Audrey Coutts

Search results

• 2024

  Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

  Baillie, J. K. & PHOSP-COVID Collaborative Group, Apr 2024, In: Nature Immunology. 25, 4, p. 607-621 35 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

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  • Coronavirus 100%
  • Cognitive Disorders 22%
  • Brain 11%
  • Myeloid 11%
  • Nerve Tissue 11%
• 2023

  Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19

  Sidhu, J. K., Siggins, M. K., Liew, F., Russell, C. D., Uruchurtu, A. S. S., Davis, C., Turtle, L., Moore, S. C., Hardwick, H. E., Oosthuyzen, W., Thomson, E. C., Semple, M. G., Baillie, J. K., Openshaw, P. J. M., Thwaites, R. S. & ISARIC4C Investigators, 22 Dec 2023, In: The Journal of Infectious Diseases. p. 1-13

  Research output: Contribution to journal › Article › peer-review

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  • COVID-19 100%
  • Inflammation 100%
  • Antivirus Agent 100%
  • Cytokine 50%
  • Infection 50%

• Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

  ISARIC4C Investigators, 22 Dec 2023, In: Nature Communications. 14, 1, 8487.

  Research output: Contribution to journal › Article › peer-review

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  • COVID-19 100%
  • Cytokine 100%
  • Brain 100%
  • Autoantibodies 100%
  • Brain Injury 100%

• International Pediatric COVID-19 Severity Over the Course of the Pandemic

  International Severe Acute Respiratory Infection Consortium (ISARIC4C) groupPediatric Active Enhanced Disease Surveillance (PAEDS) Network group, Baillie, K., Britton, P. N. & Short, K. R., 1 Oct 2023, In: JAMA pediatrics. 177, 10, p. 1073-1084 12 p.

  Research output: Contribution to journal › Article › peer-review

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  • COVID-19 100%
  • Pediatrics 100%
  • Child 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 88%
  • Severe Acute Respiratory Syndrome 88%

• Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

  GenOMICC Investigators, Law, A., Hendry, S. C. & Baillie, J. K., 27 Jul 2023, In: Nature. 619, 7971, p. E61

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

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  • Meta-Analysis 100%
  • COVID-19 100%
  • Genetic Variability 100%
  • Genome Wide Association Study 100%
  • Meta Analysis 100%

• Adeno-associated virus 2 infection in children with non-A-E hepatitis

  DIAMONDS consortium, Ho, A., Orton, R., Tayler, R., Asamaphan, P., Herder, V., Davis, C., Tong, L., Smollett, K., Manali, M., Allan, J., Rawlik, K., McDonald, S. E., Vink, E., Pollock, L., Gannon, L., Evans, C., McMenamin, J., Roy, K., Marsh, K., & 37 othersDivala, T., Holden, M. T. G., Lockhart, M., Yirrell, D., Currie, S., O'Leary, M., Henderson, D., Shepherd, S. J., Jackson, C., Gunson, R., MacLean, A., McInnes, N., Bradley-Stewart, A., Battle, R., Hollenbach, J., Henderson, P., Odam, M., Chikowore, P., Oosthuyzen, W., Chand, M., Hamilton, M. S., Estrada-Rivadeneyra, D., Levin, M., Avramidis, N., Pairo-Castineira, E., Vitart, V., Wilkie, C., Palmarini, M., Ray, S., Robertson, D. L., da Silva Filipe, A., Willett, B. J., Breuer, J., Semple, M. G., Turner, D., Baillie, J. K. & Thomson, E. C., May 2023, In: Nature. 617, 7961, p. 555-563 25 p.

  Research output: Contribution to journal › Article › peer-review

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  • Child 100%
  • Infection 100%
  • Adeno Associated Virus 2 100%
  • Hepatitis 100%
  • Polymerase Chain Reaction 60%

• Genomic investigations of unexplained acute hepatitis in children

  DIAMONDS consortium, Chikowore, P. & Baillie, K., May 2023, In: Nature. 617, 7961, p. 564-573 36 p.

  Research output: Contribution to journal › Article › peer-review

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  • Acute Hepatitis 100%
  • Child 100%
  • Adeno Associated Virus 2 100%
  • Hepatitis 100%
  • Liver 66%

• GWAS and meta-analysis identifies 49 genetic variants underlying critical Covid-19

  GenOMICC Investigators, SCOURGE Consortium, ISARIC4C Investigators, 23andMe Covid-19 Team, Pairo-Castineira, E., Rawlik, K., Bretherick, A. D., Qi, T., Wu, Y., Nassiri, I., McConkey, G. A., Zechner, M., Klaric, L., Griffiths, F., Oosthuyzen, W., Kousathanas, A., Richmond, A., Millar, J., Russell, C. D., Malinauskas, T., & 39 othersThwaites, R., Morrice, K., Keating, S., Maslove, D. M., Nichol, A. D., Semple, M. G., Knight, J., Shankar-Hari, M., Summers, C., Hinds, C., Horby, P., Ling, L., McAuley, D. F., Montgomery, H., Openshaw, P. J. M., Begg, C., Walsh, T. S., Tenesa, A., Flores, C., Riancho, J. A., Rojas-Martinez, A., Lapunzina, P., Yang, J., Ponting, C. P., Wilson, J. F., Vitart, V., Abedalthagafi, M. S., Luchessi, A., Parra, E. J., Cruz, R., Carracedo, A., Fawkes, A., Murphy, L., Rowan, K., Pereira, A. C., Law, A., Fairfax, B. P., Clohisey Hendry, S. & Baillie, J. K., May 2023, In: Nature. 617, 7962, p. 764-768 30 p.

  Research output: Contribution to journal › Article › peer-review

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  • PDE4A 100%

• The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection

  ISARIC4C Investigators, Baillie, J. K. & Digard, P., 13 Mar 2023, (E-pub ahead of print) In: Genome Biology. 24, 1, p. 1-23 22 p., 47.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • SARS Coronavirus 100%
  • Polymerase 100%
  • Infection 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Virus Genome 37%
• 2022

  SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

  ISARIC4C Investigators, Liew, F., Talwar, S., Cross, A., Willett, B. J., Scott, S., Logan, N., Siggins, M. K., Swieboda, D., Sidhu, J. K., Efstathiou, C., Moore, S. C., Davis, C., Mohamed, N., Nunag, J., King, C., Thompson, A. A. R., Rowland-Jones, S. L., Docherty, A. B., Chalmers, J. D., & 22 othersHo, L-P., Horsley, A., Raman, B., Poinasamy, K., Marks, M., Kon, O. M., Howard, L., Wootton, D. G., Dunachie, S., Quint, J. K., Evans, R. A., Wain, L. V., Fontanella, S., de Silva, T. I., Ho, A., Harrison, E., Baillie, J. K., Semple, M. G., Brightling, C., Thwaites, R. S., Turtle, L. & Openshaw, P. J. M., 16 Dec 2022, (E-pub ahead of print) In: EBioMedicine. p. 104402

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Immunoglobulin A 100%
  • COVID-19 100%
  • Plasma 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Immunity 25%

• Whole genome sequencing reveals host factors underlying critical Covid-19

  GenOMICC Investigators, Kousathanas, A., Pairo-Castineira, E., Rawlik, K., Stuckey, A., Odhams, C. A., Walker, S., Russell, C. D., Malinauskas, T., Wu, Y., Millar, J., Shen, X., Elliott, K. S., Griffiths, F., Oosthuyzen, W., Morrice, K., Keating, S., Wang, B., Rhodes, D., Klaric, L., & 57 othersZechner, M., Parkinson, N., Siddiq, A., Goddard, P., Donovan, S., Maslove, D., Nichol, A., Semple, M. G., Zainy, T., Maleady-Crowe, F., Todd, L., Salehi, S., Knight, J., Elgar, G., Chan, G., Arumugam, P., Patch, C., Rendon, A., Bentley, D., Kingsley, C., Kosmicki, J. A., Horowitz, J. E., Baras, A., Abecasis, G. R., Ferreira, M. A. R., Justice, A., Mirshahi, T., Oetjens, M., Rader, D. J., Ritchie, M. D., Verma, A., Fowler, T. A., Shankar-Hari, M., Summers, C., Hinds, C., Horby, P., Ling, L., McAuley, D., Montgomery, H., Openshaw, P. J. M., Elliott, P., Walsh, T., Tenesa, A., Fawkes, A., Murphy, L., Rowan, K., Ponting, C. P., Vitart, V., Wilson, J. F., Yang, J., Bretherick, A. D., Scott, R. H., Hendry, S. C., Moutsianas, L., Law, A., Caulfield, M. J. & Baillie, J. K., 7 Jul 2022, In: Nature. 607, p. 97-103

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Whole Genome Sequencing 100%
  • Host Factor 100%
  • Host 100%
  • Association 40%
  • Population Dynamics 40%

• SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

  OPTIC Consortium, 3 Feb 2022, In: Cell. 185, 3, p. 467-484.e15

  Research output: Contribution to journal › Article › peer-review

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  • Virus 100%
  • Antibody Response 100%
  • Neutralizing Antibody 100%
  • Neutralization 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
• 2021

  Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity

  WES/WGS Working Group Within the HGI, 10 Dec 2021, (E-pub ahead of print) In: Human Genetics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • COVID-19 100%
  • Genetics 60%
  • Nested Gene 60%
  • Host 40%
  • Genome Wide Association Study 40%

• Mapping the human genetic architecture of COVID-19

  COVID-19 Host Genetics Initiative, Baillie, J. K., Wilson, J. F., Bulteel, N., Hayward, C., Klaric, L., Porteous, D. J., Russell, C. D., Tenesa, A., Norman, L., Scott-Brown, J. & Swann, O., 8 Jul 2021, (E-pub ahead of print) In: Nature.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • SARS Coronavirus 100%
  • Genetic Architecture 100%
  • Human Genetics 100%
  • Host 75%
  • Genetics 75%

• Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice.

  Bell, R., Villalobos, E., Nixon, M., Miguelez-Crespo1, A., Murphy, L., Fawkes, A., Coutts, A., Sharp, M. G., Koerner, M., Allan, E., Meijer, O. C., Houtman, R., Odermatt, A., Beck, K. R., Denham, S. G., Lee, P., Homer, N., Walker, B. R. & Morgan, R. A., Jun 2021, In: Molecular Metabolism. 48, 101225.

  Research output: Contribution to journal › Article › peer-review

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  • Glucose 100%
  • Leaner Mutant Mouse 100%
  • Reductase 100%
  • Glucocorticoid 100%
  • Adipose Tissue 100%
• 2015

  DNA immunoprecipitation semiconductor sequencing (DIP-SC-seq) as a rapid method to generate genome wide epigenetic signatures

  Thomson, J. P., Fawkes, A., Ottaviano, R., Hunter, J. M., Shukla, R., Mjoseng, H. K., Clark, R., Coutts, A., Murphy, L. & Meehan, R. R., 18 May 2015, In: Scientific Reports. 5, 9778.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Epigenetics 100%
  • DNA 100%
  • Sequencing 100%
  • Immunoprecipitation 100%
  • Semiconductor 100%