Christopher Haslett

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• Active

  Clinical Validation of Optical Molecular Alveoscopy for the Immediate Bed-Side Diagnosis of Pneumonia in the Intensive Care Unit

  Dhaliwal, K., Akram, A., Craven, T., Haslett, C., Parker, R., Walsh, T. & Williams, C.

  UK-based charities

  1/07/20 → 1/07/26

  Project: Research

  • Keratitis 100%
  • Enalapril Maleate 100%
  • Bacterium 100%
  • Point of Care Systems 100%
  • Ex Vivo 42%
• Finished

  EPSRC IRC Proteus - Multiplexed 'Touch and Tell' Optical Molecular Sensing and Imaging - Lifetime and Beyond

  Bradley, M., Bradley, M., Dhaliwal, K., Dhaliwal, K., Haslett, C., Henderson, R., Walsh, T. & Walsh, T.

  Engineering and Physical Sciences Research Council

  1/01/19 → 1/06/23

  Project: Research

• EPSRC IRC Proteus - Multiplexed 'Touch And Tell' Optical Molecular Sensing And Imaging - Lifetime And Beyond

  Dhaliwal, K., Haslett, C. & Walsh, T.

  EPSRC

  1/01/19 → 1/06/23

  Project: Research

  • Lifespan 100%
  • Fluorescence 100%
  • Time 83%
  • Fluorescence Lifetime 75%
  • Sensor 70%

• Interventional Biophotonics ¿¿¿ A UK Healthcare Technology Accelerator Facility

  Dhaliwal, K., Bradley, M., Bruce, A., Garden, J., Haslett, C., Henderson, R., Mair, J., Moore, A., Newby, D., Tait, J. & Walsh, T.

  MRC

  1/03/18 → 29/02/20

  Project: Research

• Proteus Participation in CARB-X

  Walsh, T., Dhaliwal, K. & Haslett, C.

  Non-EU other

  1/04/17 → 31/07/19

  Project: Research

  • Confocal Laser Scanning Microscopy 100%
  • Ex Vivo 100%
  • Bacterium 100%
  • Tissues 100%
  • Lung 100%

• Optimising Innate Host Defence to Combat Antimicrobial Resistance

  Dockrell, D., Baillie, K., Bradley, M., Brown, H., Dhaliwal, K., Fitzgerald, R., Haslett, C., Hume, D., Rossi, A., Walmsley, S. & Whyte, M.

  MRC

  1/12/16 → 30/11/22

  Project: Research

  • Staphylococcus Aureus 100%
  • Staphylococcus aureus 95%
  • Mouse Model 71%
  • Clone 64%
  • Host 63%

• Ahsan Akram - Scottish Alliance Framework Agreement

  Frame, M., Ball, K., Brunton, V. & Haslett, C.

  UK industry, commerce and public corporations

  1/09/14 → 31/07/17

  Project: Research

• Ahsan Akram - Scottish Alliance Framework Agreement

  Haslett, C.

  Scottish Power

  1/09/14 → 31/08/15

  Project: Research

• Molecular Probes to Define the Pulmonary Macrophage Response in Rat and Man

  Dhaliwal, K., Haslett, C. & Vendrell Escobar, M.

  UK central government bodies/local authorities, health and hospital authorities

  15/12/13 → 14/06/14

  Project: Research

• Multiplexed 'Touch and Tell' Optical Molecular Sensing and Imaging

  Haslett, C.

  EPSRC

  1/10/13 → 31/03/19

  Project: Research

  • pH 100%
  • Lung 83%
  • Fiber 66%
  • Surface Enhanced Raman Spectroscopy 66%
  • Optics 66%

• DEVELOPMENTAL CLINICAL STUDIES-VALIDATION OF THE UTILITY OF A NOVEL SMARTPROBE DETECTING NEUTROPHIL ACTIVATION/ELASTASE ACTIVITY IN ACUTE LUNG INJURY

  Haslett, C., Dhaliwal, K. & Walsh, T.

  MRC

  1/08/13 → 31/07/16

  Project: Research

  • Lung 100%
  • Neutrophil 59%
  • Imaging Technique 59%
  • Obstetric Delivery 59%
  • Patient 59%

• The role of cyclin-dependent kinase-9 inhibition in promoting the resolution of chronic inflammation

  Rossi, A. & Haslett, C.

  MRC

  1/05/13 → 30/10/19

  Project: Research

  • Neutrophil 100%
  • Neutrophil Granulocyte 88%
  • Serositis 83%
  • Cells 69%
  • Inflammation 62%

• A new paradigm for testing pathway tractability in lung disease

  Hirani, N., Dhaliwal, K. & Haslett, C.

  MRC

  1/05/13 → 30/06/17

  Project: Research

  • Neutrophil 100%
  • Autofluorescence 55%
  • Randomized Controlled Trial 55%
  • Cytokine Production 55%
  • Pneumonia 55%

• Molecular Optical Imaging of Key Targets in the Fibrogenic Pathway in Man

  Bradley, M., Dhaliwal, K., Haslett, C., Hirani, N. & McGorum, B.

  MRC

  1/09/12 → 31/12/15

  Project: Research

  • Lung 100%
  • Optics 99%
  • Tissues 80%
  • Thrombin 59%
  • Probe 55%

• Immediate Point of Care Molecular Diagnostics for Lung Inflammation/Infection in Critical Care

  Haslett, C. & Bradley, M.

  UK-based charities

  1/09/11 → 30/04/16

  Project: Research

• THE AMY-LTAB TRANSGENIC MOUSE MODEL OF TERTIARY LYMPHOID PRGAN-INDUCED NON-HODGLIN'S LYMPHOMA

  Haslett, C.

  UK-based charities

  1/07/11 → 30/06/13

  Project: Research

• In vivo Chemistry

  Bradley, M., Frame, M. & Haslett, C.

  EPSRC

  1/12/10 → 29/02/12

  Project: Research

• LSRll Flow Cytometer and a FACSAria II Cell Sorter for QMRI

  Anderton, S., Ffrench-Constant, C., Gregory, C., Haslett, C. & Saunders, P.

  UK-based charities

  1/02/10 → 31/01/15

  Project: Research

  • Immunotherapy 100%
  • Antigen 50%
  • Experimental Autoimmune Encephalomyelitis 50%
  • Peptide 50%
  • T Cell 37%

• Functional Optical Imagingin Mouse and Man

  Mole, D., Auer, M., Bradley, M., Dhaliwal, K., Harrison, E., Haslett, C., Mowat, C., Simpson, J., Walkinshaw, M. & Wigmore, S.

  MRC

  1/10/09 → 31/03/12

  Project: Research

  • Flow 100%
  • Cell Labeling 100%
  • Cellular Imaging 100%
  • Peptoid 100%
  • Serine Protease 100%

• Molecular Imaging in the Lung

  Haslett, C. & Newby, D.

  UK-based charities

  1/04/09 → 31/03/10

  Project: Research

• Multimodal smart imaging of critical inflammatory processes in murine models of pulmonary fibrosis

  Haslett, C., Bradley, M. & Simpson, J.

  MRC

  2/02/09 → 1/02/12

  Project: Research

  • Fluorescein 100%
  • Inflammation 75%
  • Peptoid 50%
  • Fluorescence Resonance Energy Transfer 50%
  • Cellular Imaging 50%

• CDK inhibition therapy and potential for novel imaging biomarkers in idiopathic pulmonary fibrosisCDK inhibition therapy and potential for novel imaging biomarkers in idiopathic pulmonary fibrosis

  Haslett, C., Hirani, N. & Rossi, A.

  MRC

  1/12/08 → 30/11/11

  Project: Research

  • Programmed Cell Death 100%
  • Eosinophil 100%
  • Allergic Inflammation 100%
  • Cyclin Dependent Kinase Inhibitor 100%
  • Serositis 31%

• Clinical Research Imaging Centre

  Newby, D., Bastin, M., Critchley, H., Deary, I., Fox, K., Haslett, C., Johnstone, E., Seckl, J., Walker, B., Wardlaw, J. & Wilmut, I.

  MRC

  1/08/08 → 31/07/13

  Project: Research

  • Magnetic Resonance Imaging 100%
  • Patient 83%
  • Diagnosis 70%
  • Aortic Stenosis 70%
  • Image Quality 70%

• The role of Mcl-1 in CDK inhibitor-mediated neutrophil apoptosis and enhanced resolution of bleomycin induced lung injury

  Rossi, A. & Haslett, C.

  UK-based charities

  1/11/07 → 31/10/10

  Project: Research

• Regulation of pulmonary inflammation : the role of P2X7 receptors in LL-37-mediated control of granulocyte apoptosis and function

  Davidson, D. & Haslett, C.

  1/10/07 → 30/09/11

  Project: University Awarded Project Funding

• can long term nebulised gentamicin reduce the bacterial burden, break the vicious cycle of inflammation and improve quality of life in patients with brochiectasis

  Simpson, J., Govan, J. & Haslett, C.

  UK central government bodies/local authorities, health and hospital authorities

  1/05/07 → 30/06/10

  Project: Research

• The role of the human cathelicidin LL-37 as an immunomodulator in infcetious lung disease. RCD Fellowship for Dr D J Davidson

  Haslett, C.

  UK-based charities

  1/03/06 → 28/02/10

  Project: Research

• The role of macrophaged in ischaemic acute renal failure.

  Haslett, C.

  UK-based charities

  1/10/05 → 30/09/08

  Project: Research

• Shert/Cruden Medical Research Scholarship Dr A MacDuff: The role of the tissue macrophage in the sensing and regulation of hypoxic/hyperoxic tissue injury

  Haslett, C.

  UK-based charities

  1/11/04 → 30/07/06

  Project: Research

• Edinburgh centre for inflammation research

  Savill, J. & Haslett, C.

  MRC

  30/09/04 → 30/09/10

  Project: Research

  • Hydroxysteroid Dehydrogenase 100%
  • Glucocorticoid 92%
  • Mast Cell Degranulation 50%
  • 11beta Hydroxysteroid Dehydrogenase 1 50%
  • Mast Cell 50%

• Internationl Prize Fellowship for Donald J Davidson: The role of host defence peptide LL-37 in modulation cell differentitation ans the inate and acquired host immune responses

  Haslett, C.

  UK-based charities

  1/08/04 → 30/07/06

  Project: Research

• Elafin overexpression and myocardial protection.

  Gray, G., Haslett, C., Sallenave, J. & Webb, D.

  UK-based charities

  1/07/03 → 30/06/04

  Project: Research

• Activation and increased longevity of Eosinophils in Hypoxic conditions

  Rossi, A., Dransfield, I. & Haslett, C.

  UK-based charities

  1/07/02 → 30/06/05

  Project: Research

  • Neutrophil 100%
  • Glucocorticoid 100%
  • Survival 100%
  • Oxygen 100%
  • Aptitude 100%

• Mechanisms underlying RAF medicated integrin suppression

  Sethi, T., Haslett, C. & Lad, Y.

  UK-based charities

  1/05/02 → 30/04/04

  Project: Research

• Fellowship - Dr Stuart McKechnie

  Harrison, D., Haslett, C. & Salter, D.

  UK-based charities

  1/04/02 → 31/03/05

  Project: Research

• Role of protein inhibitors in innate immunity

  Sallenave, J. & Haslett, C.

  UK-based charities

  1/02/02 → 31/01/05

  Project: Research

• New Programme Grant to pump-prime Pulmonary Cellular & Molecular Imagining in Edinburgh

  Haslett, C.

  Other

  1/02/02 → 30/06/13

  Project: Research

• Use od Adeno-associated virus (AAV) as a gene delivery vector in murine emphyema models.

  Sallenave, J. & Haslett, C.

  Other

  1/12/01 → 30/11/03

  Project: Research

• FELLOWSHIP DR S HART

  Haslett, C.

  MRC

  1/10/01 → 30/09/06

  Project: Research

• Fellowship - Dr J McCafferty

  Haslett, C. & McCafferty, J.

  UK-based charities

  1/08/01 → 31/07/03

  Project: Research

• Prize Fellowship for Marta Corsin-Jiminez

  Haslett, C.

  UK-based charities

  1/03/01 → 31/12/02

  Project: Research

• Lung epithelial cell protection mechanisms in sequential hypoxic/hyperoxic injury

  Haslett, C. & Harrison, D.

  UK-based charities

  1/02/01 → 31/01/04

  Project: Research

• The sheep as a model for antiprotease gene therapy in emphysema

  Collie, D., Haslett, C. & Sallenave, J.

  UK-based charities

  1/10/00 → 30/09/05

  Project: Research

• Clinical Training Fellowship for Dr L Murray. The role of neutrophil death factors (including Fas/Fas-ligand) in the control of

  Haslett, C.

  MRC

  1/08/00 → 31/07/03

  Project: Research

• Genetic augmentation of small molecular weight antiproteinases as a cytoprotective strategy in inflammatory lung injury

  Haslett, C. & Sallenave, J.

  MRC

  1/06/00 → 31/05/03

  Project: Research

• BACTERIAL INFECTION - LUNG

  Haslett, C.

  UK-based charities

  1/09/99 → 31/03/02

  Project: Research

• Laboratory-based test of fitness to drive

  Douglas, N., Engleman, H. & Haslett, C.

  UK-based charities

  1/08/99 → 31/07/02

  Project: Research

• LEUKOTRIENES/GRANUL APOPTOSIS

  Haslett, C. & Rossi, A.

  UK industry, commerce and public corporations

  1/12/98 → 30/11/00

  Project: Research

• Clostridium difficile and herd immunity: developing control strategies by inferential stochastic modelling

  Poxton, I., Fox, K., Haslett, C., Mullins, J., Seckl, J. & Webb, D.

  UK central government bodies/local authorities, health and hospital authorities

  1/10/98 → 30/09/01

  Project: Research

• ADV F/SHIP FOR MED & DENT GRAD

  Haslett, C.

  UK-based charities

  1/08/98 → 31/07/01

  Project: Research