Andrew McIntosh

2025

Immunological drivers and potential novel drug targets for major psychiatric, neurodevelopmental, and neurodegenerative conditions

Dardani, C., Robinson, J. W., Jones, H. J., Rai, D., Stergiakouli, E., Grove, J., Gardner, R., McIntosh, A. M., Havdahl, A., Hemani, G., Davey Smith, G., Richardson, T. G., Gaunt, T. R. & Khandaker, G. M., 25 Apr 2025, (E-pub ahead of print) In: Molecular Psychiatry.

Research output: Contribution to journal › Article › peer-review

Open Access

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A novel framework to build saliva-based DNA methylation biomarkers: quantifying systemic chronic inflammation as a case study

Schmunk, L. J., Call, T. P., McCartney, D. L., Javaid, H., Hastings, W. J., Jovicevic, V., Kojadinovic, D., Tompkinson, N., Zlamalova, E., McGee, K. C., Sullivan, J., Campbell, A., McIntosh, A. M., Ovari, V., Wishart, K., Behrens, C. E., Stone, E., Gavrilov, M., Thompson, R. & Jackson, T. & 4 others, Lord, J. M., Stubbs, T. M., Marioni, R. E. & Martin-Herranz, D. E., Apr 2025, In: Aging Cell. 24, 4, p. e14444 e14444.

Research output: Contribution to journal › Article › peer-review

Open Access

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Sociodemographic, clinical, and genetic factors associated with self-reported antidepressant response outcomes in the UK Biobank

Kamp, M., Lo, C. W. H., Kokkinidis, G., Chauhan, M., Gillett, A. C., AMBER Research Team, McIntosh, A. M., Pain, O. & Lewis, C. M., 12 Mar 2025, In: Psychological Medicine. 55, p. e80

Research output: Contribution to journal › Article › peer-review

Open Access

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Insights from a methylome-wide association study of antidepressant exposure

Davyson, E., Shen, X., Huider, F., Adams, M. J., Borges, K., McCartney, D. L., Barker, L. F., van Dongen, J., Boomsma, D. I., Weihs, A., Grabe, H. J., Kühn, L., Teumer, A., Völzke, H., Zhu, T., Kaprio, J., Ollikainen, M., David, F. S., Meinert, S. & Stein, F. & 22 others, Forstner, A. J., Dannlowski, U., Kircher, T., Tapuc, A., Czamara, D., Binder, E. B., Brückl, T., Kwong, A. S. F., Yousefi, P., Wong, C. C. Y., Arseneault, L., Fisher, H. L., Mill, J., Cox, S. R., Redmond, P., Russ, T. C., van den Oord, E. J. C. G., Aberg, K. A., Penninx, B. W. J. H., Marioni, R. E., Wray, N. R. & McIntosh, A. M., 24 Feb 2025, (E-pub ahead of print) In: Nature Communications. 16, 1, p. 1908

Research output: Contribution to journal › Article › peer-review

Open Access

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Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 6 Feb 2025, In: Cell. 188, 3, p. 640-652.e9

Research output: Contribution to journal › Article › peer-review

Open Access

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Associations between IL-6 and trajectories of depressive symptoms across the life course: Evidence from ALSPAC and UK Biobank cohorts

Edmondson-Stait, A. J., Davyson, E., Shen, X., Adams, M. J., Khandaker, G. M., Miron, V. E., McIntosh, A. M., Lawrie, S. M., Kwong, A. S. F. & Whalley, H. C., 27 Jan 2025, (E-pub ahead of print) In: European Psychiatry. p. 1-54 54 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Blood-based epigenome-wide association study and prediction of alcohol consumption

Bernabeu, E., Chybowska, A. D., Kresovich, J. K., Suderman, M., McCartney, D. L., Hillary, R. F., Corley, J., Valdés-Hernández, M. D. C., Maniega, S. M., Bastin, M. E., Wardlaw, J. M., Xu, Z., Sandler, D. P., Campbell, A., Harris, S. E., McIntosh, A. M., Taylor, J. A., Yousefi, P., Cox, S. R. & Evans, K. L. & 3 others, Robinson, M. R., Vallejos, C. A. & Marioni, R. E., 25 Jan 2025, In: Clinical Epigenetics. 17, 1

Research output: Contribution to journal › Article › peer-review

Open Access

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Genomics yields biological and phenotypic insights into bipolar disorder

O’connell, K. S., Koromina, M., Van der veen, T., Boltz, T., David, F. S., Yang, J. M. K., Lin, K.-H., Wang, X., Coleman, J. R. I., Mitchell, B. L., Mcgrouther, C. C., Rangan, A. V., Lind, P. A., Koch, E., Harder, A., Parker, N., Bendl, J., Adorjan, K., Agerbo, E. & Albani, D. & 290 others, Alemany, S., Alliey-Rodriguez, N., Als, T. D., Andlauer, T. F. M., Antoniou, A., Ask, H., Bass, N., Bauer, M., Beins, E. C., Bigdeli, T. B., Pedersen, C. B., Boks, M. P., Børte, S., Bosch, R., Brum, M., Brumpton, B. M., Brunkhorst-Kanaan, N., Budde, M., Bybjerg-Grauholm, J., Byerley, W., Cabana-Domínguez, J., Cairns, M. J., Carpiniello, B., Casas, M., Cervantes, P., Chatzinakos, C., Chen, H.-C., Clarence, T., Clarke, T.-K., Claus, I., Coombes, B., Corfield, E. C., Cruceanu, C., Cuellar-Barboza, A., Czerski, P. M., Dafnas, K., Dale, A. M., Dalkner, N., Degenhardt, F., Depaulo, J. R., Djurovic, S., Drange, O. K., Escott-Price, V., Fanous, A. H., Fellendorf, F. T., Ferrier, I. N., Forty, L., Frank, J., Frei, O., Freimer, N. B., Fullard, J. F., Garnham, J., Gizer, I. R., Gordon, S. D., Gordon-Smith, K., Greenwood, T. A., Grove, J., Guzman-Parra, J., Ha, T. H., Hahn, T., Haraldsson, M., Hautzinger, M., Havdahl, A., Heilbronner, U., Hellgren, D., Herms, S., Hickie, I. B., Hoffmann, P., Holmans, P. A., Huang, M.-C., Ikeda, M., Jamain, S., Johnson, J. S., Jonsson, L., Kalman, J. L., Kamatani, Y., Kennedy, J. L., Kim, E., Kim, J., Kittel-Schneider, S., Knowles, J. A., Kogevinas, M., Kranz, T. M., Krebs, K., Kushner, S. A., Lavebratt, C., Lawrence, J., Leber, M., Lee, H.-J., Liao, C., Lucae, S., Lundberg, M., Macintyre, D. J., Maier, W., Maihofer, A. X., Malaspina, D., Manchia, M., Maratou, E., Martinsson, L., Mattheisen, M., Mcgregor, N. W., Mcinnis, M. G., Mckay, J. D., Medeiros, H., Meyer-Lindenberg, A., Millischer, V., Morris, D. W., Moutsatsou, P., Mühleisen, T. W., O’donovan, C., Olsen, C. M., Panagiotaropoulou, G., Papiol, S., Pardiñas, A. F., Park, H. Y., Perry, A., Pfennig, A., Pisanu, C., Potash, J. B., Quested, D., Regeer, E. J., Rice, J. P., Rivera, M., Schulte, E. C., Senner, F., Shadrin, A., Shilling, P. D., Sigurdsson, E., Sindermann, L., Sirignano, L., Siskind, D., Slaney, C., Sloofman, L. G., Smeland, O. B., Smith, D. J., Sobell, J. L., Soler artigas, M., Stein, D. J., Stein, F., Su, M.-H., Sung, H., Świątkowska, B., Terao, C., Tesfaye, M., Tesli, M., Thorgeirsson, T. E., Thorp, J. G., Toma, C., Tondo, L., Tooney, P. A., Tsai, S.-J., Tsermpini, E. E., Vawter, M. P., Vedder, H., Vreeker, A., Walters, J. T. R., Winsvold, B. S., Witt, S. H., Won, H.-H., Ye, R., Zandi, P. P., Young, A. H., Zillich, L., 23andMe Research Team, Estonian Biobank Research Team, Genoplan Research Team, HUNT All-In Psychiatry, PGC-FG Single cell working group, Genomic Psychiatry Cohort (GPC) Investigators, Cooperative Studies Program (CSP) #572, Million Veteran Program (MVP), Adolfsson, R., Alda, M., Alfredsson, L., Backlund, L., Baune, B. T., Bellivier, F., Bengesser, S., Berrettini, W. H., Biernacka, J. M., Boehnke, M., Børglum, A. D., Breen, G., Carr, V. J., Catts, S., Cichon, S., Corvin, A., Craddock, N., Dannlowski, U., Dikeos, D., Etain, B., Ferentinos, P., Frye, M., Fullerton, J. M., Gawlik, M., Gershon, E. S., Goes, F. S., Green, M. J., Grigoroiu-Serbanescu, M., Hauser, J., Henskens, F. A., Hjerling-Leffler, J., Hougaard, D. M., Hveem, K., Iwata, N., Jones, I., Jones, L. A., Kahn, R. S., Kelsoe, J. R., Kircher, T., Kirov, G., Kuo, P.-H., Landén, M., Leboyer, M., Li, Q. S., Lissowska, J., Lochner, C., Loughland, C., Luykx, J. J., Martin, N. G., Mathews, C. A., Mayoral, F., Mcelroy, S. L., Mcintosh, A. M., Mcmahon, F. J., Medland, S. E., Melle, I., Mitchell, P. B., Mors, O., Mortensen, P. B., Müller-Myhsok, B., Myers, R. M., Myung, W., Neale, B. M., Nievergelt, C. M., Nordentoft, M., Nöthen, M. M., Nurnberger, J. I., O’donovan, M. C., Oedegaard, K. J., Olsson, T., Owen, M. J., Paciga, S. A., Pantelis, C., Pato, C. N., Pato, M. T., Patrinos, G. P., Pawlak, J. M., Ramos-Quiroga, J. A., Reif, A., Reininghaus, E. Z., Ribasés, M., Rietschel, M., Ripke, S., Rouleau, G. A., Roussos, P., Saito, T., Schall, U., Schalling, M., Schofield, P. R., Schulze, T. G., Scott, L. J., Scott, R. J., Serretti, A., Smoller, J. W., Squassina, A., Stahl, E. A., Stefansson, H., Stefansson, K., Stordal, E., Streit, F., Sullivan, P. F., Turecki, G., Vaaler, A. E., Vieta, E., Vincent, J. B., Waldman, I. D., Weickert, C. S., Weickert, T. W., Werge, T., Whiteman, D. C., Zwart, J.-A., Edenberg, H. J., Mcquillin, A., Forstner, A. J., Mullins, N., Di florio, A., Ophoff, R. A., Andreassen, O. A. & Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, 22 Jan 2025, In: Nature.

Research output: Contribution to journal › Article › peer-review

2024

White matter microstructure in obesity and bipolar disorders: an ENIGMA bipolar disorder working group study in 2186 individuals

Dietze, L. M. F., Mcwhinney, S. R., Favre, P., Abé, C., Alexander, N., Barkhau, C., Benedetti, F., Berk, M., Bøen, E., Boye, B., Brosch, K., Canales-Rodríguez, E. J., Cannon, D. M., Carruthers, S. P., Corkum, E. L. V., Dannlowski, U., Díaz-Zuluaga, A. M., Dohm, K., Elvsåshagen, T. & Flinkenflügel, K. & 63 others, Fortea, L., Furlong, L. S., Goldstein, B. I., Grotegerd, D., Gruber, M., Haarman, B. C. M., Howells, F. M., Jahanshad, N., Jamalabadi, H., Jansen, A., Karantonis, J. A., Kennedy, K. G., Kircher, T. T. J., Klahn, A. L., Kochunov, P., Kraus, A., Landén, M., López-Jaramillo, C., Macintosh, B. J., Mazza, E., Mcdonald, C., Mcintosh, A. M., Meinert, H., Meinert, S., Melloni, E. M. T., Mitchell, P. B., Nenadić, I., Opel, N., Phillips, M., Piguet, C., Polosan, M., Pomarol-Clotet, E., Pouchon, A., Radua, J., Roberts, G., Ross, A. J., Rossell, S. L., Salvador, R., Sim, K., Soares, J. C., Zunta-Soares, G. B., Stein, F., Straube, B., Suo, C., Teutenberg, L., Thomas-Odenthal, F., Thomopoulos, S. I., Usemann, P., Van rheenen, T. E., Versace, A., Vieta, E., Vilajosana, E., Mwangi, B., Wen, W., Whalley, H. C., Wu, M.-J., Andreassen, O. A., Ching, C. R. K., Thompson, P. M., Houenou, J., Hajek, T., The ENIGMA Bipolar Disorder Working Group & The ENIGMA BMI-X Working Group, 5 Nov 2024, In: Molecular Psychiatry.

Research output: Contribution to journal › Article › peer-review

Genome-wide meta-analysis of ascertainment and symptom structures of major depression in case-enriched and community cohorts

Adams, M. J., Thorp, J. G., Jermy, B. S., Kwong, A. S. F., Kõiv, K., Grotzinger, A. D., Nivard, M. G., Marshall, S., Milaneschi, Y., Baune, B. T., Müller-Myhsok, B., Penninx, B. W. J. H., Boomsma, D. I., Levinson, D. F., Breen, G., Pistis, G., Grabe, H. J., Tiemeier, H., Berger, K. & Rietschel, M. & 15 others, Magnusson, P. K., Uher, R., Hamilton, S. P., Lucae, S., Lehto, K., Li, Q. S., Byrne, E. M., Hickie, I. B., Martin, N. G., Medland, S. E., Wray, N. R., Tucker-Drob, E. M., Lewis, C. M., Mcintosh, A. M. & Derks, E. M., 26 Sept 2024, (E-pub ahead of print) In: Psychological Medicine. 54, 12, p. 3459-3468

Research output: Contribution to journal › Article › peer-review

Open Access

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Fine-mapping genomic loci refines bipolar disorder risk genes

Koromina, M., Ravi, A., Panagiotaropoulou, G., Schilder, B. M., Humphrey, J., Braun, A., Bidgeli, T., Chatzinakos, C., Coombes, B., Kim, J., Liu, X., Terao, C., O 'Connell, K. S., Adams, M., Adolfsson, R., Alda, M., Alfredsson, L., Andlauer, T. F. M., Andreassen, O. A. & Antoniou, A. & 110 others, Baune, B. T., Bengesser, S., Biernacka, J., Boehnke, M., Bosch, R., Cairns, M., Carr, V. J., Casas, M., Catts, S., Cichon, S., Corvin, A., Craddock, N., Dafnas, K., Dalkner, N., Dannlowski, U., Degenhardt, F., Di Florio, A., Dikeos, D., Fellendorf, F. T., Ferentinos, P., Forstner, A. J., Forty, L., Frye, M., Fullerton, J. M., Gawlik, M., Gizer, I. R., Gordon-Smith, K., Green, M. J., Grigoroiu-Serbanescu, M., Guzman-Parra, J., Hahn, T., Henskens, F., Hillert, J., Jablensky, A. V., Jones, L., Jones, I., Jonsson, L., Kelsoe, J. R., Kircher, T., Kirov, G., Kittel-Schneider, S., Kogevinas, M., Landén, M., Leboyer, M., Lenger, M., Lissowska, J., Lochner, C., Loughland, C., MacIntyre, D., Martin, N. G., Maratou, E., Mathews, C. A., Mayoral, F., McElroy, S. L., McGregor, N. W., McIntosh, A., McQuillin, A., Michie, P., Milanova, V., Mitchell, P. B., Moutsatsou, P., Mowry, B., Müller-Myhsok, B., Myers, R., Nenadić, I., Nöthen, M. M., O'Donovan, C., O'Donovan, M., Ophoff, R. A., Owen, M. J., Pantelis, C., Pato, C., Pato, M. T., Patrinos, G. P., Pawlak, J. M., Perlis, R. H., Porichi, E., Posthuma, D., Ramos-Quiroga, J. A., Reif, A., Reininghaus, E. Z., Ribasés, M., Rietschel, M., Schall, U., Schulze, T. G., Scott, L., Scott, R. J., Serretti, A., Weickert, C. S., Smoller, J. W., Artigas, M. S., Stein, D. J., Streit, F., Toma, C., Tooney, P., Vieta, E., Vincent, J. B., Waldman, I. D., Weickert, T., Witt, S. H., Świątkowska, B., Hong, K. S. S., Ikeda, M., Iwata, N., Ripke, S., Won, H.-H., Edenberg, H. J., Raj, T., Coleman, J. R. I. & Mullins, N., 17 Sept 2024, medRxiv.

Research output: Working paper › Preprint

DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain

Gadd, D., Smith, H., Mullin, D., Chybowska, O., Hillary, R., Kimenai, D. M., Bernabeu, E., Cheng, Y., Fawns-Ritchie, C., Campbell, A., Page, D., Taylor, A., Corley, J., Valdés Hernández, M. C., Muñoz Maniega, S., Bastin, M. E., Wardlaw, J. M., Walker, R., Evans, K. L. & McIntosh, A. M. & 8 others, Hayward, C., Russ, T. C., Harris, S. E., Welsh, P., Sattar, N., Cox, S. R., McCartney, D. L. & Marioni, R. E., 10 Sept 2024, In: Nature. 16, 124.

Research output: Contribution to journal › Article › peer-review

Open Access

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Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis

Li, D., Pain, O., Fabbri, C., Wong, W. L. E., Lo, C. W. H., Ripke, S., Cattaneo, A., Souery, D., Dernovsek, M. Z., Henigsberg, N., Hauser, J., Lewis, G., Mors, O., Perroud, N., Rietschel, M., Uher, R., Maier, W., Baune, B. T., Biernacka, J. M. & Bondolfi, G. & 9 others, Kato, M., Domschke, K., Liu, Y.-L., Serretti, A., Tsai, S.-J., Weinshilboum, R., McIntosh, A. M., Lewis, C. M. & GSRD Consortium, the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 19 Jul 2024, In: Translational Psychiatry. 14, 1, 296.

Research output: Contribution to journal › Article › peer-review

Open Access

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Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants

Kanjira, S. C., Adams, M. J., Jiang, Y., Tian, C., Lewis, C. M., Kuchenbaecker, K. & Mcintosh, A. M., 16 Jul 2024, (E-pub ahead of print) In: Molecular Psychiatry.

Research output: Contribution to journal › Article › peer-review

Open Access

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Prevalence and correlates of common mental disorders among participants of the Uganda Genome Resource: Opportunities for psychiatric genetics research

Kalungi, A., Kinyanda, E., Akena, D. H., Gelaye, B., Ssembajjwe, W., Mpango, R. S., Ongaria, T., Mugisha, J., Makanga, R., Kakande, A., Kimono, B., Amanyire, P., Kirumira, F., Lewis, C. M., McIntosh, A. M., Kuchenbaecker, K., Nyirenda, M., Kaleebu, P. & Fatumo, S., 14 Jul 2024, (E-pub ahead of print) In: Molecular Psychiatry.

Research output: Contribution to journal › Article › peer-review

Open Access

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Generation Scotland: an update on Scotland's longitudinal family health study

Milbourn, H., McCartney, D., Richmond, A., Campbell, A., Flaig, R., Robertson, S., Fawns-Ritchie, C., Hayward, C., Marioni, R. E., McIntosh, A. M., Porteous, D. J., Whalley, H. C. & Sudlow, C., 21 Jun 2024, In: BMJ Open. 14, 6, e084719.

Research output: Contribution to journal › Article › peer-review

Open Access

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Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease

Bergstedt, J., Pasman, J. A., Ma, Z., Harder, A., Yao, S., Parker, N., Treur, J. L., Smit, D. J. A., Frei, O., Shadrin, A. A., Meijsen, J. J., Shen, Q., Hägg, S., Tornvall, P., Buil, A., Werge, T., Hjerling-Leffler, J., Als, T. D., Børglum, A. D. & Lewis, C. M. & 6 others, Mcintosh, A. M., Valdimarsdóttir, U. A., Andreassen, O. A., Sullivan, P. F., Lu, Y. & Fang, F., 17 Jun 2024, (E-pub ahead of print) In: Nature Cardiovascular Research. 3, 6, p. 754-769

Research output: Contribution to journal › Article › peer-review

Open Access

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Generation Scotland: an update on Scotland’s longitudinal family health study

Milbourn, H., Mccartney, D., Richmond, A., Campbell, A., Flaig, R., Robertson, S., Fawns-Ritchie, C., Hayward, C., Marioni, R. E., Mcintosh, A. M., Porteous, D. J., Whalley, H. C. & Sudlow, C., 1 Jun 2024, (E-pub ahead of print) In: BMJ Open. 14, 6, p. e084719

Research output: Contribution to journal › Article › peer-review

Open Access

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The circulating proteome and brain health: Mendelian randomisation and cross-sectional analyses

Walker, R. M., Chong, M., Perrot, N., Pigeyre, M., Gadd, D. A., Stolicyn, A., Shi, L., Campbell, A., Shen, X., Whalley, H. C., Nevado-Holgado, A., McIntosh, A. M., Heitmeier, S., Rangarajan, S., O'Donnell, M., Smith, E. E., Yusuf, S., Whiteley, W. N. & Paré, G., 18 May 2024, In: Translational Psychiatry. 14, 1, p. 204

Research output: Contribution to journal › Article › peer-review

Open Access

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Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts

Grimes, P., Adams, M. J., Thng, G., Edmondson-Stait, A., Lu, Y., McIntosh, A. M., Cullen, B., Henrik, L., Whalley, H. & Kwong, A., 15 May 2024, In: JAMA Psychiatry.

Research output: Contribution to journal › Article › peer-review

Open Access

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Blood-based epigenome-wide analyses of chronic low-grade inflammation across diverse population cohorts

Hillary, R. F., Ng, H. K., McCartney, D. L., Elliott, H. R., Walker, R. M., Campbell, A., Huang, F., Direk, K., Welsh, P., Sattar, N., Corley, J., Hayward, C., McIntosh, A. M., Sudlow, C., Evans, K. L., Cox, S. R., Chambers, J. C., Loh, M., Relton, C. L. & Marioni, R. E. & 2 others, Yousefi, P. D. & Suderman, M., 8 May 2024, In: Cell Genomics. 4, 5, 100544.

Research output: Contribution to journal › Article › peer-review

Open Access

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Blood-based epigenome-wide analysis of chronic low-grade inflammation across diverse population cohorts

Hillary, R., McCartney, D. L., Elliott, H. R., Walker, R. M., Campbell, A., Huang, F., Direk, K., Welsh, P., Sattar, N., Hayward, C., McIntosh, A. M., Sudlow, C. L. M., Evans, K., Cox, S. R., Relton, C. L., Marioni, R. E., Yousefi, P. D. & Suderman, M. J., 8 May 2024, In: Cell Genomics. 4, 5, 29 p., 100544.

Research output: Contribution to journal › Article › peer-review

Open Access

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Antidepressant Exposure and DNA Methylation: Insights from a Methylome-Wide Association Study

Davyson, E., Shen, X., Huider, F., Adams, M., Borges, K., McCartney, D., Barker, L., Van Dongen, J., Boomsma, D., Weihs, A., Grabe, H., Kühn, L., Teumer, A., Völzke, H., Zhu, T., Kaprio, J., Ollikainen, M., David, F. S., Meinert, S. & Stein, F. & 22 others, Forstner, A. J., Dannlowski, U., Kircher, T., Tapuc, A., Czamara, D., Binder, E. B., Brückl, T., Kwong, A., Yousefi, P., Wong, C. C. Y., Arseneault, L., Fisher, H. L., Mill, J., Cox, S., Redmond, P., Russ, T. C., van den Oord, E., Aberg, K. A., Penninx, B., Marioni, R. E., Wray, N. R. & McIntosh, A. M., 3 May 2024, medRxiv.

Research output: Working paper › Preprint

Genome-wide study of half a million individuals with major depression identifies 697 independent associations, infers causal neuronal subtypes and biological targets for novel pharmacotherapies

McIntosh, A. M., Lewis, C. M., Adams, M. J. & Psychiatric Genomics Consortium Major Depressive Disorder Working Group, 1 May 2024, medRxiv.

Research output: Working paper › Preprint

Disrupted limbic-prefrontal effective connectivity in response to fearful faces in lifetime depression

Stolicyn, A., Harris, M. A., De Nooij, L., Shen, X., Macfarlane, J. A., Campbell, A., McNeil, C. J., Sandu, A.-L., Murray, A. D., Waiter, G. D., Lawrie, S. M., Steele, J. D., McIntosh, A. M., Romaniuk, L. & Whalley, H. C., 15 Apr 2024, In: Journal of Affective Disorders (JAD). 351, p. 983-993

Research output: Contribution to journal › Article › peer-review

Open Access

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The Potential of Genomics and Electronic Health Records to Invigorate Drug Development

Nisbet, L. N. & McIntosh, A. M., 15 Apr 2024, In: Biological Psychiatry. 95, 8, p. 715-717 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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A comprehensive hierarchical comparison of structural connectomes in Major Depressive Disorder cases v. controls in two large population samples.

Thng, G., Shen, X., Stolicyn, A., Adams, M. J., Yeung, H. W., Batziou, V., Conole, E. L. S., Buchanan, C. R., Lawrie, S. M., Bastin, M. E., McIntosh, A. M., Deary, I. J., Tucker-Drob, E. M., Cox, S. R., Smith, K. M., Romaniuk, L. & Whalley, H. C., 18 Mar 2024, (E-pub ahead of print) In: Psychological Medicine. p. 1-12 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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General and specific patterns of cortical gene expression as spatial correlates of complex cognitive functioning

Moodie, J. E., Harris, S. E., Harris, M. A., Buchanan, C. R., Davies, G., Taylor, A., Redmond, P., Liewald, D. C. M., Valdés Hernández, M. D. C., Shenkin, S., Russ, T. C., Muñoz Maniega, S., Luciano, M., Corley, J., Stolicyn, A., Shen, X., Steele, D., Waiter, G., Sandu, A.-L. & Bastin, M. E. & 6 others, Wardlaw, J. M., McIntosh, A., Whalley, H., Tucker-Drob, E. M., Deary, I. J. & Cox, S. R., Mar 2024, In: Human Brain Mapping. 45, 4, 21 p., e26641.

Research output: Contribution to journal › Article › peer-review

Open Access

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Cognitive ability in early life and risk of depression in adulthood: A systematic review and meta-analysis

Ball, E. L., Morillo, L. G., Poyner, E., Mcintosh, A. M. & Iveson, M. H., 16 Feb 2024, (E-pub ahead of print) In: Journal of Affective Disorders (JAD).

Research output: Contribution to journal › Article › peer-review

Open Access

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Epigenetic Contributions to Clinical Risk Prediction of Cardiovascular Disease

Chybowska, A. D., Gadd, D. A., Cheng, Y., Bernabeu, E., Campbell, A., Walker, R. M., McIntosh, A. M., Wrobel, N., Murphy, L., Welsh, P., Sattar, N., Price, J. F., McCartney, D. L., Evans, K. L. & Marioni, R. E., 30 Jan 2024, (E-pub ahead of print) In: Circulation: Genomic and Precision Medicine. p. e004265

Research output: Contribution to journal › Article › peer-review

Open Access

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Cohort profile: The Scottish SHARE Mental Health (SHARE-MH) cohort - linkable survey, genetic and routinely collected data for mental health research

Iveson, M. H., Ball, E. L., Doherty, J., Pugh, C., Vashishta, S., Palmer, C. N. A. & McIntosh, A., 12 Jan 2024, In: BMJ Open. 14, 1, p. e078246

Research output: Contribution to journal › Article › peer-review

Open Access

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Neuroanatomical dimensions in medication-free individuals with major depressive disorder and treatment response to SSRI antidepressant medications or placebo

Fu, C. H. Y., Antoniades, M., Erus, G., Garcia, J. A., Fan, Y., Arnone, D., Arnott, S. R., Chen, T., Choi, K. S., Fatt, C. C., Frey, B. N., Frokjaer, V. G., Ganz, M., Godlewska, B. R., Hassel, S., Ho, K., Mcintosh, A. M., Qin, K., Rotzinger, S. & Sacchet, M. D. & 29 others, Savitz, J., Shou, H., Singh, A., Stolicyn, A., Strigo, I., Strother, S. C., Tosun, D., Victor, T. A., Wei, D., Wise, T., Zahn, R., Anderson, I. M., Craighead, W. E., Deakin, J. F. W., Dunlop, B. W., Elliott, R., Gong, Q., Gotlib, I. H., Harmer, C. J., Kennedy, S. H., Knudsen, G. M., Mayberg, H. S., Paulus, M. P., Qiu, J., Trivedi, M. H., Whalley, H. C., Yan, C.-G., Young, A. H. & Davatzikos, C., 12 Jan 2024, In: Nature Mental Health.

Research output: Contribution to journal › Article › peer-review

Open Access

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Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

Meng, X., Navoly, G., Giannakopoulou, O., Levey, D. F., Koller, D., Pathak, G. A., Koen, N., Lin, K., Adams, M. J., Rentería, M. E., Feng, Y., Gaziano, J. M., Stein, D. J., Zar, H. J., Campbell, M. L., van Heel, D. A., Trivedi, B., Finer, S., McQuillin, A. & Bass, N. & 63 others, Chundru, V. K., Martin, H. C., Huang, Q. Q., Valkovskaya, M., Chu, C.-Y., Kanjira, S., Kuo, P.-H., Chen, H.-C., Tsai, S.-J., Liu, Y.-L., Kendler, K. S., Peterson, R. E., Cai, N., Fang, Y., Sen, S., Scott, L. J., Burmeister, M., Loos, R. J. F., Preuss, M. H., Actkins, K. V., Davis, L. K., Uddin, M., Wani, A. H., Wildman, D. E., Aiello, A. E., Ursano, R. J., Kessler, R. C., Kanai, M., Okada, Y., Sakaue, S., Rabinowitz, J. A., Maher, B. S., Uhl, G., Eaton, W., Cruz-Fuentes, C. S., Martinez-Levy, G. A., Campos, A. I., Millwood, I. Y., Chen, Z., Li, L., Wassertheil-Smoller, S., Jiang, Y., Tian, C., Martin, N. G., Mitchell, B. L., Byrne, E. M., Awasthi, S., Coleman, J. R. I., Ripke, S., PGC-MDD Working Group, China Kadoorie Biobank Collaborative Group, the 23andMe Research Team, Genes and Health Research Team, BioBank Japan Project, Sofer, T., Walters, R. G., McIntosh, A. M., Polimanti, R., Dunn, E. C., Stein, M. B., Gelernter, J., Lewis, C. M. & Kuchenbaecker, K., 4 Jan 2024, (E-pub ahead of print) In: Nature Genetics.

Research output: Contribution to journal › Article › peer-review

Open Access

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2023

Childhood cognitive ability and self-harm and suicide in later life

Iveson, M. H., Ball, E. L., Whalley, H. C., Deary, I. J., Cox, S. R., Batty, G. D., John, A. & Mcintosh, A. M., 29 Dec 2023, (E-pub ahead of print) In: SSM - population health. 25, p. 101592

Research output: Contribution to journal › Article › peer-review

Open Access

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Classification accuracy of structural and functional connectomes across different depressive phenotypes

Yeung, H. W., Stolicyn, A., Shen, X., Adams, M. J., Romaniuk, L., Thng, G., Buchanan, C. R., Tucker-Drob, E. M., Bastin, M. E., Mcintosh, A. M., Cox, S. R., Smith, K. M. & Whalley, H. C., 20 Dec 2023, In: Imaging Neuroscience.

Research output: Contribution to journal › Article › peer-review

Open Access

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Integration of datasets for individual prediction of DNA methylation-based biomarkers

Merzbacher, C., Ryan, B., Goldsborough, T., Hillary, R. F., Campbell, A., Murphy, L., McIntosh, A. M., Liewald, D., Harris, S. E., Mcrae, A. F., Cox, S. R., Cannings, T. I., Vallejos, C. A., McCartney, D. L. & Marioni, R. E., 5 Dec 2023, In: Genome Biology. 24, 1, p. 278

Research output: Contribution to journal › Article › peer-review

Open Access

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Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 1 Dec 2023, In: The American Journal of Psychiatry. 180, p. 884-895

Research output: Contribution to journal › Article › peer-review

Childhood intelligence and risk of depression in later-life: A longitudinal data-linkage study

Ball, E. L., Altschul, D. M., Cox, S. R., Deary, I. J., McIntosh, A. M. & Iveson, M. H., 24 Nov 2023, In: SSM - population health. 25, p. 1-7

Research output: Contribution to journal › Article › peer-review

Open Access

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Comprehensive Assessment of Sleep Duration, Insomnia and Brain Structure within the UK Biobank Cohort

Stolicyn, A., Lyall, L. M., Lyall, D. M., Høier, N., Adams, M. J., Shen, X., Cole, J. H., McIntosh, A. M., Whalley, H. C. & Smith, D. J., 27 Oct 2023, (E-pub ahead of print) In: Sleep.

Research output: Contribution to journal › Article › peer-review

Open Access

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Metabolomic investigation of major depressive disorder identifies a potentially causal association with polyunsaturated fatty acids

Davyson, E., Shen, X., Gadd, D. A., Bernabeu, E., Hillary, R. F., McCartney, D. L., Adams, M., Marioni, R. & McIntosh, A. M., 15 Oct 2023, In: Biological Psychiatry. 94, 8, p. 630-639

Research output: Contribution to journal › Article › peer-review

Open Access

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GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors

Docherty, A. R., Mullins, N., Ashley-Koch, A. E., Qin, X., Coleman, J. R. I., Shabalin, A., Kang, J., Murnyak, B., Wendt, F., Adams, M. J., Campos, A. I., Diblasi, E., Fullerton, J. M., Kranzler, H. R., Bakian, A. V., Monson, E. T., Rentería, M. E., Walss-Bass, C., Andreassen, O. A. & Behera, C. & 236 others, Bulik, C. M., Edenberg, H. J., Kessler, R. C., Mann, J. J., Nurnberger, J. I., Pistis, G., Streit, F., Ursano, R. J., Polimanti, R., Dennis, M., Garrett, M., Hair, L., Harvey, P., Hauser, E. R., Hauser, M. A., Huffman, J., Jacobson, D., Madduri, R., Mcmahon, B., Oslin, D. W., Trafton, J., Awasthi, S., Berrettini, W. H., Bohus, M., Chang, X., Chen, H.-C., Chen, W. J., Christensen, E. D., Crow, S., Duriez, P., Edwards, A. C., Fernández-Aranda, F., Galfalvy, H., Gandal, M., Gorwood, P., Guo, Y., Hafferty, J. D., Hakonarson, H., Halmi, K. A., Hishimoto, A., Jain, S., Jamain, S., Jiménez-Murcia, S., Johnson, C., Kaplan, A. S., Kaye, W. H., Keel, P. K., Kennedy, J. L., Kim, M., Klump, K. L., Levey, D. F., Li, D., Liao, S.-C., Lieb, K., Lilenfeld, L., Marshall, C. R., Mitchell, J. E., Okazaki, S., Otsuka, I., Pinto, D., Powers, A., Ramoz, N., Ripke, S., Roepke, S., Rozanov, V., Scherer, S. W., Schmahl, C., Sokolowski, M., Starnawska, A., Strober, M., Su, M.-H., Thornton, L. M., Treasure, J., Ware, E. B., Watson, H. J., Witt, S. H., Woodside, D. B., Yilmaz, Z., Zillich, L., Adolfsson, R., Agartz, I., Alda, M., Alfredsson, L., Appadurai, V., Artigas, M. S., Van der auwera, S., Azevedo, M. H., Bass, N., Bau, C. H. D., Baune, B. T., Bellivier, F., Berger, K., Biernacka, J. M., Bigdeli, T. B., Binder, E. B., Boehnke, M., Boks, M. P., Braff, D. L., Bryant, R., Budde, M., Byrne, E. M., Cahn, W., Castelao, E., Cervilla, J. A., Chaumette, B., Corvin, A., Craddock, N., Djurovic, S., Foo, J. C., Forstner, A. J., Frye, M., Gatt, J. M., Giegling, I., Grabe, H. J., Green, M. J., Grevet, E. H., Grigoroiu-Serbanescu, M., Gutierrez, B., Guzman-Parra, J., Hamshere, M. L., Hartmann, A. M., Hauser, J., Heilmann-Heimbach, S., Hoffmann, P., Ising, M., Jones, I., Jones, L. A., Jonsson, L., Kahn, R. S., Kelsoe, J. R., Kendler, K. S., Kloiber, S., Koenen, K. C., Kogevinas, M., Krebs, M.-O., Leboyer, M., Landén, M., Lee, P. H., Levinson, D. F., Liao, C., Lissowska, J., Mayoral, F., Mcelroy, S. L., Mcgrath, P., Mcguffin, P., Mcquillin, A., Mehta, D., Melle, I., Mitchell, P. B., Molina, E., Morken, G., Nievergelt, C., Nöthen, M. M., O’donovan, M. C., Ophoff, R. A., Owen, M. J., Pato, C., Pato, M. T., Penninx, B. W. J. H., Potash, J. B., Power, R. A., Preisig, M., Quested, D., Ramos-Quiroga, J. A., Reif, A., Ribasés, M., Richarte, V., Rietschel, M., Rivera, M., Roberts, A., Roberts, G., Rouleau, G. A., Rovaris, D. L., Sanders, A. R., Schofield, P. R., Schulze, T. G., Scott, L. J., Serretti, A., Shi, J., Sirignano, L., Sklar, P., Smeland, O. B., Smoller, J. W., Sonuga-Barke, E. J. S., Trzaskowski, M., Tsuang, M. T., Turecki, G., Vilar-Ribó, L., Vincent, J. B., Völzke, H., Walters, J. T. R., Weickert, C. S., Weickert, T. W., Weissman, M. M., Williams, L. M., Wray, N. R., Zai, C. C., Agerbo, E., Børglum, A. D., Breen, G., Demontis, D., Gelernter, J., Glatt, S. J., Erlangsen, A., Hougaard, D. M., Hwu, H.-G., Kuo, P.-H., Lewis, C. M., Li, Q. S., Liu, C.-M., Martin, N. G., Mcintosh, A. M., Medland, S. E., Mors, O., Nordentoft, M., Olsen, C. M., Porteous, D., Smith, D. J., Stahl, E. A., Stein, M. B., Wasserman, D., Werge, T., Whiteman, D. C., Willour, V., VA Million Veteran Program, MVP Suicide Exemplar Workgroup, Suicide Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Eating Disorder Working Group of the Psychiatric Genomics Consortium, German Borderline Genomics Consortium, Coon, H., Beckham, J. C., Kimbrel, N. A. & Ruderfer, D. M., 1 Oct 2023, In: The American Journal of Psychiatry. 180, 10, p. 723-738

Research output: Contribution to journal › Article › peer-review

Open Access

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The Heterogeneity of Depression

Lynall, M.-E. & McIntosh, A. M., 1 Oct 2023, In: The American Journal of Psychiatry. 180, 10, p. 703-704 2 p.

Research output: Contribution to journal › Article › peer-review

Psychosis Endophenotypes: A Gene-Set-Specific Polygenic Risk Score Analysis

Wang, B., Irizar, H., Thygesen, J. H., Zartaloudi, E., Austin-Zimmerman, I., Bhat, A., Harju-Seppänen, J., Pain, O., Bass, N., Gkofa, V., Alizadeh, B. Z., van Amelsvoort, T., Arranz, M. J., Bender, S., Cahn, W., Stella Calafato, M., Crespo-Facorro, B., Di Forti, M., Genetic Risk and Outcome of Psychosis (GROUP) Study & Giegling, I. & 28 others, de Haan, L., Hall, J., Hall, M.-H., van Haren, N., Iyegbe, C., Kahn, R. S., Kravariti, E., Lawrie, S. M., Lin, K., Luykx, J. J., Mata, I., McDonald, C., McIntosh, A. M., Murray, R. M., Psychosis Endophenotypes International Consortium (PEIC), Picchioni, M., Powell, J., Prata, D. P., Rujescu, D., Rutten, B. P. F., Shaikh, M., Simons, C. J. P., Toulopoulou, T., Weisbrod, M., van Winkel, R., Kuchenbaecker, K., McQuillin, A. & Bramon, E., 14 Aug 2023, (E-pub ahead of print) In: Schizophrenia Bulletin.

Research output: Contribution to journal › Article › peer-review

Open Access

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Sociodemographic, mental health, and physical health factors associated with participation within re-contactable mental health cohorts: an investigation of the GLAD Study

Bright, S. J., Hübel, C., Young, K. S., Bristow, S., Peel, A. J., Rayner, C., Mundy, J., Palmos, A. B., Purves, K. L., Kalsi, G., Armour, C., Jones, I. R., Hotopf, M., McIntosh, A. M., Smith, D. J., Walters, J. T. R., Rogers, H. C., Thompson, K. N., Adey, B. N. & Monssen, D. & 9 others, Kakar, S., Malouf, C. M., Hirsch, C., Glen, K., Kelly, E. J., Veale, D., Eley, T. C., Breen, G. & Davies, M. R., 26 Jul 2023, In: BMC Psychiatry. 23, 1, p. 542

Research output: Contribution to journal › Article › peer-review

Open Access

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General and specific patterns of cortical gene expression as substrates of complex cognitive functioning

Moodie, J. E., Harris, S., Harris, M., Buchanan, C., Taylor, A., Redmond, P., Liewald, D. C., Shenkin, S. D., Russ, T. C., Muñoz Maniega, S., Luciano, M., Corley, J., Stolicyn, A., Shen, X., Bastin, M., Wardlaw, J. M., McIntosh, A. M., Whalley, H., Tucker-Drob, E. M. & Deary, I. J. & 1 others, Cox, S. R., 20 Jul 2023, bioRxiv.

Research output: Working paper › Preprint

Blood-based epigenome-wide analyses of nineteen common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals

Hillary, R., McCartney, D. L., Smith, H., Bernabeu, E., Gadd, D., Chybowska, A., Cheng, Y., Murphy, L., Wrobel, N., Walker, R., Hayward, C., Evans, K. L., McIntosh, A. M. & Marioni, R. E., 6 Jul 2023, In: PLoS Medicine. 20, 7, e1004247.

Research output: Contribution to journal › Article › peer-review

Open Access

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Polygenic risk prediction: why and when out-of-sample prediction R2 can exceed SNP-based heritability.

Wang, X., Walker, A., Revez, J. A., Ni, G., Adams, M. J., McIntosh, A. M. & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 6 Jul 2023, In: American Journal of Human Genetics. 110, 7, p. 1207-1215 9 p.

Research output: Contribution to journal › Article › peer-review

Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

Schizophrenia Working Group of the Psychiatric Genomics Consortium, Stanley Global Asia Initiatives, Psychosis Endophenotypes International Consortium, Wellcome Trust Case Control Consortium, Hsu, Y.-H. H., Pintacuda, G., Liu, R., Nacu, E., Kim, A., Tsafou, K., Petrossian, N., Crotty, W., Suh, J. M., Riseman, J., Martin, J. M., Biagini, J. C., Mena, D., Ching, J. K. T., Malolepsza, E. & Li, T. & 13 others, Singh, T., Ge, T., Egri, S. B., Tanenbaum, B., Stanclift, C. R., Apffel, A. M., Huang, H., Carr, S. A., Schenone, M., Jaffe, J., Fornelos, N., Eggan, K. C. & Lage, K., 19 May 2023, In: iScience. 26, 5, 106701.

Research output: Contribution to journal › Article › peer-review

Open Access

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Phenome-wide analyses identify an association between the parent-of-origin effects dependent methylome and the rate of aging in humans

Gao, C., Amador, C., Walker, R., Campbell, A., Madden, R., Adams, M. J., Bai, X., Liu, Y., Li, M., Hayward, C., Porteous, D. J., Shen, X., Evans, K. L., Haley, C. S., McIntosh, A. M., Navarro, P. & Zeng, Y., 15 May 2023, In: Genome Biology. 24, p. 1-28 28 p., 117.

Research output: Contribution to journal › Article › peer-review

Open Access

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Genetic examination of the Mood Disorder Questionnaire and its relationship with bipolar disorder

Mundy, J., Hübel, C., Adey, B. N., Davies, H. L., Davies, M. R., Coleman, J. R. I., Hotopf, M., Kalsi, G., Lee, S. H., McIntosh, A. M., Rogers, H. C., Eley, T. C., Murray, R. M., Vassos, E. & Breen, G., 13 May 2023, (E-pub ahead of print) In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics.

Research output: Contribution to journal › Article › peer-review

Open Access

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Andrew McIntosh

Research output

Search results