Research output per year
Research output per year
Personal profile
Biography
I direct the advanced imaging resource which comprises 20 different imaging systems and image informatics. As well as this I work to develop new methodologies relevant to the research carried out at the Human Genetics Unit. I have a particular focus on methodologies applied to super-resolution imaging and development of biocompatible substrates for advanced imaging through the Edinburgh Interdisciplinary Super-Resolution Consortium www.esric.org
Education/Academic qualification
Cell Biology, Doctor of Philosophy (PhD), The role of RhoGTPases in macrophage motility and morphology, University of London
21 Sept 2000 → 1 Feb 2005
Award Date: 1 Feb 2005
Molecular and Cellular Biochemistry, Master of Biochemistry, University of Oxford
1 Oct 1995 → 1 Jun 1999
Award Date: 15 Jun 1999
External positions
Committee member European Light Microscopy Initiative
28 May 2016 → …
Committee member, British Society of Cell Biology
1 Oct 2015 → …
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Collaborations and top research areas from the last five years
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The V-ATPase complex component RNAseK is required for lysosomal hydrolase delivery and autophagosome degradation
Makar, A., Boraman, A., Mosen, P., Simpson, J., Marques , J., Michelberger, T., Aitken, S., Wheeler, A. P., Winter, D., von Kriegsheim, A. & Gammoh, N., 5 Sept 2024, (E-pub ahead of print) In: Nature Communications.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
DNMT3B PWWP mutations cause hypermethylation of heterochromatin
Taglini, F., Kafetzopoulos, I., Rolls, W., Musialik, K. I., Yang Lee, H., Zhang, Y., Marenda, M., Kerr, L., M. Finan, H., Rubio Ramon, C., Gautier, P., Wapenaar, H., Kumar, D., Davidson-Smith, H., Wills, J., Murphy, L., Wheeler, A. P., Wilson, M. D. & Sproul, D., 30 Jan 2024, In: EMBO Reports.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Mena regulates nesprin-2 to control actin– 1 nuclear lamina associations, trans-nuclear 2 membrane signalling and gene expression
Li Mow Chee, F., Beernaert Dominguez, B., Griffith, B., Loftus, A., Kumar, Y., Wills, J., Lee, M., Valli, J., Wheeler, A. P., Armstrong, J. D., Parsons, M., Leigh, I. M., Proby, C., von Kriegsheim, A., Bickmore, W. A., Frame, M. C. & Byron, A., 23 Mar 2023, (E-pub ahead of print) In: Nature Communications.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Non-fitting FLIM-FRET facilitates analysis of protein interactions in live zebrafish embryos
Auer, J. M. T., Murphy, L. C., Xiao, D., Li, D. U. & Wheeler, A. P., 30 Nov 2022, (E-pub ahead of print) In: Journal of Microscopy.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Mena regulates the LINC complex to control actin–nuclear lamina associations, trans-nuclear membrane signalling and cancer gene expression
Chee, F. L. M., Beernaert, B., Loftus, A., Kumar, Y., Griffith, B. G. C., Wills, J. C., Wheeler, A. P., Armstrong, J. D., Parsons, M., Leigh, I. M., Proby, C. M., Kriegsheim, A. V., Bickmore, W. A., Frame, M. C. & Byron, A., 31 Aug 2021, bioRxiv.Research output: Working paper
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ESRIC Summer school
Wheeler, A. (Organiser)
31 Jul 2017 → 4 Aug 2017Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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Edinburgh Super Resolution Summer School
Wheeler, A. (Organiser)
Aug 2014 → Aug 2017Activity: Participating in or organising an event types › Participation in conference
Projects
- 4 Finished
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Upgrade of Andor Dragonfly for Four Dimensional Cellular Medicine and Super-resolution microscopy
Wheeler, A. (Principal Investigator), Mill, P. (Co-investigator), Murphy, L. (Co-investigator) & Patton, E. (Co-investigator)
1/11/22 → 31/10/23
Project: Research
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Multimodal coherent Raman and two-photon fluorescence imaging as a discovery tool in bioscience
Brunton, V. (Principal Investigator), Lee, M. (Co-investigator) & Wheeler, A. (Co-investigator)
1/11/20 → 30/06/21
Project: Research
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Investigating the Bio-Physical Properties of SAF-A Assembly via Live-Cell SuperResolution Microscopy, Machine Learning and Molecular Dynamics Simulations Proposed
Marenda, M. (Principal Investigator), Gilbert, N. (Co-investigator), Papadopoulos, D. (Co-investigator) & Wheeler, A. (Co-investigator)
1/10/19 → 31/12/20
Project: Research
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Beta test of Andor Dragonfly Imaging system
Wheeler, A. (Principal Investigator)
21/03/16 → 2/10/17
Project: Non-Funded Commission or Consultancy work