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Fellow of the Royal Society of Edinburgh
McIntosh, Andrew (Recipient), 1 Apr 2021
Prize: Election to learned society
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Good Research Practice Award
Beange, Iona (Recipient), McIntosh, Andrew (Recipient), Adams, Mark (Recipient), Whalley, Heather (Recipient), Kirkham, Elizabeth (Recipient), Iveson, Matthew (Recipient), Kwong, Alex (Recipient), Lewins, Melissa (Recipient), Chan, Stella (Recipient), MacSweeney, Niamh (Recipient), Barbu, Miruna (Recipient), Romaniuk, Liana (Recipient), Ecks, Stefan (Recipient), Higgins, Charlotte (Recipient), Smith, Daniel (Recipient), Campbell, Morag Allan (Recipient), Goodall, Karen (Recipient), Christie, Hope (Recipient), Happer, Rachel (Recipient) & Boynton, Petra M (Recipient), Dec 2022
Prize: Prize (including medals and awards)
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Hub For Metabolic Psychiatry
Smith, D., McIntosh, A., Whalley, H., Lawrie, S. & Campbell, I.
1/04/24 → 31/03/29
Project: Research
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Psychosis Recovery Orientation in Malawi by Improving Services and Engagement
Lawrie, S., Allardyce, J. & McIntosh, A.
1/04/22 → 31/03/27
Project: Research
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Psychosis Recovery Orientation in Malawi by Improving Services and Engagement
Lawrie, S., Allardyce, J., Jain, S., Macbeth, A., McIntosh, A. & Pickersgill, M.
1/03/22 → 28/02/27
Project: Research
Datasets
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Comparison of DNA methylation profiles from Generation Scotland blood samples stored on Whatman FTA cards and in EDTA tubes: EWAS summary statistics
Porteous, D. (Creator), Evans, K. (Creator), McCafferty, S. (Creator), Walker, R. (Creator), MacGillivray, L. (Creator), Wrobel, N. (Creator), Kerr, S. (Creator), Morris, S. (Creator), Campbell, A. (Creator) & McIntosh, A. (Creator), Edinburgh DataShare, 26 Feb 2019
DOI: 10.7488/ds/2502, https://doi.org/10.1101/546606
Dataset
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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Howard, D. (Creator), Adams, M. (Creator), Clarke, T. (Creator), Hafferty, J. (Creator), Gibson, J. (Creator), Shirali, M. (Creator), Coleman, J. (Creator), Ward, J. (Creator), Wigmore, E. (Creator), Alloza, C. (Creator), Barbu, M. (Creator), Xu, E. (Creator), Whalley, H. (Creator), Marioni, R. (Creator), Porteous, D. (Creator), Davies, G. (Creator), Deary, I. (Creator), Hemani, G. (Creator), Tian, C. (Creator), Hinds, D. (Creator), Team, 2. R. (Creator), Consortium, M. D. D. W. G. O. T. P. G. (Creator), Trzaskowshi, M. (Creator), Byrne, E. (Creator), Ripke, S. (Creator), Smith, D. (Creator), Sullivan, P. (Creator), Wray, N. (Creator), Breen, G. (Creator), Shen, X. (Creator), Lewis, C. (Creator) & McIntosh, A. (Creator), Edinburgh DataShare, 30 Jan 2019
DOI: 10.7488/ds/2458
Dataset
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Summary statistics for three depression phenotypes in UK Biobank.
Howard, D. M. (Creator), Adams, M. (Creator), Shirali, M. (Creator), Clarke, T. (Creator), Marioni, R. (Creator), Davies, G. (Creator), Alloza, C. (Creator), Shen, X. (Creator), Barbu, M. (Creator), Wigmore, E. (Creator), Gibson, J. (Creator), Hagenaars, S. (Creator), Lewis, C. M. (Creator), Ward, J. (Creator), Haley, C. (Creator), Breen, G. (Creator), Deary, I. (Creator) & McIntosh, A. (Creator), Edinburgh DataShare, 5 Mar 2018
DOI: 10.7488/ds/2350
Dataset
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STratifying Resilience and Depression Longitudinally (STRADL): A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments
Adams, M. (Creator), McIntosh, A. (Owner), Hawkins, E. (Data Manager), Habota, T. (Creator), Steele, J. D. (Creator), Whalley, H. (Creator), Porteous, D. (Project Leader), Deary, I. (Project Leader), Murray, A. (Creator) & Campbell, A. (Data Manager), Edinburgh DataVault, 2019
DOI: 10.7488/8f68f1ae-0329-4b73-b189-c7288ea844d7
Dataset
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Generation Scotland Age x Sex Epigenome Wide Association Study Summary Statistics
Boutin, T. (Creator), Morris, S. (Creator), Campbell, A. (Creator), Murray, A. (Creator), Whalley, H. (Creator), Hayward, C. (Creator), Evans, K. (Creator), Chandra, T. (Creator), Deary, I. (Creator), McIntosh, A. (Creator), Yang, J. (Creator), Visscher, P. (Creator), McRae, A. (Creator), Marioni, R. (Creator), Porteous, D. (Creator), McCartney, D. (Creator), Zhang, F. (Creator), Hillary, R. (Creator), Zhang, Q. (Creator), Stevenson, A. (Creator), Walker, R. (Creator) & Bermingham, M. (Creator), Edinburgh DataShare, 31 Jan 2020
DOI: 10.7488/ds/2709
Dataset
Press/Media
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Andrew McIntosh & David Howard find nearly 80 genes that could be linked to depression
Andrew McIntosh, David Howard & David M. Howard
4/02/19 → 5/02/19
10 items of Media coverage
Press/Media: Research
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£2.2m boost for pioneering research into mental health conditions
31/03/18
3 items of Media coverage
Press/Media: Research
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A study into the causes of clinical depression to receive £4.7 million in the hopes new treatments can be developed
12/05/14
12 items of Media coverage
Press/Media: Research
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Prof Andrew McIntosh links chronic pain to partners of people with depression
17/08/16
13 items of Media coverage
Press/Media: Research
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