Personal profile
Biography
I am a biostatistician with broad methodological expertise in machine learning (doctoral training) and genetic epidemiology (post-doctoral training). The aims of my research programme are to understand disease pathogenesis, and to inform decisions around disease diagnosis, prognosis, and treatment using probabilistic models and computational approaches. Much of my work is on developing methods and tools to enable such predictive and causal inferences through the analysis of large-scale, high-dimensional datasets, combining genetic and biomarker data with clinical outcomes. I mostly research the aetiology and management of autoimmune diseases, especially rheumatoid arthritis and type 1 diabetes, though the methods I develop are more broadly applicable.
I am funded by Versus Arthritis as a Career Development Fellow and I am a Lecturer at the Usher Institute, University of Edinburgh, where together with Paul McKeigue, I lead the Target Genetics and Precision Medicine group. I am also an affiliate of the Institute of Genetics and Cancer, where I work closely with the Diabetes Medical Informatics and Epidemiology group, led by Helen Colhoun.
Education/Academic qualification
Doctor of Philosophy (PhD), Probabilistic Models for Melodic Sequences, University of Edinburgh
Award Date: 1 Jan 2013
Artificial Intelligence, Master in Science, University of Edinburgh
Award Date: 1 Sept 2008
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Collaborations and top research areas from the last five years
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Genome-Wide Aggregated Trans-Effects Analysis Implicates Deficient Type III Interferon Signaling as a Key Cause of Inflammatory Bowel Disease
McKeigue, P. M., Iakovliev, A., Erabadda, B., Colhoun, H. M. & Spiliopoulou, A., 1 Nov 2025, In: Inflammatory Bowel Diseases. 31, 11, p. 3172-3182 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Genome-Wide Aggregated Trans Effects Analysis for Circulating Proteins Indicates a Key Role of Immune Checkpoints in Type 1 Diabetes
Zhou, X., Iakovliev, A., McGurnaghan, S., Erabadda, B., Hayward, C., McKeigue, P. M., Spiliopoulou, A. & Colhoun, H. M., 1 Oct 2025, In: Diabetes . 74, 10, p. 1873-1884Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Discovery of core genes for systemic lupus erythematosus via genome-wide aggregated trans-effects analysis
Iakovliev, A., Castellini-Pérez, O., Erabadda, B., Martín, J., Barturen, G., McKeigue, P. M., Carnero-Montoro, E., Alarcón-Riquelme, M. E. & Spiliopoulou, A., Oct 2025, In: Genes and Immunity. 26, 5, p. 497-508Research output: Contribution to journal › Article › peer-review
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Association between methylation quantitative trait loci and colorectal cancer risk, survival and cancer recurrence
Mesa Eguiagaray, I., Iakovliev, A., Li, X., Timofeeva, M., He, Y., Zhang, X., Din, F. V. N., Farrington, S. M., Spiliopoulou, A., Dunlop, M. G. & Theodoratou, E., 12 Jun 2025, (E-pub ahead of print) In: British Journal of Cancer. 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Associations of genetic factors with vascular diabetes complications: an umbrella review
Zhou, X., Xu, W., Spiliopoulou, A. & Theodoratou, E., 21 Mar 2025, In: Journal of Global Health. 15, 18 p., 04081.Research output: Contribution to journal › Article › peer-review
Open AccessFile
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Research Summer School in Statistical Omics 2014
Spiliopoulou, A. (Trainer)
1 Aug 2014 → 14 Aug 2014Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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Edinburgh International Science Festival 2014
Spiliopoulou, A. (Presenter)
16 Apr 2014 → 17 Apr 2014Activity: Participating in or organising an event types › Public Engagement – Festival/Exhibition
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Edinburgh Alliance for Complex Trait Genetics 6th meeting
Spiliopoulou, A. (Speaker)
2 Apr 2014Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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Exploiting methodological and technological innovations for targeted treatment and precision medicine
Spiliopoulou, A. (Principal Investigator)
1/06/25 → 31/05/30
Project: Research
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Combining genetics of omics biomarkers and Bayesian predictive models to improve genotypic predictors of clinical and treatment outcomes in autoimmune diseases
Spiliopoulou, A. (Principal Investigator)
1/08/21 → 31/07/23
Project: Research
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Combining genetics of omics biomarkers and Bayesian predictive models to improve genotypic predictors of clinical and treatment outcomes in autoimmune diseases
Spiliopoulou, A. (Principal Investigator)
1/08/21 → 31/07/24
Project: Research
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The Development and Validation of a Transcriptomic-Based Model for Classifying and Predicting Treatment Response in Rheumatoid Arthritis Patients (TRACT-RA)
Spiliopoulou, A. (Principal Investigator), McKeigue, P. (Co-investigator) & Williams, J. (Co-investigator)
5/04/21 → 31/07/21
Project: Research
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The Development and Validation of a Transcriptomic-Based Model for Classifying and Predicting Treatment Response in Rheumatoid Arthritis Patients (TRACT-RA)
McKeigue, P. (Principal Investigator) & Spiliopoulou, A. (Co-investigator)
5/04/21 → 14/01/24
Project: Research
Datasets
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Trans-eQTL effects on risk of type 1 diabetes: a test of the sparse effector (omnigenic) hypothesis of complex trait genetics (supplementary data)
Iakovliev, A. (Creator), McGurnaghan, S. (Researcher), Hayward, C. (Producer), Colombo, M. (Researcher), Lipschutz, D. (Researcher), Spiliopoulou, A. (Researcher), Colhoun, H. (Project Leader) & McKeigue, P. (Project Leader), Zenodo, 30 Mar 2023
DOI: 10.5281/zenodo.7786862, https://www.cell.com/ajhg/pdf/S0002-9297(23)00127-1.pdf
Dataset