Research output per year
Research output per year
Personal profile
Biography
Barry joined the Institute of Animal Health Neuropathogenesis Unit (IAH-NPU) in 2000. Here he worked on transmissible spongiform encephalopathy (TSE) or prion infectious agents. Barry has been responsible for undergraduate and postgraduate training since 2012 and was most recently promoted to Lecturer in 2021. His research aims to identify how various cell types are involved in the maintenance of brain health and responses to neuroinflammation and neurodegeneration such as during prion infection.
Research students
PhD
Sasha Pokrovskaya 2023-
Emma Green (Advisor) 2020-
Reiss Pal 2020-2023
MSc
Clara Gomez-Dunlop 2022
Joe Reynolds 2020
Christianus Wijaya 2019
Honours/Veterinary
Lauryn Walmsley-Rowe 2023
Claire Banner 2022
Rebecca Bruce 2021
Danica Ariyadasa-Sáez 2019
Laura Tetlow 2016
Caroline Wood 2015
Lester Thoo 2014
Kah Yap 2013
Mark Laloo 2013
Matthew Helsby 2012
Current Research Interests
Analysis of the role of specific immune cells and mediators in
prion pathogenesis, including during co-infections.
Understanding the basis of immune priming and the nature and
consequences of immune responses to pathogens in vivo.
Development of strategies to potentiate immunity.
My research in a nutshell
Prion diseases are prototypical protein-misfolding neurodegenerative disorders. Using this model we study how protein-misfolding within the brain results in activation of the supporting glia cells, impacts upon brain function and ultimately leads to loss of the connections (synapses) and death of brain cells (neurons). The goal of my research is to understand how this happens and how other infections and activation of the immune system may influence neurodegeneration. the ultimate goal of my research is to identify potential therapeutic treatments for these currently untreatable conditions.
Education/Academic qualification
Doctor of Philosophy (PhD), The University of Edinburgh
2016
Award Date: 14 Jul 2016
Neuroscience, Master of Science, University of Edinburgh
2007
Bachelor of Science (Honours), The University of Edinburgh
1998
Keywords
- RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
- Neurodegeneration
- Prion diseases
- Dementia
- Glia
- QR180 Immunology
- Innate immunity
- Dendritic cells
- Myeloid heamatopoeisis
- QH426 Genetics
- Conditional transgenesis
College Research Themes
- College of Medicine and Veterinary Medicine
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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CNS macrophage populations differentially rely on an intronic Csf1r enhancer for their development
Munro, D., Bradford, B., Mariani, S., Hampton, D., Vink, C., Chandran, S., Hume, D., Pridans, C. & Priller, J., 15 Dec 2020, In: Development.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
The effects of immune system modulation on prion disease susceptibility and pathogenesis
Mabbott, N., Bradford, B., Pal, R., Young, R. & Donaldson, D., 2 Oct 2020, In: International Journal of Molecular Sciences.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Accelerated onset of CNS prion disease in mice co-infected with a gastrointestinal helminth pathogen during the preclinical phase
Donaldson, D., Bradford, B., Else, K. J. & Mabbott, N., 12 Mar 2020, In: Scientific Reports. 10, 4554 (2020).Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Discrimination of prion strain targeting in the central nervous system via reactive astrocyte heterogeneity in CD44 expression
Bradford, B., Wijaya, C. & Mabbott, N., 10 Sept 2019, In: Frontiers in Cellular Neuroscience. 13, 411.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations.
Rojo, R., Raper, A., Ozdemir, D. D., Lefevre, L., Grabert, K., Wollscheid-Lengeling, E., Bradford, B., Caruso, M., Gazova, I., Sanchez, A., Lisowski, Z. M., Alves, J., Molina-Gonzalez, I., Davtyan, H., Lodge, R. J., Glover, J. D., Wallace, R., Munro, D. A. D., David, E., Amit, I., & 10 others, 19 Jul 2019, In: Nature Communications. 10, 3215.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Activities
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International Journal of Molecular Sciences (Journal)
Barry Bradford (Peer reviewer)
22 Jan 2021 → 22 Jan 2023Activity: Publication peer-review and editorial work types › Publication peer-review
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Journal of Animal Science and Biotechnology (Journal)
Barry Bradford (Peer reviewer)
1 Jan 2018 → 31 Dec 2018Activity: Publication peer-review and editorial work types › Publication peer-review
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Increased susceptibility to oral Trichuris muris infection in the specific absence of CXCR5-expressing mononuclear phagocytes
Barry Bradford (Assessor)
1 May 2018Activity: Academic talk or presentation types › Oral presentation
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BMC Veterinary Research (Journal)
Barry Bradford (Peer reviewer)
1 Jan 2018 → 31 Dec 2018Activity: Publication peer-review and editorial work types › Publication peer-review
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Prion 2017
Barry Bradford (Participant)
23 May 2017 → 26 May 2017Activity: Participating in or organising an event types › Participation in conference
Projects
- 2 Finished
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Defining Astrocyte heterogeneity and CD44 across neurodegenerative diseases
Bradford, B., Mabbott, N. & Smith, C.
1/01/20 → 31/12/20
Project: Research
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BSI: British Society for Immunology Travel Award
14/01/13 → 19/01/13
Project: Research Collaboration with external organisation