Bill Earnshaw

2020

Analysis of complex DNA rearrangements during early stages of HAC formation

Pesenti, E., Liskovykh, M., Okazaki, K., Mallozzi, A., Reid, C., Abad, M. A., Jeyaprakash, A. A., Kouprina, N., Larionov, V., Masumoto, H. & Earnshaw, W. C., 18 Dec 2020, In: ACS Synthetic Biology. 9, 12, p. 3267-3287 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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APC/CCdh1 is required for the termination of CPC activity upon mitotic exit

Tsunematsu, T., Arakaki, R., Kawai, H., Ruppert, J., Tsuneyama, K., Earnshaw, W. C., Pagano, M. & Kudo, Y., 15 Sep 2020, In: Journal of Cell Science.

Research output: Contribution to journal › Article › peer-review

Open Access

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CENP-B creates alternative epigenetic chromatin states permissive for CENP-A or heterochromatin assembly

Otake, K., Ohzeki, J., Shono, N., Kugou, K., Okazaki, K., Nagase, T., Yamakawa, H., Kouprina, N., Larionov, V., Kimura, H., Earnshaw, W. C. & Masumoto, H., 11 Aug 2020, In: Journal of Cell Science. 133, jcs.243303.

Research output: Contribution to journal › Article › peer-review

Open Access

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Chromokinesin KIF4A teams up with Stathmin 1 to regulate abscission in a SUMO-dependent manner

Cuijpers, S., Willemstein, E., Ruppert, J., van Elsland, D. M., Earnshaw, B. & Vertegaal, A. C. O., 24 Jul 2020, In: Journal of Cell Science.

Research output: Contribution to journal › Article › peer-review

Open Access

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H3K9me maintenance on a Human Artificial Chromosome is required for 3 segregation but not centromere epigenetic memory

Martins, N. M. C., Cisneros Soberanis, F., Pesenti, E., Kochanova, N., Shang, W-H., Hori, T., Nagase, T., Kimura, H., Larionov, V., Masumoto, H., Fukagawa, T. & Earnshaw, B., 24 Jul 2020, In: Journal of Cell Science. 133, jcs242610.

Research output: Contribution to journal › Article › peer-review

Open Access

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2019

A novel assay to screen siRNA libraries identifies protein kinases as required for chromosome transmission

Liskovykh, M., Goncharov, N. V., Petrov, N., Aksenova, V., Pegoraro, G., Ozbun, L. L., Reinhold, W. C., Varma, S., Dasso, M., Kumeiko, V., Masumoto, H., Earnshaw, W. C., Larionov, V. & Kouprina, N., 12 Sep 2019, In: Genome Research. 29, 9

Research output: Contribution to journal › Article › peer-review

Open Access

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Borealin–nucleosome interaction secures chromosome association of the chromosomal passenger complex

Abad, M. A., Ruppert, J., Buzuk, L., Wear, M., Zou, J., Webb, K., Kelly, D., Voigt, P., Rappsilber, J., Earnshaw, W. & Arulanandam, A., 30 Sep 2019, In: Journal of Cell Biology. 218, 12, p. 3912–3925 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Cell cycle-independent furrowing triggered by phosphomimetic mutations of the INCENP STD motif requires Plk1

Papini, D., Fant, X., Ogawa, H., Desban, N., Samejima, K., Feizbakhsh, O., Askin, B., Ly, T., Earnshaw, W. C. & Ruchaud, S., 6 Nov 2019, In: Journal of Cell Science. jcs.234401.

Research output: Contribution to journal › Article › peer-review

Open Access

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De novo formation and epigenetic maintenance of centromere chromatin

Ohzeki, J., Larionov, V., Earnshaw, W. C. & Masumoto, H., 1 Jun 2019, In: Current opinion in cell biology. 58, p. 15-25 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

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In vitro BioID: Mapping the CENP-A microenvironment with high temporal and spatial resolution

Remnant, L., Booth, D. G., Vargiu, G., Spanos, C., Kerr, A. R. W. & Earnshaw, W. C., 20 Mar 2019, In: Molecular Biology of the Cell. 30, 11, p. 1314-1325 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2018

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Ladds, M. J. G. W., van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A. R., Popova, G., Pastor Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z., Thompson, A. M. & 26 others, Svensson, R., Gustavsson, A-L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., 16 Mar 2018, In: Nature Communications. 9, 1, 14 p., 1107 (2018).

Research output: Contribution to journal › Article › peer-review

Open Access

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An intrinsic S/G checkpoint enforced by ATR

Saldivar, J. C., Hamperl, S., Bocek, M. J., Chung, M., Bass, T. E., Cisneros-Soberanis, F., Samejima, K., Xie, L., Paulson, J. R., Earnshaw, W. C., Cortez, D., Meyer, T. & Cimprich, K. A., 24 Aug 2018, In: Science. 361, 6404, p. 806-810 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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A pathway for mitotic chromosome formation

Gibcus, J. H., Samejima, K., Goloborodko, A., Samejima, I., Naumova, N., Nuebler, J., Kanemaki, M. T., Xie, L., Paulson, J. R., Earnshaw, W. C., Mirny, L. A. & Dekker, J., 9 Feb 2018, In: Science. 359, 6376, 14 p., eaao6135.

Research output: Contribution to journal › Article › peer-review

Open Access

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Functional analysis after rapid degradation of condensins and 3D-EM reveals chromatin volume is uncoupled from chromosome architecture in mitosis

Samejima, K., Booth, D. G., Ogawa, H., Paulson, J. R., Xie, L., Watson, C. A., Platani, M., Kanemaki, M. T. & Earnshaw, W. C., 22 Feb 2018, In: Journal of Cell Science. 131, 4, 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Generation of a Synthetic Human Chromosome with Two Centromeric Domains for Advanced Epigenetic Engineering Studies

Pesenti, E., Kouprina, N., Liskovykh, M., Aurich-Costa, J., Larionov, V., Masumoto, H., Earnshaw, W. C. & Molina, O., 20 Apr 2018, In: ACS Synthetic Biology. 7, 4, p. 1116-1130 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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HP1α targets the chromosomal passenger complex for activation at heterochromatin before mitotic entry

Ruppert, J. G., Samejima, K., Platani, M., Molina, O., Kimura, H., Jeyaprakash, A. A., Ohta, S. & Earnshaw, W. C., 15 Mar 2018, In: EMBO Journal. 37, 6, 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Human Artificial Chromosome with Regulated Centromere: A Tool for Genome and Cancer Studies

Kouprina, N., Petrov, N., Molina, O., Liskovykh, M., Pesenti, E., Ohzeki, J-I., Masumoto, H., Earnshaw, W. C. & Larionov, V., 21 Sep 2018, In: ACS Synthetic Biology. 7, 9, p. 1974-1989 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

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Isolation of mitotic chromosomes from vertebrate cells and characterisation of their proteome by mass spectrometry

Samejima, I. & Earnshaw, W., 12 Apr 2018, Methods in Cell Biology. Elsevier, Vol. 144. p. 329-348 20 p. (Methods in Cell Biology; vol. 144).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Method to Assemble Genomic DNA Fragments or Genes on Human Artificial Chromosome with Regulated Kinetochore Using a Multi-Integrase System

Lee, N. C. O., Kim, J-H., Petrov, N. S., Lee, H-S., Masumoto, H., Earnshaw, W. C., Larionov, V. & Kouprina, N., 19 Jan 2018, In: ACS Synthetic Biology. 7, 1, p. 63-74 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint

Combes, G., Barysz, H., Garand, C., Gama Braga, L., Alharbi, I., Thebault, P., Murakami, L., Bryne, D. P., Stankovic, S., Eyers, P. A., Bolanos-Garcia, V. M., Earnshaw, W. C., Maciejowski, J., Jallepalli, P. V. & Elowe, S., 19 Mar 2018, In: Current biology : CB. 28, 6, p. 872-883 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Seh1 targets GATOR2 and Nup153 to mitotic chromosomes

Platani, M., Samejima, I., Samejima, K., Kanemaki, M. T. & Earnshaw, W. C., 1 May 2018, In: Journal of Cell Science. 131, 9, 16 p., jcs213140.

Research output: Contribution to journal › Article › peer-review

Open Access

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Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy

Lee, H-S., Carmena, M., Liskovykh, M., Peat, E., Kim, J-H., Oshimura, M., Masumoto, H., Teulade-Fichou, M-P., Pommier, Y., Earnshaw, W. C., Larionov, V. & Kouprina, N., 30 Aug 2018, In: Cancer Research.

Research output: Contribution to journal › Article › peer-review

Open Access

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Two interlinked bistable switches govern mitotic control in mammalian cells

Rata, S., Suarez Peredo Rodriguez, M. F., Joseph, S., Peter, N., Echegaray Iturra, F., Yang, F., Madzvamuse, A., Ruppert, J. G., Samejima, K., Platani, M., Alvarez-Fernandez, M., Malumbres, M., Earnshaw, W. C., Novak, B. & Hochegger, H., 3 Dec 2018, In: Current Biology. 28, 23, p. 3824-3832.e6

Research output: Contribution to journal › Article › peer-review

Open Access

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2017

Ki-67 and the Chromosome Periphery Compartment in Mitosis

Booth, D. G. & Earnshaw, W. C., 1 Dec 2017, In: Trends In Cell Biology. 27, 12, p. 906-916 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

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Mitotic post-translational modifications of histones promote chromatin compaction in vitro

Zhiteneva, A., Bonfiglio, J. J., Makarov, A., Colby, T., Vagnarelli, P., Schirmer, E. C., Matic, I. & Earnshaw, W. C., 13 Sep 2017, In: Open Biology. 7, 9

Research output: Contribution to journal › Article › peer-review

Open Access

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Molecular Basis for Cdk1 Regulated Timing of Mis18 Complex Assembly and CENP-A Deposition

Spiller, F., Medina-Pritchard, B., Alba Abad, M., Wear, M., Molina, O., Earnshaw, W. & Arulanandam, A., 4 Apr 2017, In: EMBO Reports. e201643564.

Research output: Contribution to journal › Article › peer-review

Open Access

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Nano Random Forests to mine protein complexes and their relationships in quantitative proteomics data

Montaño-gutierrez, L., Ohta, S., Kustatscher, G., Earnshaw, B. & Rappsilber, J., 5 Jan 2017, In: Molecular Biology of the Cell.

Research output: Contribution to journal › Article › peer-review

Open Access

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Stepwise unfolding supports a subunit model for vertebrate kinetochores

Vargiu, G., Makarov, A., Allan, J., Fukagawa, T. & Earnshaw, W., 21 Mar 2017, In: Proceedings of the National Academy of Sciences. 114, 12, p. 3133-3138 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Using human artificial chromosomes to study centromere assembly and function

Molina, O., Kouprina, N., Masumoto, H., Larionov, V. & Earnshaw, W., 1 Oct 2017, In: Chromosoma. p. 559-575 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2016

3D-CLEM reveals that a major portion of mitotic chromosomes is not Chromatin

Booth, D., Beckett, A. J., Molina, O., Samejima, I., Masumoto, H., Kouprina, N., Larionov, V., Prior, I. A. & Earnshaw, W., 17 Nov 2016, In: Molecular Cell. 64, 4, p. 790-802 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Auxin/AID versus conventional knockouts: Distinguishing the roles of CENP-T/W in mitotic kinetochore assembly and stability

Wood, L., Booth, D. G., Vargiu, G., Ohta, S., deLima Alves, F., Samejima, K., Fukagawa, T., Rappsilber, J. & Earnshaw, W. C., 20 Jan 2016, In: Open Biology. 6, 1, 150230.

Research output: Contribution to journal › Article › peer-review

Open Access

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Development of a novel HAC-based "gain of signal" quantitative assay for measuring chromosome instability (CIN) in cancer cells

Kim, J. H., Lee, H. S., Lee, N. C. O., Goncharov, N. V., Kumeiko, V., Masumoto, H., Earnshaw, W. C., Kouprina, N. & Larionov, V., 22 Mar 2016, In: Oncotarget. 7, 12, p. 14841-14856 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance: H3K4me2 is necessary for kinetochore assembly and function

Molina, O., Vargiu, G., Alba Abad, M., Zhiteneva, A., Arulanandam, J., Masumoto, H., Kouprina, N., Larionov, V. & Earnshaw, W., 14 Nov 2016, In: Nature Communications. 51 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3

Martins, N. M. C., Bergmann, J. H., Shono, N., Kimura, H., Larionov, V., Masumoto, H. & Earnshaw, W. C., 1 Jan 2016, In: Molecular Biology of the Cell. 27, 1, p. 177-96 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation

Ohzeki, J-I., Shono, N., Otake, K., Martins, N. M. C., Kugou, K., Kimura, H., Nagase, T., Larionov, V., Earnshaw, W. C. & Masumoto, H., 6 Jun 2016, In: Developmental Cell. 37, 5, p. 413-27 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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PREditOR: A synthetic biology approach to removing heterochromatin from cells

Molina, O., Carmena, M., Maudlin, I. E. & Earnshaw, W. C., 6 Dec 2016, In: Chromosome Research. 24, 4, p. 495-509

Research output: Contribution to journal › Article › peer-review

Open Access

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Proteomics analysis with a nano Random Forest approach reveals novel functional interactions regulated by SMC complexes on mitotic chromosomes

Ohta, S., Montaňo-Gutierrez, L. F., Alves, F. D. L., Ogawa, H., Toramoto, I., Sato, N., Morrison, C. G., Takeda, S., Hudson, D. F., Rappsilber, J. & Earnshaw, W. C., 1 Aug 2016, In: Molecular and Cellular Proteomics. 15, 8, p. 2802-2818 56 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2015

Aurora B Overexpression Causes Aneuploidy and p21^Cip1 Repression during Tumor Development

González-Loyola, A., Fernández-Miranda, G., Trakala, M., Partida, D., Samejima, K., Ogawa, H., Cañamero, M., de Martino, A., Martínez-Ramírez, Á., de Cárcer, G., de Castro., I. P., Earnshaw, W. C. & Malumbres, M., 3 Aug 2015, In: Molecular and Cellular Biology. 35, 20, p. 3566-3578 13 p.

Research output: Contribution to journal › Article › peer-review

CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly

Ohta, S., Wood, L., Toramoto, I., Yagyu, K. I., Fukagawa, T. & Earnshaw, W. C., 15 Apr 2015, In: Molecular Biology of the Cell. 26, 7, p. 1225-1237 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly

Shono, N., Ohzeki, J. I., Otake, K., Martins, N. M. C., Nagase, T., Kimura, H., Larionov, V., Earnshaw, W. C. & Masumoto, H., 2015, In: Journal of Cell Science. 128, 24, p. 4572-4587 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Discovering centromere proteins: from cold white hands to the A, B, C of CENPs

Earnshaw, W. C., 23 Jun 2015, In: Nature reviews Molecular cell biology. 16, 7, p. 443-449 7 p.

Research output: Contribution to journal › Article › peer-review

Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTAVP64 expression cassette

Kononenko, A. V., Lee, N. C. O., Liskovykh, M., Masumoto, H., Earnshaw, W. C., Larionov, V. & Kouprina, N., 20 May 2015, In: Nucleic Acids Research. 43, 9, e57.

Research output: Contribution to journal › Article › peer-review

Open Access

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Genetic and epigenetic regulation of centromeres: A look at HAC formation

Ohzeki, J. I., Larionov, V., Earnshaw, W. C. & Masumoto, H., 1 Jan 2015, In: Chromosome Research . 23, 1, p. 87-103 17 p.

Research output: Contribution to journal › Article › peer-review

Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes

Platani, M., Trinkle-Mulcahy, L., Porter, M., Arulanandam, A. & Earnshaw, W. C., 6 Jul 2015, In: Journal of Cell Biology. 210, 1, p. 45-62 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Panspecies small-molecule disruptors of heterochromatin-mediated transcriptional gene silencing

Castonguay, E., White, S. A., Kagansky, A., St-Cyr, D. J., Castillo, A. G., Brugger, C., White, R., Bonilla, C., Spitzer, M., Earnshaw, W. C., Schalch, T., Ekwall, K., Tyers, M. & Allshire, R. C., 1 Jan 2015, In: Molecular and Cellular Biology. 35, 4, p. 662-674 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Reed-sternberg cells form by abscission failure in the presence of functional aurora B kinase

Xavier de Carvalho, A., Maiato, H., Maia, A. F., Ribeiro, S. A., Pontes, P., Bickmore, W., Earnshaw, W. C. & Sambade, C., 1 May 2015, In: PLoS ONE. 10, 5, p. e0124629

Research output: Contribution to journal › Article › peer-review

Open Access

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TD-60 links RalA GTPase function to the CPC in mitosis

Papini, D., Langemeyer, L., Abad, M. A., Kerr, A., Samejima, I., Eyers, P. A., Arulanandam, A., Higgins, J. M. G., Barr, F. A. & Earnshaw, W. C., 9 Jul 2015, In: Nature Communications. 6, 7678.

Research output: Contribution to journal › Article › peer-review

Open Access

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The inner centromere protein (INCENP) coil is a single α-helix (SAH) domain that binds directly to microtubules and is important for chromosome passenger complex (CPC) localization and function in mitosis

Samejima, K., Platani, M., Wolny, M., Ogawa, H., Vargiu, G., Knight, P. J., Peckham, M. & Earnshaw, W. C., 28 Aug 2015, In: Journal of Biological Chemistry. 290, 35, p. 21460-21472 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Three-dimensional topology of the SMC2/SMC4 subcomplex from chicken condensin I revealed by cross-linking and molecular modelling

Barysz, H., Kim, J. H., Chen, Z. A., Hudson, D. F., Rappsilber, J., Gerloff, D. L. & Earnshaw, W. C., 1 Jan 2015, In: Open Biology. 5, 2, 150005.

Research output: Contribution to journal › Article › peer-review

Open Access

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Whole-proteome genetic analysis of dependencies in assembly of a vertebrate kinetochore

Samejima, I., Spanos, C., De Lima Alves, F., Hori, T., Perpelescu, M., Zou, J., Rappsilber, J., Fukagawa, T. & Earnshaw, W. C., 14 Dec 2015, In: Journal of Cell Biology. 211, 6, p. 1141-1156 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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