Chris Ponting

Search results

• 2025

  High order expression dependencies finely resolve cryptic states and subtypes in single cell data

  Jansma, A., Yao, Y., Wolfe, J., Del Debbio, L., Beentjes, S. V., Ponting, C. P. & Khamseh, A., 2 Jan 2025, In: Molecular Systems Biology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fine Resolution 100%
• 2024

  Evidence supports a causal association between allele-specific vitamin D receptor binding and multiple sclerosis among Europeans

  Adams, C., Manouchehrinia, A., Quach, H. L., Quacha, D. L., Olsson, T., Kockumb, I., Schaefer, C., Ponting, C. P., Alfredsson, L. & Barcellos, L. F., 12 Feb 2024, In: Proceedings of the National Academy of Sciences of the United States of America.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Allele 100%
  • Vitamin D 100%
  • Receptor Binding 100%
  • Multiple Sclerosis 100%
  • Vitamin D Receptor 100%

• The histone binding capacity of SPT2 controls chromatin structure and function in Metazoa

  Saredi, G., Carelli, F. N., Rolland, S. G. M., Furlan, G., Piquet, S., Appert, A., Sanchez-Pulido, L., Price, J. L., Alcón, P., Lampersberger, L., Déclais, A-C., Ramakrishna, N. B., Toth, R., Macartney, T., Alabert, C., Ponting, C. P., Polo, S. E., Miska, E. A., Gartner, A., Ahringer, J., & 1 othersRouse, J., 18 Jan 2024, In: Nature Structural & Molecular Biology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chromatin Structure 100%
  • Histone 100%
  • Caenorhabditis Elegans 40%
  • Orthology 40%
  • Germline 20%

• Comparison of T-cell Receptor Diversity of people with Myalgic Encephalomyelitis versus controls

  Dibble, J., Ferneyhough, B., Roddis, M., millington, S., Fischer, M. D., Parkinson, N. J. & Ponting, C. P., 4 Jan 2024, In: BMC Research Notes.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chronic Fatigue Syndrome 100%
  • T Lymphocyte Receptor 100%
  • T Cell Receptor 100%
  • Chronic Disorder 100%
  • Multiple Sclerosis 25%
• 2023

  A second update on mapping the human genetic architecture of COVID-19

  The COVID-19 Host Genetics Initiative, 6 Sept 2023, In: Nature. 621, 7977, p. E7-E26

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Typing myalgic encephalomyelitis by infection at onset: A DecodeME study

  Bretherick, A. D., Mcgrath, S. J., Devereux-Cooke, A., Leary, S., Northwood, E., Redshaw, A., Stacey, P., Tripp, C., Wilson, J., Chowdhury, S., Lewis, I., Almelid, Ø., Baby, S. V., Baker, T., Becher, H., Boutin, T., Clyde, M., Garcia, D., Ireland, J., Kerr, S. M., & 6 othersMcdowall, E., Perry, D., Samms, G. L., Vitart, V., Wolfe, J. C. & Ponting, C. P., 22 Aug 2023, In: NIHR Open Research. 3, p. 20

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Infection 100%
  • Chronic Fatigue Syndrome 100%
  • Infectious Mononucleosis 8%
  • Cognitive Defect 4%
  • COVID-19 4%

• Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

  GenOMICC Investigators, Law, A., Hendry, S. C. & Baillie, J. K., 27 Jul 2023, In: Nature. 619, 7971, p. E61

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  File

  • COVID-19 100%
  • Meta-Analysis 100%
  • Genome Wide Association Study 100%
  • Meta Analysis 100%

• Human Genetics Seen Through An Evolutionary Lens

  Ponting, C. P., 10 May 2023, In: Cell Genomics. 3, 100323.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Human Genetics 100%

• GWAS and meta-analysis identifies 49 genetic variants underlying critical Covid-19

  GenOMICC Investigators, SCOURGE Consortium, ISARIC4C Investigators, 23andMe Covid-19 Team, Pairo-Castineira, E., Rawlik, K., Bretherick, A. D., Qi, T., Wu, Y., Nassiri, I., McConkey, G. A., Zechner, M., Klaric, L., Griffiths, F., Oosthuyzen, W., Kousathanas, A., Richmond, A., Millar, J., Russell, C. D., Malinauskas, T., & 39 othersThwaites, R., Morrice, K., Keating, S., Maslove, D. M., Nichol, A. D., Semple, M. G., Knight, J., Shankar-Hari, M., Summers, C., Hinds, C., Horby, P., Ling, L., McAuley, D. F., Montgomery, H., Openshaw, P. J. M., Begg, C., Walsh, T. S., Tenesa, A., Flores, C., Riancho, J. A., Rojas-Martinez, A., Lapunzina, P., Yang, J., Ponting, C. P., Wilson, J. F., Vitart, V., Abedalthagafi, M. S., Luchessi, A., Parra, E. J., Cruz, R., Carracedo, A., Fawkes, A., Murphy, L., Rowan, K., Pereira, A. C., Law, A., Fairfax, B. P., Clohisey Hendry, S. & Baillie, J. K., May 2023, In: Nature. 617, 7962, p. 764-768 30 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genetic Divergence 100%
  • Genome-Wide Association Study 100%
  • Genetics 33%
  • Genotyping 33%
  • Whole Genome Sequencing 33%

• An ependymal cell census identifies heterogeneous and ongoing cell maturation in the adult mouse spinal cord that changes dynamically on injury

  Rodrigo Albors, A., Singer, G. A., Llorens-Bobadilla, E., Frisén, J., May, A. P., Ponting, C. P. & Storey, K. G., 19 Jan 2023, In: Developmental Cell. 58, 3, p. 239-255.e10

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ependymal Cell 100%
  • Cell Maturation 100%
  • Stem Cell 33%
  • Spinal Cord Potential 14%
  • Transcriptome 11%
• 2022

  OAF: a new member of the BRICHOS family

  Sanchez-Pulido, L. & Ponting, C. P., 24 Nov 2022, In: Bioinformatics Advances. 2, 1, 5 p., vbac087.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Coevolution 100%
  • COVID-19 100%
  • Amyloid Protein 100%
  • Coronavirinae 50%

• Genome-Wide Analysis of Human Long Noncoding RNAs: A Provocative Review

  Ponting, C. P. & Haerty, W., 31 Aug 2022, In: Annual Review of Genomics and Human Genetics. 23, p. 153-172

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Genome Wide Association Study 100%
  • Long Noncoding RNA 100%
  • Long Non-Coding RNA 75%
  • Transcriptional Noise 25%
  • Human Development 25%

• DecodeME: Community recruitment for a large genetics study of myalgic encephalomyelitis / chronic fatigue syndrome

  Devereux-Cooke, A., Leary, S., McGrath, S., Northwood, E., Redshaw, A., Shepherd, C., Stacey, P., Tripp, C., Wilson, J., Mar Countess of Mar, M., Boobyer, D., Bromiley, S., Chowdhury, S., Dransfield, C., Almas, M., Almelid, Ø., Buchanan, D., Garcia, D., Ireland, J., Kerr, S., & 8 othersLewis, I., Migdal, M., McDowall, E., Murray, P., Perry, D., Ponting, C. P., Vitart, V. & Wolfe, J., 19 Jul 2022, (E-pub ahead of print) In: Bmc neurology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genetics 100%
  • Lived Experience 100%
  • Diagnostic Test 100%
  • Ethics 100%
  • Chronic Fatigue Syndrome 100%

• Whole genome sequencing reveals host factors underlying critical Covid-19

  GenOMICC Investigators, Kousathanas, A., Pairo-Castineira, E., Rawlik, K., Stuckey, A., Odhams, C. A., Walker, S., Russell, C. D., Malinauskas, T., Wu, Y., Millar, J., Shen, X., Elliott, K. S., Griffiths, F., Oosthuyzen, W., Morrice, K., Keating, S., Wang, B., Rhodes, D., Klaric, L., & 57 othersZechner, M., Parkinson, N., Siddiq, A., Goddard, P., Donovan, S., Maslove, D., Nichol, A., Semple, M. G., Zainy, T., Maleady-Crowe, F., Todd, L., Salehi, S., Knight, J., Elgar, G., Chan, G., Arumugam, P., Patch, C., Rendon, A., Bentley, D., Kingsley, C., Kosmicki, J. A., Horowitz, J. E., Baras, A., Abecasis, G. R., Ferreira, M. A. R., Justice, A., Mirshahi, T., Oetjens, M., Rader, D. J., Ritchie, M. D., Verma, A., Fowler, T. A., Shankar-Hari, M., Summers, C., Hinds, C., Horby, P., Ling, L., McAuley, D., Montgomery, H., Openshaw, P. J. M., Elliott, P., Walsh, T., Tenesa, A., Fawkes, A., Murphy, L., Rowan, K., Ponting, C. P., Vitart, V., Wilson, J. F., Yang, J., Bretherick, A. D., Scott, R. H., Hendry, S. C., Moutsianas, L., Law, A., Caulfield, M. J. & Baillie, J. K., 7 Jul 2022, In: Nature. 607, p. 97-103

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Whole Genome Sequencing 100%
  • Host Factor 100%
  • Genetics 50%
  • Genetic Divergence 50%
  • Blood Coagulation Factor 50%

• The genetics of ME: a commentary on Hajdarevic et al

  McGrath, S. J. & Ponting, C. P., 14 Jun 2022, (E-pub ahead of print) In: Brain, Behavior, and Immunity.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  File

• Refining the domain architecture model of the replication origin firing factor Treslin/TICRR

  Ferreira, P., Sanchez-Pulido, L., Marko, A., Ponting, C. P. & Boos, D., 1 May 2022, In: Life Science Alliance. 5, 5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ku70 100%
  • Origin of Replication 100%
  • DNA Replication Origin 100%
  • Von Willebrand Factor 50%
  • Human Cell 50%

• Mapping the developing human cardiac endothelium at single cell resolution identifies MECOM as a regulator of arteriovenous gene expression

  McCracken, I., Dobie, R., Bennett, M., Passi, R., Beqqali, A., Henderson, N. C., Mountford, J. C., Riley, P. R., Ponting, C. P., Smart, N., Brittan, M. & Baker, A. H., 25 Feb 2022, In: Cardiovascular Research.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gene Expression 100%
  • Endothelial Cell 100%
  • MDS1 and EVI1 Complex Locus Protein 100%
  • Vascularization 80%
  • Vascularity 66%

• Citrullination Was Introduced into Animals by Horizontal Gene Transfer from Cyanobacteria

  Cummings, T. F. M., Gori, K., Sanchez-Pulido, L., Gavriilidis, G., Moi, D., Mann (nee Wilson), A. R., Murchison, E., Dessimoz, C., Ponting, C. P. & Christophorou, M. A., 3 Feb 2022, In: Molecular Biology and Evolution. 39, 2, 20 p., msab317.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Horizontal Gene Transfer 100%
  • Citrullination 100%
  • Cyanobacteria 100%
  • Lineages 33%
  • Conserved Sequence 33%

• PERCC1, a new member of the YAP/TAZ/FAM181 transcriptional co-regulator family

  Sanchez-Pulido, L., Jia, S., Hansen, C. G. & Ponting, C. P., 3 Feb 2022, (E-pub ahead of print) In: Advances in Bioinformatics. 2, 1, vbac008.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • YAP/TAZ 100%
  • Transcription Factors 100%
  • Gene Expression 33%
  • Bioinformatics 33%
• 2021

  Extending the Horizon of Homology Detection with Coevolution-based structure prediction.

  Sanchez-Pulido, L. & Ponting, C. P., 14 Jun 2021, (E-pub ahead of print) In: Journal of Molecular Biology.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
• 2020

  Genetic mechanisms of critical illness in Covid-19

  The GenOMICC Investigators, The ISARIC4C Investigators, The Covid-19 Human Genetics Initiative, 23andMe Investigators, BRACOVID Investigators, Gen-COVID Investigators, Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A., Rawlik, K., Parkinson, N., Pasko, D., Walker, S., Richmond, A., Fourman, M. H., Law, A., Furniss, J., Gountouna, E., Wrobel, N., & 42 othersRussell, C. D., Moutsianas, L., Wang, B., Meynert, A. M., Yang, Z., Zhai, R., Zheng, C., Griffith, F., Oosthuyzen, W., Shih, B., Keating, S., Zechner, M., Haley, C. S., Porteous, D., Hayward, C., Knight, J., Summers, C., Shankar-Hari, M., Turtle, L., Ho, A., Hinds, C., Horby, P., Nichol, A., Maslove, D. M., Ling, L., Klenerman, P., McAuley, D. F., Montgomery, H. E., Walsh, T. S., Shen, X., Rowan, K., Fawkes, A., Murphy, L., Ponting, C. P., Tenesa, A., Caulfield, M., Scott, R., Openshaw, P., Semple, M. G., Vitart, V., Wilson, J. & Baillie, J. K., 11 Dec 2020, (E-pub ahead of print) In: Nature. n/a, n/a.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Enzyme Activator 100%

• Genetic mechanisms of critical illness in Covid-19

  Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A. D., Rawlik, K., Parkinson, N., Pasko, D., Walker, S., Richmond, A., Fourman, M. H., Law, A., Furniss, J., Gountouna, E., Wrobel, N., Russell, C. D., Moutsianas, L., Wang, B., Meynert, A. M., Yang, Z., Zhai, R., & 39 othersZheng, C., Griffith, F., Oosthuyzen, W., Shih, B., Keating, S., Zechner, M., Haley, C., Porteus, D. J., Hayward, C., Knight, J., Summers, C., Shankar-Hari, M., Turtle, L., Ho, A., Hinds, C., Horby, P., Nichol, A., Maslove, D. M., Ling, L., Klenerman, P., McAuley, D. F., Montgomery, H., Walsh, T. S., The GenOMICC Investigators, The ISARIC4C Investigators, The Covid-19 Human Genetics Initiative, Shen, X., Rowan, K., Fawkes, A., Murphy, L., Ponting, C. P., Tenesa, A., Caulfield, M., Scott, R., Openshaw, P. J. M., Semple, M. G., Vitart, V., Wilson, J. F. & Baillie, J. K., 25 Sept 2020, medRxiv.

  Research output: Working paper

  • Genetics 100%
  • Genetic Mechanism 100%
  • Genome-Wide Association Study 100%
  • Genetic Divergence 50%
  • OAS1 50%

• Genetics Needs Non-geneticists

  Ponting, C. P., 1 Sept 2020, In: Trends in Genetics.

  Research output: Contribution to journal › Comment/debate

  Open Access

  File

  • Genetics 100%

• Ageing compromises mouse thymus function and remodels epithelial cell differentiation

  Baran-Gale, J., Morgan, M. D., Maio, S., Dhalla, F., Calvo-Asensio, I., Deadman, M. E., Handel, A. E., Maynard, A., Chen, S., Green, F., Sit, R. V., Neff, N. F., Darmanis, S., Tan, W., May, A. P., Marioni, J. C., Ponting, C. P. & Holländer, G. A., 25 Aug 2020, (E-pub ahead of print) In: eLIFE. 9, 8, e56221.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • T Cell 100%
  • Cell Differentiation 100%
  • Epithelial Cell 100%
  • Precursor 100%
  • Thymus Function 100%

• Genetic Risk Factors of ME/CFS: A Critical Review

  Dibble, J. J., McGrath, S. J. & Ponting, C. P., 3 Aug 2020, (E-pub ahead of print) In: Human Molecular Genetics.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Genome-Wide Association Study 100%
  • Genetic Risk 100%
  • Chronic Fatigue Syndrome 100%
  • Candidate Gene 50%
  • Genetic Determinism 50%

• Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits

  Bretherick, A. D., Canela-Xandri, O., Joshi, P. K., Clark, D. W., Rawlik, K., Boutin, T. S., Zeng, Y., Amador, C., Navarro, P., Rudan, I., Wright, A. F., Campbell, H., Vitart, V., Hayward, C., Wilson, J. F., Tenesa, A., Ponting, C. P., Baillie, K. & Haley, C., 6 Jul 2020, In: PLoS Genetics. 16, 7, e1008785.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mendelian Randomization 100%
  • Proteome 75%
  • Quantitative Trait Locus 50%
  • Pleiotropy 25%
  • Fatty Acid-Binding Protein 25%

• Identification of region-specific astrocyte subtypes at single cell resolution

  Batiuk, M., Martirosyan, A., Wahis, J., de Vin, F., Marneffe, C., Kusserow, C., Koeppen, S., Viana, J. F., Oliveira, J. F., Voet, T., Ponting, C., Belgard, T. G. & Holt, M., 5 Mar 2020, In: Nature Communications.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Transcriptional dynamics of pluripotent stem cell-derived endothelial cell differentiation revealed by single-cell RNA sequencing

  McCracken, I. R., Taylor, R. S., Kok, F. O., de la Cuesta, F., Dobie, R., Henderson, B. E. P., Mountford, J. C., Caudrillier, A., Henderson, N. C., Ponting, C. P. & Baker, A. H., 1 Mar 2020, In: European Heart Journal. 41, 9, p. 1024–1036

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Stem Cell 100%
  • Dynamics 100%
  • Cellular Differentiation 100%
  • RNA Sequence 100%
  • Embryonic Stem Cell 75%

• Hexa-Longin domain scaffolds for inter-Rab signalling

  Sanchez-Pulido, L. & Ponting, C. P., 15 Feb 2020, In: Bioinformatics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hermansky-Pudlak Syndrome 100%
  • Guanine Nucleotide Exchange Factor 100%
  • HPS1 50%
  • Cilium 50%
  • Protein Complexes 50%

• Biologically indeterminate yet ordered promiscuous gene expression in single medullary thymic epithelial cells

  Dhalla, F., Baran-Gale, J., Maio, S., Chappell, L., Holländer, G. A. & Ponting, C. P., 2 Jan 2020, In: EMBO Journal. 39, 18 p., e101828.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epithelial Cells 100%
  • Gene Expression 100%
  • Transcriptome 33%
  • Thymocyte 33%
  • Tissue Specificity 33%
• 2019

  Resolving the fibrotic niche of human liver cirrhosis at single-cell level

  Ramachandran, P., Dobie, R., Wilson-Kanamori, J. R., Dora, E. F., Henderson, B. E. P., Luu, N. T., Portman, J. R., Matchett, K. P., Brice, M., Marwick, J. A., Taylor, R. S., Efremova, M., Vento-Tormo, R., Carragher, N. O., Kendall, T. J., Fallowfield, J. A., Harrison, E. M., Mole, D. J., Wigmore, S. J., Newsome, P. N., & 8 othersWeston, C. J., Iredale, J. P., Tacke, F., Pollard, J. W., Ponting, C. P., Marioni, J. C., Teichmann, S. A. & Henderson, N. C., 21 Nov 2019, In: Nature. 575, 7783, p. 512–518

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Macrophage 100%
  • Cell Level 100%
  • Fibrogenesis 100%
  • Liver Cirrhosis 100%
  • Lineages 50%

• Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis

  Dobie, R., Wilson-Kanamori, J. R., Henderson, B., Smith, J., Matchett, K., Portman, J., Wallenborg, K., Picelli, S., Zagórska, A., Pendem, S. V., Hudson, T. E., Wu, M. M., Budas, G. R., Breckenridge, D. G., Harrison, E., Mole, D. J., Wigmore, S. J., Ramachandran, P., Ponting, C. P., Teichmann, S. A., & 2 othersMarioni, J. C. & Henderson, N. C., 12 Nov 2019, In: Cell Reports. 29, 7, p. 1832-1847.e8

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Transcriptomics 100%
  • Mesenchyme 100%
  • Liver Fibrosis 100%
  • Hepatic Stellate Cell 100%
  • Zonation 100%

• Zebrafish MITF-low melanoma subtype models reveal transcriptional subclusters and MITF-independent residual disease

  Travnickova, J., Wojciechowska, S., Khamseh, A., Gautier, P., Brown, D. V., Lefevre, T., Brombin, A., Ewing, A., Capper, A., Spitzer, M., Dilshat, R., Semple, C. A., Mathers, M. E., Lister, J. A., Steingrimsson, E., Voet, T., Ponting, C. P. & Patton, E. E., Nov 2019, In: Cancer Research. 79, 22, p. 5769-5784 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Minimal Residual Disease 100%
  • Melanocyte 100%
  • Transcription Factors 100%
  • Melanoma 100%
  • Zebra Fish 100%

• The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity

  Sirey, T. M., Roberts, K., Haerty, W., Bedoya-Reina, O., Rogatti-Granados, S., Tan, J. Y., Li, N., Heather, L. C., Carter, R. N., Cooper, S., Finch, A. J., Wills, J., Morton, N. M., Marques, A. C. & Ponting, C. P., 12 Aug 2019, In: eLIFE. 8, 31 p., e45051.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Enzymatic Activity 100%
  • Long Noncoding RNA 100%
  • Enzyme Activity 100%
  • Long Non-Coding RNA 100%
  • Protein Subunit 100%

• Identification of functional long non-coding RNAs in C. elegans

  Akay, A., Jordan, D., Navarro, I. C., Wrzesinski, T., Ponting, C., Miska, E. A. & Haerty, W., 18 Feb 2019, In: BMC Biology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7

  Köhler, K., Sanchez-Pulido, L., Höfer, V., Marko, A., Ponting, C. P., Snijders, A. P., Feederle, R., Schepers, A. & Boos, D., 29 Jan 2019, (E-pub ahead of print) In: PLoS Biology. 17, 1, p. e2006767

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cyclin C 100%
  • Cyclin-Dependent Kinase 8 7%

• The Human Cell Atlas: making Cell Space for disease

  Ponting, C., 14 Jan 2019, (E-pub ahead of print) In: Disease Models and Mechanisms.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File
• 2018

  Single cell RNA-seq reveals profound transcriptional similarity between Barrett's oesophagus and oesophageal submucosal glands

  Owen, R. P., White, M. J., Severson, D. T., Braden, B., Bailey, A., Goldin, R., Wang, L. M., Ruiz-Puig, C., Maynard, N. D., Green, A., Piazza, P., Buck, D., Middleton, M. R., Ponting, C. P., Schuster-Böckler, B. & Lu, X., 15 Oct 2018, In: Nature Communications. 9, 1, p. 4261

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Barrett Esophagus 100%
  • RNA Sequencing 100%
  • Esophagus 100%
  • Cell Population 14%
  • Morphology 14%

• Comprehensively profiling the chromatin architecture of tissue restricted antigen expression in thymic epithelial cells over development

  Handel, A. E., Shakama-Dorn, N., Zhanybekova, S., Maio, S., Graedel, A. N., Zuklys, S., Ponting, C. & Hollander, G. A., 19 Sept 2018, (E-pub ahead of print) In: Frontiers in Immunology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Complexities of post-transcriptional regulation and the modeling of ceRNA crosstalk

  Smillie, C. L., Sirey, T. & Ponting, C. P., Jun 2018, In: Critical reviews in biochemistry and molecular biology. p. 1-15 15 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • MicroRNA 100%
  • Post-Transcriptional Regulation 100%
  • Gene Expression 100%
  • Transcriptome 50%
  • Protein Expression 50%

• The long non-coding RNA Paupar promotes KAP1-dependent chromatin changes and regulates olfactory bulb neurogenesis

  Pavlaki, I., Alammari, F., Sun, B., Clark, N., Sirey, T., Lee, S., Woodcock, D. J., Ponting, C., Szele, F. & Vance, K. W., 15 May 2018, In: EMBO Journal.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• The Phenotypic Spectrum of Xia-Gibbs Syndrome

  Jiang, Y., Wangler, M. F., McGuire, A. L., Lupski, J. R., Posey, J. E., Murdock, D. R., Khayat, M. M., Sanchez-Pulido, L., Ponting, C., Xia, F., Hunter, J. V., Meng, Q., Murugan, M. & Gibbs, R. A., 25 Apr 2018, (E-pub ahead of print) In: The American Journal of Medical Genetics - Part A (AJMG).

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• TMEM132: an ancient architecture of cohesin and immunoglobulin domains define a new family of neural adhesion molecules

  Sanchez-Pulido, L. & Ponting, C. P., 1 Mar 2018, In: Bioinformatics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2017

  Science Forum: The Human Cell Atlas

  Human Cell Atlas Meeting Participants, Regev, A., Teichmann, S. A., Lander, E. S., Amit, I., Benoist, C., Birney, E., Bodenmiller, B., Campbell, P. J., Carninci, P., Clatworthy, M., Clevers, H., Deplancke, B., Dunham, I., Eberwine, J., Eils, R., Enard, W., Farmer, A., Fugger, L., Göttgens, B., & 31 othersHacohen, N., Haniffa, M., Hemberg, M., Kim, S. K., Klenerman, P., Kriegstein, A., Lein, E., Linnarsson, S., Lundberg, E., Lundeberg, J., Majumder, P., Marioni, J. C., Merad, M., Mhlanga, M., Nawijn, M., Netea, M., Nolan, G., Pe'er, D., Phillipakis, A., Ponting, C. P., Quake, S. R., Reik, W., Rozenblatt-Rosen, O., Sanes, J. R., Satija, R., Schumacher, T. N., Shalek, A. K., Shapiro, E., Sharma, P., Shin, J. W. & Stegle, O., 5 Dec 2017, In: eLIFE. 6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gene Expression 100%
  • Physiological State 100%
  • Molecular Profiling 100%
  • Human Tissue 100%
  • Diseases 100%

• Big knowledge from big data in functional genomics

  Ponting, C., 14 Nov 2017, In: Emerging Topics in Life Sciences.

  Research output: Contribution to journal › Comment/debate

  Open Access

  File

• Biological function in the twilight zone of sequence conservation

  Ponting, C., 16 Aug 2017, In: BMC Biology.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

• ELIXIR-UK role in bioinformatics training at the national level and across ELIXIR

  Larcombe, L., Hendricusdottir, R., Attwood, T. K., Bacall, F., Beard, N., Bellis, L., Dunn, W., Hancock, J., Nenadic, A., Orengo, C., Overduin, B., Sansone, S. A., Thurston, M., Viant, M., Winder, C., Goble, C., Ponting, C. & Rustici, G., 21 Jun 2017, (E-pub ahead of print) In: F1000Research.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Identification of genetic variants affecting vitamin D receptor binding and associations with autoimmune disease

  Gallone, G., Haerty, W., Disanto, G., Ramagopalan, S. V., Ponting, C. P. & Berlanga-Taylor, A. J., 1 Jun 2017, In: Human Molecular Genetics. 26, 11, p. 2164-2176 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Receptor Binding 100%
  • Autoimmune Disease 100%
  • Genetic Divergence 100%
  • Vitamin D 100%
  • Binding Affinity 40%

• An open and transparent process to select ELIXIR Node Services as implemented by ELIXIR-UK

  Hancock, J. M., Game, A., Ponting, C. P. & Goble, C. A., 20 Mar 2017, In: F1000Research. 5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Committees 100%
  • Bioinformatics 100%
  • Continuous Process 100%
  • Nodes 100%

• Single Cell Multi-omics:multiple measurements from single cells

  Macaulay, I. C., Ponting, C. & Voet, T., Feb 2017, In: Trends in Genetics.

  Research output: Contribution to journal › Literature review › peer-review

  Open Access

  File