Personal profile
Current Research Interests
My aim is to investigate and characterize the magnetic nano-particle in the musculoskeletal tissues using several molecular and cell biological techniques. Nanoparticles can be biofunctionalized with different biomolecules required to be delivered to the cells to obtain an specific effect like drugs, growth factors and nucleic acids for gene therapy. Artificially made nanoparticles exert toxic effects on human cell lines. To overcome this concern we are trying to generate human cells able to synthesize de novo magnetic nanoparticles in the similar manner in which magnetotactic bacteria are producing nanoscale magnetosomes consisting of the iron oxide mineral magnetite act as microscopic compasses that allow bacteria to sense direction. The aim is to develop nano magnetic particle for tissue regeneration and orthopedic surgery. These can be imagined as fixed stations that offer a long living assistance to tissue engineering by controlling growth factors delivery in situ and monitoring the tissues.
Besides, above, other project in the laboratory is being undertaken such as role of IL13 and its receptors in the prognosis of Osteoarthritis (OA). IL-13 is potentially useful in the therapeutic treatment of OA, as it could regulate the major pathological process of this disease by reducing the production of proinflammatory cytokines and metalloproteases, and favoring the production of its receptors such as IL-1RA1and ILRA2.
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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CXCR4 is a response gene for parathyroid hormone which affects osteoblast and osteoclast function in vitro
Larraz-Prieto, B., Lind, L. H., Olesen, J. B., Azfer, A., Hansen, M. S., Frost, M., Jafari, A., Farquharson, C., Ralston, S. H., Søe, K. & Alonso, N., May 2025, In: Bone & Joint Research. 14, 5, p. 463-476 14 p.Research output: Contribution to journal › Article › peer-review
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Genome-wide association study identifies genetic variants which predict the response of bone mineral density to teriparatide therapy
Alonso, N., Albagha, O. M. E., Azfer, A., Larraz Prieto, B., Berg, K., Riches, P., Ostanek, B., Kocjan, T., Marc, J., Langdahl, B. L. & Ralston, S. H., Jul 2023, In: Annals of the Rheumatic Diseases. 82, 7, p. 985-991Research output: Contribution to journal › Article › peer-review
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Probiotics inhibit cartilage damage and progression of osteoarthritis in mice
Sophocleous, A., Azfer, A., Huesa, C. & Ralston, S. H., 19 Oct 2022, In: Calcified Tissue International and Musculoskeletal Research.Research output: Contribution to journal › Article › peer-review
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Gorham-Stout case report: a multi-omic analysis reveals recurrent fusions as new potential drivers of the disease
Yébenes Mayordomo, M., Al Shboul, S., Gómez-herranz, M., Azfer, A., Meynert, A., Salter, D., Hayward, L., Oniscu, A., Patton, J. T., Hupp, T., Arends, M. J. & Alfaro, J. A., 6 Jun 2022, In: Journal Title BMC Medical Genomics. 15, 1, p. 128Research output: Contribution to journal › Article › peer-review
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Targeted Inactivation of Rin3 Increases Trabecular Bone Mass by Reducing Bone Resorption and Favouring Bone Formation
Vallet, M., Sophocleous, A., Törnqvist, A. E., Azfer, A., Hof, R. V., Albagha, O. M. & Ralston, S. H., 16 Mar 2021, (E-pub ahead of print) In: Calcified Tissue International and Musculoskeletal Research.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Projects
- 2 Finished
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1. Role of MCSF as an autocrine and paracrine factor in Paget¿s Disease of Bone
Azfer, A. (Principal Investigator) & Albagha, O. (Co-investigator)
1/08/20 → 31/07/22
Project: Research
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1. Role of MCSF as an autocrine and paracrine factor in Paget�s Disease of Bone
Azfer, A. (Principal Investigator) & Albagha, O. (Co-investigator)
1/08/20 → 31/07/22
Project: Research