Research output per year
Research output per year
- 32 results
Search results
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2023
Distinct neuroinflammatory signatures exist across genetic and sporadic amyotrophic lateral sclerosis cohorts
Rifai, O. M., O’Shaughnessy, J., Dando, O. R., Munro, A. F., Sewell, M. D. E., Abrahams, S., Waldron, F. M., Sibley, C. R. & Gregory, J. M., 14 Jul 2023, In: Brain.Research output: Contribution to journal › Article › peer-review
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2022
Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice
Paterson, H., Yu, S., Artigas, N., Prado, M., Haberman, N., Wang, Y-F., Jobbins, A., Pahita, E., Mokochinski, J., Hall, Z., Guerin, M., Paulo, J., Ng, S. S., Villarroya, F., Rashid, S. T., Goff, W. L., Lenhard, B., Cebola, I., Finley, D., Gygi, S., & 2 others, 19 Dec 2022, In: Nature Metabolism. 4, 12, p. 1812-1829 39 p.Research output: Contribution to journal › Article › peer-review
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Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72‐ALS
Rifai, O. M., Longden, J., O'Shaughnessy, J., Sewell, M. D. E., Pate, J., McDade, K., Daniels, M. J. D., Abrahams, S., Chandran, S., McColl, B. W., Sibley, C. R. & Gregory, J. M., 1 Dec 2022, In: The Journal of Pathology. 258, 4, p. 366-381 16 p.Research output: Contribution to journal › Article › peer-review
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Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis
Taha, D., Clarke, B., Hall, C., Tyzack, G., Ziff, O., Greensmith, L., Kalmar, B., Ahmed, M., Alam, A., Thelin, E. P., Garcia, N., Helmy, A., Sibley, C. R. & Patani, R., 1 Feb 2022, In: Brain. 145, 2, p. 481-489 43 p.Research output: Contribution to journal › Article › peer-review
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2021
A flexible microfluidic system for single-cell transcriptome profiling elucidates phased transcriptional regulators of cell cycle
Davey, K., Wong, D., Konopacki, F., Kwa, E., Ly, T., Fiegler, H. & Sibley, C. R., 12 Apr 2021, In: Scientific Reports. 11, 13 p., 7918.Research output: Contribution to journal › Article › peer-review
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Elucidating the cellular dynamics of the brain with single-cell RNA sequencing
Cardona-alberich, A., Tourbez, M., Pearce, S. F. & Sibley, C. R., 27 Jan 2021, (E-pub ahead of print) In: Rna biology. p. 1-22 22 p.Research output: Contribution to journal › Article › peer-review
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2019
A systems view of spliceosomal assembly and branchpoints with iCLIP
Briese, M., Haberman, N., Sibley, C., Faraway, R., Elser, A., Chakrabarti, A., Wang, Z., König, J., Perera, D., Wickramasinghe, V. O., Venkitaraman, A. R., Luscombe, N., Saieva, L., Pellizzoni, L., Smith, C., Curk, T. & Ule, J., 1 Oct 2019, In: Nature Structural & Molecular Biology. 26, 10, p. 930-940 11 p.Research output: Contribution to journal › Article › peer-review
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P-TEFb activation by RBM7 shapes a pro-survival transcriptional response to genotoxic stress
Bugai, A., Quaresma, A. J. C., Friedel, C. C., Lenasi, T., Düster, R., Sibley, C. R., Fujinaga, K., Kukanja, P., Hennig, T., Blasius, M., Geyer, M., Ule, J., Dölken, L. & Barborič, M., 18 Apr 2019, In: Molecular Cell. 74, 2, p. 254-267.e10 13 p.Research output: Contribution to journal › Article › peer-review
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2018
Exon junction complex shapes the transcriptome by repressing recursive splicing
Blazquez, L., Emmett, W., Faraway, R., Pineda, J. M. B., Bajew, S., Gohr, A., Haberman, N., Sibley, C. R., Bradley, R. K., Irimia, M. & Ule, J., 1 Nov 2018, In: Molecular Cell. 72, 3, p. 496-509.e9 14 p.Research output: Contribution to journal › Article › peer-review
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Identification of expression quantitative trait loci associated with schizophrenia and affective disorders in normal brain tissue
UK Brain Expression Consortium, 24 Aug 2018, In: PLoS Genetics. 14, 8, p. e1007607Research output: Contribution to journal › Article › peer-review
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Individual nucleotide resolution UV cross-linking and immunoprecipitation (iCLIP) to determine protein-RNA interactions
Sibley, C. R., 2018, RNA Detection: Methods and Protocols. Gaspar, I. (ed.). Springer, Vol. 1649. p. 427-454 28 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
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2017
A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models
Tyzack, G. E., Hall, C. E., Sibley, C. R., Cymes, T., Forostyak, S., Carlino, G., Meyer, I. F., Schiavo, G., Zhang, S-C., Gibbons, G. M., Newcombe, J., Patani, R. & Lakatos, A., 27 Oct 2017, In: Nature Communications. 8, 1, 17 p., 1164.Research output: Contribution to journal › Article › peer-review
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Erratum to: Insights into the design and interpretation of iCLIP experiments
Haberman, N., Huppertz, I., Attig, J., König, J., Wang, Z., Hauer, C., Hentze, M. W., Kulozik, A. E., Le Hir, H., Curk, T., Sibley, C. R., Zarnack, K. & Ule, J., 15 Aug 2017, In: Genome Biology. 18, 1, p. 154Research output: Contribution to journal › Article › peer-review
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Progressive motor neuron pathology and the role of astrocytes in a Human Stem Cell Model of VCP-Related ALS
Hall, C. E., Yao, Z., Choi, M., Tyzack, G. E., Serio, A., Luisier, R., Harley, J., Preza, E., Arber, C., Crisp, S. J., Watson, P. M. D., Kullmann, D. M., Abramov, A. Y., Wray, S., Burley, R., Loh, S. H. Y., Martins, L. M., Stevens, M. M., Luscombe, N. M., Sibley, C. R., & 4 others, 30 May 2017, In: Cell Reports. 19, 9, p. 1739-1749 11 p.Research output: Contribution to journal › Article › peer-review
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Transcript-specific characteristics determine the contribution of endo- and exonucleolytic decay pathways during the degradation of nonsense-mediated decay substrates
Ottens, F., Boehm, V., Sibley, C. R., Ule, J. & Gehring, N. H., 1 May 2017, (E-pub ahead of print) In: RNA. 23, 8, p. 1224-1236 13 p.Research output: Contribution to journal › Article › peer-review
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Insights into the design and interpretation of iCLIP experiments
Haberman, N., Huppertz, I., Attig, J., König, J., Wang, Z., Hauer, C., Hentze, M. W., Kulozik, A. E., Le Hir, H., Curk, T., Sibley, C. R., Zarnack, K. & Ule, J., 16 Jan 2017, In: Genome Biology. 18, 1, p. 7Research output: Contribution to journal › Article › peer-review
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2016
Novel RNA-based strategies for therapeutic gene silencing
Sibley, C. R., Seow, Y. & Wood, M. J. A., 14 Dec 2016, (E-pub ahead of print) In: Molecular Therapy. 18, 3, p. 466-476 11 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Lessons from non-canonical splicing
Sibley, C. R., Blazquez, L. & Ule, J., 31 May 2016, In: Nature Reviews Genetics. 17, 7, p. 407-421 15 p.Research output: Contribution to journal › Review article › peer-review
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The interaction of PRC2 with RNA or chromatin is mutually antagonistic
Beltran, M., Yates, C. M., Skalska, L., Dawson, M., Reis, F. P., Viiri, K., Fisher, C. L., Sibley, C. R., Foster, B. M., Bartke, T., Ule, J. & Jenner, R. G., 9 May 2016, (E-pub ahead of print) In: Genome Research. 26, 7, p. 896-907 12 p.Research output: Contribution to journal › Article › peer-review
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2015
Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5' splice site strength
Wickramasinghe, V. O., Gonzàlez-Porta, M., Perera, D., Bartolozzi, A. R., Sibley, C. R., Hallegger, M., Ule, J., Marioni, J. C. & Venkitaraman, A. R., 21 Sept 2015, In: Genome Biology. 16, p. 201Research output: Contribution to journal › Article › peer-review
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Recursive splicing in long vertebrate genes
Sibley, C. R., Emmett, W., Blazquez, L., Faro, A., Haberman, N., Briese, M., Trabzuni, D., Ryten, M., Weale, M. E., Hardy, J., Modic, M., Curk, T., Wilson, S. W., Plagnol, V. & Ule, J., 21 May 2015, In: Nature. 521, 7552, p. 371-375 5 p.Research output: Contribution to journal › Article › peer-review
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2014
Regulation of gene expression through production of unstable mRNA isoforms
Sibley, C. R., 11 Aug 2014, In: Biochemical Society Transactions. 42, 4, p. 1196-1205 10 p.Research output: Contribution to journal › Review article › peer-review
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iCLIP: protein-RNA interactions at nucleotide resolution
Huppertz, I., Attig, J., D'Ambrogio, A., Easton, L. E., Sibley, C. R., Sugimoto, Y., Tajnik, M., König, J. & Ule, J., Feb 2014, In: Methods. 65, 3, p. 274-287 14 p.Research output: Contribution to journal › Article › peer-review
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2013
CLIPing the brain: studies of protein-RNA interactions important for neurodegenerative disorders
Modic, M., Ule, J. & Sibley, C. R., 30 Sept 2013, In: Molecular and Cellular Neuroscience. 56, p. 429-35 7 p.Research output: Contribution to journal › Review article › peer-review
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2012
Silencing of Parkinson's disease-associated genes with artificial mirtron mimics of miR-1224
Sibley, C. R., Seow, Y., Curtis, H., Weinberg, M. S. & Wood, M. J. A., 30 Jul 2012, In: Nucleic Acids Research. 40, 19, p. 9863-75 13 p.Research output: Contribution to journal › Article › peer-review
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The greatest catch: Big game fishing for mRNA-bound proteins
Sibley, C. R., Attig, J. & Ule, J., 17 Jul 2012, In: Genome Biology. 13, 7, 163.Research output: Contribution to journal › Article › peer-review
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Artificial mirtron-mediated gene knockdown: Functional DMPK silencing in mammalian cells
Seow, Y., Sibley, C. R. & Wood, M. J. A., Jul 2012, In: RNA. 18, 7, p. 1328-37 10 p.Research output: Contribution to journal › Article › peer-review
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Mirtrons, an emerging class of atypical miRNA
Curtis, H. J., Sibley, C. R. & Wood, M. J. A., 27 Jun 2012, In: Wiley Interdisciplinary Reviews: RNA. 3, 5, p. 617-32 16 p.Research output: Contribution to journal › Review article › peer-review
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Using human pluripotent stem cells to study post-transcriptional mechanisms of neurodegenerative diseases
Patani, R., Sibley, C. R., Chandran, S. & Ule, J., 26 Jun 2012, In: Brain Research. 1462, p. 129-138 10 p.Research output: Contribution to journal › Article › peer-review
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2011
The miRNA pathway in neurological and skeletal muscle disease: implications for pathogenesis and therapy
Sibley, C. R. & Wood, M. J. A., Nov 2011, In: Journal of Molecular Medicine. 89, 11, p. 1065-77 13 p.Research output: Contribution to journal › Review article › peer-review
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Identification of allele-specific RNAi effectors targeting genetic forms of Parkinson's disease
Sibley, C. R. & Wood, M. J. A., 21 Oct 2011, In: PLoS ONE. 6, 10, p. e26194Research output: Contribution to journal › Article › peer-review
Open Access -
The biogenesis and characterization of mammalian microRNAs of mirtron origin
Sibley, C. R., Seow, Y., Saayman, S., Dijkstra, K. K., El Andaloussi, S., Weinberg, M. S. & Wood, M. J. A., 13 Sept 2011, In: Nucleic Acids Research. 40, 1, p. 438-448 11 p.Research output: Contribution to journal › Article › peer-review
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