Christopher Gregory

2023

Hijacking Homeostasis: Regulation of the Tumour Microenvironment by Apoptosis

Gregory, C. D., 8 Aug 2023, In: Immunological reviews.

Research output: Contribution to journal › Article › peer-review

Open Access

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Extracellular Vesicles Arising from Apoptosis: Forms, Functions and Applications

Gregory, C. D. & Rimmer, M., 9 Jun 2023, (E-pub ahead of print) In: Journal of Pathology. 260, 5, p. 592-608

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2022

Assembling a global database of child pneumonia studies to inform WHO pneumonia management algorithm: Methodology and applications

World Health Organization Pneumonia Research Partnership to Assess WHO Recommendation (PREPARE) study group, Martin, H., Falconer, J., Addo-Yobo, E., Aneja, S., Arroyo, L. M., Asghar, R., Awasthi, S., Banajeh, S., Bari, A., Basnet, S., Bavdekar, A., Bhandari, N., Bhatnagar, S., Bhutta, Z. A., Brooks, A., Chadha, M., Chisaka, N., Chou, M., Clara, A. W., & 59 othersColbourn, T., Cutland, C., D'Acremont, V., Echavarria, M., Gentile, A., Gessner, B., Gregory, C. J., Hazir, T., Hibberd, P. L., Hirve, S., Hooli, S., Iqbal, I., Jeena, P., Kartasasmita, C. B., King, C., Libster, R., Lodha, R., Lozano, J. M., Lucero, M., Lufesi, N., MacLeod, W. B., Madhi, S. A., Mathew, J. L., Maulen-Radovan, I., McCollum, E. D., Mino, G., Mwansambo, C., Neuman, M. I., Nguyen, N. T. V., Nunes, M. C., Nymadawa, P., O'Grady, K-A. F., Pape, J-W., Paranhos-Baccala, G., Patel, A., Picot, V. S., Rakoto-Andrianarivelo, M., Rasmussen, Z., Rouzier, V., Russomando, G., Ruvinsky, R. O., Sadruddin, S., Saha, S. K., Santosham, M., Singhi, S., Soofi, S., Strand, T. A., Sylla, M., Thamthitiwat, S., Thea, D. M., Turner, C., Vanhems, P., Wadhwa, N., Wang, J., Zaman, S. M., Campbell, H., Nair, H., Qazi, S. A. & Nisar, Y. B., 29 Dec 2022, In: Journal of Global Health. 12, p. 04075

Research output: Contribution to journal › Article › peer-review

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The Apoptosis Paradox in Cancer

Morana, O., Wood, W. & Gregory, C. D., 25 Jan 2022, In: International Journal of Molecular Sciences. 23, 3, p. 1328

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2021

The transformative impact of extracellular vesicles on developing sperm

Rimmer, M., Gregory, C. D. & Mitchell, R. T., 21 Jul 2021, In: Reproduction & Fertility. 2, 3, p. R51–R66 16 p.

Research output: Contribution to journal › Article › peer-review

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Extracellular vesicles in urological malignancies

Rimmer, M. P., Gregory, C. D. & Mitchell, R. T., 18 May 2021, In: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1876, 1, 30 p., 188570.

Research output: Contribution to journal › Article › peer-review

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2020

Potential oncogenic effect of the MERTK-dependent apoptotic-cell clearance pathway in starry-sky B-cell lymphoma

Farnworth-McHugh, S., Barth, N., Melville, L., Paterson, M., Lynch, C., Holland, P., Dransfield, I. & Gregory, C. D., 20 Aug 2020, In: Frontiers in Immunology. 11, 8, 8 p., 1759.

Research output: Contribution to journal › Article › peer-review

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2019

Moving beyond size and phosphatidylserine exposure: evidence for a diversity of apoptotic cell-derived extracellular vesicles in vitro

Poon, I. K. H., Parkes, M. A. F., Jiang, L., Atkin-smith, G. K., Tixeira, R., Gregory, C. D., Ozkocak, D. C., Rutter, S. F., Caruso, S., Santavanond, J. P., Paone, S., Shi, B., Hodge, A. L., Hulett, M. D., Chow, J. D. Y., Phan, T. K. & Baxter, A. A., 26 Apr 2019, (E-pub ahead of print) In: Journal of Extracellular Vesicles. 8, 1, p. 1608786

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An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade

Vuong, L., Kouverianou, E., Rooney, C. M., McHugh, B. J., Howie, S. E. M., Gregory, C. D., Forbes, S. J., Henderson, N. C., Zetterberg, F. R., Nilsson, U. J., Leffler, H., Ford, P., Pedersen, A., Gravelle, L., Tantawi, S., Schambye, H., Sethi, T. & MacKinnon, A. C., 1 Apr 2019, In: Cancer Research. 79, 7, p. 1480-1492

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2018

Editorial: The Immunomodulatory Properties of Extracellular Vesicles From Pathogens, Immune Cells, and Non-immune Cells

Poon, I. K. H., Gregory, C. D. & Kaparakis-liaskos, M., 19 Dec 2018, In: Frontiers in Immunology. 9

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Open Access

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TCTP in Extracellular Vehicles: Dangerous Cargo?

Jandl, K., Gregory, C. D. & Kwapiszewska, G., 20 Jun 2018, In: American Journal of Respiratory Cell and Molecular Biology.

Research output: Contribution to journal › Article › peer-review

Open Access

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Apoptotic Tumor Cell-Derived Extracellular Vesicles as Important Regulators of the Onco-Regenerative Niche

Gregory, C. D. & Dransfield, I., 23 May 2018, In: Frontiers in Immunology. 9, p. 1111

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The STAT3-IL10-IL6 pathway is a novel regulator of macrophage efferocytosis and phenotypic conversion in sterile liver injury

Campana, L., Starkey Lewis, P., Pellicoro, A., Aucott, R., Man, J., O'Duibhir, E., Mok, S. E., Ferreira-Gonzalez, S., Livingstone, E., Greenhalgh, S., Hull, K. L., Kendall, T. J., Vernimmen, D., Henderson, N. C., Boulter, L., Gregory, C. D., Feng, Y., Anderton, S. M., Forbes, S. J. & Iredale, J. P., Feb 2018, In: The Journal of Immunology. 200, 3, p. 1169-1187

Research output: Contribution to journal › Article › peer-review

Open Access

2017

An apoptosis-driven “onco-regenerative niche”: roles of tumour-associated macrophages and extracellular vesicles

Gregory, C. & Paterson, M., 20 Nov 2017, (E-pub ahead of print) In: Philosophical Transactions of the Royal Society B: Biological Sciences.

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Extracellular Vesicles Arising from Apoptotic Cells in Tumors: Roles in Cancer Pathogenesis and Potential Clinical Applications

Lynch, C., Panagopoulou, M. & Gregory, C. D., 22 Sept 2017, In: Frontiers in Immunology. 8

Research output: Contribution to journal › Article › peer-review

Open Access

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Modulation of macrophage antitumor potential by apoptotic lymphoma cells

Voss, J. J. L. P., Ford, C. A., Petrova, S., Melville, L., Paterson, M., Pound, J. D., Holland, P., Giotti, B., Freeman, T. C. & Gregory, C. D., Jun 2017, In: Cell Death & Differentiation (CDD). 24, 6, p. 971-983 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2016

A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies

Subiros-funosas, R., Mendive-tapia, L., Sot, J., Pound, J. D., Barth, N., Varela, Y., Goñi, F., Paterson, M., Gregory, C. D., Albericio, F., Dransfield, I., Lavilla Grifols, R. & Vendrell, M., 15 Dec 2016, (E-pub ahead of print) In: Chemical Communications.

Research output: Contribution to journal › Article › peer-review

Open Access

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Vasopressin Regulates Extracellular Vesicle Uptake by Kidney Collecting Duct Cells

Oosthuyzen, W., Scullion, K. M., Ivy, J. R., Morrison, E. E., Hunter, R. W., Starkey Lewis, P. J., O'Duibhir, E., Street, J. M., Caporali, A., Gregory, C. D., Forbes, S. J., Webb, D. J., Bailey, M. A. & Dear, J. W., Nov 2016, In: Journal of the American Society of Nephrology. 27, 11, p. 3345-3355

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Open Access

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2015

Oncogenic Properties of Apoptotic Tumor Cells in Aggressive B Cell Lymphoma

Ford, C. A., Petrova, S., Pound, J. D., Voss, J. J. L. P., Paterson, M., Farnworth, S. L., Gallimore, A. M., Cuff, S., Wheadon, H., Dobbin, E., Ogden, C. A., Dumitriu, I. E., Dunbar, D. R., Murray, P. G., Ruckerl, D., Allen, J. E., Hume, D. A., van Rooijen, N., Goodlad, J. R., Freeman, T. C., & 1 othersGregory, C. D., 2 Mar 2015, In: Current Biology. 25, 5, p. 577-588 12 p.

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Loading of nuclear autoantigens prototypically recognized by systemic lupus erythematosus sera into late apoptotic vesicles requires intact microtubules and myosin light chain kinase activity

Zirngibl, M., Fuernrohr, B. G., Janko, C., Munoz, L. E., Voll, R. E., Gregory, C. D., Schett, G. & Herrmann, M., Jan 2015, In: Clinical & Experimental Immunology. 179, 1, p. 39-49 11 p.

Research output: Contribution to journal › Article › peer-review

2014

Sinister self-sacrifice: the contribution of apoptosis to malignancy

Willems, J. J. L. P., Arnold, B. P. & Gregory, C. D., 4 Jul 2014, In: Frontiers in Immunology. 5, p. 299

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Open Access

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Macrophages Engulfing Apoptotic Cells Produce Nonclassical Retinoids To Enhance Their Phagocytic Capacity

Sarang, Z., Joós, G., Garabuczi, É., Rühl, R., Gregory, C. D. & Szondy, Z., 15 Jun 2014, In: The Journal of Immunology. 192, 12, p. 5730-5738 9 p.

Research output: Contribution to journal › Article › peer-review

CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist

Sarvi, S., Mackinnon, A. C., Avlonitis, N., Bradley, M., Rintoul, R. C., Rassl, D. M., Wang, W., Forbes, S. J., Gregory, C. D. & Sethi, T., Mar 2014, In: Cancer Research. 74, 5, p. 1554-1565 12 p.

Research output: Contribution to journal › Article › peer-review

2013

Quantification of human urinary exosomes by nanoparticle tracking analysis

Oosthuyzen, W., Sime, N. E. L., Ivy, J., Turtle, E. J., Street, J. M., Pound, J., Bath, L. E., Webb, D. J., Gregory, C. D., Bailey, M. A. & Dear, J. W., 1 Dec 2013, In: The Journal of Physiology. 591, Pt 23, p. 5833-42 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Coexpression analysis of large cancer datasets provides insight into the cellular phenotypes of the tumour microenvironment

Doig, T., Hume, D. A., Theocharidis, T., Goodlad, J., Gregory, C. D. & Freeman, T. C., 11 Jul 2013, In: BMC Genomics. 14, n/a, 469.

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Innate recognition of apoptotic cells: novel apoptotic cell-associated molecular patterns revealed by crossreactivity of anti-LPS antibodies

Tennant, I., Pound, J. D., Marr, L. A., Willems, J. J. L. P., Petrova, S., Ford, C. A., Paterson, M., Devitt, A. & Gregory, C. D., 2013, In: Cell Death & Differentiation (CDD). 20, 5

Research output: Contribution to journal › Article › peer-review

2012

Pure populations of murine macrophages from cultured embryonic stem cells. Application to studies of chemotaxis and apoptotic cell clearance

Zhuang, L., Pound, J. D., Willems, J. J. L. P., Taylor, A. H., Forrester, L. M. & Gregory, C. D., 30 Nov 2012, In: Journal of Immunological Methods. 385, 1-2, p. 1-14 14 p.

Research output: Contribution to journal › Article › peer-review

2011

Leukocyte migratory responses to apoptosis: the attraction and the distraction

Gregory, C. D., Rossi, A. G., Bournazou, I., Zhang, L. & Willems, J. J. L. P., 2011, In: Cell Adhesion and Migration. 5, 4, p. 293-7 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Time evolution of collisionless shock in counterstreaming laser-produced plasmas

Kuramitsu, Y., Sakawa, Y., Morita, T., Gregory, C. D., Waugh, J. N., Dono, S., Aoki, H., Tanji, H., Koenig, M., Woolsey, N. & Takabe, H., 2011, In: Physical Review Letters. 106, 17, p. 175002

Research output: Contribution to journal › Article › peer-review

2010

Microenvironmental influences of apoptosis in vivo and in vitro

Gregory, C. D. & Pound, J. D., Sept 2010, In: Apoptosis. 15, 9, p. 1029-1049 21 p.

Research output: Contribution to journal › Article › peer-review

Inhibition of eosinophil migration by lactoferrin

Bournazou, I., Mackenzie, K. J., Duffin, R., Rossi, A. G. & Gregory, C. D., Feb 2010, In: Immunology & Cell Biology. 88, 2, p. 220-223 4 p.

Research output: Contribution to journal › Article › peer-review

2009

TGF-beta induces apoptosis in human B cells by transcriptional regulation of BIK and BCL-XL

Spender, L. C., O'Brien, D. I., Simpson, D., Dutt, D., Gregory, C. D., Allday, M. J., Clark, L. J. & Inman, G. J., Apr 2009, In: Cell Death & Differentiation (CDD). 16, 4, p. 593-602 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Trappin-2 promotes early clearance of Pseudomonas aeruginosa through CD14-dependent macrophage activation and neutrophil recruitment

Wilkinson, T. S., Dhaliwal, K., Hamilton, T. W., Lipka, A. F., Farrell, L., Davidson, D. J., Duffin, R., Morris, A. C., Haslett, C., Govan, J. R. W., Gregory, C. D., Sallenave, J-M. & Simpson, A. J., Apr 2009, In: The American Journal of Pathology. 174, 4, p. 1338-1346 9 p.

Research output: Contribution to journal › Article › peer-review

Human Dendritic Cells Produce TGF-beta 1 under the Influence of Lung Carcinoma Cells and Prime the Differentiation of CD4(+)CD25(+)Foxp3(+) Regulatory T Cells

Dumitriu, I. E., Dunbar, D. R., Howie, S. E., Sethi, T. & Gregory, C. D., 1 Mar 2009, In: The Journal of Immunology. 182, 5, p. 2795-2807 13 p.

Research output: Contribution to journal › Article › peer-review

Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin

Bournazou, I., Pound, J. D., Duffin, R., Bournazos, S., Melville, L. A., Brown, S. B., Rossi, A. G. & Gregory, C. D., Jan 2009, In: Journal of Clinical Investigation. 119, 1, p. 20-32 13 p.

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Open Access

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Direct density measurement of shock-compressed iron using hard x rays generated by a short laser pulse

Brambrink, E., Wei, H. G., Barbrel, B., Audebert, P., Benuzzi-Mounaix, A., Boehly, T., Endo, T., Gregory, C. D., Kimura, T., Kodama, R., Ozaki, N., Park, H-S. & Koenig, M., 2009, In: Physical Review E. 80, 5 Pt 2, p. 056407

Research output: Contribution to journal › Article › peer-review

Effect of reentrant cone geometry on energy transport in intense laser-plasma interactions

Lancaster, K. L., Sherlock, M., Green, J. S., Gregory, C. D., Hakel, P., Akli, K. U., Beg, F. N., Chen, S. N., Freeman, R. R., Habara, H., Heathcote, R., Hey, D. S., Highbarger, K., Key, M. H., Kodama, R., Krushelnick, K., Nakamura, H., Nakatsutsumi, M., Pasley, J., Stephens, R. B., & 9 othersStorm, M., Tampo, M., Theobald, W., Van Woerkom, L., Weber, R. L., Wei, M. S., Woolsey, N. C., Yabuuchi, T. & Norreys, P. A., 2009, In: Physical Review E. 80, 4 Pt 2, p. 045401

Research output: Contribution to journal › Article › peer-review

Inhibitory effects of persistent apoptotic cells on monoclonal antibody production in vitro: simple removal of non-viable cells improves antibody productivity by hybridoma cells in culture

Gregory, C. D., Pound, J. D., Devitt, A., Wilson-Jones, M., Ray, P. & Murray, R. J., 2009, In: mAbs. 1, 4, p. 370-6 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2008

CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

Truman, L. A., Ford, C. A., Pasikowska, M., Pound, J. D., Wilkinson, S. J., Dumitriu, I. E., Melville, L., Melrose, L. A., Ogden, C. A., Nibbs, R., Graham, G., Combadiere, C. & Gregory, C. D., 15 Dec 2008, In: Blood. 112, 13, p. 5026-5036 11 p.

Research output: Contribution to journal › Article › peer-review

2006

"Dirty little secrets"--endotoxin contamination of recombinant proteins

Wakelin, S. J., Sabroe, I., Gregory, C. D., Poxton, I. R., Forsythe, J. L. R., Garden, O. J. & Howie, S. E. M., 15 Jul 2006, In: Immunology Letters. 106, 1, p. 1-7 7 p.

Research output: Contribution to journal › Article › peer-review

2005

Enhanced apoptotic cell clearance capacity and B cell survival factor production by IL-10-activated macrophages: implications for Burkitt's lymphoma

Ogden, C. A., Pound, J. D., Batth, B. K., Owens, S., Johannessen, I., Wood, K. & Gregory, C. D., 1 Mar 2005, In: The Journal of Immunology. 174, 5, p. 3015-23 9 p.

Research output: Contribution to journal › Article › peer-review

2004

Persistence of apoptotic cells without autoimmune disease or inflammation in CD14-/- mice

Devitt, A., Parker, K. G., Ogden, C. A., Oldreive, C., Clay, M. F., Melville, L. A., Bellamy, C. O., Lacy-Hulbert, A., Gangloff, S. C., Goyert, S. M. & Gregory, C. D., 20 Dec 2004, In: Journal of Cell Biology. 167, 6, p. 1161-70 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Macrophage chemotaxis to apoptotic Burkitt's lymphoma cells in vitro: role of CD14 and CD36

Truman, L. A., Ogden, C. A., Howie, S. E. M. & Gregory, C. D., 2004, In: Immunobiology. 209, 1-2, p. 21-30 10 p.

Research output: Contribution to journal › Article › peer-review

1999

The differentiation of semantic dementia and frontal lobe dementia (temporal and frontal variants of frontotemporal dementia) from early Alzheimer's disease: a comparative neuropsychological study

Hodges, J. R., Patterson, K., Ward, R., Garrard, P., Bak, T., Perry, R. & Gregory, C., 1999, In: Cognitive Neuropsychology. 13, 1, p. 31-40 10 p.

Research output: Contribution to journal › Article › peer-review

Christopher Gregory

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