Research output per year
Research output per year
Personal profile
My research in a nutshell
My research group aims to understand how RNA metabolism is regulated in the central nervous system in both health and disease. A diverse range of wet and dry-lab techniques are used to achieve this (e.g human induced pluripotent stem cell culture, CLIP, single-cell RNA sequencing, gene regulatory network modelling). Accordingly, the group is positioned to work at the interface of systems biology, RNA biology and molecular neuroscience. Our on-going research programmes are focussed specifically upon ALS and autism.
Website: http://www.thesibleylab.com
Twitter: https://twitter.com/TheSibleyLab
E-mail: [email protected]
External positions
SIDB principal investigator, Simons Initiative for the Developing Brain
8 May 2019 → …
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Distinct neuroinflammatory signatures exist across genetic and sporadic amyotrophic lateral sclerosis cohorts
Rifai, O. M., O’Shaughnessy, J., Dando, O. R., Munro, A. F., Sewell, M. D. E., Abrahams, S., Waldron, F. M., Sibley, C. R. & Gregory, J. M., 14 Jul 2023, In: Brain.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice
Paterson, H., Yu, S., Artigas, N., Prado, M., Haberman, N., Wang, Y-F., Jobbins, A., Pahita, E., Mokochinski, J., Hall, Z., Guerin, M., Paulo, J., Ng, S. S., Villarroya, F., Rashid, S. T., Goff, W. L., Lenhard, B., Cebola, I., Finley, D., Gygi, S., & 2 others, 19 Dec 2022, In: Nature Metabolism. 4, 12, p. 1812-1829 39 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72‐ALS
Rifai, O. M., Longden, J., O'Shaughnessy, J., Sewell, M. D. E., Pate, J., McDade, K., Daniels, M. J. D., Abrahams, S., Chandran, S., McColl, B. W., Sibley, C. R. & Gregory, J. M., 1 Dec 2022, In: The Journal of Pathology. 258, 4, p. 366-381 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis
Taha, D., Clarke, B., Hall, C., Tyzack, G., Ziff, O., Greensmith, L., Kalmar, B., Ahmed, M., Alam, A., Thelin, E. P., Garcia, N., Helmy, A., Sibley, C. R. & Patani, R., 1 Feb 2022, In: Brain. 145, 2, p. 481-489 43 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A flexible microfluidic system for single-cell transcriptome profiling elucidates phased transcriptional regulators of cell cycle
Davey, K., Wong, D., Konopacki, F., Kwa, E., Ly, T., Fiegler, H. & Sibley, C. R., 12 Apr 2021, In: Scientific Reports. 11, 13 p., 7918.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Projects
- 12 Finished
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Understanding the molecular signature of neuronal-astrocyte-microglia crosstalk in motor neuron disease
1/05/22 → 30/04/24
Project: Research
Datasets
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Sequencing of freshly produced RNA following exposure of cells to DNA damage-inducing UV mimetic 4-hydroxyaminoquinolone (4-NQO)
Bugai, A. (Creator), Quaresma, A. J. C. (Creator), Friedel, C. C. (Creator), Lenasi, T. (Creator), Sibley, C. (Creator), Kukanja, P. (Creator), Fujinaga, K. (Creator), Blasius, M. (Creator), Hennig, T. (Creator), Ule, J. (Creator), Dölken, L. (Creator) & Barborič, M. (Creator), National Center for Biotechnology Information (Gene Expression Omnibus), 9 Apr 2019
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE110272
Dataset