Andrew McIntosh

Accepting PhD Students

PhD projects

PhD Projects 1. Identifying genetic and environmental risk factors for depression 2. Identifying the heterogeneity underlying depressive illnesses 3. Studying the longitudinal changes before and after the onset of depression 4. Identifying the mechanisms of psychological resilience

Biography

Andrew McIntosh is Professor of Biological Psychiatry at the University of Edinburgh and Director of the UKRI Mental Health Platform. He qualified in Medicine from Aberdeen before completing postgraduate training in Edinburgh. He is involved in several genetic consortia, including ENIGMA and the Psychiatric Genomics Consortium (PGC). He co-chairs to Major Depressive Disorder Working Group of the PGC.

My research in a nutshell

Professor McIntosh’s aims to better understand the causes and consequences of depression and other related psychiatric disorders. He currently works with large population-based studies in both the UK, Africa and globally.

Research Interests

The genetic and environmental causes of major depressive disorder
The mechanisms and causal consequences of depression
Public enagagement around the use of mental health data in research

Education/Academic qualification

Doctor of Medicine, Commonalities and differences between schizophrenia and bipolar disorder, University of Edinburgh

Award Date: 1 Jun 2004

Master of Science, Applied Statistics, Edinburgh Napier University

Award Date: 1 Jan 2004

Master of Philosophy (MPhil), Anatomy of the functional psychoses, University of Edinburgh

Award Date: 1 Jan 2000

Medicine, Bachelor of Medicine and Bachelor of Surgery, University of Aberdeen

Award Date: 1 Jan 1995

Bachelor of Science, Close coupling of mRNA synthesis to amino acid metabolism, University of Aberdeen

Award Date: 1 Jan 1992

Keywords

RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry

Research Themes and Networks

Edinburgh Mental Health Network

Fingerprint

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1 Similar Profiles

Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 6 Feb 2025, In: Cell. 188, 3, p. 640-652.e9
Research output: Contribution to journal › Article › peer-review

Open Access
File
Uncovering the genetic architecture of major depression
McIntosh, A., Sullivan, P. F. & Lewis, C. M., 3 Apr 2019, (E-pub ahead of print) In: Neuron.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
Parent of origin genetic effects on methylation in humans are common and influence complex trait variation
Zeng, Y., Amador, C., Xia, C., Marioni, R., Sproul, D., Walker, R. M., Morris, S. W., Bretherick, A., Canela-Xandri, O., Boutin, T. S., Clark, D. W., Campbell, A., Rawlik, K., Hayward, C., Nagy, R., Tenesa, A., Porteous, D. J., Wilson, J. F., Deary, I. J. & Evans, K. L. & 3 others, McIntosh, A. M., Navarro, P. & Haley, C. S., 27 Mar 2019, In: Nature Communications. 10, 13 p., 1383.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Insights from a methylome-wide association study of antidepressant exposure
Davyson, E., Shen, X., Huider, F., Adams, M. J., Borges, K., McCartney, D. L., Barker, L. F., van Dongen, J., Boomsma, D. I., Weihs, A., Grabe, H. J., Kühn, L., Teumer, A., Völzke, H., Zhu, T., Kaprio, J., Ollikainen, M., David, F. S., Meinert, S. & Stein, F. & 22 others, Forstner, A. J., Dannlowski, U., Kircher, T., Tapuc, A., Czamara, D., Binder, E. B., Brückl, T., Kwong, A. S. F., Yousefi, P., Wong, C. C. Y., Arseneault, L., Fisher, H. L., Mill, J., Cox, S. R., Redmond, P., Russ, T. C., van den Oord, E. J. C. G., Aberg, K. A., Penninx, B. W. J. H., Marioni, R. E., Wray, N. R. & McIntosh, A. M., 24 Feb 2025, (E-pub ahead of print) In: Nature Communications. 16, 1, 1908.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling
Strom, N. I., Verhulst, B., Bacanu, S.-A., Cheesman, R., Purves, K. L., Gedik, H., Mitchell, B. L., Kwong, A. S., Faucon, A. B., Singh, K., Medland, S., Colodro-Conde, L., Krebs, K., Hoffmann, P., Herms, S., Gehlen, J., Ripke, S., Awasthi, S., Palviainen, T. & Tasanko, E. M. & 117 others, Peterson, R. E., Adkins, D. E., Shabalin, A. A., Adams, M. J., Iveson, M. H., Campbell, A., Thomas, L. F., Winsvold, B. S., Drange, O. K., Børte, S., Ter Kuile, A. R., Naamanka, J., Nguyen, T.-H., Meier, S. M., Corfield, E. C., Hannigan, L., Levey, D. F., Czamara, D., Weber, H., Choi, K. W., Pistis, G., Couvy-Duchesne, B., Van der Auwera, S., Teumer, A., Karlsson, R., Garcia-Argibay, M., Lee, D., Wang, R., Bjerkeset, O., Stordal, E., Bäckman, J., Salum, G. A., Zai, C. C., Kennedy, J. L., Zai, G., Tiwari, A. K., Heilmann-Heimbach, S., Schmidt, B., Kaprio, J., Kennedy, M. M., Boden, J., Havdahl, A., Middeldorp, C. M., Lopes, F. L., Akula, N., McMahon, F. J., Binder, E. B., Fehm, L., Ströhle, A., Castelao, E., Tiemeier, H., Stein, D. J., Whiteman, D., Olsen, C., Fuller, Z., Wang, X., Wray, N. R., Byrne, E. M., Lewis, G., Timpson, N. J., Davis, L. K., Hickie, I. B., Gillespie, N. A., Milani, L., Schumacher, J., Woldbye, D. P., Forstner, A. J., Nöthen, M. M., Hovatta, I., Horwood, J., Copeland, W. E., Maes, H. H., McIntosh, A. M., Andreassen, O. A., Zwart, J.-A., Mors, O., Børglum, A. D., Mortensen, P. B., Ask, H., Reichborn-Kjennerud, T., Najman, J. M., Stein, M. B., Gelernter, J., Milaneschi, Y., Penninx, B. W., Boomsma, D. I., Maron, E., Erhardt-Lehmann, A., Rück, C., Kircher, T. T., Melzig, C. A., Alpers, G. W., Arolt, V., Domschke, K., Smoller, J. W., Preisig, M., Martin, N. G., Lupton, M. K., Luik, A. I., Reif, A., Grabe, H. J., Larsson, H., Magnusson, P. K., Oldehinkel, A. J., Hartman, C. A., Breen, G., Docherty, A. R., Coon, H., Conrad, R., Lehto, K., Veterans Affairs Million Veteran Program, FinnGen, the 23andMe Research Team, Deckert, J., Eley, T. C., Mattheisen, M. & Hettema, J. M., 3 Feb 2026, (E-pub ahead of print) In: Nature Genetics.
Research output: Contribution to journal › Article › peer-review

Open Access
File

Song writing workshop for harmony choir
McIntosh, A. (Speaker)
13 Nov 2017
Activity: Participating in or organising an event types › Public Engagement – Public lecture/debate/seminar
Resilience Ceilidh on mental health
McIntosh, A. (Contributor)
3 Feb 2018
Activity: Participating in or organising an event types › Public Engagement – Festival/Exhibition
Mental Health in STEM Panel
McIntosh, A. (Advisor)
12 Nov 2018
Activity: Participating in or organising an event types › Public Engagement – Public lecture/debate/seminar
Scottish Parliament
McIntosh, A. (Contributor), Iveson, M. (Contributor) & Deary, I. (Contributor)
6 Feb 2019
Activity: Visiting an external institution types › Research and Teaching at External Organisation
Celebration of Scottish Health Research Cohorts
McIntosh, A. (Advisor), Lawrie, S. (Invited speaker), Porteous, D. (Invited speaker), Deary, I. (Invited speaker), Batty, G. D. (Invited speaker), Black, C. (Invited speaker) & Beange, I. (Advisor)
10 Jun 2018
Activity: Participating in or organising an event types › Public Engagement – Public lecture/debate/seminar

Clarivate Analytics Highly Cited Researcher
McIntosh, A. (Recipient), Nov 2018
Prize: Other distinctions
Association of European Psychiatrists Poster Prize 2007
McIntosh, A. (Recipient), 2002
Prize: Prize (including medals and awards)
Fellow of the Academy of Medical Sciences
McIntosh, A. (Recipient), 27 Jun 2022
Prize: Election to learned society
Fellow of the Royal Society of Edinburgh
McIntosh, A. (Recipient), 1 Apr 2021
Prize: Election to learned society
Good Research Practice Award
Beange, I. (Recipient), McIntosh, A. (Recipient), Adams, M. (Recipient), Whalley, H. (Recipient), Kirkham, E. (Recipient), Iveson, M. (Recipient), Kwong, A. (Recipient), Lewins, M. (Recipient), Chan, S. (Recipient), MacSweeney, N. (Recipient), Barbu, M. (Recipient), Romaniuk, L. (Recipient), Ecks, S. (Recipient), Higgins, C. (Recipient), Smith, D. (Recipient), Campbell, M. A. (Recipient), Goodall, K. (Recipient), Christie, H. (Recipient), Happer, R. (Recipient) & Boynton, P. M. (Recipient), Dec 2022
Prize: Prize (including medals and awards)

15 Active
45 Finished

The Open Psychiatry Project: a co-produced web interface and platform for mental health omic data and federated data analysis
McIntosh, A. (Principal Investigator)
University of Cambridge
2/02/26 → 1/02/29
Project: Research
Mental Health Mission (Mood Clinic)
Smith, D. (Principal Investigator) & McIntosh, A. (Co-investigator)
National Institute for Health Research
1/10/24 → 31/01/28
Project: Research
DATAMIND: The Data Hub for Mental Health Informatics Research and Development (Phase 2)
McIntosh, A. (Principal Investigator)
Swansea University
1/09/24 → 31/08/29
Project: Research
Mental Health platform Collaboration and Innovation fund
McIntosh, A. (Principal Investigator)
Medical Research Council
1/08/24 → 31/03/29
Project: Research
Director of mental health platform
McIntosh, A. (Principal Investigator)
UKRI (formerly RCUK)
1/08/24 → 31/03/29
Project: Research

Comparison of DNA methylation profiles from Generation Scotland blood samples stored on Whatman FTA cards and in EDTA tubes: EWAS summary statistics
Porteous, D. (Creator), Evans, K. (Creator), McCafferty, S. (Creator), Walker, R. (Creator), MacGillivray, L. (Creator), Wrobel, N. (Creator), Kerr, S. (Creator), Morris, S. (Creator), Campbell, A. (Creator) & McIntosh, A. (Creator), Edinburgh DataShare, 26 Feb 2019
DOI: 10.7488/ds/2502, https://doi.org/10.1101/546606
Dataset
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Howard, D. (Creator), Adams, M. (Creator), Clarke, T.-K. (Creator), Hafferty, J. (Creator), Gibson, J. (Creator), Shirali, M. (Creator), Coleman, J. (Creator), Ward, J. (Creator), Wigmore, E. (Creator), Alloza, C. (Creator), Barbu, M. (Creator), Xu, E. (Creator), Sibley, H. (Creator), Marioni, R. (Creator), Porteous, D. (Creator), Davies, G. (Creator), Deary, I. (Creator), Hemani, G. (Creator), Tian, C. (Creator), Hinds, D. (Creator), Team, 2. R. (Creator), Consortium, M. D. D. W. G. O. T. P. G. (Creator), Trzaskowshi, M. (Creator), Byrne, E. (Creator), Ripke, S. (Creator), Smith, D. (Creator), Sullivan, P. (Creator), Wray, N. (Creator), Breen, G. (Creator), Shen, X. (Creator), Lewis, C. (Creator) & McIntosh, A. (Creator), Edinburgh DataShare, 30 Jan 2019
DOI: 10.7488/ds/2458
Dataset
Summary statistics for three depression phenotypes in UK Biobank.
Howard, D. M. (Creator), Adams, M. J. (Creator), Shirali, M. (Creator), Clarke, T.-K. (Creator), Marioni, R. (Creator), Davies, G. (Creator), Alloza, C. (Creator), Shen, X. (Creator), Barbu, M. (Creator), Wigmore, E. (Creator), Gibson, J. (Creator), Hagenaars, S. (Creator), Lewis, C. M. (Creator), Ward, J. (Creator), Haley, C. (Creator), Breen, G. (Creator), Deary, I. (Creator) & McIntosh, A. (Creator), Edinburgh DataShare, 5 Mar 2018
DOI: 10.7488/ds/2350
Dataset
STratifying Resilience and Depression Longitudinally (STRADL): A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments
Adams, M. (Creator), McIntosh, A. (Owner), Hawkins, E. (Data Manager), Habota, T. (Creator), Steele, J. D. (Creator), Whalley, H. (Creator), Porteous, D. (Project Leader), Deary, I. (Project Leader), Murray, A. (Creator) & Campbell, A. (Data Manager), Edinburgh DataVault, 2019
DOI: 10.7488/8f68f1ae-0329-4b73-b189-c7288ea844d7
Dataset
Scottish Family Mental Health (SFMH) Study Dataset
Cooper, A. (Creator), Blackwood, D. (Creator), Lawrie, S. (Creator), McIntosh, A. (Creator), Romaniuk, L. (Creator), Semple, S. (Creator), Duff, B. (Creator) & Whalley, H. (Creator), Edinburgh DataVault, 10 Oct 2023
DOI: 10.7488/7f08e5f1-b300-4a32-bd18-ef511f82c390
Dataset

Andrew McIntosh & David Howard find nearly 80 genes that could be linked to depression
McIntosh, A., Howard, D. & Howard, D. M.
4/02/19 → 5/02/19
10 items of Media coverage
Press/Media: Research
£2.2m boost for pioneering research into mental health conditions
McIntosh, A.
31/03/18
3 items of Media coverage
Press/Media: Research
A study into the causes of clinical depression to receive £4.7 million in the hopes new treatments can be developed
McIntosh, A.
12/05/14
12 items of Media coverage
Press/Media: Research
Prof Andrew McIntosh links chronic pain to partners of people with depression
McIntosh, A.
17/08/16
13 items of Media coverage
Press/Media: Research
Hopes to open NHS ketamine clinic for treatment resistant depression
McIntosh, A. & Ross, A.
23/06/25
1 Media contribution
Press/Media: Research

Andrew McIntosh

Personal profile

Biography

My research in a nutshell

Research Interests

Education/Academic qualification

Keywords

Research Themes and Networks

Fingerprint

Collaborations and top research areas from the last five years

Research output

Activities

Prizes

Projects

Datasets

Press/Media