Brendan Corcoran

Search results

• 2023

  TGF‐β Phospho Antibody Array Identifies Altered SMAD2, PI3K/AKT/SMAD and RAC Signalling Contribute to the Pathogenesis of Myxomatous Mitral Valve Disease

  Mcnair, A., Markby, G., Tang, Q., MacRae, V. & Corcoran, B., 16 Oct 2023, (E-pub ahead of print) In: Frontiers in Veterinary Science. 10, p. 1-12 12 p., 1202001.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Antibody 100%
  • Phenotype 100%
  • Protein 100%
  • SMAD 100%
  • Mitral Valve Disease 100%

• TGF-β induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease

  Tang, P., Markby, G., MacNair, A. J., Tang, K., Tkacz, M., Parys, M., Phadwal, K., MacRae, V. & Corcoran, B., Jun 2023, In: Cell proliferation. 56, 6, p. 1-23 23 p., e13435.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Myofibroblast 100%
  • PI3K/AKT/mTOR Pathway 100%
  • Canine Model 100%
  • Phenotype 100%
  • Modulation 100%

• p53 regulates mitochondrial dynamics in vascular smooth muscle cell calcification.

  Phadwal, K., Tang, Q., Luijten, I., Zhao, J-F., Corcoran, B., Semple, R. K., Ganley, I. G. & MacRae, V., 13 Jan 2023, In: International Journal of Molecular Sciences. 24, 2, 1643.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mitochondrial Dynamics 100%
  • P53 100%
  • Protein 60%
  • Phosphorylation 60%
  • Cell Aging 60%
• 2022

  Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor

  Phadwal, K., Koo, E., Jones, R. A., Forsythe, R., Tang, K., Tang, Q., Corcoran, B., Caporali, A. & MacRae, V., 27 Sept 2022, (E-pub ahead of print) In: Journal of Cellular Physiology. 237, 11, p. 4303-4316 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Autophagy 100%
  • Blood Vessel Calcification 100%
  • Receptor 100%
  • Glycon 100%
  • Therapeutic Procedure 20%

• The Role of Transforming Growth Factor-β Signaling in Myxomatous Mitral Valve Degeneration

  Tang, P., Mcnair, A., Phadwal, K., MacRae, V. & Corcoran, B., 17 May 2022, In: Frontiers in Cardiovascular Medicine. 9, 872288.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Mitral Valve 100%
  • Transforming Growth Factor 100%
  • Degeneration 100%
  • Dog 100%
  • Myxomatous Degeneration 66%
• 2021

  Topographical distribution and radiographic pattern of lung lesions in canine eosinophilic bronchopneumopathy

  Lo, E. J. Y., Schwarz, T. & Corcoran, B. M., 12 Aug 2021, In: Journal of Small Animal Practice. 62, p. 655-661

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lung 100%
  • Lung Lesion 100%
  • Eosinophilic 100%
  • Eosinophilia 42%
  • Dog 42%
• 2020

  Comparative transcriptomic profiling of myxomatous mitral valve disease in the Cavalier King Charles Spaniel

  Markby, G., MacRae, V., Corcoran, B. & Summers, K., 23 Sept 2020, (E-pub ahead of print) In: BMC Veterinary Research.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Transcriptomics 100%
  • Cavalier King Charles Spaniel 100%
  • Breed 43%
  • Breeds 43%
  • Dog 31%

• Expression of calcification and extracellular matrix genes in the cardiovascular system of the healthy domestic sheep (Ovis aries).

  Tsang, G., Clark, E., Markby, G., Bush, S., Hume, D., Corcoran, B., MacRae, V. & Summers, K., 8 Sept 2020, (E-pub ahead of print) In: Frontiers in Genetics. 11

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Extracellular Matrix 100%
  • Cardiovascular System 100%
  • Calcification 100%
  • Domestic Sheep 100%
  • Nested Gene 100%

• Glucocorticoid metabolism and the action of 11 beta-hydroxysteroid dehydrogenase 2 in canine congestive heart failure

  Bode, L., Markby, G., Boag, A., Martinez-Pereira, Y., Corcoran, B., Farquharson, C., Sooy, K., Homer, N., Jamieson, P. & Culshaw, G., 4 May 2020, (E-pub ahead of print) In: The Veterinary Journal.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cortisol 100%
  • Glucocorticoid 100%
  • Dog 50%
  • Cortisone 50%
  • Mineralocorticoid Receptor 33%

• Disease severity-associated gene expression in canine myxomatous mitral valve disease is dominated by TGFß signalling

  Markby, G., MacRae, V., Summers, K. & Corcoran, B., 27 Apr 2020, (E-pub ahead of print) In: Frontiers in Genetics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chemokine 100%
  • Dog 100%
  • Tumor Necrosis Factor 100%
• 2019

  Survival of Activated Myofibroblasts in Canine Myxomatous Mitral Valve Disease and the Role of Apoptosis

  Blake, R., Markby, G., Culshaw, G., Martinez-Pereira, Y., Lu, C. & Corcoran, B., 13 Nov 2019, (E-pub ahead of print) In: Research in Veterinary Science. 128, p. 99-106 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Survival 100%
  • Programmed Cell Death 100%
  • Mitral Valve Disease 100%
  • Myofibroblast 100%
  • Apoptosis 100%

• Evaluation of Canine 2D cell cultures as models of myxomatous mitral valve degeneration

  Tan, K., Markby, G., Muirhead, R., Blake, R., Bergeron, L., Fici, G. J., Summers, K., MacRae, V. & Corcoran, B., 15 Aug 2019, In: PLoS ONE.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Interstitial Cell 100%
  • Mitral Valve 100%
  • Degeneration 100%
  • Cell Culture 100%
  • Evaluation Study 100%

• Research in Pulmonary Fibrosis Across Species: Unleashing Discovery Through Comparative Biology

  Comparative Biology of Pulmonary Fibrosis Group, 11 Feb 2019, (E-pub ahead of print) In: The American Journal of the Medical Sciences.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2018

  Development and Evaluation of a Tissue-Engineered Fibrin-Based Canine Mitral Valve 3D Cell Culture System

  Liu, M., Flanagan, T. C., Jockenhovel, S., Black, A., Lu, C. C., French, A., Argyle, D. & Corcoran, B., 31 Mar 2018, (E-pub ahead of print) In: Journal of Comparative Pathology. 160, p. 23-33 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fibrin 100%
  • Mitral Valve 100%
  • Engineered Tissue 100%
  • Evaluation Study 100%
  • Cells 75%

• Exploiting novel valve interstitial cell lines to study calcific aortic valve disease

  Tsang, H., Cui, L., Farquharson, C., Corcoran, B., Summers, K. & MacRae, V., Feb 2018, In: Molecular Medicine Reports. 17, 2, p. 2100-2106

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Interstitial Cell 100%
  • Cell Line 100%
  • Aortic Valve Disease 100%
  • Calcification 100%
  • Isotopes of Calcium 75%
• 2017

  Isolation and characterization of primary rat valve interstitial cells: a new model to study aortic valve calcification

  Cui lin, L., Zhu, D., Markby, G., Corcoran, B., Farquharson, C. & MacRae, V., 20 Nov 2017, (E-pub ahead of print) In: Journal of Visualized Experiments (JoVE). 2017, 129

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hypercalcemia 100%
  • Rat 100%
  • Aortic Valve Disease 100%
  • Cell Marker 100%
  • Calcification 100%

• Comparative Transcriptomic Profiling and Gene Expression for Myxomatous Mitral Valve Disease in the Dog and Human

  Markby, G. R., Summers, K. M., MacRae, V. E. & Corcoran, B. M., 17 Jul 2017, In: Veterinary Sciences. 4, 3, 34.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dog 100%

• Further characterisation of computed tomographic and clinical features for staging and prognosis of idiopathic pulmonary fibrosis in west highland white terriers

  Thierry, F., Handel, I., Corcoran, B. & Schwarz, T., Jul 2017, In: Veterinary Radiology & Ultrasound. 58, 4, p. 284-294

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • West Highland White Terrier 100%
  • Dog 37%
  • Echocardiography 12%

• Myxomatous Degeneration of the Canine Mitral Valve: From Gross Changes to Molecular Events

  Markby, G., Summers, K., MacRae, V., Del-Pozo, J. & Corcoran, B., May 2017, In: Journal of Comparative Pathology. 156, 4, p. 371-383

  Research output: Contribution to journal › Literature review › peer-review

  Open Access

  File

  • Dog 100%

• Investigating calcific aortic valve disease using novel immortalised sheep and rat valve interstitial cell lines

  Tsang, H-G., Cui, L., Farquharson, C., Corcoran, B. M., Summers, K. M. & MacRae, V. E., Apr 2017, In: Heart. 103, p. A7-A7 1 p.

  Research output: Contribution to journal › Meeting abstract › peer-review
• 2016

  Correlation between computed tomographic and clinical findings in idiopathic pulmonary fibrosis in West Highland White Terriers.

  Thierry, F., Handel, I., Hammond, G., King, L., Corcoran, B. & Schwarz, T., 30 Nov 2016, In: Veterinary Radiology & Ultrasound. 57, 6, p. 649 1 p.

  Research output: Contribution to journal › Meeting abstract › peer-review

• Vascular calcification and the cardiovascular transcriptome

  Tsang, H., Cui, L., Farquharson, C., Corcoran, B. M., Summers, K. M. & MacRae, V. E., Oct 2016, In: International Journal of Experimental Pathology. 97, 5, p. A2-A3 2 p.

  Research output: Contribution to journal › Meeting abstract › peer-review

• Comparison of cellular changes in cavalier King Charles spaniel and mixed breed dogs with myxomatous mitral valve disease

  Lu, C., Liu, M., Culshaw, G., French, A. & Corcoran, B., Jun 2016, In: Journal of Veterinary Cardiology. 18, 2, p. 100-109

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dog 100%
  • Muscle 20%

• Prevalence of pancreatic, hepatic and renal microscopic lesions in post-mortem samples from cavalier King Charles spaniels

  Kent, A. C. C., Constantino-Casas, F., Rusbridge, C., Corcoran, B., Carter, M., Ledger, T. & Watson, P. J., Apr 2016, In: Journal of Small Animal Practice. 57, 4, p. 188-193

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chronic Pancreatitis 100%

• Large animal models of cardiovascular disease

  Tsang, H-G., Rashdan, N., Whitelaw, C., Corcoran, B., Summers, K. & MacRae, V., 24 Feb 2016, (E-pub ahead of print) In: Cell Biochemistry and Function. 34, 3, p. 113–132

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cardiovascular Disease 100%
  • Animal Models 100%
  • Pathological Process 25%
  • Heart Valve 25%
  • Ossification 25%
• 2015

  Culture and characterisation of canine mitral valve interstitial and endothelial cells

  Liu, M. M., Flanagan, T. C., Lu, C. C., French, A. T., Argyle, D. J. & Corcoran, B. M., 1 Apr 2015, In: Veterinary Journal. 204, 1, p. 32-39

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dog 100%
  • Muscle 100%
  • Platelet 50%
  • Myofibroblast 50%

• Gene network and canonical pathway analysis in canine myxomatous mitral valve disease: A microarray study

  Lu, C-C., Liu, M-M., Culshaw, G., Clinton, M., Argyle, D. J. & Corcoran, B. M., Apr 2015, In: Veterinary Journal. 204, 1, p. 23-31 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dog 100%
  • Transforming Growth Factor 33%
  • Endothelin 33%

• Developmental pathways and endothelial to mesenchymal transition in canine myxomatous mitral valve disease

  Lu, C., Liu, M., Clinton, M., Culshaw, G., Argyle, D. J. & Corcoran, B. M., 2015, In: The Veterinary Journal. 206, 3, p. 377-384

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Reverse Transcription Polymerase Chain Reaction 100%
  • Mitral Valve Disease 100%
  • Basement Membrane 75%
  • Cell Differentiation 50%
  • Immunohistochemistry 50%
• 2014

  Limited genetic divergence between dog breeds from geographically isolated countries

  Summers, K. M., Ogden, R., Clements, D. N., French, A. T., Gow, A. G., Powell, R., Corcoran, B., Mellanby, R. J. & Schoeman, J. P., 20 Oct 2014, In: Veterinary Record. 175, 22, 562.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Viraemic frequencies and seroprevalence of non-primate hepacivirus and equine pegiviruses in horses and other mammalian species

  Lyons, S., Kapoor, A., Schneider, B. S., Wolfe, N. D., Culshaw, G., Corcoran, B., Durham, A. E., Burden, F., McGorum, B. C. & Simmonds, P., 9 May 2014, In: Journal of General Virology. 95, 8, p. 1701-1711

  Research output: Contribution to journal › Article › peer-review

  • Horse 100%
  • Donkey 30%
  • Dog 20%
  • Hepatitis C 20%
  • Enzootic 10%

• Bridging the gulf between academia and practice

  Pirie, S., Argyle, D., Corcoran, B., Mellanby, R. & Handel, I., 26 Apr 2014, In: Veterinary Record. 174, 17, p. i-i

  Research output: Contribution to journal › Article › peer-review
• 2013

  An official American thoracic society workshop report: comparative pathobiology of fibrosing lung disorders in humans and domestic animals

  ATS Comparative Biology of Lung Fibrosis Working Group, Roman, J., Brown, K. K., Olson, A., Corcoran, B. M. & Williams, K. J., Dec 2013, In: Annals of the American Thoracic Society. 10, 6, p. S224-9

  Research output: Contribution to journal › Article › peer-review

  • Silo-Filler's Disease 100%
  • Human 100%
  • Lung Disease 100%
  • Diseases 100%
  • Domestic Animal 100%

• Cell maceration scanning electron microscopy and computer-derived porosity measurements in assessment of connective tissue microstructure changes in the canine myxomatous mitral valve

  Han, R. I., Impoco, G., Culshaw, G., French, A. T., Black, A. & Corcoran, B. M., Aug 2013, In: Veterinary Journal. 197, 2, p. 502-505

  Research output: Contribution to journal › Article › peer-review

  • Scanning Electron Microscopy 100%
  • Porosity 100%
  • Sample 66%
  • Thickness 33%
  • Collagen 33%

• Morphological changes to endothelial and interstitial cells and to the extra-cellular matrix in canine myxomatous mitral valve disease (endocardiosis)

  Han, R. I., Clark, C. H., Black, A., French, A., Culshaw, G. J., Kempson, S. A. & Corcoran, B. M., Aug 2013, In: The Veterinary Journal. 197, 2, p. 388-394

  Research output: Contribution to journal › Article › peer-review

  • Interstitial Cell 100%
  • Morphology 100%
  • Extracellular Matrix 100%
  • Mitral Valve Disease 100%
  • Endothelial Cell 66%

• Population structure and genetic heterogeneity in popular dog breeds in the UK

  Mellanby, R. J., Ogden, R., Clements, D. N., French, A. T., Gow, A., Powell, R., Corcoran, B., Schoeman, J. P. & Summers, K. M., Apr 2013, In: Veterinary Journal. 196, 1, p. 92-97 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Breeds 100%
  • Population Structure 100%
  • Dog Breed 100%
  • Genetic Heterogeneity 100%
  • Population Genetics 100%
• 2012

  Canine tissue-specific expression of multiple small leucine rich proteoglycans

  Yang, C-H., Culshaw, G. J., Liu, M. -M., Lu, C. -C., French, A. T., Clements, D. N. & Corcoran, B. M., Aug 2012, In: The Veterinary Journal. 193, 2, p. 374-380 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Leucine 100%
  • Proteoglycan 100%
  • Tissues 100%
  • Lumican 25%
  • Real-Time Polymerase Chain Reaction 25%

• Cellular changes in the mitral valve of Cavalier King Charles Spaniel with late-stage myxomatous mitral valve disease

  Lu, C. C., Culshaw, G., French, A. & Corcoran, B., 2012, In: Advances in Animal Biosciences. 3, 1, p. 171 1 p.

  Research output: Contribution to journal › Meeting abstract › peer-review

• Characterisation and cardiac directed differentiation of canine adult cardiac stem cells

  Hodgkiss-Geere, H. M., Argyle, D., Corcoran, B., Whitelaw, B., Milne, E., Bennett, D. & Argyle, S., 2012, In: Veterinary Journal. 191, 2, p. 176-182 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Cardiac Stem Cell 100%
  • Adult 100%
  • Differentiation 100%
  • Cells 100%
  • Directed Differentiation 100%

• Characterisation and differentiation potential of bone marrow derived canine mesenchymal stem cells

  Hodgkiss-Geere, H. M., Argyle, D. J., Corcoran, B. M., Whitelaw, B., Milne, E., Bennett, D. & Argyle, S. A., 2012, In: Veterinary Journal. 194, 3, p. 361-368 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Bone Marrow 100%
  • Differentiation 100%
  • Mesenchymal Stem Cell 100%
  • Cardiomyocyte 40%
  • Morphology 40%

• Evidence for increased probability of cardiac death in dogs with pulmonic stenosis questionable Reply

  Francis, A. J., Johnson, M. J. S., Culshaw, G. C., Corcoran, B. M., Martin, M. W. S. & French, A. T., 2012, In: Journal of Small Animal Practice. 53, 5, p. 306-309 4 p.

  Research output: Contribution to journal › Letter › peer-review

• Expression of carboxymethyllysine, an advanced glycation end product, in myxomatous mitral valve disease and the mitral valve of healthy dogs

  Liu, M. M., Pang, L. Y., Corcoran, B. M., Culshaw, G. J. & French, A. T., 2012, In: Advances in Animal Biosciences. 3, 1, p. 173 1 p.

  Research output: Contribution to journal › Meeting abstract › peer-review

• Genome-wide analysis of mitral valve disease in Cavalier King Charles Spaniels

  French, A. T., Ogden, R., Eland, C., Hemani, G., Pong-Wong, R., Corcoran, B. M. & Summers, K. M., 2012, In: The Veterinary Journal. 193, 1, p. 283-286

  Research output: Contribution to journal › Article › peer-review

  • Cavalier King Charles Spaniel 100%
  • Genetics 50%
  • Dogs 25%
  • Genome-Wide Association Study 25%
  • Breeds 25%

• Nonprimate hepaciviruses in domestic horses, United kingdom

  Lyons, S., Kapoor, A., Sharp, C., Schneider, B. S., Wolfe, N. D., Culshaw, G., Corcoran, B., McGorum, B. C. & Simmonds, P., 2012, In: Emerging Infectious Diseases. 18, 12, p. 1976-82 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Horse 100%
  • Dog 60%
  • Donkey 20%
  • Pig 20%
  • Rodent 20%
• 2011

  Cardiac Specific Gene Expression Changes in Long Term Culture of Murine Mesenchymal Stem Cells

  Hodgkiss-Geere, H. M., Argyle, D. J., Corcoran, B. M., Whitelaw, B., Milne, E., Bennett, D. & Argyle, S. A., 2011, In: International Journal of Stem Cells. 4, 2, p. 143-148 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Differentiation 100%
  • Mesenchymal Stem Cell 100%
  • Gene Expression 100%
  • Culture 100%
  • Stem Cell 100%

• Further characterisation of the clinical features of chronic pulmonary disease in West Highland white terriers

  Corcoran, B. M., King, L. G., Schwarz, T., Hammond, G. & Sullivan, M., 2011, In: Veterinary Record. 168, 13, p. 355 1 p.

  Research output: Contribution to journal › Article › peer-review

• Genome wide analysis of mitral valve disease in Cavalier King Charles Spaniels

  French, A. T., Ogden, R., Eland, C., Hemani, G., Pong-Wong, R., Corcoran, B. & Summers, K. M., 2011, In: Advances in Animal Biosciences. 2, 1, p. 54 1 p.

  Research output: Contribution to journal › Meeting abstract › peer-review

• Outcome in 55 dogs with pulmonic stenosis that did not undergo balloon valvuloplasty or surgery

  Francis, A. J., Johnson, M. J. S., Culshaw, G. C., Corcoran, B. M., Martin, M. W. S. & French, A. T., 2011, In: Journal of Small Animal Practice. 52, 6, p. 282-288 7 p.

  Research output: Contribution to journal › Article › peer-review

• Use of non-invasive methods to collect DNA for genome wide analysis from companion animals

  French, A. T., Ogden, R., Eland, C., Hemani, G., Corcoran, B. & Summers, K. M., 2011, In: Advances in Animal Biosciences. 2, 1, p. 53 1 p.

  Research output: Contribution to journal › Meeting abstract › peer-review
• 2010

  The Mitral Valve: Development, Structure, Pathology & Tissue Engineering

  Black, A., Corcoran, B. M., Heying, R., Jockenhoevel, S. & Flanagan, T. C., 1 Jan 2010, Advances in Cardiovascular Research, Vol 1. Schmitt, L. & Konig, T. (eds.). Hauppauge, NY: Nova Science Publishers Inc, Vol. 1. p. 1-45 45 p. (Advances in Cardiovascular Research).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Mitral Valve 100%
  • Tissue Engineering 100%
  • Pathology 100%
  • Development 100%
  • Mitral Valve Disease 50%

• Structural and Cellular Changes in Canine Myxomatous Mitral Valve Disease: An Image Analysis Study

  Han, R. I., Black, A., Culshaw, G., French, A. T. & Corcoran, B. M., Jan 2010, In: Journal of Heart Valve Disease. 19, 1, p. 60-70 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitral Valve Disease 100%
  • Image Analysis 100%
  • Dog 80%
  • Morphology 40%
  • Cells 40%