Personal profile
My research in a nutshell
I am a Developmental Biologist and Physiologist, interested in the genetic basis of organ form and function. I aim to understand how cells organise themselves into tissues and organs of complex anatomies from simple beginnings, and how these organs work for the benefit of the organism. We use insect models and exploit technologies including genomics, imaging, informatics, and in vivo analysis to understand gene function at cell, organ and whole-animal levels in renal, gut and cardiovascular systems. Our goal is to reveal fundamental mechanisms of organogenesis and apply this knowledge to understand the organs of our own body in health and disease. I have generated novel insect models for human kidney function, which have been adopted by labs worldwide.
Teaching
My teaching portfolio encompasses a wide range of topics (cell and developmental biology, genetics, physiology and pharmacology) delivered to Pre-, Junior- and Senior-Honours students in Biomedical Sciences and to MBChB students.
Undergraduate:
Year 2: Biomedical Sciences 2, Cells to Organisms 2
Year 3: Anatomy & Development 3, Applied Pharmacology 3, Physiology 3
Year 4: Anatomy & Development 4, Disease & Development
MBChB:
Year 1
Postgraduate:
MSc by Research Biomedical Sciences (Life Sciences)
Research Interests
Organ Development and Physiology, Organ Evolution
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Collaborations and top research areas from the last five years
Research output
- 7 Article
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Elevated Piezo levels cause structural and functional alterations in Drosophila garland nephrocytes
Hazelton-Cavill, P., Alornyo, K. K., Bouchard, M., Schulz, K., Huber, T. B., Denholm, B. & Koehler, S., Apr 2026, In: Life Science Alliance. 9, 4, e202503515.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Piezo buffers mechanical stress via modulation of intracellular Ca 2+ handling in the Drosophila heart.
Zechini, L., Camilleri-Brennan, J., Walsh, J., Beaven, R., Moran, O., Hartley, P. S., Diaz, M. & Denholm, B., 14 Sept 2022, In: Frontiers in physiology. 13, 1003999.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A Unique Malpighian Tubule Architecture in Tribolium castaneum Informs the Evolutionary Origins of Systemic Osmoregulation in Beetles
Koyama, T., Naseem, M. T., Kolosov, D., Vo, C. T., Mahon, D., Jakobsen, A. S. S., Jensen, R. L., Denholm, B., O'Donnell, M. & Halberg, K. A., 29 Mar 2021, (E-pub ahead of print) In: Proceedings of the National Academy of Sciences (PNAS).Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Transgenic Tarantula Toxin: a novel tool to study mechanosensitive ion channels in Drosophila
Beqja, D., Haidar, S., Nikolaev, M., Shen, Y. & Denholm, B., 28 Sept 2020, (E-pub ahead of print) In: Journal of Insect Physiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Release and spread of Wingless is required to pattern the proximo-distal axis of Drosophila renal tubules
Beaven, R. & Denholm, B., 10 Aug 2018, In: eLIFE. 7, e35373.Research output: Contribution to journal › Article › peer-review
Open AccessFile
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Exploring unique osmoregulatory adaptations in a globally devastating insect pest
Denholm, B. (Principal Investigator) & Beaven, R. (Co-investigator)
Biotechnology and Biological Sciences Research Council
1/09/23 → 31/05/27
Project: Research
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Cell and molecular architecture of a countercurrent exchange system in a beetle
Denholm, B. (Principal Investigator)
1/01/20 → 7/02/23
Project: Research
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Cell and molecular architecture of a countercurrent exchange system in a beetle
Denholm, B. (Principal Investigator)
1/01/20 → 7/08/23
Project: Research
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Mechanisms of cardiac mechanotransduction in Drosophila: implications for the Frank-Starling law of the heart.
Denholm, B. (Principal Investigator)
15/03/18 → 14/03/19
Project: Research
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Molecular and cellular physiology of a powerful water-conserving system in beetles
Denholm, B. (Principal Investigator)
1/08/16 → 31/07/17
Project: Research